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Neuropsychiatric Electrophysiology 2016年第1期2卷 1-34页

作者： Igor Timofeev Leon Kenemans P. F. Fabene A. Ahnaou Sebastian Olbrich Robert Oostenveld Martijn Arns Nash Boutros Fernando Lopes da Silva Ole Jensen Sandra K. Loo Hans-Peter Landolt Jan Mathijs Schoffelen Alida A. Gouw Arjan Hillebrand Matteo Demuru Peterjan Ris Philip Scheltens Cornelis J. Stam Ida A. Nissen Ilse E. C. W. van Straaten Jaap C. Reijneveld Sonja Simpraga Ricardo Alvarez-Jimenez Huibert D. Mansvelder Joop M. A. van Gerven Geert Jan Groeneveld Simon-Shlomo Poil Klaus Linkenkaer-Hansen Michel J. A. M. van Putten Marleen C. Tjepkema-Cloostermans Jeannette Hofmeijer Claudio Babiloni Antonio Ivano Triggiani Roberta Lizio Susanna Cordone Antonio Brunetti Giacomo Tattoli Vitoantonio Bevilacqua Andrea Soricelli Raffaele Ferri Flavio Nobili Loreto Gesualdo José Carlos Millán-Calenti Ana Buján Rosanna Tortelli Valentina Cardinali Orietta Barulli Antonio Giannini Pantaleo Spagnolo Silvia Armenise Grazia Buenza Gaetano Scianatico Giancarlo Logroscino Giovanni B. Frisoni Claudio Del Percio Joerg F. Hipp Robert Comley Darren Bentley Michael Derks Pilar Garces Frederic Knoflach Sian Lennon-Chrimes Stephane Nave Jana Noldeke Nick Seneca Gerhard Trube Christoph Wandel Andrew WThomas Maria-Clemancia Hernandez Berrie Gerrits Madelon A. Vollebregt Roy P. C. Kessels Donna Palmer Evian Gordon Tieme W. P. Janssen Dirk J. Heslenfeld Rosa van Mourik Katleen Geladé Athanasios Maras Jaap Oosterlaan Daniel Brandeis Christian Sander Ulrich Hegerl Nash N. Boutros Alexandra Kirsten Anna-Lena Dohrmann Galina Surova T. A. Iseger J. L. Kenemans M. Arns Marcel A. Pawlowski Marek Adamczyk Thorsten Mikoteit Axel Steiger Martien J. Kas Karlijn I. van Aerde Clementina M. van Rijn Marijtje L. A. Jongsma Philip L. C. van den Broek Jan van Egmond C. Walsh L. Raeymaekers R. Biermans N. V. Manyakov C. Wintmolders A. Bottelbergs K. Van Kolen D. Moechars J. A. Kemp W. H. Drinkenburg Nicola Marzano Susanna Lopez Giuseppe Noce Cristina Bagnoli Paolo Maria Rossini Flavio Mariano Nobili David Bartres Faz Olivier Blin Pierre Payoux Regis Bordet Bernh Department of Psychiatry and Neuroscience Université Laval Québec Canada Centre de recherche de l’Institut universitaire en santé mentale de Québec (CRIUSMQ) Université Laval Québec Canada Experimental Psychology Helmholtz Institute Utrecht University Utrecht Netherlands Department Neuroscience Biomedicine and Movement School of Medicine University of Verona Verona Italy A Division of Janssen Pharmaceutica NV Department of Neuroscience Discovery Janssen Research & Development Beerse Belgium Department for Psychiatry Psychotherapy and Psychosomatic University of Zurich Zurich Switzerland Donders Institute for Brain Cognition and Behaviour Radboud University Nijmegen The Netherlands NatMEG Karolinska Institute Stockholm Sweden euroCare group Munich Germany Research Institute Brainclinics Nijmegen The Netherlands Department of Experimental Psychology Utrecht University Utrecht The Netherlands University of Missouri-Kansas City Kansas City USA Centre of Neuroscience Swammerdam Institute for Life Sciences University of Amsterdam Amsterdam The Netherlands School of Psychology University of Birmingham Birmingham UK Department of Psychiatry and Biobehavioral Sciences UCLA Los Angeles USA Institute of Pharmacology and Toxicology University of Zürich Zürich Switzerland Zürich Center for interdisciplinary Sleep Research University of Zürich Zürich Switzerland Donders Institute Radboud University Nijmegen The Netherlands Alzheimer Center and Department of Neurology Neuroscience Campus Amsterdam VU University Medical Center Amsterdam The Netherlands Department of Clinical Neurophysiology and MEG Center Neuroscience Campus Amsterdam VU University Medical Center Amsterdam The Netherlands Department of Clinical Neurophysiology and MEG Center VU University Medical Center Amsterdam The Netherlands Brain Tumor Center Amsterdam & Department of Neurology VU University Medical Center Amsterdam The Netherlands Department Integrative Neurophysiology CNCR Neuroscie

