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International Conference on data Engineering

作者： Bo Peng Zhiyun Ren Srinivasan Parthasarathy Xia Ning Department of Computer Science and Engineering The Ohio State University Department of Biomedical Informatics The Ohio State University Department of Computer Science and Engineering Translational Data Analytics Institute The Ohio State University Department of Biomedical Informatics Department of Computer Science and Engineering Translational Data Analytics Institute The Ohio State University

Sequential recommendation aims to identify and recommend the next few items of users’ interest. It becomes an effective tool to help users select their favorite items from a variety of options. A key challenge in sequential recommendation is to learn the patterns and dynamics, which are most pertinent to inform future interactions of users. With the prosperity of deep learning, many deep models, particularly based on recurrent neural networks [1] and with attention mechanisms [2] , [3] , have been developed for sequential recommendation purposes. However, our analysis demonstrates that, these deep models, particularly those with attention mechanisms, may not always learn meaningful attention weights from the extremely sparse recommendation data, and thus, could degrade the recommendation performance. Therefore, in this study, instead of deep models, we develop novel, effective and efficient hybrid associations models (HAM) to better learn from the sparse and limited recommendation data. This study has been published in IEEE Transactions on Knowledge and data Engineering. Please refer to the full manuscript [4] for more details.

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eCeLLM: generalizing large language models for E-commerce from large-scale, high-quality instruction data 24

eCeLLM: generalizing large language models for E-commerce fr...

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Proceedings of the 41st International Conference on Machine Learning

作者： Bo Peng Xinyi Ling Ziru Chen Huan Sun Xia Ning Department of Computer Science and Engineering The Ohio State University Department of Computer Science and Engineering and Translational Data Analytics Institute The Ohio State University Department of Computer Science and Engineering and Translational Data Analytics Institute and Department of Biomedical Informatics The Ohio State University

With tremendous efforts in developing effective e-commerce models, conventional e-commerce models show limited success in generalist e-commerce modeling, and suffer from unsatisfactory performance on new users and new products - a typical out-of-domain generalization challenge. Meanwhile, large language models (LLMs) demonstrate outstanding performance in generalist modeling and out-of-domain generalizability in many fields. Toward fully unleashing their power for e-commerce, in this paper, we construct ECInstruct, the first open-sourced, large-scale, and high-quality benchmark instruction dataset for e-commerce. Leveraging ECInstruct, we develop eCeLLM, a series of e-commerce LLMs, by instruction-tuning general-purpose LLMs. Our comprehensive experiments and evaluation demonstrate that eCeLLM models substantially outperform baseline models, including the most advanced GPT-4, and the state-of-the-art task-specific models in in-domain evaluation. Moreover, eCeLLM exhibits excellent generalizability to out-of-domain settings, including unseen products and unseen instructions, highlighting its superiority as a generalist e-commerce model. Both the ECInstruct dataset and the eCeLLM models show great potential in empowering versatile and effective LLMs for e-commerce. ECInstruct and eCeLLM models are publicly accessible through https://***/eCeLLM/.

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Conserved spatial subtypes and cellular neighborhoods of cancer-associated fibroblasts revealed by single-cell spatial multi-omics

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Cancer Cell 2025年第5期43卷 905-924.e6页

