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Lessons Learned from Assessing Trustworthy AI in Practice

Digital Society 2023年第3期2卷 1-25页

作者： Vetter, Dennis Amann, Julia Bruneault, Frédérick Coffee, Megan Düdder, Boris Gallucci, Alessio Gilbert, Thomas Krendl Hagendorff, Thilo van Halem, Irmhild Hickman, Eleanore Hildt, Elisabeth Holm, Sune Kararigas, Georgios Kringen, Pedro Madai, Vince I. Wiinblad Mathez, Emilie Tithi, Jesmin Jahan Westerlund, Magnus Wurth, Renee Zicari, Roberto V. Computational Vision and Artificial Intelligence Lab Goethe University Frankfurt Frankfurt Am Main Germany Z-Inspection® Initiative Venice Italy Health Ethics and Policy Lab ETH Zurich Zurich Switzerland Strategy and Innovation Careum Foundation Zurich Switzerland Philosophie Departement Collège André-Laurendeau Montréal Canada École Des Médias Université du Québec À Montréal Montréal Canada Department of Medicine Division of Infectious Diseases and Immunology New York University Grossman School of Medicine New York City USA Department of Computer Science University of Copenhagen Copenhagen Denmark Digital Life Initiative Cornell Tech New York City USA Cluster of Excellence “Machine Learning: New Perspectives for Science” University of Tuebingen Tuebingen Germany School of Law University of Bristol Bristol UK Center for the Study of Ethics in the Professions Illinois Institute of Technology Chicago USA Department of Business Management and Analytics Arcada University of Applied Sciences Helsinki Finland Department of Food & Resource Economics University of Copenhagen Copenhagen Denmark Department of Physiology Faculty of Medicine University of Iceland Reykjavik Iceland QUEST Centre for Responsible Research Berlin Institute of Health Charité Universitätsmedizin Berlin Berlin Germany Faculty of Computing Engineering and the Built Environment School of Computing and Digital Technology Birmingham City University Birmingham UK Parallel Computing Labs Intel Santa Clara USA School of Economics Innovation and Technology Kristiania University College Oslo Norway Data Science Graduate School Seoul National University Seoul South Korea

Building artificial intelligence (AI) systems that adhere to ethical standards is a complex problem. Even though a multitude of guidelines for the design and development of such trustworthy AI systems exist, these guidelines focus on high-level and abstract requirements for AI systems, and it is often very difficult to assess if a specific system fulfills these requirements. The Z-Inspection® process provides a holistic and dynamic framework to evaluate the trustworthiness of specific AI systems at different stages of the AI lifecycle, including intended use, design, and development. It focuses, in particular, on the discussion and identification of ethical issues and tensions through the analysis of socio-technical scenarios and a requirement-based framework for ethical and trustworthy AI. This article is a methodological reflection on the Z-Inspection® process. We illustrate how high-level guidelines for ethical and trustworthy AI can be applied in practice and provide insights for both AI researchers and AI practitioners. We share the lessons learned from conducting a series of independent assessments to evaluate the trustworthiness of real-world AI systems, as well as key recommendations and practical suggestions on how to ensure a rigorous trustworthiness assessment throughout the lifecycle of an AI system. The results presented in this article are based on our assessments of AI systems in the healthcare sector and environmental monitoring, where we used the framework for trustworthy AI proposed in the Ethics Guidelines for Trustworthy AI by the European Commission’s High-Level Expert Group on AI. However, the assessment process and the lessons learned can be adapted to other domains and include additional frameworks.

