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arXiv 2020年

作者： Trobia, José Gabrick, Enrique C. Seifert, Evandro G. Borges, Fernando S. Protachevicz, Paulo R. Szezech, José D. Iarosz, Kelly C. Santos, Moises S. Caldas, Iberê L. Tian, Kun Ren, Hai-Peng Grebogi, Celso Batista, Antonio M. Graduate Program in Science - Physics State University of Ponta Grossa Ponta GrossaPR84030-900 Brazil Department of Mathematics and Statistics State University of Ponta Grossa Ponta GrossaPR84030-900 Brazil Department of Physics State University of Ponta Grossa Ponta GrossaPR84030-900 Brazil Center for Mathematics Computation and Cognition Federal University of ABC São Bernardo do CampoSP09606-045 Brazil Institute of Physics University of São Paulo São PauloSP05508-900 Brazil Faculty of Telêmaco Borba FATEB Telêmaco BorbaPR84266-010 Brazil Graduate Program in Chemical Engineering Federal Technological University of Paraná Ponta Grossa Paraná84016-210 Brazil Shaanxi Key Lab of Complex System Control and Intelligent Information Processing Xi’an University of Technology Xi’an710048 China Xi’an Technological University Xi’an710021 China Institute for Complex Systems and Mathematical Biology University of Aberdeen AberdeenAB24 3UE United Kingdom

Cancer is a term used to refer to a large set of diseases. The cancerous cells grow and divide and, as a result, they form tumours that grow in size. The immune system recognise the cancerous cells and attack them, though, it can be weakened by the cancer. One type of cancer treatment is chemotherapy, which uses drugs to kill cancer cells. Clinical, experimental, and theoretical research has been developed to understand the dynamics of cancerous cells with chemotherapy treatment, as well as the interaction between tumour growth and immune system. We study a mathematical model that describes the cancer growth, immune system response, and chemotherapeutic agents. The immune system is composed of resting cells that are converted to hunting cells to combat the cancer. In this work, we consider drug sensitive and resistant cancer cells. We show that the tumour growth can be controlled not only by means of different chemotherapy protocols, but also by the immune system that attacks both sensitive and resistant cancer cells. Furthermore, for all considered protocols, we demonstrate that the time delay from resting to hunting cells plays a crucial role in the combat against cancer cells. Copyright © 2020, The Authors. All rights reserved.

关键词： Chemotherapy

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The example of using the Xiaomi cameras in inventory of monumental objects-first results 5

The example of using the Xiaomi cameras in inventory of monu...

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2017 ISPRS TC II - 5th International Workshop LowCost 3D - Sensors, Algorithms, Applications

作者： Markiewicz, J.S. Lapiñski, S. Bienkowski, R. Kaliszewska, A. Faculty of Geodesy and Cartography Department of Photogrammetry Remote Sensing and Spatial Information Systems Warsaw University of Technology Warsaw Poland Faculty of Geodesy and Cartography Division of Engineering Geodesy and Control Surveying System Warsaw University of Technology Warsaw Poland System Research Institute Polish Academy of Sciences Poland

At present, digital documentation recorded in the form of raster or vector files is the obligatory way of inventorying historical objects. Today, photogrammetry is becoming more and more popular and is becoming the standard of documentation in many projects involving the recording of all possible spatial data on landscape, architecture, or even single objects. Low-cost sensors allow for the creation of reliable and accurate three-dimensional models of investigated objects. This paper presents the results of a comparison between the outcomes obtained when using three sources of image: Low-cost Xiaomi cameras, a full-frame camera (Canon 5D Mark II) and middle-frame camera (Hasselblad-Hd4). In order to check how the results obtained from the two sensors differ the following parameters were analysed: The accuracy of the orientation of the ground level photos on the control and check points, the distribution of appointed distortion in the self-calibration process, the flatness of the walls, the discrepancies between point clouds from the low-cost cameras and references data. The results presented below are a result of co-operation of researchers from three institutions: The systems Research Institute PAS, The department of Geodesy and Cartography at the Warsaw University of Technology and the National Museum in Warsaw. © 2017 Authors.

关键词： Cameras

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Stability and Neimark-Sacker bifurcation analysis for single gene discrete system with delay

Stability and Neimark-Sacker bifurcation analysis for single...