作者： Liu, Yunhe Sinjab, Ansam Min, Jimin Han, Guangchun Paradiso, Francesca Zhang, Yuanyuan Wang, Ruiping Pei, Guangsheng Dai, Yibo Liu, Yang Cho, Kyung Serk Dai, Enyu Basi, Akshay Burks, Jared K. Rajapakshe, Kimal I. Chu, Yanshuo Jiang, Jiahui Zhang, Daiwei Yan, Xinmiao Guerrero, Paola A. Serrano, Alejandra Li, Mingyao Hwang, Tae Hyun Futreal, Andrew Ajani, Jaffer A. Solis Soto, Luisa M. Jazaeri, Amir A. Kadara, Humam Maitra, Anirban Wang, Linghua Department of Genomic Medicine The University of Texas MD Anderson Cancer Center Houston 77030 TX United States Department of Translational Molecular Pathology The University of Texas MD Anderson Cancer Center Houston 77030 TX United States Sheikh Ahmed Center for Pancreatic Cancer Research The University of Texas MD Anderson Cancer Center Houston 77030 TX United States The University of Texas MD Anderson Cancer Center UTHealth Houston Graduate School of Biomedical Sciences (GSBS) Houston 77030 TX United States Department of Leukemia The University of Texas MD Anderson Cancer Center Houston 77030 TX United States Department of Biostatistics Epidemiology and Informatics Perelman School of Medicine University of Pennsylvania Philadelphia 19104 PA United States Department of Surgery Vanderbilt University Medical Center Nashville 37232 TN United States Department of Gastrointestinal Medical Oncology The University of Texas MD Anderson Cancer Center Houston 77030 TX United States Department of Gynecologic Oncology and Reproductive Medicine The University of Texas MD Anderson Cancer Center Houston 77030 TX United States The James P. Allison Institute The University of Texas MD Anderson Cancer Center Houston 77030 TX United States Institute for Data Science in Oncology The University of Texas MD Anderson Cancer Center Houston 77030 TX United States

Cancer-associated fibroblasts (CAFs) are a multifaceted cell population essential for shaping the tumor microenvironment (TME) and influencing therapy responses. Characterizing the spatial organization and interactions of CAFs within complex tissue environments provides critical insights into tumor biology and immunobiology. In this study, through integrative analyses of over 14 million cells from 10 cancer types across 7 spatial transcriptomics and proteomics platforms, we discover, validate, and characterize four distinct spatial CAF subtypes. These subtypes are conserved across cancer types and independent of spatial omics platforms. Notably, they exhibit distinct spatial organizational patterns, neighboring cell compositions, interaction networks, and transcriptomic profiles. Their abundance and composition vary across tissues, shaping TME characteristics, such as levels, distribution, and state composition of tumor-infiltrating immune cells, tumor immune phenotypes, and patient survival. This study enriches our understanding of CAF spatial heterogeneity in cancer and paves the way for novel approaches to target and modulate CAFs. © 2025 Elsevier Inc.

关键词： cancer-associated fibroblast cell-cell communication cellular neighborhood lymphoid aggregate pan-cancer spatial multi-omics spatial transcriptomics tertiary lymphoid structure tumor associated macrophage tumor microenvironment

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Changing life expectancy in European countries 1990–2021: a subanalysis of causes and risk factors from the Global Burden of Disease Study 2021

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The Lancet Public Health 2025年第3期10卷 e172-e188页