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Mangrove: learning Galaxy Properties from Merger Trees

arXiv

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arXiv 2022年

作者： Jespersen, Christian Kragh Cranmer, Miles Melchior, Peter Ho, Shirley Somerville, Rachel S. Gabrielpillai, Austen Department of Astrophysical Sciences Princeton University PrincetonNJ08544 United States Center for Statistics and Machine Learning Princeton University PrincetonNJ08544 United States Center for Computational Astrophysics Flatiron Institute 162 5th Avenue New YorkNY10010 United States Department of Physics Carnegie Mellon University PittsburghPA15217 United States Institute for Astrophysics and Computational Sciences Catholic University of America 620 Michigan Ave. DC20064 United States Astrophysics Science Division NASA/GSFC 8800 Greenbelt Rd GreenbeltMD20771 United States Center for Research and Exploration in Space Science and Technology NASA/GSFC 8800 Greenbelt Rd GreenbeltMD20771 United States

Efficiently mapping baryonic properties onto dark matter is a major challenge in astrophysics. Although semi-analytic models (SAMs) and hydrodynamical simulations have made impressive advances in reproducing galaxy observables across cosmologically significant volumes, these methods still require significant computation times, representing a barrier to many applications. Graph Neural Networks (GNNs) have recently proven to be the natural choice for learning physical relations. Among the most inherently graph-like structures found in astrophysics are the dark matter merger trees that encode the evolution of dark matter halos. In this paper we introduce a new, graph-based emulator framework, Mangrove, and show that it emulates the galactic stellar mass, cold gas mass and metallicity, instantaneous and time-averaged star formation rate, and black hole mass —as predicted by a SAM— with root mean squared error up to two times lower than other methods across a (75Mpc/h)3 simulation box in 40 seconds, 4 orders of magnitude faster than the SAM. We show that Mangrove allows for quantification of the dependence of galaxy properties on merger history. We compare our results to the current state of the art in the field and show significant improvements for all target properties. Mangrove is publicly available.a) Copyright © 2022, The Authors. All rights reserved.

关键词： Galaxies

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Braix Risk Score: An Automated Mammogram-Based Biomarker for Breast Cancer Created by Applying Artificial Intelligence

SSRN

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SSRN 2024年

作者： Hopper, John L. Nguyen, Tuong Linh Elliott, Michael S. Al-Qershi, Osamah Schmidt, Daniel F. Makalic, Enes Li, Shuai Fox, Samantha K. Dowty, James G. Peña-Solorzano, Carlos Andres Kwok, Chun Fung Chen, Yuanhong Wang, Chong Lippey, Jocelyn F. Brotchie, Peter Carneiro, Gustavo McCarthy, Davis J. Frazer, Helen M.L. Centre for Epidemiology & Biostatistics Melbourne School of Population and Global Health University of Melbourne Victoria Australia Bioinformatics and Cellular Genomics Unit St Vincent’s Institute of Medical Research Victoria Australia Melbourne Integrative Genomics School of Mathematics and Statistics School of BioSciences Faculty of Science University of Melbourne Victoria Australia Faculty of Information Technology Monash University ClaytonVIC Australia Centre for Cancer Genetic Epidemiology Department of Public Health and Primary Care University of Cambridge Cambridge United Kingdom Precision Medicine School of Clinical Sciences at Monash Health Monash University ClaytonVIC Australia Murdoch Children’s Research Institute Royal Children’s Hospital ParkvilleVIC Australia School of Computer Science Australian Institute for Machine Learning University of Adelaide SA Australia Department of Surgery St Vincent’s Hospital Melbourne VIC Australia Faculty of Medicine Dentistry and Health Sciences University of Melbourne Victoria Australia St Vincent’s BreastScreen St Vincent’s Hospital Melbourne VIC Australia Department of Radiology St Vincent’s Hospital Melbourne VIC Australia Centre for Vision Speech and Signal Processing University of Surrey United Kingdom BreastScreen Victoria VIC Australia