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Chinese control Conference

作者： Feng Liu Qicheng Mei Fenglan Sun Xinmei Wang Hua O. Wang Hubei key Laboratory of Advanced Control and Intelligent Automation for Complex Systems Wuhan China School of Automation China University of Geosciences Wuhan China Research Center of System Theory and Application Chongqing University of Posts and Telecommunications Chongqing China Department of Mechanical Engineering Boston University Boston MA USA

The network structure and functional properties of gene regulatory system and their relationships arc an important research field in systems biology. In this paper, a new improved model is proposed based on the study of gene expression process. The model takes into account the effect of protein concentration on the gene expression, so as to obtain a new bifurcation point and improve the performance of the system. The validity of the model is verified by theoretical analysis and data simulation.

关键词： Mathematical model Proteins Stability analysis Bifurcation Biological system modeling Delays RNA

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Black Box Modelling and Simulating the Dynamic Indoor Relative Humidity of a Laboratory Using Autoregressive–moving-average (ARMA) Model

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IOP Conference Series: Materials Science and engineering 2020年第1期884卷

作者： S F M Hussein M K Mohd Fitri Alif A O Al Rabeei A Faruq S M Zulkapli M S Noorazizi S A Zaki S S Abdullah Biologically Inspired System and Technology (Bio-iST) iKohza Department of Electronic Systems Engineering (ESE) Malaysia-Japan International Institute of Technology (MJIIT) UniversitiTeknologi Malaysia (UTM) Kuala Lumpur Jalan Sultan Yahya Petra (Jalan Semarak) 54100 Kuala Lumpur MALAYSIA. Department of Control and Mechatronics Engineering (CMED) School of Electrical Engineering Faculty of Engineering UniversitiTeknologi Malaysia (UTM) Johor Bahru 81310 Johor DarulTakzim MALAYSIA. Department of Electrical Engineering Faculty of Engineering Universitas Muhammadiyah Malang. Jl. Raya Tlogomas 246 65144 Malang INDONESIA. Engineering Department Razak Faculty of Technology and Informatics UniversitiTeknologi Malaysia (UTM) Kuala Lumpur Jalan Sultan Yahya Petra (Jalan Semarak) 54100 Kuala Lumpur MALAYSIA. Wind Engineering for (Urban Artificial Man-made) Environment Laboratory Department of Mechanical Precision Engineering (MPE) Malaysia-Japan International Institute of Technology (MJIIT) UniversitiTeknologi Malaysia (UTM) Kuala Lumpur Jalan Sultan Yahya Petra (Jalan Semarak) 54100 Kuala Lumpur MALAYSIA.

Modelling and simulation of the dynamic indoor relative humidity behaviour of a building is essential to test any proposed thermal comfort controller and strategy in the building. Like other plants, the dynamic indoor relative humidity behaviour of a building can be developed based on the white box model, black box model, and grey box model. This research focuses on the usage of autoregressive–moving-average (ARMA) model, a type of black box model to represent the dynamic indoor relative humidity behaviour of Industrial Instrumentation Laboratory at Malaysia-Japan International Institute of Technology (MJIIT), UniversitiTeknologi Malaysia (UTM) Kuala Lumpur and uses the real recorded data from the laboratory and minimal knowledge regarding the physical characteristics of the humidity behaviour in the laboratory. The performance of the ARMA model developed in this research is compared with the real recorded data from the laboratory. Result obtained shows that the ARMA model is enough for modelling and simulating the dynamic indoor relative humidity behaviour of the laboratory

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Genome-wide association study of long COVID