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Classes and phyla of the kingdom Fungi

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Fungal Diversity 2024年第1期124卷 1-165页

作者： Nalin N.Wijayawardene Kevin D.Hyde Kirill V.Mikhailov Gabor Peter Andre Aptroot Carmen L.A.Pires‑Zottarelli Bruno T.Goto Yuri S.Tokarev Danny Haelewaters Samantha C.Karunarathna Paul M.Kirk Andre L.C.M.de A.Santiago Ramesh K.Saxena Nathan Schoutteten Madhara K.Wimalasena Vladimir V.Aleoshin Abdullah M.S.Al‑Hatmi Kahandawa G.S.U.Ariyawansa Amanda R.Assuncao Thushara C.Bamunuarachchige Hans‑Otto Baral D.Jayarama Bhat Janusz Błaszkowski Teun Boekhout Nattawut Boonyuen Michael Brysch‑Herzberg Bin Cao Jonathan Cazabonne Xue‑Mei Chen Claudia Coleine Dong‑Qin Dai Heide‑Marie Daniel Suzana B.G.da Silva Francisco Adriano de Souza Somayeh Dolatabadi Manish K.Dubey Arun K.Dutta Aseni Ediriweera Eleonora Egidi Mostafa S.Elshahed Xinlei Fan Juliana R.B.Felix Mahesh C.A.Galappaththi Marizeth Groenewald Li‑Su Han Bo Huang Vedprakash G.Hurdeal Anastasia N.Ignatieva Gustavo H.Jeronimo Ana L.de Jesus Serhii Kondratyuk Jaturong Kumla Martin Kukwa Qirui Li Juliana L.R.Lima Xiao‑Yong Liu Wenhua Lu H.Thorsten Lumbsch Hugo Madrid Franco Magurno Guy Marson Eric H.C.McKenzie Audrius Menkis Armin Mešić Elaine C.R.Nascimento Elena S.Nassonova Yong Nie Naasson V.L.Oliveira Emilia A.Ossowska Julia Pawłowska Ursula Peintner Igor R.Pozdnyakov Bhagya M.Premarathne A.K.Hasith Priyashantha C.Alisha Quandt Mariana B.Queiroz Kunhiraman C.Rajeshkumar Mubashar Raza Niranjan Roy Milan C.Samarakoon Alessandra A.Santos Lidiane A.Santos Felix Schumm Laura Selbmann Faruk Selcuk D.Rabern Simmons Anastasia V.Simakova Maudy Th.Smith Onden Paraparath Sruthi Nakarin Suwannarach Kazuaki Tanaka Saowaluck Tibpromma Elias O.Tomas Merve Ulukapı Nicolas Van Vooren Dhanushka N.Wanasinghe Evi Weber Qianzhen Wu Er Fu Yang Ryuichi Yoshioka Noha H.Youssef Annemarie Zandijk Gui‑Qing Zhang Jin‑Yong Zhang Heng Zhao RuiLin Zhao Oleg A.Zverkov Marco Thines Sergey A.Karpov Center for Yunnan Plateau Biological Resources Protection and Utilization College of Biological Resource and Food EngineeringQujing Normal UniversityQujing 655011YunnanPeople’s Republic of China Tropical Microbiology Research Foundation 96/N/10Meemanagoda RoadPannipitiya 10230Sri Lanka Department of Bioprocess Technology Faculty of TechnologyRajarata UniversityMihintaleSri Lanka Center of Excellence in Fungal Research Mae Fah Luang UniversityChiang Rai 57100Thailand School of Science Mae Fah Luang UniversityChiangRai 57100Thailand Innovative Institutefor Plant Health Zhongkai University of Agriculture and EngineeringGuangzhou 510225People’s Republic of China CAS Key Laboratory for Plant Biodiversity and Biogeography of East Asia(KLPB) Kunming Institute of BotanyChinese Academy of ScienceKunmingYunnanChina Belozersky Institute of Physicochemical Biology Lomonosov Moscow State UniversityLeninskye Gory1Build.40Moscow 119991Russian Federation Kharkevich Institute for Information Transmission Problems Russian Academy of SciencesMoscow 127051Russian Federation National Collection of Agricultural and Industrial Microorganisms Institute of Food Science and TechnologyHungarian University of Agriculture and Life SciencesSomlóiút 14‑161118 BudapestHungary Instituto de Biociências Universidade Federal de Mato Grosso do SulAvenida Costa e Silvas/n Bairro UniversitárioCampo GrandeMS CEP 79070‑900Brazil Instituto de Pesquisas Ambientais Secretaria do Meio AmbienteInfraestrutura e LogísticaAv.Miguel Stéfano 3687São PauloSP CEP 04301‑902Brazil Departamento de Botânica e Zoologia Universidade Federal do Rio Grande do NorteCampus UniversitárioNatalRN 59078-900Brazil All-Russian Institute of Plant Protection Sh.Podbelskogo 3PushkinSt.Petersburg 196608Russia Research Group Mycology Department of BiologyGhent University9000 GhentBelgium Faculty of Science University of South Bohemia37005ČeskéBudějoviceCzech Republic Department of Ecology and Evolutionary Biology University of Colora

