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A novel prognostic target-gene signature and nomogram based on an integrated bioinformatics analysis in hepatocellular carcinoma

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BIOCELL 2022年第5期46卷 1261-1288页

作者： RUI XU QIBIAO WU YUHAN GONG YONGZHE WU QINGJIA CHI DA SUN Department of Engineering Structure and Mechanics School of ScienceWuhan University of TechnologyWuhan430070China Department of Geotechnical Engineering Wuhan University of TechnologyWuhan430070China Engineering Laboratory of Zhejiang Province for Pharmaceutical Development of Growth Factors&Biomedicine Collaborative Innovation Center of Wenzhou Institute of Life SciencesWenzhou UniversityWenzhou325035China

There is currently no effective solution to the problem of poor prognosis and recurrence of *** technology of immunotherapy and prognosis of genetic material has made continuous progress in recent *** the study,a 5-gene signature was established for the prognosis of HCC through biological information,and the immune infiltration of HCC patients was *** studied HCC patients’immune infiltration,the paper screened the differential target genes of miR-126-3p in HCC downloaded from TCGA database,and uses WGCNA method to select the modular genes highly relevant to M2 *** we use LASSO and COX regression analysis technology to establish the 5-gene *** nomogram is established by combining the prognostic score and clinical *** was empolyed to observe the immune infiltration in HCC *** revealed the biological pathways of HCC-related genes through GSEA and *** bioinformatics analysis of 2495 differential target genes finally constructed a 5-gene signature with a reliable prognostic ability(CDCA8,SLC41A3,PPM1G,TCOF1,GRPEL2).The combination of prognostic score and AJCC_Stage resulted in a more reliable prognosis *** the same time,10 immune cells that are differentially expressed in HCC patients were also found.8 GSEA pathways related to the prognosis were *** the study,a reliable 5-gene signature was established based on the differential target gene of miR-126-3p to study the immune infiltration in HCC *** provides help for HCC-related prognosis research and immunotherapy.

关键词： Hepatocellular carcinoma Prognostic signature Differentially expressed genes microRNA

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Experimental study on seismic response and progressive failure characteristics of bedding rock slopes

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Journal of Rock Mechanics and geotechnical engineering 2022年第5期14卷 1394-1405页

作者： Mingdong Zang Guoxiang Yang Jinyu Dong Shengwen Qi Jianxian He Ning Liang School of Engineering and Technology China University of Geosciences(Beijing)Beijing100083China Institute of Geosafety China University of Geosciences(Beijing)Beijing100083China Research Institute of Geotechnical Engineering and Hydraulic Structure North China University of Water Resources and Electric PowerZhengzhou450011China Key Laboratory of Shale Gas and Geoengineering Institute of Geology and GeophysicsChinese Academy of SciencesBeijing100029China Innovation Academy for Earth Science Chinese Academy of SciencesBeijing100029China University of Chinese Academy of Sciences Beijing100049China Department of Geotechnical Engineering School of Civil EngineeringSouthwest Jiaotong UniversityChengdu610031China

Bedding rock slopes are common geological features in nature that are prone to failure under strong earthquakes. Their failures induce catastrophic landslides and form barrier lakes, posing severe threats to people’s lives and property. Based on the similarity criteria, a bedding rock slope model with a length of3 m, a width of 0.8 m, and a height of 1.6 m was constructed to facilitate large-scale shaking table *** results showed that with the increase of vibration time, the natural frequency of the model slope decreased, but the damping ratio increased. Damage to the rock mass structure altered the dynamic characteristics of the slope;therefore, amplification of the acceleration was found to be nonlinear and uneven. Furthermore, the acceleration was amplified nonlinearly with the increase of slope elevation along the slope surface and the vertical section, and the maximum acceleration amplification factor(AAF) occurred at the slope crest. Before visible deformation, the AAF increased with increasing shaking intensity;however, it decreased with increasing shaking intensity after obvious deformation. The slope was likely to slide along the bedding planes at a shallow depth below the slope surface. The upper part of the slope mainly experienced a tensile-shear effect, whereas the lower part suffered a compressive-shear force. The progressive failure process of the model slope can be divided into four stages, and the dislocated rock mass can be summarized into three zones. The testing data provide a good explanation of the dynamic behavior of the rock slope when subjected to an earthquake and may serve as a helpful reference in implementing antiseismic measures for earthquake-induced landslides.