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Nature Genetics 2025年 1-16页

作者： Lammi, Vilma Nakanishi, Tomoko Jones, Samuel E. Andrews, Shea J. Karjalainen, Juha Cortés, Beatriz O’Brien, Heath E. Ochoa-Guzman, Ana Fulton-Howard, Brian E. Broberg, Martin Haapaniemi, Hele H. Kanai, Masahiro Pirinen, Matti Schmidt, Axel Mitchell, Ruth E. Mousas, Abdou Mangino, Massimo Huerta-Chagoya, Alicia Sinnott-Armstrong, Nasa Cirulli, Elizabeth T. Vaudel, Marc Kwong, Alex S. F. Maiti, Amit K. Marttila, Minttu M. Posner, Daniel C. Rodriguez, Alexis A. Batini, Chiara Minnai, Francesca Dearman, Anna R. Warmerdam, C. A. Robert Sequeros, Celia B. Winkler, Thomas W. Jordan, Daniel M. Rešcenko, Raimonds Miano, Lorenzo Lane, Jacqueline M. Chung, Ryan K. Guillen-Guio, Beatriz Leavy, Olivia C. Carvajal-Silva, Laura Aguilar-Valdés, Kevin Frangione, Erika Guare, Lindsay Vergasova, Ekaterina Marouli, Eirini Striano, Pasquale Zainulabid, Ummu Afeera Kumar, Ashutosh Ahmad, Hajar Fauzan Edahiro, Ryuya Azekawa, Shuhei Maj, Carlo Pensel, Max C. Miller, Abigail Nöthen, Markus M. Behzad, Pari Schultz, Sonja Heggemann, Julia Balla, Daniella Morrison, David R. Mooser, Vincent Perley, Danielle Ragoussis, Jiannis Rousseau, Simon Shi, Fangyi Lathrop, G. Mark Yanishevsky, Solomia Laurent, Laetitia Auld, Daniel Bertrand, Mylene Boisclair, Ariane Bourque, Guillaume Bujold, David Durand, Madeleine Adra, Darin St-Cyr, Janick Niemi, Mari E. K. Iyengar, Sudha K. Cai, Tianxi Cho, Kelly Sarvadhavabhatla, Sannidhi Donaire, Maria Sophia Valenzuela-Jorquera, Héctor Lamoza, Eduardo Arévalo, Tamara V. Retamales-Ortega, Rocío Sanhueza, Sergio Selman, Carolina S. Silva, Andrea X. Alarcon, Teresa A. Martínez, Matías F. Quiroga, Romina Zuñiga-Pacheco, Paula Zapata-Contreras, Daniela Yáñez, Cristian E. Quiñones, Luis A. Tobar-Calfucoy, Eduardo A. Monardes-Ramírez, Virginia A. Signore, Iskra A. Guajardo, Lissette G. Figueroa, Alvaro Oróstica, Karen Y. Muñoz, Christian A. Fuentes-Guajardo, Macarena Bocchieri, Pamela Cabrera, Camilo Echeverria, Cesar A. Cerpa, Leslie C. Donoso, Gerardo Gutiérrez-Richards, Scarlett Nova-Lamperti, Estefania Saez Hidalgo Institute for Molecular Medicine Finland (FIMM) Helsinki Institute of Life Science (HiLIFE) University of Helsinki Helsinki Finland Department of Human Genetics McGill University Montreal QC Canada Centre for Clinical Epidemiology Department of Medicine Lady Davis Institute Jewish General Hospital McGill University Montreal QC Canada Kyoto-McGill International Collaborative Program in Genomic Medicine Graduate School of Medicine Kyoto University Kyoto Japan Department of Genome Informatics Graduate School of Medicine the University of Tokyo Tokyo Japan Research Fellow Japan Society for the Promotion of Science Tokyo Japan Department of Psychiatry and Behavioral Sciences University of California San Francisco San Francisco CA United States Program in Medical and Population Genetics Broad Institute of Harvard and MIT Cambridge MA United States Stanley Center for Psychiatric Research Broad Institute of Harvard and MIT Cambridge MA United States Analytic and Translational Genetics Unit Massachusetts General Hospital Boston MA United States Genomes for Life-GCAT Lab CORE Program Germans Trias i Pujol Research Institute (IGTP) Badalona Spain Grup de REcerca en Impacte de les Malalties Cròniques i les seves Trajectòries (GRIMTra) Barcelona Spain Sano Genetics Limited London United Kingdom Unidad de Biología Molecular y Medicina Genómica Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán Mexico City Mexico Genetics and Genomic Sciences Icahn School of Medicine at Mount Sinai New York City NY United States Broad Institute Cambridge MA United States Analytical and Translational Genetics Unit Massachusetts General Hospital Harvard Medical School Boston MA United States Department of Mathematics and Statistics University of Helsinki Helsinki Finland Department of Public Health University of Helsinki Helsinki Finland Institute of Human Genetics University of Bonn School of Medicine and University Hospital Bonn Bonn Germany MRC Integrat

Infections can lead to persistent symptoms and diseases such as shingles after varicella zoster or rheumatic fever after streptococcal infections. Similarly, severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) infection can result in long coronavirus disease (COVID), typically manifesting as fatigue, pulmonary symptoms and cognitive dysfunction. The biological mechanisms behind long COVID remain unclear. We performed a genome-wide association study for long COVID including up to 6,450 long COVID cases and 1,093,995 population controls from 24 studies across 16 countries. We discovered an association of FOXP4 with long COVID, independent of its previously identified association with severe COVID-19. The signal was replicated in 9,500 long COVID cases and 798,835 population controls. Given the transcription factor FOXP4’s role in lung physiology and pathology, our findings highlight the importance of lung function in the pathophysiology of long COVID. © The Author(s) 2025.

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systematic Approach for Finding the Linearizable Regions in Dynamic Power system Models

Systematic Approach for Finding the Linearizable Regions in ...