作者： Steel, Nicholas Bauer-Staeb, Clarissa Maria Mercedes Ford, John A. Abbafati, Cristiana Abdalla, Mohammed Altigani Abdelkader, Atef Abdi, Parsa Zuñiga, Roberto Ariel Abeldaño Abiodun, Olugbenga Olusola Abolhassani, Hassan Abu-Gharbieh, Eman Abukhadijah, Hana J. Abu-Zaid, Ahmed Addo, Isaac Yeboah Addolorato, Giovanni Adekanmbi, Victor Adetunji, Juliana Bunmi Adeyeoluwa, Temitayo Esther Agardh, Emilie E. Agyemang-Duah, Williams Ahmad, Danish Ahmed, Ayman Ahmed, Syed Anees Akinosoglou, Karolina Akkaif, Mohammed Ahmed Al Awaidy, Salah Al Hasan, Syed Mahfuz Al Zaabi, Omar Ali Mohammed Aldridge, Robert W. Algammal, Abdelazeem M. Al-Gheethi, Adel Ali Saeed Ali, Abid Ali, Mohammed Usman Ali, Syed Shujait Ali, Waad Alicandro, Gianfranco Alif, Sheikh Mohammad Al-Jumaily, Adel Allebeck, Peter Alrawashdeh, Ahmad Al-Rifai, Rami H. Alsabri, Mohammed A. Alshahrani, Najim Z. Aluh, Deborah Oyine Al-Wardat, Mohammad Al-Zyoud, Walid A. Amiri, Sohrab Anderlini, Deanna Andrei, Catalina Liliana Anil, Abhishek Anvari, Saeid Anyasodor, Anayochukwu Edward Appiah, Seth Christopher Yaw Aquilano, Michele Arabloo, Jalal Arafat, Mosab Areda, Demelash Aremu, Abdulfatai Armani, Keivan Armocida, Benedetta Ärnlöv, Johan Asaduzzaman, Muhammad Astell-Burt, Thomas Aujayeb, Avinash Ausloos, Marcel Azadnajafabad, Sina Aziz, Shahkaar Azzam, Ahmed Y. Babu, Giridhara Rathnaiah Badache, Andreea Corina Badiye, Ashish D. Bahramian, Saeed Baig, Atif Amin Baker, Jennifer L. Bansal, Hansi Bärnighausen, Till Winfried Barone, Mark Thomaz Ugliara Barrow, Amadou Barteit, Sandra Bashir, Shahid Bashiru, Hameed Akande Basso, João Diogo Bastan, Mohammad-Mahdi Basu, Sanjay Batra, Kavita Bauckneht, Matteo Baune, Bernhard T. Beghi, Massimiliano Beiranvand, Maryam Béjot, Yannick Bell, Michelle L. Bello, Olorunjuwon Omolaja Belo, Luis Beloukas, Apostolos Beneke, Alice A. Bettencourt, Paulo J.G. Bhagavathula, Akshaya Srikanth Bhala, Neeraj Bhaskar, Sonu Bisulli, Francesca Bjørge, Tone Bodunrin, Aadam Olalekan Carvajal, Alejandro Botero Bouaoud, Souad Brayne, Carol Brenner, H Department of Primary Care and Public Health University of East Anglia Norwich United Kingdom Office for Health Improvement and Disparities Department of Health and Social Care London United Kingdom Department of Legal and Economic Studies La Sapienza University Rome Italy Rome Italy Hull York Medical School University of Hull Hull United Kingdom Department of Mathematics and Sciences Ajman University Ajman United Arab Emirates Department of Medicine Memorial University St. John's NL Canada Postgraduate Department University of Sierra Sur Miahuatlan de Porfirio Diaz Mexico Yhteiskuntadatatieteen keskus (Centre for Social Data Science) Helsinki Finland Department of Internal Medicine Federal Medical Centre Abuja Nigeria Research Center for Immunodeficiencies Tehran University of Medical Sciences Tehran Iran Department of Medical Biochemistry and Biophysics Karolinska Institutet (Karolinska Institute) Stockholm Sweden Department of Clinical Sciences University of Sharjah Sharjah United Arab Emirates Department of Biopharmaceutics and Clinical Pharmacy University of Jordan Amman Jordan Medical Research Center Hamad Medical Corporation Doha Qatar Department of Biochemistry and Molecular Medicine Alfaisal University Riyadh Saudi Arabia College of Graduate Health Sciences University of Tennessee Memphis TN United States School of Medicine Sydney NSW Australia Centre for Social Research in Health University of New South Wales Sydney NSW Australia Internal Medicine and Alcohol Related Disease Unit Fondazione Policlinico Universitario A. Gemelli IRCCS Rome Italy Department of Medical and Surgical Sciences Università Cattolica di Roma (Catholic University of Rome) Rome Italy Department of Obstetrics and Gynecology University of Texas Medical Branch Galveston TX United States Department of Biochemistry Osun State University Osogbo Nigeria Department of Pharmacology and Therapeutics University of Medical Sciences Ondo Ondo Nigeria Department of Veteri

