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Rapid synthesis of curcuminoid pyrazoles with antiviral effects through one-pot combinatorial modification of total curcuminoids

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Research and Reports in Medicinal Chemistry 2015年 5卷 41页

作者： Jie Wu Hong-Jin Tang Jiao-Jiao Xu Juan Ye Hai-Yan Tian Yao-Lan Li Ren-Wang Jiang 1 Institute of Traditional Chinese Medicine and Natural Products College of Pharmacy Jinan University Guangzhou2 Department of Pharmacy Renmin Hospital of Wuhan University 1 Institute of Traditional Chinese Medicine and Natural Products College of Pharmacy Jinan University Guangzhou 3 Department of Pharmacy Hospital of Huazhong University of Science and Technology Wuhan 1 Institute of Traditional Chinese Medicine and Natural Products College of Pharmacy Jinan University Guangzhou4 Shenzhen Engineering Laboratory of Lingnan Herbal Resource Development and Application Shenzhen Institute for Drug Control Shenzhen People’s Republic of China

:Four new curcuminoid pyrazoles (1–4) were synthesized by one-pot combinatorial modification of the total curcuminoid extract, through chemical transformation of β-diketone functionalities byp-chlorophenylhydrazine. All four curcuminoid pyrazoles were identified by spectroscopic methods, and the structure of compound 4 was further confirmed by single-crystal X-ray analysis. Compounds 1 and 2, with a long conjugated system and at least one methoxy substitution, showed a more potent antiviral effect than did the corresponding natural product, curcumin. The rapid synthesis of curcuminoid pyrazoles with improved antiviral activity highlights the great potential of one-pot combinatorial modification for the diversification of natural products with improved bioactivities.

关键词： curcumin one-pot combinatorial modification antiviral

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Exploring Organizational Learning Mechanisms in Small‐Size Business Enterprises

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New Horizons in Adult Education and human resource development 2013年第1期22卷 4 - 23页

作者： Carroll M. Graham Fredrick M. Nafukho Assistant Professor Human Resource Development Program College of Technology Indiana State University Associate Professor and Chair HRD Program Department of Education Administration & Human Resource Development College of Education and Human Development Texas A&M University

The primary purpose of this study was to determine the importance of existing organizational learning mechanisms and establish the size and magnitude of the relationship among the organizational learning mechanisms. Of great import also was to determine whether statistically significant relationships existed among the organizational learning mechanisms. An exploratory correlational research design was utilized to survey 498 employees from seven small‐size business enterprises located in the Southern and Mid‐Western United States. Mean scores indicated that respondents perceived leadership and evaluative inquiry as the prevalent learning mechanisms within the organizations studied. According to the findings, certain types of small‐size business enterprises exhibit organizational learning characteristics more so than do others involved in the study. The results of the correlation analysis showed that the learning mechanisms leadership and culture had the highest level of association, followed by culture and systems and structures.

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4th Pediatric Allergy and Asthma Meeting (PAAM)

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Clinical and Translational Allergy 2016年第S1期6卷 1-1页

