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Annual Northeast bioengineering Conference

作者： Yan Zhang Leiming Yu David Kaeli Lee Makowski Department of Electrical and Computer Engineering Departments of Bioengineering Northeastern University Boston MA

Cellulose in maize is an ideal candidate for a sustainable and renewable energy source because of its global abundance. X-ray scattering has been used as an experimental technique to study cellulose fibrils during processing. In order to understand the impact of chemical or physical treatments on structural parameters such as diameter, twist and coiling, we are simulating X-ray scattering from large bundles of cellulose. Because the structure of these fibrils is non-periodic, these calculations are computationally intensive. In this paper, we describe a GPU-based molecular scattering algorithm developed to calculate X-ray scattering intensity from molecular models of cellulose fibrils. The implementation on Graphics Processing Units (GPUs) greatly accelerates the calculation compared to an optimized CPU program, enabling the assessment of hundreds of models for the cellulose fibril structure.

关键词： Graphics processing units Scattering Computational modeling X-ray diffraction Atomic measurements Biological system modeling Data models

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Handheld high-throughput plasmonic biosensor using computational on-chip imaging

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Light(Science & Applications) 2014年第1期3卷 388-397页

作者： Arif E Cetin Ahmet F Coskun Betty C Galarreta Min Huang David Herman Aydogan Ozcan Hatice Altug Department of Electrical and Computer Engineering Boston UniversityBostonMA 02215USA Departments of Electrical Engineering and Bioengineering University of CaliforniaLos Angeles(UCLA)Los AngelesCA 90095USA Division of Chemistry and Chemical Engineering California Institute of TechnologyPasadenaCA 91125USA Pontificia Universidad Catolica del Peru Departamento de Ciencias-QuimicaAvenida Universitaria 1801Lima 32Peru Bioengineering Department Ecole Polytechnique Federale de Lausanne(EPFL)Lausanne CH-1015Switzerland California NanoSystems Institute University of California Los AngelesLos Angeles(UCLA)Los AngelesCA90095USA

We demonstrate a handheld on-chip biosensing technology that employs plasmonic microarrays coupled with a lens-free computational imaging system towards multiplexed and high-throughput screening of biomolecular interactions for point-of-care applications and resource-limited *** lightweight and field-portable biosensing device,weighing 60 g and 7.5 cm tall,utilizes a compact optoelectronic sensor array to record the diffraction patterns of plasmonic nanostructures under uniform illumination by a single-light emitting diode tuned to the plasmonic mode of the *** a sensitive plasmonic array design that is combined with lens-free computational imaging,we demonstrate label-free and quantitative detection of biomolecules with a protein layer thickness down to 3 *** large-scale plasmonic microarrays,our on-chip imaging platform enables simultaneous detection of protein mono-and bilayers on the same platform over a wide range of biomolecule *** this handheld device,we also employ an iterative phase retrieval-based image reconstruction method,which offers the ability to digitally image a highly multiplexed array of sensors on the same plasmonic chip,making this approach especially suitable for high-throughput diagnostic applications in field settings.

关键词： computational imaging high-throughput biodetection lens-free imaging on-chip sensing plasmonics point of care diagnostics telemedicine

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A nonasymptotic homogenization theory of electromagnetic metamaterials

A nonasymptotic homogenization theory of electromagnetic met...

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International Conference on Electromagnetics in Advanced Applications (ICEAA)

作者： Igor Tsukerman Vadim Markel Department of Electrical and Computer Engineering University of Akron Akron OH USA Departments of Radiology and Bioengineering University of Pennsylvania Philadelphia PA USA

We propose a new homogenization methodology for periodic electromagnetic structures (photonic crystals and metamaterials). The physical essence of this methodology is in seeking effective material parameters that provide, in some sense, the best approximation of Bloch impedances as well as dispersion relations over an ensemble of physical modes in the structure. Mathematically, the homogenization problem is solved by approximating the fields on the fine and coarse scales with the respective eigenmodes that satisfy Maxwell's equations and boundary conditions as accurately as possible.