Background: Decades of steady improvements in life expectancy in Europe slowed down from around 2011, well before the COVID-19 pandemic, for reasons which remain disputed. We aimed to assess how changes in risk factors and cause-specific death rates in different European countries related to changes in life expectancy in those countries before and during the COVID-19 pandemic. Methods: We used data and methods from the Global Burden of Diseases, Injuries, and Risk Factors Study 2021 to compare changes in life expectancy at birth, causes of death, and population exposure to risk factors in 16 European Economic Area countries (Austria, Belgium, Denmark, Finland, France, Germany, Greece, Iceland, Ireland, Italy, Luxembourg, the Netherlands, Norway, Portugal, Spain, and Sweden) and the four UK nations (England, Northern Ireland, Scotland, and Wales) for three time periods: 1990–2011, 2011–19, and 2019–21. Changes in life expectancy and causes of death were estimated with an established life expectancy cause-specific decomposition method, and compared with summary exposure values of risk factors for the major causes of death influencing life expectancy. Findings: All countries showed mean annual improvements in life expectancy in both 1990–2011 (overall mean 0·23 years [95% uncertainty interval [UI] 0·23 to 0·24]) and 2011–19 (overall mean 0·15 years [0·13 to 0·16]). The rate of improvement was lower in 2011–19 than in 1990–2011 in all countries except for Norway, where the mean annual increase in life expectancy rose from 0·21 years (95% UI 0·20 to 0·22) in 1990–2011 to 0·23 years (0·21 to 0·26) in 2011–19 (difference of 0·03 years). In other countries, the difference in mean annual improvement between these periods ranged from –0·01 years in Iceland (0·19 years [95% UI 0·16 to 0·21] vs 0·18 years [0·09 to 0·26]), to –0·18 years in England (0·25 years [0·24 to 0·25] vs 0·07 years [0·06 to 0·08]). In 2019–21, there was an overall decrease in mean annual life expectancy a

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$\mathop {\mathtt {HAM}}$HAM: Hybrid Associations Models for Sequential Recommendation

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IEEE Transactions on Knowledge and data Engineering 2021年第10期34卷 4838-4853页

作者： Bo Peng Zhiyun Ren Srinivasan Parthasarathy Xia Ning Department of Computer Science and Engineering The Ohio State University Columbus OH USA Department of Biomedical Informatics The Ohio State University Columbus OH USA Department of Biomedical Informatics Department of Computer Science and Engineering Translational Data Analytics Institute The Ohio State University Columbus OH USA

Sequential recommendation aims to identify and recommend the next few items for a user that the user is most likely to purchase/review, given the user's purchase/rating trajectories. It becomes an effective tool to help users select favorite items from a variety of options. In this manuscript, we developed hybrid associations models ( $\mathop {\mathtt {HAM}}\limits$ ) to generate sequential recommendations using three factors: 1) users’ long-term preferences, 2) sequential, high-order and low-order association patterns in the users’ most recent purchases/ratings, and 3) synergies among those items. $\mathop {\mathtt {HAM}}\limits$ uses simplistic pooling to represent a set of items in the associations, and element-wise product to represent item synergies of arbitrary orders. We compared $\mathop {\mathtt {HAM}}\limits$ models with the most recent, state-of-the-art methods on six public benchmark datasets in three different experimental settings. Our experimental results demonstrate that $\mathop {\mathtt {HAM}}\limits$ models significantly outperform the state of the art in all the experimental settings. with an improvement as much as 46.6 percent. In addition, our run-time performance comparison in testing demonstrates that $\mathop {\mathtt {HAM}}\limits$ models are much more efficient than the state-of-the-art methods. and are able to achieve significant speedup as much as 139.7 folds.

关键词： Adaptation models Benchmark testing Trajectory Tools Recurrent neural networks Markov processes Image color analysis

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Modeling Path Importance for E_ective Alzheimer's Disease Drug Repurposing

Modeling Path Importance for E_ective Alzheimer's Disease Dr...