关键词： Bedding rock slope Large-scale shaking table test Seismic response Progressive failure characteristics

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A Novel Triaxial Failure Criterion Based on the Skeleton Packing Theory for Hybrid Steel Fiber Reinforced Self-Compacting Concrete

SSRN

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SSRN 2024年

作者： Gong, Chenjie Kang, Lei Ding, Wenqi Zheng, Keren School of Civil Engineering Hunan Provincial Key Laboratory for Disaster Prevention and Mitigation of Rail Transit Engineering Structure Central South University Changsha China School of Civil Engineering Central South University Changsha China Department of Geotechnical Engineering Key Laboratory of Geotechnical and Underground Engineering Ministry of Education College of Civil Engineering Tongji University Shanghai20092 China

The application of hybrid steel fiber reinforced self-compacting concrete (HSFRSCC) contributes to promoting the pouring quality and ductility of tunnel precast segments. During the stage of assembly and service, precast segments are inevitably in the complex stress state of compression, bending and shear. However, there were very limited studies on the multi-axial failure performance of HSFRSCC, which can be adopted as a novel cementitious matrix material of segment. In the present research, the closest-packed particle skeleton was firstly determined through the compressible packing model (CPM) with double-correction of fiber disturbance parameter and interaction coefficient, facilitating the mix design of HSFRSCC. Three types of cylindrical specimens with different skeleton volume fraction of 58%, 60% and 62% were prepared to perform triaxial compression test. Experimental results indicated that the factors affecting different failure mechanism of HSFRSCC mainly included the confining pressure, skeleton volume fraction, and synergistic effect of confining pressure and steel fiber. Through the scanning electron microscope (SEM) technique, the influence of interface transition zone (ITZ) and steel fibers on triaxial failure mechanism was elucidated. The triaxial failure criterion for HSFRSCC was established, including the formula of triaxial strength, compression meridian and deviatoric plane trace. This work can comprehensively evaluate the failure behavior of HSFRSCC under complex stress, and provide a basis for the precise design of precast segments. © 2024, The Authors. All rights reserved.

关键词： Failure (mechanical)

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INNOVATIVE ANALYSIS METHODS OF ENERGY PERFORMANCE OF BUILDINGS 9

INNOVATIVE ANALYSIS METHODS OF ENERGY PERFORMANCE OF BUILDIN...

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9th International Conference on New Energy and Future Energy Systems, NEFES 2024

作者： Hegedűs, Dániel László Tóth, Olivér Hajdu, Árpád Károlyfi, Kitti Ajtayné Horváth, Tamás Szalai, Dóra Department of Architecture and Building Construction Széchenyi István University Egyetem tér 1 GyőrH-9026 Hungary Department of Structure and Geotechnical Engineering Széchenyi István University Egyetem tér 1 GyőrH-9026 Hungary TSPC BIM Kft. Dunakapu tér 7 GyőrH-9022 Hungary

ISBN: (纸本)9781837241880

In the current era of architecture, sustainability and energy efficiency are becoming increasingly important, while at the same time, advanced technological tools and analytical methods are reshaping the design and construction of buildings. Architects must think responsibly and globally, as buildings account for a significant proportion of the world's energy use. As architects, we have a responsibility to create ecologically optimal facilities for the long term. With this in mind, we would like to present applications that trace the chronological milestones in the development of energy analysis. This paper provides a detailed overview of the different methods of energy analysis. The methods include software developed specifically for energy analysis, an analysis add-on built into modeling software, and among the more innovative technologies, we have also examined parametric design and methodologies based on artificial intelligence algorithms. We have tried to select these methodologies and software in a diversified way to get a more comprehensive picture of how they work. The main aim of this paper is to compare the conclusions drawn from case studies of our previous energy research and from the studies of these energy software, partly subjectively and partly with an objective perspective that tightens subjectivity. As such, a set of criteria we have defined will guide the structure of this analysis. In this article, we will try to highlight the advantages and disadvantages of each method, and we will also try to consider the importance of 3D model-based analysis. © The Institution of engineering & Technology 2024.

关键词： Energy utilization

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Innovative analysis methods of energy performance of buildings

Innovative analysis methods of energy performance of buildin...