Fungi are one of the most diverse groups of organisms with an estimated number of species in the range of 2–3 *** higher-level ranking of fungi has been discussed in the framework of molecular phylogenetics since Hibbett et al.,and the definition and the higher ranks(e.g.,phyla)of the‘true fungi’have been revised in several subsequent *** accumulation of novel genomic data and the advancements in phylogenetics now facilitate a robust and precise foundation for the higher-level classification within the *** study provides an updated classification of the kingdom Fungi,drawing upon a comprehensive phylogenomic analysis of Holomycota,with which we outline well-supported nodes of the fungal tree and explore more contentious *** accept 19 phyla of Fungi,***,Ascomycota,Basidiobolomycota,Basidiomycota,Blastocladiomycota,Calcarisporiellomycota,Chytridiomycota,Entomophthoromycota,Entorrhizomycota,Glomeromycota,Kickxellomycota,Monoblepharomycota,Mortierellomycota,Mucoromycota,Neocallimastigomycota,Olpidiomycota,Rozellomycota,Sanchytriomycota,and *** the phylogenies,Caulochytriomycota resides in Chytridiomycota;thus,the former is regarded as a synonym of the latter,while Caulochytriomycetes is viewed as a class in *** provide a description of each phylum followed by its classes.A new subphylum,Sanchytriomycotina Karpov is introduced as the only subphylum in *** subclass Pneumocystomycetidae Kirk et *** Pneumocystomycetes,Ascomycota is invalid and thus *** of fossil fungi in phyla and classes are also discussed,providing examples.

关键词： Caulochytriomycota Phylogenomic analyses Pneumocystomycetidae Sanchytriomycotina

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Author Correction: A RUNX-targeted gene switch-off approach modulates the BIRC5/PIF1-p21 pathway and reduces glioblastoma growth in mice

Communications biology

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Communications biology 2022年第1期5卷 1021页

作者： Etsuko Yamamoto Hattori Tatsuya Masuda Yohei Mineharu Masamitsu Mikami Yukinori Terada Yasuzumi Matsui Hirohito Kubota Hidemasa Matsuo Masahiro Hirata Tatsuki R Kataoka Tatsutoshi Nakahata Shuji Ikeda Susumu Miyamoto Hiroshi Sugiyama Yoshiki Arakawa Yasuhiko Kamikubo Department of Neurosurgery Graduate School of Medicine Kyoto University Kyoto City Kyoto 606-8507 Japan. Department of Human Health Sciences Graduate School of Medicine Kyoto University Department of Pediatrics Graduate School of Medicine Kyoto University Department of Diagnostic Pathology Kyoto University Hospital Drug Discovery Technology Development Office Center for iPS Cell Research and Application (CiRA) Kyoto University Department of Chemistry Graduate School of Science Kyoto University Kyoto City Kyoto 606-8502 Japan. Kyoto City Kyoto 606-8502 Japan. sugiyama.hiroshi.3s@kyoto-u.ac.jp. Kyoto City Kyoto 606-8507 Japan. yarakawa@kuhp.kyoto-u.ac.jp. Kyoto City Kyoto 606-8507 Japan. kamikubo.yasuhiko.7u@kuhp.kyoto-u.ac.jp.

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Abstracts from the Food Allergy and Anaphylaxis Meeting 2016 Abstracts

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CLINICAL AND TRANSLATIONAL ALLERGY 2017年第SUPPL 1期7卷 10-10页