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29th Pacific Symposium on Biocomputing, PSB 2024

作者： Xiang, Shunian Lawrence, Patrick J. Peng, Bo Chiang, Chienwei Kim, Dokyoon Shen, Li Ning, Xia Biomedical Informatics Department The Ohio State University ColumbusOH43210 United States Computer Science and Engineering Department The Ohio State University ColumbusOH43210 United States Department of Biostatistics Epidemiology and Informatics University of Pennsylvania PhiladelphiaPA19104 United States Translational Data Analytics Institute The Ohio State University ColumbusOH43210 United States

ISBN: (纸本)9789811286414

Recently, drug repurposing has emerged as an effective and resource-efficient paradigm for AD drug discovery. Among various methods for drug repurposing, network-based methods have shown promising results as they are capable of leveraging complex networks that integrate multiple interaction types, such as protein-protein interactions, to more effectively identify candidate drugs. However, existing approaches typically assume paths of the same length in the network have equal importance in identifying the therapeutic effect of drugs. Other domains have found that same length paths do not necessarily have the same importance. Thus, relying on this assumption may be deleterious to drug repurposing attempts. In this work, we propose MPI (Modeling Path Importance), a novel network-based method for AD drug repurposing. MPI is unique in that it prioritizes important paths via learned node embeddings, which can effectively capture a networks rich structural information. Thus, leveraging learned embeddings allows MPI to effectively differentiate the importance among paths. We evaluate MPI against a commonly used baseline method that identifies anti-AD drug candidates primarily based on the shortest paths between drugs and AD in the network. We observe that among the top-50 ranked drugs, MPI prioritizes 20.0% more drugs with anti-AD evidence compared to the baseline. Finally, Cox proportional-hazard models produced from insurance claims data aid us in identifying the use of etodolac, nicotine, and BBB-crossing ACE-INHs as having a reduced risk of AD, suggesting such drugs may be viable candidates for repurposing and should be explored further in future studies. © 2023 The Authors.

关键词： Embeddings

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A Taxonomy of Generative AI in HEOR: Concepts, Emerging Applications, and Advanced Tools - An ISPOR Working Group Report

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Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research 2025年

作者： Rachael L Fleurence Xiaoyan Wang Jiang Bian Mitchell K Higashi Turgay Ayer Hua Xu Dalia Dawoud Jagpreet Chhatwal National Institute of Biomedical Imaging and Bioengineering Bethesda MD United States. Electronic address: Rachael.fleurence@nih.gov. Tulane University School of Public Health and Tropical Medicine New Orleans LA Intelligent Medical Objects Rosemont IL United States. Health Outcomes and Biomedical Informatics College of Medicine University of Florida FL United States Biomedical Informatics Clinical and Translational Science Institute University of Florida FL United States Office of Data Science and Research Implementation University of Florida Health Gainesville FL United States Regenstrief Institute Indianapolis IN United States Biostatistics and Health Data Science School of Medicine Indiana University Indianapolis IN United States. ISPOR The Professional Society for Health Economics and Outcomes Research Lawrenceville NJ United States. Center for Health & Humanitarian Systems Georgia Institute of Technology Atlanta GA Value Analytics Labs Boston MA United States. Institute Department of Biomedical Informatics and Data Science School of Medicine Yale University New Haven CT United States. National Institute for Health and Care Excellence London United Kingdom Cairo University Faculty of Pharmacy Cairo Egypt. Institute for Technology Assessment Massachusetts General Hospital Harvard Medical School Boston MA United States Center for Health Decision Science Harvard University Boston MA United States.