关键词： Approximation methods Metamaterials Optimized production technology Electromagnetics Photonic crystals

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25th Annual Computational Neuroscience Meeting CNS-2016, Seogwipo City, South Korea, July 2-7, 2016 Abstracts

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BMC NEUROSCIENCE 2016年第1期17卷 1-112页

作者： [Anonymous] Computational Neurobiology Laboratory The Salk Institute for Biological Studies San Diego USA UNIC CNRS Gif sur Yvette France The European Institute for Theoretical Neuroscience (EITN) Paris France ATR Computational Neuroscience Laboratories Kyoto Japan Krembil Research Institute University Health Network Toronto Canada Department of Physiology University of Toronto Toronto Canada Department of Medicine (Neurology) University of Toronto Toronto Canada Department of Physics University of New Hampshire Durham USA Department of Neurophysiology Nencki Institute of Experimental Biology Warsaw Poland Department of Theory Wigner Research Centre for Physics of the Hungarian Academy of Sciences Budapest Hungary Department of Mathematical Sciences KAIST Daejoen Republic of Korea Department of Mathematics University of Houston Houston USA Department of Biochemistry & Cell Biology and Institute of Biosciences and Bioengineering Rice University Houston USA Department of Biology and Biochemistry University of Houston Houston USA Grupo de Neurocomputación Biológica Dpto. de Ingeniería Informática Escuela Politécnica Superior Universidad Autónoma de Madrid Madrid Spain Department of Biological Sciences University of Southern California Los Angeles USA Center for Neuroscience Korea Institute of Science and Technology Seoul South Korea Department of Neurology Albert Einstein College of Medicine Bronx USA Center for Neuroscience KIST Seoul South Korea Department of Neuroscience University of Science and Technology Daejon South Korea Systems Neuroscience Group QIMR Berghofer Medical Research Institute Herston Australia Department of Psychology Yonsei University Seoul South Korea Department of Psychiatry Kyung Hee University Hospital at Gangdong Seoul South Korea Department of Psychiatry Veterans Administration Boston Healthcare System and Harvard Medical School Brockton USA Department of Electrical and Electronic Engineering The University of Melbourne Parkvil

A1 Functional advantages of cell-type heterogeneity in neural circuits Tatyana O. Sharpee A2 Mesoscopic modeling of propagating waves in visual cortex Alain Destexhe A3 Dynamics and biomarkers of mental disorders Mitsuo Kawato F1 Precise recruitment of spiking output at theta frequencies requires dendritic h-channels in multi-compartment models of oriens-lacunosum/moleculare hippocampal interneurons Vladislav Sekulić, Frances K. Skinner F2 Kernel methods in reconstruction of current sources from extracellular potentials for single cells and the whole brains Daniel K. Wójcik, Chaitanya Chintaluri, Dorottya Cserpán, Zoltán Somogyvári F3 The synchronized periods depend on intracellular transcriptional repression mechanisms in circadian clocks. Jae Kyoung Kim, Zachary P. Kilpatrick, Matthew R. Bennett, Kresimir Josić O1 Assessing irregularity and coordination of spiking-bursting rhythms in central pattern generators Irene Elices, David Arroyo, Rafael Levi, Francisco B. Rodriguez, Pablo Varona O2 Regulation of top-down processing by cortically-projecting parvalbumin positive neurons in basal forebrain Eunjin Hwang, Bowon Kim, Hio-Been Han, Tae Kim, James T. McKenna, Ritchie E. Brown, Robert W. McCarley, Jee Hyun Choi O3 Modeling auditory stream segregation, build-up and bistability James Rankin, Pamela Osborn Popp, John Rinzel O4 Strong competition between tonotopic neural ensembles explains pitch-related dynamics of auditory cortex evoked fields Alejandro Tabas, André Rupp, Emili Balaguer-Ballester O5 A simple model of retinal response to multi-electrode stimulation Matias I. Maturana, David B. Grayden, Shaun L. Cloherty, Tatiana Kameneva, Michael R. Ibbotson, Hamish Meffin O6 Noise correlations in V4 area correlate with behavioral performance in visual discrimination task Veronika Koren, Timm Lochmann, Valentin Dragoi, Klaus Obermayer O7 Input-location dependent gain modulation in cerebellar nucleus neurons Maria Psarrou, Maria Schilstra, Neil Davey, Benjamin Torben-Ni

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Characteristics of skin-electrode impedance for a novel screw electrode

Characteristics of skin-electrode impedance for a novel scre...