作者： S. Tolga Yavuz Ozan Koc Ali Gungor Faysal Gok Jessica Hawley Christopher O’Brien Matthew Thomas Malcolm Brodlie Louise Michaelis Inês Mota Ângela Gaspar Susana Piedade Graça Sampaio José Geraldo Dias Miguel Paiva Mário Morais-Almeida Cristina Madureira Tânia Lopes Susana Lopes Filipa Almeida Alexandra Sequeira Fernanda Carvalho José Oliveira Fabienne Gay-Crosier Ioana-Valentina Nenciu Andreia Florina Nita Alexandru Ulmeanu Dumitru Oraseanu Carmen Zapucioiu Adrianna Machinena Olga Domínguez Sánchez Montserrat Alvaro Lozano Rosa Jiménez Feijoo Jaime Lozano Blasco Mònica Piquer Gibert Mª Teresa Giner Muñoz Marcia Dias da Costa Ana Maria Plaza Martín Ebru Arik Yilmaz Özlem Cavkaytar Betul Buyuktiryaki Ozge Soyer Cansin Sackesen Merryn Netting Adaweyah El-Merhibi Michael Gold Patrick Quinn Irmeli Penttila Maria Makrides Stavroula Giavi Antonella Muraro Roger Lauener Annick Mercenier Eugen Bersuch Isabella M. Montagner Maria Passioti Nicolò Celegato Selina Summermatter Sophie Nutten Tristan Bourdeau Yvonne M. Vissers Nikolaos G. Papadopoulos Hanneke van der Kleij Hans Warmenhoven Ronald van Ree Raymond Pieters Dirk Jan Opstelten Hans van Schijndel Joost Smit Roisin Fitzsimons Victoria Timms George Du Toit Guven Kaya Mustafa Gulec Mehmet Saldir Osman Sener Nagwa Hassan Hala Shaaban Hazem El-Hariri Ahmed Kamel Inas E. Mahfouz Papp Gabor Biro Gabor Kovacs Csaba Bo Chawes Klaus Bønnelykke Jakob Stokholm Lene Heickendorff Susanne Brix Morten Rasmussen Hans Bisgaard Henrik Wegener Hallas Lambang Arianto Maike Pincus Thomas Keil Andreas Reich Ulrich Wahn Susanne Lau Linus Grabenhenrich Sara Fagerstedt Helena Marell Hesla Emelie Johansson Helen Rosenlund Axel Mie Annika Scheynius Johan Alm Jorge Esparza-Gordillo Anja Matanovic Ingo Marenholz Anja Bauerfeind Klaus Rohde Katja Nemat Min-Ae Lee-Kirsch Magnus Nordenskjöld Marten C.G. Winge Renate Krüger Kirsten Beyer Birgit Kalb Bodo Niggemann Norbert Hübner Heather J. Cordell Maria Bradley Young-Ae Lee Hannah Gough Dirk Schramm John Beschorner Antje Schuster Carl-Peter Bauer Joha Department of Pediatric Allergy GATA School of Medicine Ankara Turkey Department of Pediatrics GATA School of Medicine Ankara Turkey Newcastle University Newcastle UK Royal Victoria Infirmary Great North Children’s Hospital Newcastle UK Great North Children’s Hospital Newcastle upon Tyne UK Immunoallergy Department CUF Descobertas Hospital Lisbon Portugal CHMA Famalicão Portugal Centro Hospitalar do Médio Ave Vila Nova de Fa Portugal Centro Hospitalar do Médio Ave Santo Tirso Portugal Clinical Allergy and Clinical Immunology Internal Medicine Federal Specialist Geneva Switzerland “Grigore Alexandrescu” Emergency Hospital for Children Bucharest Romania Carol Davila University of Medicine and Pharmacy Bucharest Romania Grigore Alexandrescu Clinical Emergency Hospital for Children Bucharest Romania Pediatric Allergy Department Hospital Sant Joan de Déu Barcelona Spain Pediatric Allergy Department Hospital Sant Joan de Déu Universitat de Barcelona Barcelona Spain Sant Joan de Déu Hospital Barcelona Spain Division of Pediatric Allergy School of Medicine Hacettepe University Ankara Turkey Department of Pediatric Allergy and Immunology Ankara Child Health and Diseases Hematology-Oncology Training and Research Hospital Ankara Turkey Women’s and Children’s Health Research Institute Adelaide Australia School of Pediatrics and Reproductive Health University of Adelaide Adelaide Australia School of Medicine The University of Adelaide Adelaide Australia South Australian Health Medical Research Institute Adelaide Australia Allergy Department 2nd Pediatric Clinic University of Athens Athens Greece Referral Centre for Food Allergy Diagnosis and Treatment Veneto Region Department of Women and Child Health Padua University Hospital Padua Italy Children’s Hospital of Eastern Switzerland St. Gallen Switzerland CK-CARE Davos Switzerland Nestlé Research Center Lausanne Switzerland Department of Surgery Oncology and Gastroenterology Veneto Institute of Oncology

WORKSHOP 4: Challenging clinical scenarios (CS01–CS06) CS01 Bullous lesions in two children: solitary mastocytoma S. Tolga Yavuz, Ozan Koc, Ali Gungor, Faysal Gok CS02 Multi-System Allergy (MSA) of cystic fibrosis: our institutional experience Jessica Hawley, Christopher O’Brien, Matthew Thomas, Malcolm Brodlie, Louise Michaelis CS03 Cold urticaria in pediatric age: an invisible cause for severe reactions Inês Mota, Ângela Gaspar, Susana Piedade, Graça Sampaio, José Geraldo Dias, Miguel Paiva, Mário Morais-Almeida CS04 Angioedema with C1 inhibitor deficiency in a girl: a challenge diagnosis Cristina Madureira, Tânia Lopes, Susana Lopes, Filipa Almeida, Alexandra Sequeira, Fernanda Carvalho, José Oliveira CS05 A child with unusual multiple organ allergy disease: what is the primer? Fabienne Gay-Crosier CS06 A case of uncontrolled asthma in a 6-year-old patient Ioana-Valentina Nenciu, Andreia Florina Nita, Alexandru Ulmeanu, Dumitru Oraseanu, Carmen Zapucioiu ORAL ABSTRACT SESSION 1: Food allergy (OP01–OP06) OP01 Food protein-induced enterocolitis syndrome: oral food challenge outcomes for tolerance evaluation in a Pediatric Hospital Adrianna Machinena, Olga Domínguez Sánchez, Montserrat Alvaro Lozano, Rosa Jimenez Feijoo, Jaime Lozano Blasco, Mònica Piquer Gibert, Mª Teresa Giner Muñoz, Marcia Dias da Costa, Ana Maria Plaza Martín OP02 Characteristics of infants with food protein-induced enterocolitis syndrome and allergic proctocolitis Ebru Arik Yilmaz, Özlem Cavkaytar, Betul Buyuktiryaki, Ozge Soyer, Cansin Sackesen OP03 The clinical and immunological outcomes after consumption of baked egg by 1–5 year old egg allergic children: results of a randomised controlled trial MerrynNetting, Adaweyah El-Merhibi, Michael Gold, PatrickQuinn, IrmeliPenttila, Maria Makrides OP04 Oral immunotherapy for treatment of egg allergy using low allergenic, hydrolysed egg Stavroula Giavi, Antonella Muraro, Roger Lauener, Annick Mercenier, Eugen Bersuch, Isabella M. Montagner, Maria Pass