OBJECTIVE:This article presents a taxonomy of generative artificial intelligence (AI) for health economics and outcomes research (HEOR), explores emerging applications, outlines methods to improve the accuracy and reliability of AI-generated outputs and describes current limitations. METHODS:Foundational generative AI concepts are defined, and current HEOR applications are highlighted, including for systematic literature reviews, health economic modeling, real-world evidence generation, and dossier development. Techniques such as prompt engineering (e.g., zero-shot, few-shot, chain-of-thought, persona pattern prompting), retrieval-augmented generation, model fine-tuning, and domain-specific models, and use of agents are introduced to enhance AI performance. Limitations associated with the use of generative AI foundation models are described. RESULTS:Generative AI demonstrates significant potential in HEOR, offering enhanced efficiency, productivity, and innovative solutions to complex challenges. While foundation models show promise in automating complex tasks, challenges persist in scientific accuracy and reproducibility, bias and fairness and operational deployment. Strategies to address these issues and improve AI accuracy are discussed. CONCLUSION:Generative AI has the potential to transform HEOR by improving efficiency and accuracy across diverse applications. However, realizing this potential requires building HEOR expertise and addressing the limitations of current AI technologies. Ongoing research and innovation will be key to shaping AI's future role in our field.

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Harnessing artificial intelligence to fill global shortfalls in biodiversity knowledge

Nature Reviews Biodiversity

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Nature Reviews Biodiversity 2025年第3期1卷 166-182页

作者： Laura J. Pollock David Rolnick Justin Kitzes Sara Beery Kaitlyn M. Gaynor Marta A. Jarzyna Tanya Berger-Wolf Oisin Mac Aodha Bernd Meyer Graham W. Taylor Devis Tuia Department of Biology McGill University Montréal Quebec Canada Mila—Quebec AI Institute Montréal Quebec Canada School of Computer Science McGill University Montréal Quebec Canada Department of Biological Sciences University of Pittsburgh Pittsburgh PA USA Faculty of AI and Decision Making Massachusetts Institute of Technology Cambridge MA USA Department of Botany University of British Columbia Vancouver British Columbia Canada Department of Zoology University of British Columbia Vancouver British Columbia Canada Department of Evolution Ecology and Organismal Biology The Ohio State University Columbus OH USA Translational Data Analytics Institute The Ohio State University Columbus OH USA Department of Computer Science and Engineering The Ohio State University Columbus OH USA Department of Electrical & Computer Engineering The Ohio State University Columbus OH USA School of Informatics University of Edinburgh Edinburgh UK Department of Data Science and AI Monash University Clayton Victoria Australia School of Engineering University of Guelph Guelph Ontario Canada Vector Institute Toronto Ontario Canada School of Architecture Civil and Environmental Engineering Ecole Polytechnique Fédérale de Lausanne Lausanne Switzerland

Large, well described gaps exist in both what we know and what we need to know to address the biodiversity crisis. Artificial intelligence (AI) offers new potential for filling these knowledge gaps, but where the biggest and most influential gains could be made remains unclear. To date, biodiversity-related uses of AI have largely focused on tracking and monitoring of wildlife populations. Rapid progress is being made in the use of AI to build phylogenetic trees and species distribution models. However, AI also has considerable unrealized potential in the re-evaluation of important ecological questions, especially those that require the integration of disparate and inherently complex data types, such as images, video, text, audio and DNA. This Review describes the current and potential future use of AI to address seven clearly defined shortfalls in biodiversity knowledge. Recommended steps for AI-based improvements include the re-use of existing image data and the development of novel paradigms, including the collaborative generation of new testable hypotheses. The resulting expansion of biodiversity knowledge could lead to science spanning from genes to ecosystems — advances that might represent our best hope for meeting the rapidly approaching 2030 targets of the Global Biodiversity Framework.

