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A biosensing system employing nanowell microelectrode arrays to record the intracellular potential of a single cardiomyocyte

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Microsystems & Nanoengineering 2022年第3期8卷 185-198页

作者： Yuting Xiang Haitao Liu Wenjian Yang Zhongyuan xu Yue Wu Zhajian Tang Zhjing Zhu Zhiyong Zeng Depeng Wang Tianxing Wang Ning Hu Diming Zhang Department of Obstetrics and Gynecology Affiliated Dongguan People's HospitalSouthern Medical UniversityDongguan 523058China Research Center for Inelligent Sensing Systems Zhejiang LaboratoryHangzhou 311100China Research Center for Humanoid Sensing Zhejiang LaboratoryHangzhou 311100China Key Laboratory of Novel Target and Drug Study for Neural Repair of Zhejiang Province School of MedicineSchool of Computer&Computing ScienceZhejiang University City CollegeHangzhou 310015China School of Brain Science and Brain Medicine Zhejiang UniversityHangzhou 310058China School of Automation Nanjing University of Science and TechnologyNanjing 210094China College of Energy and Power Engineering Nanjing University of Aeronautics and AstronauticsNanjing 210016China E-Link Care Meditech Co. LtdHangzhou 310011China ZJU-Hangzhou Global Scientific and Technological Innovation Center Department of ChemitryZhejiang UniversityHangzhou 310058China

Electrophysiological recording is a widely used method to investigate cardiovascular pathology,pharmacology and developmental *** arrays record the electrical potential of cells in a minimally invasive and highthroughput ***,commonly used microelectrode arays primarily employ planar microelectrodes and cannot work in applications that require a recording of the intracellular action potential of a single *** this study,we proposed a novel measuring method that is able to record the intracellular action potential of a single cardiomyocyte by using a nanowell patterned microelectrode array(NWMEA).The NWMEA consists of five nanoscale wells at the center of each circular planar *** pulse electroporation was applied to the NWMEA to penetrate the cardiomyocyte membrane,and the intracellular action potential was continuously *** intracellular potential recording of cardiomyocytes by the NWMEA measured a potential signal with a higher quality(213.76±25.85%),reduced noise root-mean-square(~33%),and higher signal-to-noise ratio(254.36±12.61%)when compared to those of the extracellular *** to previously reported nanopillar microelectrodes,the NWMEA could ensure single cell electroporation and acquire high-quality action potential of cardiomyocytes with reduced fabrication *** NWMEA-based biosensing system is a promising tool to record the intracellular action potential of a single cell to broaden the usage of microelectrode arrays in electrophysiological investigation.

关键词： arrays potential record

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A Survey of Recent Advances in Optimization Methods for Wireless Communications

arXiv

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arXiv 2024年

作者： Liu, Ya-Feng Chang, Tsung-Hui Hong, Mingyi Wu, Zheyu So, Anthony Man-Cho Jorswieck, Eduard A. Yu, Wei The State Key Laboratory of Scientific and Engineering Computing Institute of Computational Mathematics and Scientific/Engineering Computing Academy of Mathematics and Systems Science Chinese Academy of Sciences Beijing100190 China The School of Science and Engineering The Chinese University of Hong Kong Shenzhen Shenzhen China Shenzhen Research Institute of Big Data China The Department of Electrical and Computer Engineering University of Minnesota MinneapolisMN55455 United States The Department of Systems Engineering and Engineering Management The Chinese University of Hong Kong Hong Kong The Institute for Communication Technology Technische Universitat Braunschweig Germany The Edward S. Rogers Sr. Department of Electrical and Computer Engineering University of Toronto TorontoONM5S 3G4 Canada