作者： [Anonymous] Department of Pediatrics Children’s Hospital Roubaix France Division of Pulmonology and Allergology Department of Pediatrics Faculty of Medicine and Children’s Hospital Lille France Allergy Vigilance Network Vandoeuvre les Nancy France Université Lille 2 CHU Lille EA 2694 - Santé Publique: épidémiologie et qualité des soins Lille France Biostatistics Unit Maison Régionale de la Recherche Clinique CHRU Lille Lille France Department of Allergology Emile Durkheim Hospital Epinal France Centre d’Epidémiologie sur les Causes Médicales de Décès INSERM CHU de Bicêtre Le Kremlin-Bicêtre France The Allergy Vigilance Network University Hospital Nancy Nancy France Pediatric Pulmonology and Allergy Department Hôpital Jeanne de Flandre CHU Lille Lille France Charité - Universitätsmedizin Berlin Berlin Germany Institute for Social Medicine Epidemiology and Health Economics Charité - Universitätsmedizin Berlin Berlin Germany Institute of Social Medicine Epidemiology and Health Economics Charité Universitätsmedizin Berlin Berlin Germany Department of Dermatology and Allergology Comprehensive Allergy Center Charité Charité – Universitätsmedizin Berlin Berlin Germany Department of Dermatology and Allergy Allergie-Centrum-Charité Charité-Universiätsmedizin Berlin Berlin Germany Department of Dermatology and Allergology Comprehensive Allergy Center Charité Charité Universitätsmedizin Berlin Berlin Germany University Hospital Basel Basel Switzerland Allergy Unit Department of Dermatology University Hospital Basel Switzerland Universitätsklinikum Salzburg Salzburg Austria Department of Dermatology and Allergy Centre Odense Research Center for Anaphylaxis (ORCA) Odense University Hospital Odense Denmark Odense University Hospital Odense Denmark Serviço de ImunoalergologiaCentro Hospitalar de São João E.P.E. Porto Portugal GRIAC Research Institute University of Groningen University Medical Center Groningen Groningen The Netherlands Serviço de Imunoalergologia Centr

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Publisher Correction: Global estimates on the number of people blind or visually impaired by cataract: a meta-analysis from 2000 to 2020

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Eye (London, England) 2024年第11期38卷 2229-2231页

作者： Konrad Pesudovs Hugh R. Taylor Tabassom Sedighi Rupert R. A. Bourne Shahina Pardhan Van Charles Lansingh John H. Kempen Ian Tapply Arthur G. Fernandes Maria Vittoria Cicinelli Alessandro Arrigo Nicolas Leveziel Serge Resnikoff Seth Flaxman Mukkharram M. Bikbov Tasanee Braithwaite Alain Bron Ching-Yu Cheng Monte A. Del Monte Joshua R. Ehrlich Leon B. Ellwein David Friedman João M. Furtado Gus Gazzard Ronnie George M. Elizabeth Hartnett Jost B. Jonas Rim Kahloun Moncef Khairallah Rohit C. Khanna Janet Leasher Julie-Anne Little Vinay Nangia Michal Nowak Tunde Peto Pradeep Ramulu Fotis Topouzis Mitiadis Tsilimbaris Ya Xing Wang Ningli Wang Paul Svitil Briant Theo Vos Katrin Burkart Kaleb Coberly Xiaochen Dai Stephen S. Lim Tomislav Mestrovic Ali H. Mokdad Christopher J. L. Murray Jaimie D. Steinmetz Awoke Misganaw Yohannes Habtegiorgis Abate Mohammad Abdollahi Mozhan Abdollahi Ayele Mamo Abebe Olumide Abiodun Richard Gyan Aboagye Woldu Aberhe Abrha Hasan Abualruz Hiwa Abubaker Ali Eman Abu-Gharbieh Salahdein Aburuz Tadele Girum Girum Adal Mesafint Molla Adane Isaac Yeboah Addo Qorinah Estiningtyas Sakilah Adnani Muhammad Sohail Afzal Muhammad Umair Shahin Aghamiri Bright Opoku Ahinkorah Aqeel Ahmad Sajjad Ahmad Ali Ahmadi Siamak Sabour Ayman Ahmed Haroon Ahmed Ahmad Samir Alfaar Abid Ali Syed Shujait Shujait Ali Awais Altaf Hubert Amu Emmanuel Manu Sofia Androudi Rodrigo Anguita Abhishek Anil Rimple Jeet Kaur Muhammad Aaqib Shamim Saeid Anvari Anayochukwu Edward Anyasodor Francis Appiah Jalal Arabloo Haleh Ayatollahi Mosab Arafat Damelash Areda Reza Arefnezhad Brhane Berhe Aregawi Akeza Awealom Asgedom Tahira Ashraf Seyyed Shamsadin Athari Bantalem Tilaye Tilaye Atinafu Birhan Tsegaw Taye Maha Moh’d Wahbi Atout Alok Atreya Ahmed Y. Azzam Hassan Babamohamadi Sara Bagherieh Yogesh Bahurupi Atif Amin Baig Shumaila Nargus Biswajit Banik Mainak Bardhan Saurav Basu Kavita Batra Nebiyou Simegnew Bayileyegn Fatemeh Bazvand Addisu Shunu Beyene Awoke Masrie Asrat Derese Devidas S. Bhagat Akshaya Srikanth Bhagavathula Pankaj Bh Medicine & Health University of New South Wales Sydney NSW Australia School of Optometry and Vision Science University of New South Wales Sydney NSW Australia School of Population and Global Health University of Melbourne Carlton VIC Australia Vision and Eye Research Institute Anglia Ruskin University Cambridge UK HelpMeSee Instituto Mexicano de Oftalmologia Santiago de Querétaro Mexico University of Miami Gables FL USA University of Utah Salt Lake City UT USA Chief Medical Office HelpMeSee New York NY USA Mexican Institute of Ophthalmology Queretaro Mexico Department of Ophthalmology Massachusetts Eye and Ear/Shepens Eye Research Institute/Harvard Medical School Boston MA USA Eye Unit MyungSung Christian Medical Center (MCM) Comprehensive Specialized Hospital and MyungSun Medical College Addis Ababa Ethiopia Department of Ophthalmology Addis Ababa University Addis Ababa Ethiopia Sight for Souls Bellevue WA USA Department of Ophthalmology Harvard University Boston MA USA Eye Unit MyungSung Medical College Addis Ababa Ethiopia Addenbrooke’s Hospital Cambridge UK Department of Ophthalmology Cambridge University Hospitals Cambridge UK Federal University of Sao Paolo Sao Paolo SP Brazil University of Calgary Calgary AB Canada Department of Ophthalmology and Visual Sciences Federal University of São Paulo Sao Paulo Brazil School of Medicine Vita-Salute San Raffaele University Milan Italy Department of Ophthalmology IRCCS San Raffaele Scientific Institute Milan Italy Department of Ophthalmology San Raffaele Scientific Institute Milano Italy IRCCS San Raffaele Scientific Institute Vita-Salute University Milan Italy Scientific Institute San Raffaele Hospital Vita-Salute University Milan Italy University of Poitiers Poitiers France CHU de Poitiers Poitiers France Ophthalmology Department CHU de Poitiers (Poitiers University Hospital) Poitiers France Unité 1084 National Institute of Health and Medical Research (INSERM) Poitiers France