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9th International Conference on New Energy and Future Energy Systems (NEFES 2024)

作者： Dániel László Hegedűs Olivér Tóth Árpád Hajdu Kitti Ajtayné Károlyfi Tamás Horváth Dóra Szalai Department of Architecture and Building Construction Széchenyi István University H-9026 Győr Egyetem tér 1 Hungary Department of Structure and Geotechnical Engineering Széchenyi István University H-9026 Győr Egyetem tér 1 Hungary

ISBN: (数字)9781837241880

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Damage assessment of an ancient fort in India 16

Damage assessment of an ancient fort in India

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16th Asian Regional Conference on Soil Mechanics and geotechnical engineering, ARC 2019

作者： Bhowmik, Tamali Haridasan, H. Menon, A. Banerjee, S. National Center of Safety of Heritage Structure Department of Civil Engineering IIT Madras India Geotechnical Engineering Division Department of Civil Engineering IIT Madras India

The historical fort of Bhatner at Hanumangarh, Rajasthan in India was built around 1700years ago using burnt clay bricks with lime mortar. This fort complex has three gateway adorned with arches and tri-arch colonnaded *** gateway structures are significantly distressed and several cracks on arches and vaults of gateway possibly are observed. The current paper presents a detailed geotechnical and structural investigation to find out the root cause of the distress in the fort. For geotechnical Investigation, the methodology followed for the geotechnical test comprises of appropriate sub- soil exploration including field investigation at 4 bore hole locations and relevant laboratory tests on soil samples for determining allowable bearing pressure of the soil. In structural investigation, settlement analysis has been performed on the 3D Finite element model of the fort considering gravity load and earth pressure on the fort wall using TNO DIANA software package. The study concludes that the distresses shown on the structure especially at Gateway 2 and 3 are due to soil settlement. Copyright © Soil Mechanics and geotechnical engineering, ARC *** rights reserved.

关键词： Arches

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Seepage Propagation Simulation of a Tunnel Gasketed Joint Using the Cohesive Zone Model

SSRN

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SSRN 2023年

作者： Gong, Chenjie Cheng, Mingjin Peng, Yicheng Ding, Wenqi Ge, Yangyang Song, Jianrong School of Civil Engineering Hunan Provincial Key Laboratory for Disaster Prevention and Mitigation of Rail Transit Engineering Structure Central South University HN Changsha410075 China School of Civil Engineering Central South University HN Changsha410075 China Shanghai Electric Power Design Institute SH Shanghai200025 China Department of Geotechnical Engineering Key Laboratory of Geotechnical and Underground Engineering of Ministry of Education College of Civil Engineering Tongji University SH Shanghai200092 China State Key Laboratory of Special Functional Waterproof Materials Beijing Oriental Yuhong Waterproof Technology Co. Ltd. Beijing101309 China

The gasketed joint plays a critical role in the waterproof or water-leakage resistance performance of tunnel segmental linings. This study presents a novel numerical simulation method based on the cohesive zone model (CZM) to accurately analyze the seepage phenomena along the interface of elastic sealing gaskets in shield tunnel joints. While traditional finite element methods are widely used, they cannot simulate interface opening, limiting their applicability. To overcome this challenge, the proposed method leverages the concept of hydraulic fracturing and redefines the seepage problem as a seepage problem of elastic impermeable media. By establishing a two-dimensional hydraulic fracturing model using the CZM, this study conducts a comprehensive sensitivity analysis of the cohesive element parameters and validates the accuracy and effectiveness of simulating seepage along the interface of elastic impermeable media. Based on the insights gained from the sensitivity analysis, a seepage calculation model is successfully developed, considering the unique characteristics of elastic sealing gaskets. The model is applied to three cross-sectional shapes of elastic sealing gaskets, and their seepage characteristics are analyzed based on the interface opening displacement and liquid pressure distributions during seepage. The results highlight the SC4 cross-sectional shape, which exhibits minimal opening displacement and the highest net water pressure at the moment of seepage occurrence, demonstrating superior waterproof performance compared to other forms. Through the introduction of the CZM, comprehensive parameter analysis, validation, and practical application, this study overcomes the limitations of traditional finite element methods in simulating interface opening. The proposed model, which more accurately captures seepage characteristics than other methods, provides an optimized simulation method for analyzing hydraulic coupling issues related to seepage at shield tun

关键词： Sensitivity analysis

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Evidence of two peaks response spectra (2prs) due to separated effects of soil and source in recent subduction earthquakes 7th

Evidence of two peaks response spectra (2prs) due to separat...