Background: Artificial intelligence (AI) algorithms to detect breast cancers from mammographic images are being developed. We evaluated the performance of an algorithm across all stages of the screening process and beyond. Methods: We used an image-specific AI-based breast cancer detection measure learnt from images of women attending BreastScreen Victoria (BRAIx cancer detection measure) to create a woman-specific standard normal mammography-based risk score (BRAIx risk score). Applying logistic regression to a random independent prospective testing cohort of 96,348 women, we estimated risk of invasive breast cancers: (i) detected at cohort entry (525);and (ii) for women given an all-clear, diagnosed during the next 4 years either at future screens (790) or during intervals between screens (308), as a function of the BRAIx risk score and other measures. We estimated the odds ratio per standard deviation (OR) and a greater risk in an upper ***: The BRAIx risk score predicted reader outcomes, recall, cancer detection and future risk. For 4-years risk, OR=2.70 (95% confidence interval (CI) 2.52 to 2.88) overall with evidence for a greater OR in the upper tail (P=10-18). The predicted absolute risk was >10% for 1% of all-clear women. BRAIx risk score was greater for women with a family history and explained 23% (95% CI 21-25%) of familial aspects of risk. Mammographic density was weakly associated with risk before (OR=1.27;95% CI 1.20 to 1.35), but not after, fitting ***: The BRAIx risk score is a strong biomarker for breast cancer that could be used to inform risk-based recall for further assessment, detection and future screening. Its use would automatically identify all-clear women at similar risk to BRCA1 and BRCA2 mutation carriers. BRAIx could also reveal insights into both familial and non-familial causes. Funding: Medical Research Future Fund, the Ramaciotti Foundation, National Breast Cancer Foundation, Cancer *** o

关键词： Mammography

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The medical algorithmic audit (vol 4, pg e384, 2022)

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LANCET DIGITAL HEALTH 2022年第6期4卷 E405-E405页

作者： Liu, X. Glocker, B. McCradden, M. M. Ghassemi, M. Denniston, A. K. Oakden-Rayner, L. Academic Unit of Ophthalmology Institute of Inflammation and Ageing College of Medical and Dental Sciences University of Birmingham UK Department of Ophthalmology University Hospitals Birmingham NHS Foundation Trust Birmingham UK Moorfields Eye Hospital NHS Foundation Trust London UK Health Data Research UK London UK Birmingham Health Partners Centre for Regulatory Science and Innovation University of Birmingham Birmingham UK Biomedical Image Analysis Group Department of Computing Imperial College London London UK The Hospital for Sick Children Toronto ON Canada Dalla Lana School of Public Health Toronto ON Canada Institute for Medical Engineering and Science and Department of Electrical Engineering and Computer Science Massachusetts Institute of Technology Cambridge MA USA National Institute of Health Research Biomedical Research Centre for Ophthalmology Moorfields Hospital London NHS Foundation Trust London UK University College London Institute of Ophthalmology London UK Australian Institute for Machine Learning University of Adelaide Adelaide SA Australia. lauren.oakden-rayner@adelaide.edu.au

Artificial intelligence systems for health care, like any other medical device, have the potential to fail. However, specific qualities of artificial intelligence systems, such as the tendency to learn spurious correlates in training data, poor generalisability to new deployment settings, and a paucity of reliable explainability mechanisms, mean they can yield unpredictable errors that might be entirely missed without proactive investigation. We propose a medical algorithmic audit framework that guides the auditor through a process of considering potential algorithmic errors in the context of a clinical task, mapping the components that might contribute to the occurrence of errors, and anticipating their potential consequences. We suggest several approaches for testing algorithmic errors, including exploratory error analysis, subgroup testing, and adversarial testing, and provide examples from our own work and previous studies. The medical algorithmic audit is a tool that can be used to better understand the weaknesses of an artificial intelligence system and put in place mechanisms to mitigate their impact. We propose that safety monitoring and medical algorithmic auditing should be a joint responsibility between users and developers, and encourage the use of feedback mechanisms between these groups to promote learning and maintain safe deployment of artificial intelligence *** © 2022 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license. Published by Elsevier Ltd.. All rights reserved.