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Mechanical properties of laminated bamboo panel

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AIP Conference Proceedings 2022年第1期2644卷

作者： Salim Salim Mohamad Amirul Haziq Salman Ahmad Mazlan Othman Norashikin Abdul Hamid Mohammad Hairi Osman Erwan Sanik 1Civil Engineering Department Centre of Diploma Studies Universiti Tun Hussein Onn Malaysia 84600 Pagoh Muar Johor Malaysia. 2Faculty of Technical and Vocational Education Universiti Tun Hussein Onn Malaysia 86400 Parit Raja Batu Pahat Johor Malaysia. 3Bamboo Jungle Adventure Teratak lhsan No. 2 Kpg Talang Tengah 31120 Sungai Siput (U) Perak Malaysia. 4School of Human Resource Development and Psychology University of Technology Malaysia T08 Level 1 Faculty of Social Sciences 81900 Skudai Johor Malaysia. 5Faculty of Engineering Technology University Tun Hussien Onn Malaysia 84600 Pagoh Muar Johor Malaysia. 6Centre of Diploma Studies Universiti Tun Hussein Onn Malaysia 84600 Pagoh Muar Johor Malaysia.

Plywood is the glued of vernier layers. In construction, it is usually used to make parts of restriction in the home or building. The thickness of plywood between 3mm to 32mm and marketed in two sizes that 91cm x 183cm and 122cm x 244cm. Bamboo is a type of plant that is unique for its fast growth. Bamboo grows up faster comparing to any other kind of wood resource and also lighter in weight. It also has a great strength which can withstand high pressure due to any kind of loads and can maintain for a long time efficiently. Using bamboo will get more beautiful artwork and attract people. Moreover, bamboo is easily found and has a reasonable price compared to timber and others. The purpose of this project is to design and produce the model of the rest house using the laminated bamboo and also to determine the mechanical properties of the bamboo which is safe and suitable to be used. The main materials that had been used to build the model are Dendrocalamus Asper which is also known as Buluh Betung. It is cut into pieces and combined together to form a laminated bamboo. Laminated bamboo has been used in every part of the model, including walls, roof, truss, and floor. Mechanic properties of laminated bamboo had undergone three tests which were compressive, tensile, and bending test according to the standards of BS EN (British and European Standard). All of these tests were conducted to know the flexibility and strength of the laminated bamboo.