Mathematical optimization is now widely regarded as an indispensable modeling and solution tool for the design of wireless communications systems. While optimization has played a significant role in the revolutionary progress in wireless communication and networking technologies from 1G to 5G and onto the future 6G, the innovations in wireless technologies have also substantially transformed the nature of the underlying mathematical optimization problems upon which the system designs are based and have sparked significant innovations in the development of methodologies to understand, to analyze, and to solve those problems. In this paper, we provide a comprehensive survey of recent advances in mathematical optimization theory and algorithms for wireless communication system design. We begin by illustrating common features of mathematical optimization problems arising in wireless communication system design. We discuss various scenarios and use cases and their associated mathematical structures from an optimization perspective. We then provide an overview of recently developed optimization techniques in areas ranging from nonconvex optimization, global optimization, and integer programming, to distributed optimization and learning-based optimization. The key to successful solution of mathematical optimization problems is in carefully choosing or developing suitable algorithms (or neural network architectures) that can exploit the underlying problem structure. We conclude the paper by identifying several open research challenges and outlining future research directions. Copyright © 2024, The Authors. All rights reserved.

关键词： Beamforming

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computing Truncated Joint Approximate Eigenbases for Model Order Reduction

arXiv

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arXiv 2022年

作者： Loring, Terry Vides, Fredy Department of Mathematics and Statistics University of New Mexico Albuquerque United States Scientific Computing Innovation Center School of Mathematics and Computer Science Universidad Nacional Autónoma de Honduras Tegucigalpa Honduras

In this document, some elements of the theory and algorithmics corresponding to the existence and computability of approximate joint eigenpairs for finite collections of matrices with applications to model order reduction, are presented. More specifically, given a finite collection $X_1,\ldots,X_d$ of Hermitian matrices in $\mathbb{C}^{n\times n}$, a positive integer $r\ll n$, and a collection of complex numbers $\hat{x}_{j,k}\in \mathbb{C}$ for $1\leq j\leq d$, $1\leq k\leq r$. First, we study the computability of a set of $r$ vectors $w_1,\ldots,w_r\in \mathbb{C}^{n}$, such that $w_k=\arg\min_{w\in \mathbb{C}^n}\sum_{j=1}^d\|X_jw-\hat{x}_{j,k} w\|^2$ for each $1\leq k \leq r$, then we present a model order reduction procedure based on the truncated joint approximate eigenbases computed with the aforementioned techniques. Some prototypical algorithms together with some numerical examples are presented as well. Copyright © 2022, The Authors. All rights reserved.

关键词： Matrix algebra

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Immersive Embedded Consumer Model Leveraging AI with Zero-Trust Architecture for Cyber-Physical System

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IEEE Transactions on Consumer Electronics 2025年

作者： Rehman, Amjad Haseeb, Khalid Kolivand, Hoshang Saba, Tanzila Al-Khasawneh, Mahmoud A. Ahmad, Shabir Ullah, Inam Lab Riyadh12435 Saudi Arabia Liverpool John Moores University School of Computer Science and Mathematics United Kingdom School of Computing and Digital Technologies Staffordshire University Liverpool Staffordshire United Kingdom University City Sharjah 1797 United Arab Emirates Hourani Center for Applied Scientific Research Al-Ahliyya Amman University Jordan School of Computing Skyline University College Sharjah United Arab Emirates Incheon Startup Park Center of Artificial Intelligence for Medical Instruments Convensia-daero Incheon204 Korea Republic of Gachon University Department of Computer Engineering Seongnam13120 Korea Republic of

The rapid expansion of the wireless network and its combination with the Consumer Internet of Things (CIoT) has introduced significant research challenges for Cyber-Physical Systems (CPS). The distributed nature of these embedded networks provides big data analytics with the integration of sensors, electronic devices, hardware, and network components. They provide diverse functionalities while sensing the observing environment based on the demand of network users with timely feedback, which supports efficient decision-making. However, CIoT devices in CPS increasingly interact with both physical and digital environments, such interaction raises the research challenges of performance optimization, data breaches, and long-run seamless connectivity. In addition, the constraint devices demanded lightweight communication methods to remain robust and enhance network stability. This paper presents an adaptive model that leverages AI-based optimization techniques with efficient data management and utilization of resources in consumer applications. Moreover, the integrated edges provide consistency and resilience of communication services in unpredictable systems, while adopting a Zero-Trust architecture with more trustworthy and secure transmissions. It increases the system's scalability and improves the response time with the limited computing power of devices for real-time processing. Simulation results demonstrated the significant outcomes of the proposed model over the dynamic scenarios for packet delivery ratio by 35.5%, network throughput by 38.7%, energy consumption by 41.6%, and latency by 45% against existing solutions. © 1975-2011 IEEE.