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Annual Northeast bioengineering Conference

作者： Wenyan Jia Jiamin Wu Di Gao Mingui Sun Robert J. Sclabassi Departments of Neurosurgery Electrical and Computer Engineering Bioengineering University of Pittsburgh Pittsburgh PA USA Department of Chemical and Petroleum Engineering Computational Diagnostics Inc. Pittsburgh PA

Our group has developed a novel dry electrode, the skin screw electrode, for EEG measurement. This electrode can be conveniently and rapidly installed on the human scalp requiring no electrolyte application and skin preparation. In this paper, we further evaluate the performance of this electrode by investigating its frequency-dependent electrical impedance at the skin-electrode interface. Comparing with the traditional disc electrode, we found that the two types of electrodes showed very different spectral properties. We also found that the impedance of the screw electrode decreases after coating with gold.

关键词： Electrodes Impedance Fasteners Electroencephalography Skin Impedance measurement Scalp

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Obesity and extent of emphysema depicted at CT

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Clinical Radiology 2015年第5期70卷 e14-e19页

作者： Gu, S. Li, R. Leader, J.K. Zheng, B. Bon, J. Gur, D. Sciurba, F. Jin, C. Pu, J. Imaging Research Center Department of Radiology University of Pittsburgh PA United States Division of Biostatistics University of Texas School of Public Health TX United States School of Electrical and Computer Engineering University of Oklahoma Norman OK United States Department of Medicine University of Pittsburgh Pittsburgh PA United States Department of Radiology First Affiliated Hospital of Xi'an Jiaotong University Xi'an Shaanxi China Departments of Radiology and Bioengineering University of Pittsburgh 3362 Fifth Ave Pittsburgh 15213 PA United States

Aim: To investigate the underlying relationship between obesity and the extent of emphysema depicted at CT. Methods and materials: A dataset of 477 CT examinations was retrospectively collected from a study of chronic obstructive pulmonary disease (COPD). The low attenuation areas (LAAs;≤950 HU) of the lungs were identified. The extent of emphysema (denoted as %LAA) was defined as the percentage of LAA divided by the lung volume. The association between log-transformed %LAA and body mass index (BMI) adjusted for age, sex, the forced expiratory volume in one second as percent predicted value (FEV1% predicted), and smoking history (pack years) was assessed using multiple linear regression analysis. Results: After adjusting for age, gender, smoking history, and FEV1% predicted, BMI was negatively associated with severe emphysema in patients with COPD. Specifically, one unit increase in BMI is associated with a 0.93-fold change (95% CI: 0.91-0.96, p < 0.001) in %LAA;the estimated %LAA for males was 1.75 (95% CI: 1.36-2.26, p < 0.001) times that of females;per 10% increase in FEV1% predicated is associated with a 0.72-fold change (95% CI: 0.69-0.76, p < 0.001) in %LAA. Conclusion: Increasing obesity is negatively associated with severity of emphysema independent of gender, age, and smoking history. © 2015 The Royal College of Radiologists.

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Virus-like-particles for next generation micro/nano-biosensors

Virus-like-particles for next generation micro/nano-biosenso...

