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Annual International Conference of the IEEE engineering in Medicine and Biology Society (EMBC)

作者： T. Yamakoshi K. Yamakoshi S. Tanaka M. Nogawa Y. Sawada P. Rolfe Graduate School of Natural Science & Technology Kanazawa University Kanazawa Japan Institute of Nature and Environmental Technology Kanazawa University Kanazawa Japan Department of Human and Mechanical Systems Engineering Kanazawa University Kanazawa Japan Faculty of Medicine Sapporo Medical University Sapporo Japan Department of Communication Computer & System Science University of Geneva Genoa Italy

Long hours of automobile driving under monotonous situations may cause the lowering of what we term a driver's activation state (DAS) or in other words the production of drowsiness, resulting in an increased risk of a traffic accident. There is therefore a need to create a newly advanced system focused on the DAS in-car, hopefully thus avoiding potentially dangerous situations. In order to develop such a system as a final goal, we have firstly set out to acquire such cardiovascular variables as beat-by-beat blood pressure (BP), RR interval from ECG and normalized pulse volume (NPV) used as a peripheral vascular tone of alpha-adrenergic sympathetic activity, during presentation to the driver of a screen movie simulating monotonous travel at constant speed on a test-course. Subsequently, we have investigated the reactivity in terms of the driver's cardiovascular hemodynamics. Through the successful monitoring of cardiovascular parameters during the movie presentation obtained in 11 healthy male subjects, the following results were obtained: The monotonous driving produces a statistically significant gradual rise in BP following drowsiness, which could be explained by enhancement of sympathetic activity using a time-frequency analysis of BP and RR. This finding strongly indicates that continuous driving in such monotonous situations can make a driver considerably stressful and thus may cause a gradual increase in BP, and that this gradual BP increase may be used as a possible index relevant to the DAS. This finding was also confirmed by the analysis of NPV, suggesting that the gradual increase in BP during the monotonous driving would be rather caused by a regulation of peripheral vasomotor constriction

关键词： Hemodynamics Automobiles Cardiology Motion pictures Production Road accidents Blood pressure Biomedical monitoring Electrocardiography system testing

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design and fabrication of polymer electrostatic comb-drive actuators for micro conveyer systems

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IEEJ Transactions on Sensors and Micromachines 2006年第7期126卷 306-311页

作者： Pham, Phuc Hong Dao, Dzung Viet Amaya, Satoshi Kitada, Ryoji Li, Yigui Sugiyama, Susumu Ritsumeikan University 1-1-1 Nojihigashi Kusatsu Shiga 525-8577 Japan TOWA Corporation 122-2 Megawa Makisima Uji Kyoto 611-0041 Japan Graduate School of Science and Engineering Ritsumeikan University TOWA Corporation Faculty of Mechanical Engineering HUT Micro Nano Integrated Devices Laboratory Ritsumeikan University Japan Micro Nano Integrated Devices Laboratory Ritsumeikan University Ritsumeikan University Ritsumeikan University Shiga Japan College of Science and Engineering Department of Micro System Technology Research Institute for Micro System Technology Ritsumeikan University

We propose the design, simulation and preliminary fabrication of Micro Conveyer systems (MCS) based on polymer electrostatic comb-drive actuators using polymethylmethacrylate (PMMA). This MCS consists of linear comb actuators, rotational comb actuators, micro containers, and a ratchet mechanism. Micro containers, used for carrying micro and nano samples such as protein, cells, are moved by comb-actuators through the ratchet mechanism. The silicon MCS was fabricated and checked to confirm characteristics and working principles. Each PMMA MCS, which has dimension of 1×1 cm2, will be fabricated by using hot embossing technique or X-ray lithography. A silicon mold has to be fabricated first by using silicon wafer and ICP-RIE process. Salient advantages of PMMA comb-drive actuators are low cost, high throughput and consuming less energy compared with the counterpart using silicon because PMMA has a lower Young's modulus.

关键词： Microactuators

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A novel gene carrier responding to intracellular signal protein kinase Cα

A novel gene carrier responding to intracellular signal prot...