关键词： consumer technologies edge intelligence embedded systems information security technological development

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Stochastic Optimisation Framework using the Core Imaging Library and Synergistic Image Reconstruction Framework for PET Reconstruction

arXiv

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arXiv 2024年

作者： Papoutsellis, Evangelos da Costa-Luis, Casper Deidda, Daniel Delplancke, Claire Duff, Margaret Fardell, Gemma Gillman, Ashley Jorgensen, Jakob S. Kereta, Zeljko Ovtchinnikov, Evgueni Pasca, Edoardo Schramm, Georg Thielemans, Kris Finden Ltd Rutherford Appleton Laboratory Harwell Campus United Kingdom Scientific Computing Department Science & Technology Facilities Council Harwell Campus United Kingdom National Physical Laboratory Electricité de France Research and Development France Australian e-Health Res. Ctr. CSIRO BrisbaneQLD Australia Department of Applied Mathematics and Computer Science Technical University of Denmark Denmark Department of Computer Science University College London United Kingdom Department of Imaging and Pathology Division of Nuclear Medicine KU Leuven Leuven Belgium Institute of Nuclear Medicine University College London United Kingdom

We introduce a stochastic framework into the open- source Core Imaging Library (CIL) which enables easy development of stochastic algorithms. Five such algorithms from the literature are developed, Stochastic Gradient Descent, Stochastic Average Gradient (-Amélioré), (Loopless) Stochastic Variance Reduced Gradient. We showcase the functionality of the framework with a comparative study against a deterministic algorithm on a simulated 2D PET dataset, with the use of the open-source Synergistic Image Reconstruction Framework. We observe that stochastic optimisation methods can converge in fewer passes of the data than a standard deterministic algorithm1. © 2024, CC BY.

关键词： Positron emission tomography

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Eliminating Order Reduction on Linear, Time-Dependent ODEs with GARK Methods

arXiv

引用

arXiv 2022年

作者： Roberts, Steven Sandu, Adrian Center for Applied Scientific Computing Lawrence Livermore National Laboratory LivermoreCA United States Computational Science Laboratory Department of Computer Science Virginia Tech 2202 Kraft Dr. BlacksburgVA24060 United States

When applied to stiff, linear differential equations with time-dependent forcing, Runge-Kutta methods can exhibit convergence rates lower than predicted by the classical order condition theory. Commonly, this order reduction phenomenon is addressed by using an expensive, fully implicit Runge-Kutta method with high stage order or a specialized scheme satisfying additional order conditions. This work develops a flexible approach of augmenting an arbitrary Runge-Kutta method with a fully implicit method used to treat the forcing such as to maintain the classical order of the base scheme. Our methods and analyses are based on the general-structure additive Runge-Kutta framework. Numerical experiments using diagonally implicit, fully implicit, and even explicit Runge-Kutta methods confirm that the new approach eliminates order reduction for the class of problems under consideration, and the base methods achieve their theoretical orders of *** Codes 65L04, 65L20 Copyright © 2022, The Authors. All rights reserved.

关键词： Runge Kutta methods

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Optimizing wastewater treatment plant operations: a machine learning approach for energy consumption and climate dynamics analysis

Optimizing wastewater treatment plant operations: a machine ...