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2014 Solid-State Sensors, Actuators and Microsystems Workshop, Hilton Head 2014

作者： Fan, X.Z. Naves, L. Siwak, N.P. Brown, A. Culver, J. Ghodssi, Reza MEMS Sensors and Actuators Laboratory Departments of Electrical and Computer Engineering Institute for Systems Research University of Maryland College ParkMD20742 United States Institute for Bioscience and Biotechnology Research University of Maryland College ParkMD20742 United States Fischell Department of Bioengineering University of Maryland College ParkMD20742 United States

ISBN: (纸本)9781940470016

A novel Virus-like-particle (VLP) bioreceptor layer has been integrated with an optical microdisk resonator platform for biosensing applications. This bioreceptor layer can be genetically programmed for selective binding. An optical microdisk resonator has been functionalized for antibody binding with this receptor, demonstrating resonant frequency shifts of (Δfo) of 0.79 nm and 5.95nm after primary antibody binding and full enzyme linked immunosorbent assay (ELISA), respectively. These shifts are more than 300% higher compared to the non-specific binding of a control (non-conjugated) bioreceptor layer. The sensitivity of the optical resonator to detect primary antibody binding without the additional ELISA steps demonstrates the feasibility of this platform for rapid and simplified immunoassays on a chip. © 2014TRF.

关键词： Actuators

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Cuff-free blood pressure estimation using pulse transit time and heart rate

Cuff-free blood pressure estimation using pulse transit time...

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International Conference on Signal Processing Proceedings (ICSP)

作者： Ruiping Wang Wenyan Jia Zhi-Hong Mao Robert J. Sclabassi Mingui Sun Department of Biomedical Engineering Beijing Jiaotong University Beijing China Departments of Neurological Surgery Electrical & Computer Engineering Bioengineering University of Pittsburgh Pittsburgh PA USA Computational Diagnostics. Inc. Pittsburgh PA

It has been reported that the pulse transit time (PTT), the interval between the peak of the R-wave in electrocardiogram (ECG) and the fingertip photoplethysmogram (PPG), is related to arterial stiffness, and can be used to estimate the systolic blood pressure (SBP) and diastolic blood pressure (DBP). This phenomenon has been used as the basis to design portable systems for continuously cuff-less blood pressure measurement, benefiting numerous people with heart conditions. However, the PTT-based blood pressure estimation may not be sufficiently accurate because the regulation of blood pressure within the human body is a complex, multivariate physiological process. Considering the negative feedback mechanism in the blood pressure control, we introduce the heart rate (HR) and the blood pressure estimate in the previous step to obtain the current estimate. We validate this method using a clinical database. Our results show that the PTT, HR and previous estimate reduce the estimated error significantly when compared to the conventional PTT estimation approach (p

关键词： Heart rate Correlation Blood Silicon

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Materials Science/Clinical Medi Cine: Epidermal devices for noninvasive, precise, and continuous mapping of macrovascular and microvascular blood flow

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Science Advances 2015年第9期1卷

作者： Webb, R. Chad Ma, Yinji Krishnan, Siddharth Li, Yuhang Yoon, Stephen Guo, Xiaogang Feng, Xue Shi, Yan Seidel, Miles Cho, Nam Heon Kurniawan, Jonas Ahad, James Sheth, Niral Kim, Joseph TaylorVI, James G. Darlington, Tom Chang, Ken Huang, Weizhong Ayers, Joshua Gruebele, Alexander Pielak, Rafal M. Slepian, Marvin J. Huang, Yonggang Gorbach, Alexander M. Rogers, John A. Department of Materials Science and Engineering Frederick Seitz Materials Research Laboratory University of Illinois at Urbana-Champaign UrbanaIL61801 United States Departments of Civil and Environmental Engineering Mechanical Engineering Center for Engineering and Health Skin Disease Research Center Northwestern University EvanstonIL60208 United States Department of Engineering Mechanics Center for Mechanics and Materials Tsinghua University Beijing100084 China Institute of Solid Mechanics Beihang University Beijing100191 China National Institute of Biomedical Imaging and Bioengineering National Institutes of Health BethesdaMD20892 United States College of Aerospace and Civil Engineering Harbin Engineering University Harbin150001 China State Key Laboratory of Mechanics and Control of Mechanical Structures Nanjing University of Aeronautics and Astronautics Nanjing210016 China Genomic Medicine Section Hematology Branch National Heart Lung and Blood Institute National Institutes of Health BethesdaMD20892 United States Department of Electrical and Computer Engineering Frederick Seitz Materials Research Laboratory University of Illinois at Urbana-Champaign UrbanaIL61801 United States L'Oreál California Research Center 953 Indiana Street San FranciscoCA94107 United States Department of Medicine Sarver Heart Center Department of Biomedical Engineering University of Arizona TucsonAZ85724 United States