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55th Society of Polymer science Japan Symposium on Macromolecules

作者： Toita, Riki Kang, Jeong-Hun Jiang, Yuhua Mori, Takeshi Niidome, Takuro Ktayama, Yoshiki Graduate School of System Life Sciences Kyushu University 744 Motooka Nishi-ku Fukuoka 819-0395 Japan Department of Applied Chemistry Faculty of Engineering Kyushu University 744 Motooka Nishi-Ku Fukuoka 819-0395 Japan CREST Japan Science and Technology Corporation 4-1-8 Honcho Kawaguchi-shi Saitama 322-0012 Japan Center for Future Chemistry Kyushu University Grant-in-Aid for the 21st Century COE Program

Gene therapy has been expected as a medical approach to treat tumors, inheritable diseases and so on. For gene therapy, effective delivery of gene to the target tissue is vitally important. Previously, we have proposed a novel approach for gene therapy using a drug delivery system responding to cellular signal (D-RECS), especially to protein kinase C (PKC) α. PKCα plays an important role in the differentiation and proliferation of tumor cell. It was known that extraordinary activation of PKCα is seen in many cancers such as breast cancer, melanoma, liver cancer and so on. In this study, PKCα was used as a target protein kinase for D-RECS.

关键词： Genes

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Empirical study of the compaction of cohesive bulk solids in a roll press

Aufbereitungs-Technik/Mineral Processing

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Aufbereitungs-Technik/Mineral Processing 2006年第6期47卷 22-29页

作者： Grossmann, Lilla Tomas, Jürgen Herold, Daniela Sommer, Karl Otto-von-Guericke-Universität Magdeburg Fakultät für Verfahrens- und Systemtechnik Institut für Verfahrenstechnik Mechanische Verfahrenstechnik Technische Universität München Weihenstephan Maschinen- und Apparatekunde Otto-von-Guericke University Magdeburg Faculty of Process and System Engineering Institute of Process Engineering Department of Mechanical Process Engineering Munich University of Technology Weihenstephan Department of Machine and Equipment Science

Press agglomeration in roll presses is a widely applied process in industry. In this process, free-flowing agglomerates are formed from fine bulk solids. Compaction in a roll press is a complex process, which is influenced by many parameters. The main objective of the tests was the study of the effect of machine parameters on compaction in a roll press - the speed ratio between the feed screw and rolls and the hydraulic pressure. The tests were performed with limestone flour, bentonite and microcrystalline cellulose (MCC).

关键词： Compaction

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Evaluation of the Effect of Visual Stimulation on Humans by Simultaneous Experiment with Multiple Subjects

Evaluation of the Effect of Visual Stimulation on Humans by ...

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Annual International Conference of the IEEE engineering in Medicine and Biology Society (EMBC)

作者： N. Sugita M. Yoshizawa A. Tanaka K. Abe S. Chiba T. Yambe S. Nitta Department of Electrical and Communication Graduate School of Engineering University of Tohoku Sendai Japan Research Division on Advanced Information Technology Information Synergy Center University of Tohoku Sendai Japan Department of Human Support System Faculty of Symbiotic Systems Science Fukushima University Fukushima Japan College of Engineering Nihon University Koriyama Japan Sharp Corporation Chiba Japan Institute of Development Aging and Cancer University of Tohoku Sendai Japan

To evaluate the biological effects of visual stimulation on multiple subjects watching a same image, a more compact and low-cost device measuring both ECG and photo-plethysmogram was developed. On the basis of these physiological parameters, the maximum cross-correlation coefficient, rho max , from pulse wave transmission time to heart rate could be calculated. This index reflects the activity of the autonomic nervous system and is considered as a good index for evaluating the effect of visual stimulation on humans. The result of simultaneous experiment with 6 subjects watching a video image taken by an intentionally swaying handy camera has shown that rho max of almost all subjects decreased in the latter part of the video image and that rho max of the subjects who felt motion sickness strongly decreased after watching the video image at a time

关键词： Humans Blood pressure Biomedical engineering Electrocardiography Heart rate Pressure measurement Autonomic nervous system Cameras Psychology Image analysis

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The Proposal of the EEG Characteristics Extraction Method in Weighted Principal Frequency Components Using the RGA

The Proposal of the EEG Characteristics Extraction Method in...