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Engineer training in East Japan Transport technology Co., Ltd.

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Japanese Railway Engineering 2013年第178期 18-20页

作者： Taguchi, Hayato Human Resource Development Group Administration Department East Japan Transport Technology Co. Ltd. Japan

East Japan Transport technology Co., Ltd., Japan has introduced engineer training programs in its facility. The company's personnel training measures include the main business whose contents are divided into the maintenance and manufacturing of vehicles. Maintenance of various railway vehicles involves inspection and repair of vehicles and parts of various railway companies including JR East, running on conventional lines, linear motor car type subways, and new transportation systems. Design, installation, and maintenance of equipment required for maintenance involves planning a whole car depot with stretching from the cleaning and carrier equipment of vehicles and their parts to the part inspection equipment. Another such measure involves Vehicle manufacturing cooperating with the JR East vehicle factory. It works jointly with Niitsu Rolling Stock Plant to take care of the wide range works, including the partial manufacturing process of the vehicle which is operating in the Keihin Tohoku line, Sobu line, Yamanote line and Chuo line.

关键词： Vehicles

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Soft power: A critical factor for the effectiveness and development of a school

Soft power: A critical factor for the effectiveness and deve...

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9th IFIP International Conference on Network and Parallel Computing, NPC 2012

作者： Ko, Hui-Min Department of Technology Application and Human Resource Development National Taiwan University Taiwan

ISBN: (纸本)9783642356056

This research aims to explore the contents of a school's soft power, including culture, strategy, leadership, learning, marketing and innovation. Managing soft power not only is critical for a school's development, but also should be regarded as a indispensible asset of schools. The measures for a school to establish its soft power are: establishing core values, shaping a learning school, emphasizing on knowledge management, innovating, and introducing a more adaptive marketing strategy. A school could become more perspective and sustainable through soft power, and thus be able to deal with a fast-changing educational environment and meet practical requirements. © IFIP International Federation for Information Processing 2012.

关键词： Knowledge management

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A leadership initiative to enhance employee engagement amongst engineers at a gold mining plant in South Africa

A leadership initiative to enhance employee engagement among...

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Portland International Conference on Management of Engineering and technology (PICMET)

作者： Cecile Schultz Adéle Bezuidenhout Department People Management and Development Tshwane University of Technology Pretoria South Africa Department Human Resource Management University of South Africa Pretoria South Africa

Employee engagement mainly consists of three dimensions, namely emotional engagement, cognitive engagement and physical engagement. The aim of the current research was to determine whether a leadership initiative such as a leadership orientation workshop had a positive influence on the engagement of engineers at a gold mining plant in South Africa. A qualitative research method was utilized by conducting group interviews with engineers. Six focus group interviews with engineers from the plant were conducted. The interviews were recorded and transcribed. The narrative data was broken down into smaller units, coded and named according to the content represented. The recurring themes were then categorized and described. Categories such as bottom-up leadership, transformational leadership, charismatic leadership, authentic leadership, change leadership, mind-set training, values, strategic alignment, two-way feedback, recognition, trust, diversity, safety, relationships, job profiles, performance management and career development were identified. The charismatic leadership style of the plant manager and his commitment to engaging the engineers were strong themes throughout the research. The importance of enabling managers to become leaders was also clear. The overall perceptions were that the leadership workshop initiated employee engagement amongst the engineers.

关键词： Lead Conferences Interviews Companies Gold

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Cross-cultural training programs and expatriate adjustment effectiveness

Cross-cultural training programs and expatriate adjustment e...