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Power systems Computation Conference

作者： Johnny Leung Michel Kinnaert Jean-Claude Maun Fortunato Villella Department of Control Engineering and System Analysis Department of Bio- Electro-And Mechanical Systems Université libre de Bruxelles (ULB) Brussels Belgium Elia Grid International (EGI) Brussels Belgium

For dynamic stability assessment, TSOs are simulating large numbers of contingencies on a dynamic model that depicts their own network and beyond. This extension is needed for accurately reproducing the behavior of the real network, but intensifies in return the computational burden. In this paper, a systematic approach is proposed for finding the linearizable regions within the external area, which are suitable for model reduction. The overall idea consists in partitioning the external area into multiple clusters and assessing their level of nonlinearity individually. Upon the end of a temporary disturbance, the free motion of every cluster is confronted with the one of their linear approximation to determine a nonlinearity indicator. The responses are derived analytically to facilitate the integration into existing simulation software. The validity of the approach is assessed on the IEEE 118-bus system model for different fault locations.

关键词： Clusters Linearization Modal series method Nonlinearity indicator Power system stability

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Reference-tracking feedforward control design for linear dynamical systems through signal decomposition

Reference-tracking feedforward control design for linear dyn...

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American control Conference

作者： Yanin Kasemsinsup Raffaele Romagnoli Marcel Heertjes Siep Weiland Hans Butler Control Systems Group Department of Electrical Engineering Control Engineering and System Analysis(SAAS) Universitè Libre de Bruxelles(ULB) Belgium Control Systems Technology Group Department of Mechanical Engineering Eindhoven University of Technology P.O. Box 513 5600 MB Eindhoven The Netherlands

ISBN: (纸本)9781509045839

In this work, we study a novel approach towards the reference-tracking feedforward control design for linear dynamical systems. By utilizing the superposition property and exploiting signal decomposition together with a quadratic optimization process, we obtain a feedforward design procedure for arbitrary linear multi-input and multi-output (MIMO) systems with arbitrary time/parameter-varying characteristics. In other words, the proposed algorithm is applicable to the broad class of linear systems, i.e. linear-time-invariant (LTI), linear-time-varying (LTV) and linear-parameter-varying (LPV) systems. The interplay between the initial state, feedforward and feedback actions are elaborated in detail. The potential of the presented methodology is demonstrated through simulation examples.

关键词： design linear dynamical signal resolution DYNAMICAL systems Linear design control FEEDFORWARD control Optimization Procedure design process FEEDFORWARD Linear system

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Author Correction: Enhancing untargeted metabolomics using metadata-based source annotation

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Nature biotechnology 2023年第11期41卷 1656页

作者： Julia M Gauglitz Kiana A West Wout Bittremieux Candace L Williams Kelly C Weldon Morgan Panitchpakdi Francesca Di Ottavio Christine M Aceves Elizabeth Brown Nicole C Sikora Alan K Jarmusch Cameron Martino Anupriya Tripathi Michael J Meehan Kathleen Dorrestein Justin P Shaffer Roxana Coras Fernando Vargas Lindsay DeRight Goldasich Tara Schwartz MacKenzie Bryant Gregory Humphrey Abigail J Johnson Katharina Spengler Pedro Belda-Ferre Edgar Diaz Daniel McDonald Qiyun Zhu Emmanuel O Elijah Mingxun Wang Clarisse Marotz Kate E Sprecher Daniela Vargas-Robles Dana Withrow Gail Ackermann Lourdes Herrera Barry J Bradford Lucas Maciel Mauriz Marques Juliano Geraldo Amaral Rodrigo Moreira Silva Flavio Protasio Veras Thiago Mattar Cunha Rene Donizeti Ribeiro Oliveira Paulo Louzada-Junior Robert H Mills Paulina K Piotrowski Stephanie L Servetas Sandra M Da Silva Christina M Jones Nancy J Lin Katrice A Lippa Scott A Jackson Rima Kaddurah Daouk Douglas Galasko Parambir S Dulai Tatyana I Kalashnikova Curt Wittenberg Robert Terkeltaub Megan M Doty Jae H Kim Kyung E Rhee Julia Beauchamp-Walters Kenneth P Wright Maria Gloria Dominguez-Bello Mark Manary Michelli F Oliveira Brigid S Boland Norberto Peporine Lopes Monica Guma Austin D Swafford Rachel J Dutton Rob Knight Pieter C Dorrestein Collaborative Mass Spectrometry Innovation Center University of California San Diego La Jolla CA USA. Skaggs School of Pharmacy and Pharmaceutical Sciences University of California San Diego La Jolla CA USA. Beckman Center for Conservation Research San Diego Zoo Wildlife Alliance Escondido CA USA. Center for Microbiome Innovation Joan and Irwin Jacobs School of Engineering University of California San Diego La Jolla CA USA. Division of Biological Sciences University of California San Diego La Jolla CA USA. Department of Pediatrics School of Medicine University of California San Diego La Jolla CA USA. Bioinformatics and Systems Biology Program University of California San Diego La Jolla CA USA. Division of Rheumatology Allergy & Immunology Department of Medicine University of California San Diego La Jolla CA USA. Division of Epidemiology and Community Health School of Public Health University of Minnesota Minneapolis MN USA. Department of Integrative Physiology University of Colorado Boulder Boulder CO USA. Department of Population Health Sciences University of Wisconsin-Madison Madison WI USA. Servicio Autónomo Centro Amazónico de Investigación y Control de Enfermedades Tropicales Simón Bolívar Puerto Ayacucho Amazonas Venezuela. Department of Pediatrics Billings Clinic Billings MT USA. Department of Animal Science Michigan State University East Lansing MI USA. Department of Pharmacology Ribeirão Preto Medicinal School Center of Research in Inflammatory Diseases University of São Paulo Ribeirão Preto Sao Paolo Brazil. Multidisciplinary Health Institute Federal University of Bahia Vitória da Conquista Bahia Brazil. NPPNS Department of Biomolecular Sciences School of Pharmaceutical Sciences of Ribeirão Preto University of São Paulo Ribeirão Preto Sao Paolo Brazil. Department of Internal Medicine Ribeirão Preto Medical School Center of Research in Inflammatory Diseases University of São Paulo Ribeirão Preto Sao Paolo Brazil. Department