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SICE Annual Conference

作者： Shin-ichi Ito Yasue Mitsukura Hiroko Nakamura Miyamura Takafumi Saito Minoru Fukumi Department of Bio-Mechanics and Intelligent Systems Tokyo University of Agriculture슠and슠Technology Koganei Tokyo Japan Department of Bio-Mechanics and Intelligent Systems Tokyo University of Agriculture Agriculture and Technology Tokyo Japan Department of Bio-Mechanics and Intelligent Systems Tokyo University of Agriculture and Technology 2-24-16 Naka Koganei Tokyo 184-8588 Japan. Tel : +81-42-388-7150 E-mail: mitsu_e@cc.tuat.ac.jp Department of Information Science & Intelligent System Faculty of Engineering University of Tokushima Japan

An EEG has frequency components which can describe most of the significant features. These combinations are often unique like individual human beings and yet they have underlying basic features. These frequency components are contained the important and/or not so important components, and then each importance of these frequency components are different. The real-coded genetic algorithm (: RGA) is used for selecting and being weighted the principal characteristic frequency components. We attempt to construct mental change appearance model (: MCAM) of only one measurement point. In order to show the effectiveness of the proposed method, computer simulations are carried out by using real data

关键词： Proposals Electroencephalography Frequency Brain modeling Humans Sensor phenomena and characterization Feature extraction Data mining Intelligent systems Genetic algorithms

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Development of a virtual needle biopsy simulation system for the virtual prostate

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systems and Computers in Japan 2006年第1期37卷 93-104页

作者： Deguchi, Daisuke Mori, Kensaku Mekada, Yoshito Hasegawa, Jun-Ichi Toriwaki, Jun-Ichiro Noguchi, Masanori Graduate School of Engineering Nagoya University Nagoya 464-8603 Japan School of Computer and Cognitive Sciences Chukyo University Toyota 470-0393 Japan School of Medicine Department of Urology Kurume University Kurume 830-0011 Japan Faculty of Information Science Chukyo University Graduate School of Information Science Nagoya University Leice IEEE Japanese Society of Biomedical Engineering Japanese Society of Medical Imaging Technology Japan Medical Image Engineering Society Computer-Assisted Diagnostics Society School of Life System Science and Technology IPSJ JSAI JSMEBE JAMIT CADM JSSF IEEE CS Chukyo University Nagoya University Information Processing Society Computer-Assisted Image Diagnostics Society Department of Urology Japanese Urological Association Japan Society of Clinical Oncology Japan Cancer Society Japanese Society of Endourology and ESWL European Urological Association American Urological Association

This paper discusses the virtual prostate needle biopsy system and the construction of the virtual prostate model, considering the actual distribution of prostate abnormalities. A needle biopsy simulation is performed for the constructed virtual prostate, and the actual biopsy procedure in the clinical situation is evaluated. The prostate needle biopsy is a histologic diagnosis procedure in which a sample is acquired from the prostate tissue by needle biopsy and is inspected under a microscope. In order to achieve reliable prostate needle biopsy, it is necessary to consider systematically and numerically the number of needles required, and their locations and insertion angles. For such a purpose, a system is developed in which a virtual prostate is constructed on a computer and the biopsy procedure is evaluated quantitatively by performing virtually the prostate needle biopsy. Furthermore, two different models are constructed, for the prostate with and without hypertrophy, based on the actual statistical distribution data for prostate abnormalities. Each model is partitioned into the peripheral zone and the transition zone. The constructed virtual prostate is input into the virtual needle biopsy simulation system, and three different systematic biopsy procedures actually used at clinical sites, and four different needle biopsy procedures, are experimentally evaluated. The experiments show that the insertion angle that maximizes the hit probability is not always the same as the insertion angle that maximizes cancer sample acquisition. It is evident that the proposed method can indicate a biopsy procedure which realizes a high hit probability with a small number of needles. © 2005 Wiley Periodicals, Inc.

关键词： Biopsy

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Evaluation of electroosmotic velocity and zeta-potential in microchannel using submicron fluorescent particles

Nihon Kikai Gakkai Ronbunshu, B Hen/Transactions of the Japa...