Continuous monitoring of variations in blood flow is vital in assessing the status of microvascular and macrovascular beds for a wide range of clinical and research scenarios. Although a variety of techniques exist, most require complete immobilization of the subject, thereby limiting their utility to hospital or clinical settings. Those that can be rendered in wearable formats suffer from limited accuracy, motion artifacts, and other shortcomings that follow from an inability to achieve intimate, noninvasive mechanical linkage of sensors with the surface of the skin. We introduce an ultrathin, soft, skin-conforming sensor technology that offers advanced capabilities in continuous and precise blood flow mapping. Systematic work establishes a set of experimental procedures and theoretical models for quantitative measurements and guidelines in design and operation. Experimental studies on human subjects, including validation with measurements performed using state-of-the-art clinical techniques, demonstrate sensitive and accurate assessment of both macrovascular and microvascular flow under a range of physiological conditions. Refined operational modes eliminate long-term drifts and reduce power consumption, thereby providing steps toward the use of this technology for continuous monitoring during daily activities. © 2015 The Authors, some rights reserved.

关键词： Blood

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Introduction to the issue on biophotonics

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IEEE Journal on Selected Topics in Quantum Electronics 2014年第2期20卷 4-7页

作者： Ilev, Ilko K. Boppart, Stephen A. Andersson-Engels, Stefan Kim, Beop-Min Perelman, Lev Tuchin, Valery Center for Devices and Radiological Health U.S. Food and Drug Administration Silver Spring MD 20993 United States Beckman Institute for Advanced Science and Technology Departments of Bioengineering Electrical and Computer Engineering and Medicine University of Illinois Urbana IL 61801 United States Division of Atomic Physics Lund University Lund SE-22100 Sweden Department of Biomedical Engineering Korea University Seoul 136-703 Korea Republic of Center for Advanced Biomedical Imaging and Photonics Beth Israel Deaconess Medical Center Harvard University Boston MA 02215 United States Division of Optics and Biophotonics Saratov State University Saratov 410012 Russia Institute of Precision Mechanics and Control Russian Academy of Sciences Saratov 410028 Russia Optoelectronics and Measurement Techniques Laboratory University of Oulu Oulu FI-90014 Finland

The objective of this JSTQE Issue on Biophotonics is to highlight recent progress and trends in innovative biophotonics technology development. The papers published in this issue cover a broad range of advanced biophotonics areas summarized in the following sections: 1) bioimaging: optical coherence tomography and microscopy, nonlinear optical imaging, and novel multimodality imaging approaches; 2) biosensing: multifunctional biosensing, and novel biosensing approaches; 3) biophotonic science: mechanisms of light-cell and lighttissue interactions, advanced modeling methods in biophotonics, and light induced biophotonics effects; 4) biophotonic technology: advanced technologies in biophotonic diagnostics and therapeutics, infrared technology in biophotonics, and novel laser, biomedical and fiber optics tools and devices in biophotonics. These key research topics are highlighted as comprehensive overviews of the current status and future trends, as well as original results and recent developments in the field of biophotonics. This issue contains 33 papers, including 18 invited and 15 contributed papers authored by well-established research groups and promising scientists from all over the world. The invited papers include extended reviews on recent biophotonic developments and clinical applications in the areas of highresolution multispectral bioimaging, combined multifunctional microscopy, nonlinear deep tissue imaging, single molecule imaging, optical coherence elastography, cellular and molecular mechanisms of photobiomodulation, tissue optical clearing, clinical ultrafast laser surgery, infrared laser nerve stimulation, and novel tapered diode lasers for biophotonics. The contributed papers cover a broad variety of key biophotonic research areas including recently obtained original results on multimodal bioimaging and sensing, high resolution phase-sensitive magnetomotive optical coherence microscopy and elastography, and laser-assisted typing of polymorphic human

关键词： Special issues and sections Biophotonics

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