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Land instability Compounds the risk of sea level rise in Alexandria, Egypt

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International Journal of Applied Earth Observation and Geoinformation 2025年 141卷

作者： Rejoice Thomas Sara Zouriq Shahryar Fazli Amr Fawzy Nikolay Grisel Todorov Surendra Maharjan Wenzhao Li Erik Linstead Daniele Struppa Hesham El-Askary Earth Systems Science and Data Solutions Lab Chapman University Orange CA 92866 USA Schmid College of Science and Technology Chapman University Orange CA 92866 USA Ministry of Water Resources and Irrigation Cairo Egypt Machine Learning and Assistive Technology Lab (MLAT) Chapman University Orange CA 92866 USA Fowler School of Engineering Chapman University Orange CA 92866 USA Department of Environmental Sciences Faculty of Science Alexandria University Moharem Bek Alexandria 21522 Egypt

The coastal region of Alexandria Governorate in Egypt holds significant strategic importance for trade while being susceptible to extreme weather events. It confronts a dual challenge of the rising sea levels and, as found in this study, land instability. While much attention has been rightly directed towards sea level rise (SLR), the stability of the land warrants equal consideration. Here, a comprehensive analysis of land stability is conducted in Alexandria by measuring Line of Sight (LOS) displacements and assessing their topographical, hydrological, and coastal impacts. Persistent Scatterer Interferometry technique is used to measure the LOS displacements in association with land cover classification and elevation data. Moreover, in the absence of a recent, openly accessible Digital Elevation Model (DEM) with satisfactory resolution, we developed a novel approach to update DEM using the Small Baseline Subset method. This approach enabled us to generate a projected DEM for the year 2040, facilitating the creation of a stream network based on this “future DEM”. Our observations revealed displacements ranging from −14.0 to 6.7 mm/year, predominantly occurring in low-lying and built-up areas, suggesting anthropogenic activities as a likely cause. The current and future stream networks show stream shifting and widening. Stream shifting indicates dynamic changes in topography and hydrological conditions, while stream widening suggests alterations in the hydrological network due to increased urban runoff or changes in the natural watershed. Furthermore, we found that sea surface temperature and SLR are projected to increase until the end of the century in the Mediterranean Sea near Alexandria. This escalation raises the likelihood of intensified tropical-like hurricane events in the region, commonly referred to as “medicanes”. The importance of this research is in offering a framework for comprehensive land stability assessments, along with demonstrating the scalabili

关键词： Persistent Scatterer Interferometry Small Baseline Subset Digital Elevation Model Medicanes Sea Surface Temperature Sea Level Rise

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UCPM: Uncertainty-Guided Cross-Modal Retrieval with Partially Mismatched Pairs

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IEEE transactions on image processing : a publication of the IEEE Signal Processing Society 2025年 PP卷 PP页

作者： Quanxing Zha Xin Liu Yiu-Ming Cheung Shu-Juan Peng Xing Xu Nannan Wang Huaqiao University Department of Computer Science Xiamen 361021 China Key Laboratory of Pattern Recognition and Computer Vision Xiamen 361021 China Huaqiao University Fujian Key Laboratory of Big Data Intelligence and Security Xiamen 361021 China Hong Kong Baptist University Department of Computer Science Hong Kong Huaqiao University Department of Artificial Intelligence Xiamen 361021 China Fujian Province University Key Laboratory of Computer Vision and Machine Learning (Huaqiao University) Xiamen 361021 China University of Electronic Science and Technology of China Center for Future Multimedia School of Computer Science and Engineering Chengdu 610051 China Xidian University State Key Laboratory of Integrated Services Networks Xi’an 710071 China