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7th International Conference on Earthquake geotechnical engineering, ICEGE 2019

作者： Saragoni, G.R. Gallegos, M.F. Structure-Construction-Geotechnical Engineering Division Department of Civil Engineering University of Chile Santiago Chile Department of Structural and Geotechnical Engineering Pontifical Catholic University of Chile Santiago Chile

ISBN: (纸本)9780367143282

Accelerograms of large subduction earthquakes are characterized by their long duration of some minutes leading in some cases to absolute response spectra with two clear peaks. This particular feature is associated with the separated participation effect of source from soil response in different stages of energy release from the dominating asperities of subducted plate. In this paper, 2PRS obtained from the accelerograms of 2010 Chile, 2015 Nepal, 2016 Ecuador, and 2017 Mexico earthquakes are analyzed, showing 2PRS for large subduction earthquakes are the rule for soft soils. In addition, it is demonstrated that period of soil peak coincides with the one estimated by Nakamura method. The actual importance of 2PRS for earthquake engineering is that source peak affects houses or middle-rise buildings and soil peak affects high-rise buildings or base-isolated buildings. Therefore, design response spectra considered in seismic codes for soft soils should be modified in future in order to consider both effects. © 2019 Associazione Geotecnica Italiana, Rome, Italy.

关键词： Soils

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Influence of non-dimensional strength parameters on the seismic stability of cracked slopes

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Journal of Mountain Science 2019年第1期16卷 153-167页

作者： ZHAO Lian-heng CHENG Xiao LI De-jian ZHANG Ying-bin School of Civil Engineering Central South University Key Laboratory of Heavy-haul Railway Engineering Structure Ministry of Education Central South University Key Laboratory of Transportation Tunnel Engineering Ministry of Education Southwest Jiaotong University Department of Geotechnical Engineering School of Civil Engineering Southwest Jiaotong University

Cracks in rock or soil slopes influence the stability and durability of the slopes. Seismic forces can trigger slope disasters, particularly in the cracked slopes. Considering the nonlinear characteristics of materials, the more generalized nonlinear failure criterion proposed by Baker is adopted. The influence of non-dimensional strength parameters on the stability of cracked slopes under earthquakes is performed using the upper bound limit analysis. The seismic displacement is calculated by adopting the logarithmic spiral failure surface according to the sliding rigid block model. Based on the existing studies, two methods for the stability analysis of cracked slopes under earthquakes are introduced: the pseudo-static method(with the factor of safety(Fs) as an evaluation index), and the displacement-based method(with the seismic displacement as an evaluation index). The pseudo-static method can only determine the instantaneous stability state of the cracked slope, yet the displacement-based methodreflects the stability variation of cracked slopes during earthquakes. The results indicate that the nondimensional strength parameters affect the factor of safety and seismic displacement of slopes significantly. The non-dimensional strength parameter(n) controlling the curvature of strength function shapes on the slope stability is affected by other parameters. Owing to cracks, the effect of non-dimensional strength parameters on seismic displacement becomes more significant.

关键词： Cracked slopes Upper bound limit analysis(UBLA) Generalized nonlinear failure criterion Pseudo-static method Displacement-based method

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Influence of pile spacing on seismic response of piled raft in soft clay: centrifuge modeling

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Earthquake engineering and engineering Vibration 2019年第4期18卷 719-733页

作者： Yang Jun Yang Min Chen Haibing Guangzhou Municipal Engineering Testing Co. Ltd Guangzhou 510060 China School of Civil Engineering and Transportation South China University of Technology Guangzhou 510641 China Department of Geotechnical Engineering Tongji University Shanghai 200092 China Institute of Foundation and Structure Technologies Zhejiang Sci-Tech University Hangzhou 310018 China

In order to study the infl uence of pile spacing on the seismic response of piled raft in soft clay, a series of shaking table tests were conducted by using a geotechnical centrifuge. The dynamic behavior of acceleration, displacement and internal forces was examined. The test results indicate that the seismic acceleration responses of models are generally greater than the surrounding soil surface in the period ranges of 2–10 seconds. Foundation instant settlements for 4×4 and 3×3 piled raft (with pile spacing equal to 4 and 6 times pile diameter) are somewhat close to each other at the end of the earthquake, but reconsolidation settlements are greater for 3×3 piled raft. The seismic acceleration of superstructure, the uneven settlement of the foundation and the maximum bending moment of pile are relatively lower for 3×3 piled raft. Successive earthquakes lead to the softening behavior of soft clay, which causes a reduction of the pile bearing capacity and thus loads are transferred from the pile group to the raft. For the case of a 3×3 piled raft, there is relatively smaller change of the load sharing ratio of the pile group and raft after the earthquake and the distribution of maximum bending moments at the pile head is more uniform.

关键词： piled raft pile spacing soft clay dynamic centrifuge model test seismic response subsidence load sharing bending moment

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