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Genetic drivers of heterogeneity in type 2 diabetes pathophysiology

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Nature 2024年第8003期627卷 347-357页

作者： Ken Suzuki Konstantinos Hatzikotoulas Lorraine Southam Henry J Taylor Xianyong Yin Kim M Lorenz Ravi Mandla Alicia Huerta-Chagoya Giorgio E M Melloni Stavroula Kanoni Nigel W Rayner Ozvan Bocher Ana Luiza Arruda Kyuto Sonehara Shinichi Namba Simon S K Lee Michael H Preuss Lauren E Petty Philip Schroeder Brett Vanderwerff Mart Kals Fiona Bragg Kuang Lin Xiuqing Guo Weihua Zhang Jie Yao Young Jin Kim Mariaelisa Graff Fumihiko Takeuchi Jana Nano Amel Lamri Masahiro Nakatochi Sanghoon Moon Robert A Scott James P Cook Jung-Jin Lee Ian Pan Daniel Taliun Esteban J Parra Jin-Fang Chai Lawrence F Bielak Yasuharu Tabara Yang Hai Gudmar Thorleifsson Niels Grarup Tamar Sofer Matthias Wuttke Chloé Sarnowski Christian Gieger Darryl Nousome Stella Trompet Soo-Heon Kwak Jirong Long Meng Sun Lin Tong Wei-Min Chen Suraj S Nongmaithem Raymond Noordam Victor J Y Lim Claudia H T Tam Yoonjung Yoonie Joo Chien-Hsiun Chen Laura M Raffield Bram Peter Prins Aude Nicolas Lisa R Yanek Guanjie Chen Jennifer A Brody Edmond Kabagambe Ping An Anny H Xiang Hyeok Sun Choi Brian E Cade Jingyi Tan K Alaine Broadaway Alice Williamson Zoha Kamali Jinrui Cui Manonanthini Thangam Linda S Adair Adebowale Adeyemo Carlos A Aguilar-Salinas Tarunveer S Ahluwalia Sonia S Anand Alain Bertoni Jette Bork-Jensen Ivan Brandslund Thomas A Buchanan Charles F Burant Adam S Butterworth Mickaël Canouil Juliana C N Chan Li-Ching Chang Miao-Li Chee Ji Chen Shyh-Huei Chen Yuan-Tsong Chen Zhengming Chen Lee-Ming Chuang Mary Cushman John Danesh Swapan K Das H Janaka de Silva George Dedoussis Latchezar Dimitrov Ayo P Doumatey Shufa Du Qing Duan Kai-Uwe Eckardt Leslie S Emery Daniel S Evans Michele K Evans Krista Fischer James S Floyd Ian Ford Oscar H Franco Timothy M Frayling Barry I Freedman Pauline Genter Hertzel C Gerstein Vilmantas Giedraitis Clicerio González-Villalpando Maria Elena González-Villalpando Penny Gordon-Larsen Myron Gross Lindsay A Guare Sophie Hackinger Liisa Hakaste Sohee Han Andrew T Hattersley Christian Herder Momoko Horikoshi Annie-Green Howard Willa Centre for Genetics and Genomics Versus Arthritis Centre for Musculoskeletal Research Division of Musculoskeletal and Dermatological Sciences University of Manchester Manchester UK. Department of Diabetes and Metabolic Diseases Graduate School of Medicine University of Tokyo Tokyo Japan. Department of Statistical Genetics Osaka University Graduate School of Medicine Suita Japan. Institute of Translational Genomics Helmholtz Zentrum München German Research Center for Environmental Health Neuherberg Germany. konstantinos.hatzikotoulas@helmholtz-munich.de. Institute of Translational Genomics Helmholtz Zentrum München German Research Center for Environmental Health Neuherberg Germany. Center for Precision Health Research National Human Genome Research Institute National Institutes of Health Bethesda MD USA. British Heart Foundation Cardiovascular Epidemiology Unit Department of Public Health and Primary Care University of Cambridge Cambridge UK. Heart and Lung Research Institute University of Cambridge Cambridge UK. Department of Epidemiology School of Public Health Nanjing Medical University Nanjing China. Department of Biostatistics and Center for Statistical Genetics University of Michigan Ann Arbor MI USA. Corporal Michael J. Crescenz VA Medical Center Philadelphia PA USA. Department of Systems Pharmacology and Translational Therapeutics University of Pennsylvania Perelman School of Medicine Philadelphia PA USA. Department of Genetics University of Pennsylvania Perelman School of Medicine Philadelphia PA USA. Programs in Metabolism and Medical and Population Genetics Broad Institute of Harvard and MIT Cambridge MA USA. Diabetes Unit and Center for Genomic Medicine Massachusetts General Hospital Boston MA USA. TIMI Study Group Division of Cardiovascular Medicine Brigham and Women's Hospital Harvard Medical School Boston MA USA. William Harvey Research Institute Barts and the London School of Medicine and Dentistry Queen Mary University of London L