The manual annotation of perfectly aligned labels for cross-modal retrieval (CMR) is incredibly labor-intensive. As an alternative, the collection of co-occurring data pairs from the Internet is a remarkably cost-effective way, but which, inevitably induces the Partially Mismatched Pairs (PMPs) and therefore significantly degrades the retrieval performance without particular treatment. Previous efforts often utilize the pair-wise similarity to filter out the mismatched pairs, and such operation is highly sensitive to mismatched or ambiguous data and thus leads to sub-optimal performance. To alleviate these concerns, we propose an efficient approach, termed UCPM, i.e., Uncertainty-guided Cross-modal retrieval with Partially Mismatched pairs, which can significantly reduce the adverse impact of mismatched data pairs. Specifically, a novel Uncertainty Guided Division (UGD) strategy is sophisticatedly designed to divide the corrupted training data into confident matched (clean), easily-identifiable mismatched (noisy) and hardly-determined hard subsets, and the derived uncertainty can simultaneously guide the informative pair learning while reducing the negative impact of potential mismatched pairs. Meanwhile, an effective Uncertainty Self-Correction (USC) mechanism is concurrently presented to accurately identify and rectify the fluctuated uncertainty during the training process, which further improves the stability and reliability of the estimated uncertainty. Besides, a Trusted Margin Loss (TML) is newly designed to enhance the discriminability between those hard pairs, by dynamically adjusting their soft margins to amplify the positive contributions of matched pairs while suppressing the negative impacts of mismatched pairs. Extensive experiments on three widely-used benchmark datasets, verify the effectiveness and reliability of UCPM compared with the existing SOTA approaches, and significantly improve the robustness in both synthetic and real-world PMPs. The code i

关键词： Cross-modal retrieval partially mismatched pairs trusted margin loss uncertainty guided division uncertainty self-correction

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Evaluating the Accuracy and Reliability of Real-World Digital Mobility Outcomes in Older Adults After Hip Fracture: Cross-Sectional Observational Study

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JMIR Formative Research 2025年 9卷 e67792页

作者： Berge, Martin A. Paraschiv-Ionescu, Anisoara Kirk, Cameron Küderle, Arne Micó-Amigo, Encarna Becker, Clemens Cereatti, Andrea Del Din, Silvia Engdal, Monika Garcia-Aymerich, Judith Grønvik, Karoline B. Hansen, Clint Hausdorff, Jeffrey M. Helbostad, Jorunn L. Jansen, Carl-Philipp Johnsen, Lars Gunnar Klenk, Jochen Koch, Sarah Maetzler, Walter Megaritis, Dimitrios Müller, Arne Rochester, Lynn Schwickert, Lars Taraldsen, Kristin Vereijken, Beatrix Department of Neuromedicine and Movement Science Norwegian University of Science and Technology Trondheim Norway Laboratory of Movement Analysis and Measurement Ecole Polytechnique Federale de Lausanne Lausanne Switzerland Translational and Clinical Research Institute Faculty of Medical Sciences Newcastle University Newcastle Upon Tyne United Kingdom Machine Learning and Data Analytics Lab Department Artificial Intelligence in Biomedical Engineering Friedrich-Alexander-Universität Erlangen-Nürnberg Erlangen Germany Geriatric Center Medical Faculty Heidelberg Heidelberg University Heidelberg Germany Department of Geriatrics and Rehabilitation Robert Bosch Hospital Stuttgart Germany Department of Electronics and Telecommunications Politecnico di Torino Turin Italy National Institute for Health and Care Research Newcastle Biomedical Research Centre Newcastle University The Newcastle Upon Tyne Hospitals NHS Foundation Trust Newcastle Upon Tyne United Kingdom Barcelona Institute for Global Health Barcelona Spain Department of Medicine and Life Sciences Universitat Pompeu Fabra Catalonia Barcelona Spain CIBER Epidemiología y Salud Pública Madrid Spain Department of Neurology University Hospital Schleswig-Holstein Kiel University Kiel Germany Center for the Study of Movement Cognition and Mobility Neurological Institute Tel Aviv Medical Center Tel Aviv Israel Department of Physical Therapy Faculty of Medical & Health Sciences Tel Aviv University Tel Aviv Israel Sagol School of Neuroscience Tel Aviv University Tel Aviv Israel Rush Alzheimer’s Disease Center Rush University Medical Center Chicago IL United States Department of Orthopedic Surgery Rush Medical College Rush University Chicago IL United States Department of Orthopaedic Surgery St. Olav’s Hospital Trondheim Norway Institute of Epidemiology and Medical Biometry Ulm University Ulm Germany IB University of Health and Social Sciences Study Centre Stuttgart Stuttgart Germany Department of Sport