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Numerical Evaluation of a Robust Self-Triggered MPC Algorithm

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IFAC-PapersOnLine 2016年第22期49卷 151-156页

作者： Brunner, Florian D. Heemels, W.P.M.H. Allgöwer, Frank Institute for Systems Theory and Automatic Control University of Stuttgart Pfaffenwaldring 9 Stuttgart70569 Germany Control System Technology Group Department of Mechanical Engineering Eindhoven University of Technology Netherlands

We present numerical examples demonstrating the efficacy of a recently proposed self-triggered model predictive control scheme for disturbed linear discrete-time systems with hard constraints on the input and state. In order to reduce the amount of communication between the controller and the actuator, the control input is not re-computed at each point in time but only at certain sampling instances. These instances are determined in a self-triggered fashion in the sense that at every sampling instant the next sampling instant is computed as a function of the current system state. A compact set in the state space, whose size is a design parameter in the control scheme, is stabilized. © 2016

关键词： Discrete time control systems Digital control systems Model predictive control Predictive control systems Robustness (control systems) control inputs control schemes Design parameters Hard constraints Linear discrete time systems Predictive control Sampling instants Self triggered controls

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Non-contact transportation and rotation of micro objects by vibrating glass needle circularly under water

Non-contact transportation and rotation of micro objects by ...

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2017 IEEE International Conference on Robotics and Automation, ICRA 2017

作者： Liu, Xiaoming Kojima, Masaru Shi, Qing Wang, Huaping Sun, Tao Mae, Yasushi Huang, Qiang Arai, Tatsuo Fukuda, Toshio Intelligent Robotics Institute School of Mechatronical Engineering Key Laboratory of Biomimetic Robots and Systems Ministry of Education Key Laboratory of Intelligent Control and Decision of Complex System Beijing Institute of Technology Beijing100081 China Department of Systems Innovation Osaka University 1-3 Machikaneyama Toyonaka Osaka560-8531 Japan Faculty of Science and Engineering Meijo University 1-501 Shiogamaguchi Tenpaku-ku Nagoya468-8502 Japan

ISBN: (纸本)9781509046331

In micromanipulation, lots of methods have been developed to manipulate objects in microscale. However, few of them can be applied in both the transportation and the rotation of the micro objects. In this paper, we present a novel method to realize the non-contact transportation and rotation of the micro objects based on the vibration-induced swirl flow. A piezo actuator is set between the glass needle and a metal rod. The sine wave with controlled frequency and amplitude is input into the piezo actuator to drive the glass needle to move circularly, which is caused by resonance of the actuator and the metal rod. We place the glass needle under water and keep a limited distance to the bottom. The circular vibration of the glass needle can generate a swirl flow and low pressure around it. The low pressure can trap and transport the micro objects vertically to the glass needle, and the swirl flow can rotate the objects continuously. Finally, we realize the trap and rotation of micro object with only one piezo actuator. Experiments of transportation and rotation of microbeads are carried out, and the results demonstrate it is a simple, low-cost, effective micromanipulation method. © 2017 IEEE.

关键词： Needles

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