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Nihon Kikai Gakkai Ronbunshu, B Hen/Transactions of the Japan Society of Mechanical Engineers, Part B 2005年第709期71卷 2316-2323页

作者： Ichiyanagi, Mitsuhisa Sato, Yohei Hishida, Koichi Department of System Design Engineering Faculty of Science and Technology Keio University 3-14-1 Hiyoshi Yokohama-shi Kanagawa 223-8522 Japan

Measurements of electrophoretic and electroosmotic velocities were performed by using micron-resolution particle image velocimetry (micro-PIV) and submicron fluorescent particles. Electrophoretic velocity of particles was obtained by micro-PIV measurement in a closed cell, while electroosmotic velocity of buffer solution in a microchannel was calculated by subtracting electrophoretic verocity from observed velocity measured by micro-PIV. Both zeta-potential of particles and microchannel wall were obtained by using electrophoretic and electroosmotic velocities, respectively, which are increased with increasing pH of buffer solution, due to deprotonation. Transient process of zeta-potential at the wall surface in a T-shaped microchannel was detected by spatially-averaged electroosmotic velocities.

关键词： Electroosmosis

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An assembly scheduling problem for a flexible manufacturing cell with arrival times of outside-producted components

Nihon Kikai Gakkai Ronbunshu, C Hen/Transactions of the Japa...

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Nihon Kikai Gakkai Ronbunshu, C Hen/Transactions of the Japan Society of Mechanical Engineers, Part C 2005年第3期71卷 1032-1039页

作者： Karuno, Yoshiyuki Hasegawa, Masao Kise, Hiroshi Department of Mechanical and System Engineering Faculty of Engineering and Design Kyoto Institute of Technology Sakyo ku Kyoto-shi. Kyoto 606-8585 Japan

This paper considers an assembly scheduling problem for a flexible manufacturing cell (FMC), which consists of m dedicated machines and an assembly machine. There are n jobs to be processed in the FMC. Each of the dedicated machines produces a component of a job. In addition to m components, each job requires some other components purchased from outside. The assembly machine cannot start processing the job until both of all components produced in-house and those purchased from oustide are available. The objective is to find a schedule of the n jobs that minimizes the maximum completion time (i.e., the makespan). It has been known that the scheduling problem is strongly NP-hard even when m = 2. This paper proposes a greedy heuristic algorithm to the problem, and shows that it delivers a 2-approximation solution in O (mn 2) time. The heuristic is also examined by means of numerical experiments, and the results are reported.

关键词： Flexible manufacturing systems

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Abstracts from the 6th International Conference on the engineering of Sport, 10-14 July 2006, Olympic Hall, Munich, Germany Abstracts

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SPORTS engineering 2006年第2期9卷 107-127页

作者： [Anonymous] University of Massachusetts Lowell USA Science & Mathematics Department Kettering University Flint USA University of Illinois USA Western Michigan University USA Washington State University USA Casecade Engine USA Kanazawa University Japan Sumitomo Light Metal Japan Massachusetts Institute of Technology USA Nanyang Technological University Bioengineering Singapore University of Vienna Anthropology Austria Department of Mechanical Engineering University of Bath UK INSA Lyon France PETZL France Sports Materials Research Group University of Birmingham UK Laboratoire de Modélisation des Activités Sportives Bourget du Lac France Technical University Kaiserslautern Germany Department of Engineering Mechanics United States Air Force Academy Colorado Springs USA SRAM Corporation Colorado Springs USA Sports Engineering Research Group University of Sheffield UK Sports Engineering CSES Sheffield Hallam University USA Sports Engineering CSES Sheffield Hallam University UK Technische Universität München Germany Rush University Medical Center Chicago USA Faculty of Sports Science Department of Sport Equipment & Materials TU München Germany RMIT University Australia Institute of Health and Sports Sciences University of Tsukuba Ibaraki Japan Machine and Control Department Polytechnic University Kanagawa Japan SRI Sports Ltd. Hyogo Japan SRI Research and Development Ltd. Hyogo Japan Mizuno Corporation Osaka Japan Fukuoka Institute of Technology Fukuoka Japan University of Limerick Éire Graduate School of Engineering Hokkaido University Japan Faculty of Engineering Kitami Institute of Technology Japan University of Calgary Canada TaylorMade-adidas Golf Company USA Davis Mechanical Engineering University of California USA Davis Mechanical & Aeronautical Engineering University of California USA University of Wales Institute Cardiff Cardiff School of Sport UWIC Cardiff Cardiff School of Sport UWIC Wales Loughborough University UK Cranfield University UK Cr

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