Background: Algorithms estimating real-world digital mobility outcomes (DMOs) are increasingly validated in healthy adults and various disease cohorts. However, their accuracy and reliability in older adults after hip fracture, who often walk slowly for short durations, is underexplored. Objective: This study examined DMO accuracy and reliability in a hip fracture cohort considering walking bout (WB) duration, physical function, days since surgery, and walking aid use. Methods: In total, 19 community-dwelling participants were real-world monitored for 2.5 hours using a lower back wearable device and a reference system combining inertial modules, distance sensors, and pressure insoles. A total of 6 DMO estimates from 164 WBs from 58% (11/19) of the participants (aged 71-90 years;assessed 32-390 days after surgery;Short Physical Performance Battery [SPPB] scores of 3-12;gait speed range 0.39-1.34 m/s) were assessed against the reference system at the WB and participant level. We stratified by WB duration (all WBs, WBs of >10 seconds, WBs of 10-30 seconds, and WBs of >30 seconds) and lower versus higher SPPB scores and observed whether days since surgery and walking aid use affected DMO accuracy and reliability. Results: Across WBs, walking speed and distance ranged from 0.25 to 1.29 m/s and from 1.7 to 436.5 m, respectively. Estimation of walking speed, cadence, stride duration, number of steps, and distance stratified by WB duration showed intraclass correlation coefficients (ICCs) ranging from 0.50 to 0.99 and mean relative errors (MREs) from –6.9% to 12.8%. Stride length estimation showed poor reliability, with ICCs ranging from 0.30 to 0.49 and MREs from 6.1% to 13.2%. Walking speed and distance ICCs in the higher–SPPB score group ranged from 0.85 to 0.99, and MREs ranged from –10.1% to –1.7%. In the lower–SPPB score group, walking speed and distance ICCs ranged from 0.17 to 0.99, and MREs ranged from 13.5% to 32.6%. There was no discernible effect of time since s

关键词： active aging cadence digital mobility assessment distance free living gait walking speed wearable device

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Torus graphs for multivariate phase coupling analysis

arXiv

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arXiv 2019年

作者： Klein, Natalie Orellana, Josue Brincat, Scott Miller, Earl K. Kass, Robert E. Department of Statistics and Data Science Carnegie Mellon University Machine Learning Department Carnegie Mellon University Center for the Neural Basis of Cognition Carnegie Mellon University University of Pittsburgh Department of Brain and Cognitive Science Massachusetts Institute of Technology

Angular measurements are often modeled as circular random variables, where there are natural circular analogues of moments, including correlation. Because a product of circles is a torus, a d-dimensional vector of circular random variables lies on a d-dimensional torus. For such vectors we present here a class of graphical models, which we call torus graphs, based on the full exponential family with pairwise interactions. The topological distinction between a torus and Euclidean space has several important consequences. Our development was motivated by the problem of identifying phase coupling among oscillatory signals recorded from multiple electrodes in the brain: oscillatory phases across electrodes might tend to advance or recede together, indicating coordination across brain areas. The data analyzed here consisted of 24 phase angles measured repeatedly across 840 experimental trials (replications) during a memory task, where the electrodes were in 4 distinct brain regions, all known to be active while memories are being stored or retrieved. In realistic numerical simulations, we found that a standard pairwise assessment, known as phase locking value, is unable to describe multivariate phase interactions, but that torus graphs can accurately identify conditional associations. Torus graphs generalize several more restrictive approaches that have appeared in various scientific literatures, and produced intuitive results in the data we analyzed. Torus graphs thus unify multivariate analysis of circular data and present fertile territory for future research. Copyright © 2019, The Authors. All rights reserved.