Type 2 diabetes (T2D) is a heterogeneous disease that develops through diverse pathophysiological processes and molecular mechanisms that are often specific to cell type. Here, to characterize the genetic contribution to these processes across ancestry groups, we aggregate genome-wide association study data from 2,535,601 individuals (39.7% not of European ancestry), including 428,452 cases of T2D. We identify 1,289 independent association signals at genome-wide significance (P < 5 × 10) that map to 611 loci, of which 145 loci are, to our knowledge, previously unreported. We define eight non-overlapping clusters of T2D signals that are characterized by distinct profiles of cardiometabolic trait associations. These clusters are differentially enriched for cell-type-specific regions of open chromatin, including pancreatic islets, adipocytes, endothelial cells and enteroendocrine cells. We build cluster-specific partitioned polygenic scores in a further 279,552 individuals of diverse ancestry, including 30,288 cases of T2D, and test their association with T2D-related vascular outcomes. Cluster-specific partitioned polygenic scores are associated with coronary artery disease, peripheral artery disease and end-stage diabetic nephropathy across ancestry groups, highlighting the importance of obesity-related processes in the development of vascular outcomes. Our findings show the value of integrating multi-ancestry genome-wide association study data with single-cell epigenomics to disentangle the aetiological heterogeneity that drives the development and progression of T2D. This might offer a route to optimize global access to genetically informed diabetes care.

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Causes of blindness and vision impairment in 2020 and trends over 30 years, and prevalence of avoidable blindness in relation to VISION 2020: the Right to Sight: an analysis for the Global Burden of Disease Study (vol 2, pg 144, 2021)

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LANCET GLOBAL HEALTH 2021年第4期9卷 E408-E408页

作者： Steinmetz, Jaimie D. Vision and Eye Research Institute Anglia Ruskin University Cambridge United Kingdom Biomedical Informatics Seoul National University Hospital Seoul South Korea Institute for Health Metrics and Evaluation University of Washington Seattle WA United States Department of Health Metrics Sciences School of Medicine University of Washington Seattle WA United States Institute of Health Services Research Yonsei University Seoul South Korea Department of Ophthalmology University of Washington Seattle WA United States Department of Mathematics Imperial College London London United Kingdom WHO Collaborating Centre for Public Health Education and Training Imperial College London London United Kingdom Department of Primary Care and Public Health Imperial College London London United Kingdom School of Population and Global Health University of Melbourne Carlton VIC Australia School of Optometry and Vision Science UNSW Sydney NSW Australia Brien Holden Vision Institute Sydney Australia Department of Ophthalmology University of Adelaide Adelaide SA Australia Department of Parasitology and Mycology Jahrom University of Medical Sciences Jahrom Iran Department of Clinical Sciences University of Sharjah Sharjah United Arab Emirates Ophthalmic Research Center Shahid Beheshti University of Medical Sciences Tehran Iran Department of Ophthalmology Shahid Beheshti University of Medical Sciences Tehran Iran Research Institute for Endocrine Sciences Shahid Beheshti University of Medical Sciences Tehran Iran Ophthalmic Epidemiology Research Center Shahid Beheshti University of Medical Sciences Tehran Iran Health Services Management Department Qazvin University of Medical Sciences Qazvin Iran Department of Systems Populations and Leadership University of Michigan Ann Arbor MI United States Department of Medicine Sofia Ismail Memorial Medical Centre Bogura Bangladesh The Fred Hollows Foundation Sydney NSW Australia Berhan Public Health & Eye Care Consultancy Addis A

Hospital El Salvador: a novel paradigm of intensive care in response to COVID-19 in central America. Lancet Glob Health 2021;9: e241?42?In this Comment, the conflict of interest statement should have included the following: ?By virtue of their roles within a public hospital or the Ministry of Health, MB, LC, WH, and XS are government employees. The findings and conclusions in the Comment are only those of the authors.? This correction has been made as of Feb 26, 2021.

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Author Correction: Nrf2 contributes to the weight gain of mice during space travel

Communications biology

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Communications biology 2020年第1期3卷 566页