引用

8th IET Smart Cities Symposium (SCS 2024)

作者： Mahmoud Elshabrawy Faris H. Rizk Ahmed Mohamed Zaki Marwa M. Eid Ali E. Takieldeen Abdelhameed Ibrahim Abdelaziz A. Abdelhamid Laith Abualigah El-Sayed M. El-kenawy Computer Science and Intelligent Systems Research Center Blacksburg 24060 Virginia USA Faculty of Artificial Intelligence Delta University for Science and Technology Mansoura 35111 Egypt School of ICT Faculty of Engineering Design and Information & Communications Technology (EDICT) Bahrain Polytechnic PO Box 33349 Isa Town Bahrain Department of Computer Science College of Computing and Information Technology Shaqra University 11961 Shaqra Saudi Arabia Hourani Center for Applied Scientific Research Al-Ahliyya Amman University Amman 19328 Jordan

ISBN: (数字)9781837243105

Treatment plant optimization plays an important role in the implementation of eco-problem solutions. This article is going to cover how machine learning algorithms can determine energy consumption, climate, and wastewater features of electricity at a wastewater treatment plant in eastern Melbourne from 2014 to 2019. This study uses data obtained from the Melbourne Water and Airport weather station, which are freely available to carry out MLPRegressor, SVM, Linear Regression, Decision Tree Regression, random forest regression, and Nearest Neighbor. Through customary measures like MSE, RMSE, EVS, and others, the best model is adequately identified, which is the Random Forest Regressor model, which has 0.889285. (Lowest MSE) With these results, the plant treatment optimization processes, such as sampling for environmental analysis and the control of energy consumption, have improved.

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Dynamics of stratified-convected Eyring-Powell nanoliquid featuring chemically reactive species and Ohmic dissipation: Application of Levenberg-Marquardt artificial neural networks(ALM-ANNs)

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International Journal of Heat and Fluid Flow 2024年 108卷

作者： Shah, Zahoor Waqas, M. Asif Zahoor Raja, Muhammad Shahzad, Faisal Zamri, Nurnadiah Juraev, Nizomiddin Alanazi, Meznah M. Department of Mathematics COMSATS University Islamabad Islamabad Campus Pakistan Department of Computer Science National University of Technology Islamabad44000 Pakistan Future Technology Research Center National Yunlin University of Science and Technology 123 University Road Section 3 Yunlin Douliou64002 Taiwan Department of Mathematics Mohi-Ud-Din Islamic University Nerian Sharif AJK Pakistan Faculty of Chemical Engineering New Uzbekistan University Tashkent Uzbekistan Scientific and Innovation Department Tashkent State Pedagogical University Tashkent Uzbekistan Department of Physics College of Science Princess Nourah bint Abdulrahman University P.O. Box 84428 Riyadh11671 Saudi Arabia Department of Computer Science and Mathematics Lebanese American University Beirut Lebanon Faculty of Informatics and Computing Universiti Sultan Zainal Abidin Besut Campus Terengganu Besut Malaysia

Magnetic nanoliquids are pondered cutting-edge heat transference liquids, representing a modern generation because of their aptitude to function as smart liquids. The deployed magnetism externally exerts a readily manageable impact, escalating their adaptableness and practicality in various applications. In this analysis, electro magnetized Powell-Eyring rheological nanoliquid is modeled considering stretching cylinder based buoyancy-driven flow. Transport expressions include thermal radiation, Brownian diffusion, chemical reaction, thermophoresis, and thermal source effect. Prandtl theory of boundary-layer (BL) assists to develop the governing problems. Appropriate transformations are deployed to obtain the dimensionless problems which are then computed numerically through the novel Levenberg-Marquardt artificial neural networks(ALM-ANNs). It is worth to mention that the close agreement between the error analysis of the reference dataset and the proposed datasets roughly from E−10 to E−03, further justifies the approaches utilized in this study. Besides the excellent measures of performance in terms of MSE are achieved at level 5.77E−11, 4.41E−11, 2.09E−12, 2.16E−11, 1.03E−11, 1.65E−11, 2.00E−11, and 1.91E−11against 272, 416, 266, 391, 142, 366, 425, and 508 epochs for first instance of all eight various scenarios. The acquired outcomes are compared with alternate analytical (homotopy) scheme and good agreement is witnessed. Furthermore it is noticed that as the values of Pr,RandS1 increase in size, so does the EPFM temperature profile θ, and the evaluation of AE is between E-04 to E-10. © 2024