关键词： Graphic methods

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Brain Imaging Generation with Latent Diffusion Models

arXiv

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arXiv 2022年

作者： Pinaya, Walter H.L. Tudosiu, Petru-Daniel Dafflon, Jessica Da Costa, Pedro F. Fernandez, Virginia Nachev, Parashkev Ourselin, Sebastien Cardoso, M. Jorge Department of Biomedical Engineering School of Biomedical Engineering & Imaging Sciences King’s College London United Kingdom Data Science and Sharing Team Functional Magnetic Resonance Imaging Facility National Institute of Mental Health BethesdaMD20892 United States Machine Learning Team Functional Magnetic Resonance Imaging Facility National Institute of Mental Health BethesdaMD20892 United States Institute of Psychiatry Psychology & Neuroscience King’s College London United Kingdom Centre for Brain and Cognitive Development Birkbeck College United Kingdom Institute of Neurology University College London United Kingdom

Deep neural networks have brought remarkable breakthroughs in medical image analysis. However, due to their data-hungry nature, the modest dataset sizes in medical imaging projects might be hindering their full potential. Generating synthetic data provides a promising alternative, allowing to complement training datasets and conducting medical image research at a larger scale. Diffusion models recently have caught the attention of the computer vision community by producing photorealistic synthetic images. In this study, we explore using Latent Diffusion Models to generate synthetic images from high-resolution 3D brain images. We used T1w MRI images from the UK Biobank dataset (N=31,740) to train our models to learn about the probabilistic distribution of brain images, conditioned on covariables, such as age, sex, and brain structure volumes. We found that our models created realistic data, and we could use the conditioning variables to control the data generation effectively. Besides that, we created a synthetic dataset with 100,000 brain images and made it openly available to the scientific community. © 2022, CC BY.

关键词： Deep neural networks

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Automating airborne pollen classification: Identifying and interpreting hard samples for classifiers

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Heliyon 2025年第2期11卷 e41656页

作者： Milling, Manuel Rampp, Simon D.N. Triantafyllopoulos, Andreas Plaza, Maria P. Brunner, Jens O. Traidl-Hoffmann, Claudia Schuller, Björn W. Damialis, Athanasios CHI – Chair of Health Informatics MRI Technical University of Munich Munich Germany MCML–Munich Center for Machine Learning Germany EIHW – Chair of Embedded Intelligence for Health Care & Wellbeing University of Augsburg Augsburg Germany Institute of Environmental Medicine and Integrative Health Faculty of Medicine University Clinic of Augsburg & University of Augsburg Augsburg Germany Institute of Environmental Medicine Helmholtz Center Munich German Research Center for Environmental Health Germany Faculty of Business and Economics and Faculty of Medicine University of Augsburg Augsburg Germany Department of Technology Management and Economics Technical University of Denmark Denmark Next Generation Technology Region Zealand Denmark Christine Kühne Center for Allergy Research and Education Davos Switzerland MDSI–Munich Data Science Institute Germany GLAM–the Group on Language Audio & Music Imperial College London London United Kingdom Terrestrial Ecology and Climate Change Department of Ecology School of Biology Faculty of Sciences Aristotle University of Thessaloniki Thessaloniki Greece

Deep-learning-based classification of pollen grains has been a major driver towards automatic monitoring of airborne pollen. Yet, despite an abundance of available datasets, little effort has been spent to investigate which aspects pose the biggest challenges to the (often black-box- resembling) pollen classification approaches. To shed some light on this issue, we conducted a sample-level difficulty analysis based on the likelihood for one of the largest automatically-generated datasets of pollen grains on microscopy images and investigated the reason for which certain airborne samples and specific pollen taxa pose particular problems to deep learning algorithms. It is here concluded that the main challenges lie in A) the (partly) co-occurring of multiple pollen grains in a single image, B) the occlusion of specific markers through the 2D capturing of microscopy images, and C) for some taxa, a general lack of salient, unique features. Our code is publicly available under https://***/millinma/SDPollen © 2025

关键词： Deep learning Pollen recognition Sample difficulty analysis

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