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Multi-modality Meets Re-learning: Mitigating Negative Transfer in Sequential Recommendation

arXiv

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arXiv 2023年

作者： Peng, Bo Parthasarathy, Srinivasan Ning, Xia The Department of Computer Science and Engineering The Ohio State University ColumbusOH43210 United States The Department of Computer Science and Engineering The Translational Data Analytics Institute The Ohio State University ColumbusOH43210 United States The Department of Biomedical Informatics The Department of Computer Science and Engineering The Translational Data Analytics Institute The Ohio State University ColumbusOH43210 United States

Learning effective recommendation models from sparse user interactions represents a fundamental challenge in developing sequential recommendation methods. Recently, pre-training-based methods have been developed to tackle this challenge. Though promising, in this paper, we show that existing methods suffer from the notorious negative transfer issue, where the model adapted from the pre-trained model results in worse performance compared to the model learned from scratch in the task of interest (i.e., target task). To address this issue, we develop a method, denoted as ANT, for transferable sequential recommendation. ANT mitigates negative transfer by 1) incorporating multi-modality item information, including item texts, images and prices, to effectively learn more transferable knowledge from related tasks (i.e., auxiliary tasks);and 2) better capturing task-specific knowledge in the target task using a re-learning-based adaptation strategy. We evaluate ANT against eight state-of-the-art baseline methods on five target tasks. Our experimental results demonstrate that ANT does not suffer from the negative transfer issue on any of the target tasks. The results also demonstrate that ANT substantially outperforms baseline methods in the target tasks with an improvement of as much as 15.2%. Our analysis highlights the superior effectiveness of our re-learning-based strategy compared to fine-tuning on the target tasks. © 2023, CC BY.

关键词： Recommender systems

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An Integrated AI-Enabled System Using One Class Twin Cross Learning (OCT-X) for Early Gastric Cancer Detection

arXiv

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arXiv 2025年

作者： Liu, Xian-Xian Wei, Yuanyuan Xu, Mingkun Guo, Yongze Zhang, Hongwei Dong, Huicong Song, Qun Zhao, Qi Luo, Wei Tien, Feng Gao, Juntao Fong, Simon Department of Computer and Information Science University of Macau 999078 China Department of Biomedical Engineering The Chinese University of Hong Kong Shatin999077 Hong Kong Department of Neurology David Geffen School of Medicine University of California Los AngelesCA90095 United States Guangdong Institute of Intelligence Science and Technology Hengqin Zhuhai519031 China Department of Precision Instrument Tsinghua University Beijing100084 China Department of Gastroenterology Affiliated Hospital of Hebei University of Engineering Handan China Institute of Artificial Intelligence Chongqing Technology and Business University CO Chongqing400067 China Cancer Centre Institute of Translational Medicine Faculty of Health Sciences University of Macau Taipa519000 China MoE Frontiers Science Center for Precision Oncology University of Macau Taipa519000 China Institute of Clinical Medicine The First People’s Hospital of Foshan Guangzhou1528000 China Hebei Key Laboratory of Medical Data Science Institute of Biomedical Informatics School of Medicine Hebei University of Engineering Hebei Province Handan056038 China Tsinghua University Beijing China

Early detection of gastric cancer, a leading cause of cancer-related mortality worldwide, remains hampered by the limitations of current diagnostic technologies, leading to high rates of misdiagnosis and missed diagnoses. To address these challenges, we propose an integrated system that synergizes advanced hardware and software technologies to balance speed-accuracy. Our study introduces the One Class Twin Cross Learning (OCT-X) algorithm. Leveraging a novel fast double-threshold grid search strategy (FDT-GS) and a patch-based deep fully convolutional network, OCT-X maximizes diagnostic accuracy through real-time data processing and seamless lesion surveillance. The hardware component includes an all-in-one point-of-care testing (POCT) device with high-resolution imaging sensors, real-time data processing, and wireless connectivity, facilitated by the NI CompactDAQ and LabVIEW software. Our integrated system achieved an unprecedented diagnostic accuracy of 99.70%, significantly outperforming existing models by up to 4.47%, and demonstrated a 10% improvement in multirate adaptability. These findings underscore the potential of OCT-X as well as the integrated system in clinical diagnostics, offering a path toward more accurate, efficient, and less invasive early gastric cancer detection. Future research will explore broader applications, further advancing oncological diagnostics. Code is available at https://***/ liu37972/*** © 2025, CC BY-NC-ND.

关键词： Computer hardware description languages

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