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9th IFIP International Conference on Network and Parallel Computing, NPC 2012

作者： Kuo, Shiang-Lan Department of Technology Application and Human Resource Development National Taiwan Normal University Taiwan

ISBN: (纸本)9783642356056

The purpose of the study reported here was to explore cross-cultural training programs and expatriate adjustment effectiveness that increase effective cross-cultural interaction. Effective cross-cultural training increases trainees' knowledge, encourages them to see the personal and organizational benefits of cultural diversity and cross-cultural competence, and increases their skill and capacity to work with cultural diversity. Cross-cultural training is an effective strategy in the achievement of organizational performance targets and multicultural policy objectives. Addressing the identified limitations of current practice in CCT will increase its contribution to the development and enhancement of organizational and individual cultural competence. Moreover, developing cross-cultural training programs could add value to the firm and its people. © IFIP International Federation for Information Processing 2012.

关键词： Personnel training

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The instructional design of a web-based self-reflective learning portfolio for skill training

The instructional design of a web-based self-reflective lear...

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9th IFIP International Conference on Network and Parallel Computing, NPC 2012

作者： Lin, Hung-Chang Wang, Yao-Hua Department of Technology Application and Human Resource Development National Taiwan Normal University Taiwan

ISBN: (纸本)9783642356056

Technical education mainly focuses on the development of students' motor skills. At vocational educational schools in Taiwan, technical teachers usually teach skills in a big class. Therefore, those teachers always face the problems of not realizing students' learning process and difficulties;the evaluation is also deficient in credibility and validity. The learners' self-reflection can help teachers understand their learning process. In this study, the researchers analyze the objectives, strategies and introspection emphasis in the skill-training stages and provide recommendations for students to reflect in each phase. Then the researchers apply these recommendations as the basis of introspection to build a Web-based learning portfolio (WBLP) for skill training. The results of this study reveal that the Moodle platform conforms to the requirements of building a Web-based self-reflective learning portfolio for technical training purpose. Besides, this paper has mapped out the Moodle Modules that provide the self-reflection features for a technical-training WBLP. © IFIP International Federation for Information Processing 2012.

关键词： Students

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The difference analysis between demographic variables and personal attributes - The case of internal auditors in Taiwan

The difference analysis between demographic variables and pe...

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9th IFIP International Conference on Network and Parallel Computing, NPC 2012

作者： Chiu, Li-Jia Huang, Neng-Tang Norman Department of Technology Application and Human Resource Development National Taiwan Normal University Taiwan

ISBN: (纸本)9783642356056

Internal control plays a pivotal role in enhancing security operations and quality control in an organization. From the perspective of management, internal auditors work for ensuring effective operations and improving performance for all the management systems within the organization. They bear great responsibility and play a key role. This study aimed to explore the internal audit staff demographic variables of personality traits differences. This research selected samples of the internal auditors from domestic companies, i.e. members of the Institute of Internal Auditors, in Taipei, Hsinchu, Taichung, and Kaohsiung. A total of 567 questionnaires are issued and the number of valid questionnaires is 272. © IFIP International Federation for Information Processing 2012.

关键词： Quality control

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Skills needed by engineers in the platinum mining industry in South Africa

Skills needed by engineers in the platinum mining industry i...

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Portland International Conference on Management of Engineering and technology (PICMET)

作者： Lefaso Motsoeneng Cecile Schultz Adéle Bezuidenhout Mining Qualifications Authority South Africa Department of People Management and Development Tshwane University of Technology Pretoria South Africa Department of Human Resource Management University of South Africa Pretoria South Africa

The South African platinum mining industry faces continuous challenges in terms of increased global competition, demand for productivity, skills shortages, loss of scarce technical skills due to emigration, strikes and high turnover rates. Hence, the lack of engineering skills (technical and management skills) may seriously hamper the capacity of the mining industry to ensure that productivity and safety standards are maintained. A quantitative study was conducted on skills needed by platinum mining engineers in three provinces in South Africa. A four-point Likert-type scale questionnaire ranging from strongly agree to strongly disagree was developed. The Cronbach's alpha coefficient was above 0.8, indicating high internal reliability. The population consisted of 300 engineers in platinum mines in three provinces in South Africa. A convenience sample was used; 79 engineers volunteered to complete the questionnaire. The response rate was 26.3%. A factor analysis was conducted to determine which skills of the engineers were the main concerns. The results of the study indicated that theoretical knowledge, technical skills, management skills and engineering principles were skills needed for technology-based engineering in the platinum mines under study.

关键词： Knowledge engineering Mining industry Platinum Training Minerals Production

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