作者： Takafumi Suzuki Akira Uruno Akane Yumoto Keiko Taguchi Mikiko Suzuki Nobuhiko Harada Rie Ryoke Eriko Naganuma Nanae Osanai Aya Goto Hiromi Suda Ryan Browne Akihito Otsuki Fumiki Katsuoka Michael Zorzi Takahiro Yamazaki Daisuke Saigusa Seizo Koshiba Takashi Nakamura Satoshi Fukumoto Hironobu Ikehata Keizo Nishikawa Norio Suzuki Ikuo Hirano Ritsuko Shimizu Tetsuya Oishi Hozumi Motohashi Hirona Tsubouchi Risa Okada Takashi Kudo Michihiko Shimomura Thomas W Kensler Hiroyasu Mizuno Masaki Shirakawa Satoru Takahashi Dai Shiba Masayuki Yamamoto Department of Medical Biochemistry Tohoku University Graduate School of Medicine Sendai Japan. Department of Integrative Genomics Tohoku Medical Megabank Organization Tohoku University Sendai Japan. JEM Utilization Center Human Spaceflight Technology Directorate JAXA Tsukuba Japan. The Advanced Research Center for Innovations in Next-Generation Medicine (INGEM) Tohoku University Sendai Japan. Center for Radioisotope Sciences Tohoku University Graduate School of Medicine Sendai Japan. Institute for Animal Experimentation Tohoku University Graduate School of Medicine Sendai Japan. Department of Functional Brain Imaging Institute of Development Aging and Cancer Tohoku University Sendai Japan. Department of Molecular Hematology Tohoku University Graduate School of Medicine Sendai Japan. Department of Molecular Biotechnology and Health Sciences University of Turin 10125 Torino Italy. Division of Molecular Pharmacology & Cell Biophysics Tohoku University Graduate School of Dentistry Sendai Japan. Division of Pediatric Dentistry Tohoku University Graduate School of Dentistry Sendai Japan. Immunology Frontier Research Center Osaka University Suita Japan. Division of Oxygen Biology Tohoku University Graduate School of Medicine Sendai Japan. Department of Gene Expression Regulation Institute of Development Aging and Cancer Tohoku University Sendai Japan. Laboratory Animal Resource Center in Transborder Medical Research Center and Department of Anatomy and Embryology Faculty of Medicine University of Tsukuba Tsukuba Japan. Translational Research Program Fred Hutchinson Cancer Research Center Seattle WA USA. JEM Utilization Center Human Spaceflight Technology Directorate JAXA Tsukuba Japan. shiba.dai@jaxa.jp. Department of Medical Biochemistry Tohoku University Graduate School of Medicine Sendai Japan. masiyamamoto@med.tohoku.ac.jp. Department of Integrative Genomics Tohoku Medical Megabank Organization Tohoku University Sendai Japan. masiyamamoto@med.toho

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

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MAKING PIPING SYSTEMS FIRE-SAFE - SIMPLE SOLUTIONS FOR PREVENTING A DISASTER

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NAVAL ENGINEERS JOURNAL 1994年第3期106卷 285-295页

作者： BHASIN, V NILSEN, L GUPTA, K CONROY, D Vinod Bhasin P.E.:is a fellow engineer with the Westinghouse Electric Corporation machinery technology division Pittsburgh Pa. He has more than 19 years of experience in the supervision design application and testing of valves and actuators and has taught courses in solids mechanics for 10 years at Illinois Institute of Technology Chicago Il. Mr. Bhasin has written articles for the valve industry where he has been active in standards societies. He holds BS and MS degrees in mechanical engineering and an MS in industrial engineering. Mr. Bhasin is a member of the American Society of Mechanical Engineers (ASME) and the American Society for Testing and Materials (ASTM). He is co-chairman of the shipbuilding piping component subcommittee ASTM F25.13 and is also chairing three other task groups under ASTM F25. Lloyd Nilsen P.E.:is the piping components branch head for NavSea. His career with NavSea includes 33 years of ship design construction and repair experience. He has held various positions in the power piping design division human factors manning and controls integration branch and submarine machinery systems branch. He has a BS degree in marine engineering from N.Y. State Maritime. Mr. Nilsen is also a member of the NavSea Association of Scientists and Engineers and a registered licensed professional engineer in Virginia and Washington D.C. Karan Gupta P.E.:is a senior engineer with the Westinghouse Electric Corporation Machinery Technology Division Pittsburgh Pa. Prior to joining Westinghouse he was employed by Elliott Company Jeannette Pa. for 12 years as a metallurgical engineer. He has more than 25 years experience in metallurgical engineering including material selection and brazing and welding of piping pressure vessels and turbines. Mr. Gupta has BS and MS degrees in metallurgical engineering. He is a member of the American Welding Society (AWS) and is active in AWS filler metal subcommittee A5A. He is also a member of ASM International. Dennis Conroy: is a chemical engineer

Loss of life and property losses totaling tens of billions of dollars have piping engineers scrambling to specify ''fire-safe'' components in fire-prone locations: on board ships, and in power plants, refineries, and other perilous applications. Fire-safe valves, the first line of defense in containing a fire, were introduced some 25 years ago, with fire-safe actuators following soon afterwards. Little attention has been given, however, to designing and selecting the other piping components such as flanges, gaskets, bolting, and fittings to ensure their integrity in a fire. Just like in an electric circuit where, if a single component in series fails, the flow of electricity stops;likewise, the failure of a single piping component could result in a fire of catastrophic proportions. This paper discusses the availability of critical fire-safe components for Navy shipboard piping systems and provides some simple solutions which, if implemented, could prevent such a disaster. Discussion is provided on how a fire starts and how it reaches catastrophic proportions, the definitions of survivability and fire-safe components, materials of construction, component design, fire-safe valves and actuators, gaskets, pipe flanges, flange bolting, pipe fittings and unions, brazing and welding, insulation, composite piping materials, and other related subjects. Details are also provided on 78 fires that have occurred on Navy surface ships in the last ten years and their causes.

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