关键词： Boundary layers

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A hybrid FEM-PINN method for time-dependent partial differential equations

arXiv

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arXiv 2024年

作者： Feng, Xiaodong Shangguan, Haojiong Tang, Tao Wan, Xiaoliang Zhou, Tao Division of Science and Technology BNU-HKBU United International College Zhuhai519087 China School of Electrical and Computer Engineering Guangzhou Nanfang College Guangzhou510970 China Department of Mathematics Center for Computation and Technology Louisiana State University Baton Rouge70803 United States Institute of Computational Mathematics and Scientific/Engineering Computing Academy of Mathematics and Systems Science Chinese Academy of Sciences Beijing China

In this work, we present a hybrid numerical method for solving evolution partial differential equations (PDEs) by merging the time finite element method with deep neural networks. In contrast to the conventional deep learning-based formulation where the neural network is defined on a spatiotemporal domain, our methodology utilizes finite element basis functions in the time direction where the space-dependent coefficients are defined as the output of a neural network. We then apply the Galerkin or collocation projection in the time direction to obtain a system of PDEs for the space-dependent coefficients which is approximated in the framework of PINN. The advantages of such a hybrid formulation are twofold: statistical errors are avoided for the integral in the time direction, and the neural network’s output can be regarded as a set of reduced spatial basis functions. To further alleviate the difficulties from high dimensionality and low regularity, we have developed an adaptive sampling strategy that refines the training set. More specifically, we use an explicit density model to approximate the distribution induced by the PDE residual and then augment the training set with new time-dependent random samples given by the learned density model. The effectiveness and efficiency of our proposed method have been demonstrated through a series of numerical experiments. © 2024, CC BY.

关键词： Partial differential equations

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SUBCELL LIMITING STRATEGIES FOR DISCONTINUOUS GALERKIN SPECTRAL ELEMENT METHODS

arXiv

引用

arXiv 2022年

作者： Rueda-Ramírez, Andrés M. Pazner, Will Gassner, Gregor J. Department of Mathematics and Computer Science University of Cologne Cologne50931 Germany Center for Applied Scientific Computing Lawrence Livermore National Laboratory LivermoreCA United States Center for Data and Simulation Science University of Cologne Cologne50931 Germany

We present a general family of subcell limiting strategies to construct robust high-order accurate nodal discontinuous Galerkin (DG) schemes. The main strategy is to construct compatible low order finite volume (FV) type discretizations that allow for convex blending with the high-order variant with the goal of guaranteeing additional properties, such as bounds on physical quantities and/or guaranteed entropy dissipation. For an implementation of this main strategy, four main ingredients are identified that may be combined in a flexible manner: (i) a nodal high-order DG method on Legendre-Gauss-Lobatto nodes, (ii) a compatible robust subcell FV scheme, (iii) a convex combination strategy for the two schemes, which can be element-wise or subcell-wise, and (iv) a strategy to compute the convex blending factors, which can be either based on heuristic troubled-cell indicators, or using ideas from flux-corrected transport methods. By carefully designing the metric terms of the subcell FV method, the resulting methods can be used on unstructured curvilinear meshes, are locally conservative, can handle strong shocks efficiently while directly guaranteeing physical bounds on quantities such as density, pressure or entropy. We further show that it is possible to choose the four ingredients to recover existing methods such as a provably entropy dissipative subcell shock-capturing approach or a sparse invariant domain preserving approach. We test the versatility of the presented strategies and mix and match the four ingredients to solve challenging simulation setups, such as the KPP problem (a hyperbolic conservation law with non-convex flux function), turbulent and hypersonic Euler simulations, and MHD problems featuring shocks and turbulence. Copyright © 2022, The Authors. All rights reserved.

关键词： Entropy

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