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The future of biomarkers for vascular contributions to cognitive impairment and dementia (VCID): proceedings of the 2025 annual workshop of the Albert research institute for white matter and cognition

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Geroscience 2025年 1-14页

作者： Matthew J Lennon Nikolaos Karvelas Aravind Ganesh Shawn Whitehead Farzaneh A Sorond Violeta Durán Laforet Elizabeth Head Konstantinos Arfanakis Vijaya B Kolachalama Xiao Liu Hanzhang Lu Joel Ramirez Keenan Walker Erica Weekman Cheryl L Wellington Charisse Winston Frank C Barone Roderick A Corriveau Centre for Healthy Brain Aging (CHeBA) Discipline of Psychiatry & Mental Health School of Clinical Medicine University of New South Wales Sydney NSW Australia. Matthew.lennon@unsw.edu.au. Northern Sydney Local Health District NSW Health Sydney NSW Australia. Matthew.lennon@unsw.edu.au. Departments of Neurology and Neuroscience Icahn School of Medicine at Mount Sinai New York NY USA. Department of Clinical Neurosciences and Hotchkiss Brain Institute Cumming School of Medicine University of Calgary Calgary AB Canada. Department of Anatomy and Cell Biology Schulich School of Medicine and Dentistry Western University London ON N6A5C1 Canada. Department of Neurology Division of Stroke and Neurocritical Care Northwestern University Feinberg School of Medicine Chicago IL USA. Department of Neurobiology Brudnick Neuropsychiatric Research Institute University of Massachusetts Chan Medical School Worcester MA USA. Department of Pathology & Laboratory Medicine University of California Irvine CA 92697 USA. Department of Biomedical Engineering Illinois Institute of Technology Chicago IL USA. Department of Diagnostic Radiology and Nuclear Medicine Rush University Medical Center Chicago IL USA. Rush Alzheimer's Disease Center Rush University Medical Center Chicago IL USA. Department of Medicine Boston University Chobanian & Avedisian School of Medicine Boston MA 02118 USA. Department of Computer Science and Faculty of Computing & Data Sciences Boston University Boston MA 02215 USA. Department of Biomedical Engineering The Pennsylvania State University University Park PA 16802 USA. Institute for Computational and Data Sciences The Pennsylvania State University University Park PA 16802 USA. Department of Radiology Johns Hopkins University School of Medicine Baltimore MD USA. Sunnybrook Research Institute University of Toronto Toronto ON Canada. Laboratory of Behavioral Neuroscience National Institute on Aging National Institutes of Health Baltimore

Advances in biomarkers and pathophysiology of vascular contributions to cognitive impairment and dementia (VCID) are expected to bring greater mechanistic insights, more targeted treatments, and potentially disease-modifying therapies. The 2025 Annual Workshop of the Albert Research Institute for White Matter and Cognition, sponsored by the Leo and Anne Albert Charitable Trust since 2015, focused on novel biomarkers for VCID. The meeting highlighted the complexity of dementia, emphasizing that the majority of cases involve multiple brain pathologies, with vascular pathology typically present. Potential novel approaches to diagnosis of disease processes and progression that may result in VCID included measures of microglial senescence and retinal changes, as well as artificial intelligence (AI) integration of multimodal datasets. Proteomic studies identified plasma proteins associated with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL; a rare genetic disorder affecting brain vessels) and age-related vascular pathology that suggested potential therapeutic targets. Blood-based microglial and brain-derived extracellular vesicles are promising tools for early detection of brain inflammation and other changes that have been associated with cognitive decline. Imaging measures of blood perfusion, oxygen extraction, and cerebrospinal fluid (CSF) flow were discussed as potential VCID biomarkers, in part because of correlations with classic pathological Alzheimer's disease (AD) biomarkers. MRI-visible perivascular spaces, which may be a novel imaging biomarker of sleep-driven glymphatic waste clearance dysfunction, are associated with vascular risk factors, lower cognitive function, and various brain pathologies including Alzheimer's, Parkinson's and cerebral amyloid angiopathy (CAA). People with Down syndrome are at high risk for dementia. Individuals with Down syndrome who develop dementia almost universally experience mi

关键词： Biomarkers Cognition Vascular contributions to cognitive impairment and dementia

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Ontologizing Health Systems data at Scale: Making Translational Discovery a Reality

arXiv

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arXiv 2022年

作者： Callahan, Tiffany J. Stefanski, Adrianne L. Wyrwa, Jordan M. Zeng, Chenjie Ostropolets, Anna Banda, Juan M. Baumgartner, William A. Boyce, Richard D. Casiraghi, Elena Coleman, Ben D. Collins, Janine H. Deakyne-Davies, Sara J. Feinstein, James A. Haendel, Melissa A. Lin, Asiyah Y. Martin, Blake Matentzoglu, Nicolas A. Meeker, Daniella Reese, Justin Sinclair, Jessica Taneja, Sanya B. Trinkley, Katy E. Vasilevsky, Nicole A. Williams, Andrew Zhang, Xingman A. Denny, Joshua C. Robinson, Peter N. Ryan, Patrick Hripcsak, George Bennett, Tellen D. Hunter, Lawrence E. Kahn, Michael G. Computational Bioscience Program University of Colorado Anschutz Medical Campus AuroraCO80045 United States Department of Biomedical Informatics Columbia University Irving Medical Center New YorkNY10032 United States Department of Physical Medicine and Rehabilitation School of Medicine University of Colorado Anschutz Medical Campus AuroraCO80045 United States National Human Genome Research Institute National Institutes of Health BethesdaMD20892 United States Department of Computer Science Georgia State University AtlantaGA30303 United States Department of Biomedical Informatics University of Pittsburgh School of Medicine PittsburghPA15260 United States Computer Science Università degli Studi di Milano Milan20122 Italy Division of Environmental Genomics and Systems Biology Lawrence Berkeley National Laboratory BerkeleyCA94720 United States The Jackson Laboratory for Genomic Medicine FarmingtonCT06032 United States Department of Haematology University of Cambridge Cambridge United Kingdom Department of Research Informatics & Data Science Analytics Resource Center Children’s Hospital Colorado AuroraCO80045 United States University of Colorado Anschutz School of Medicine AuroraCO80045 United States Center for Health AI University of Colorado Anschutz Medical Campus AuroraCO80045 United States Departments of Biomedical Informatics and Pediatrics University of Colorado School of Medicine AuroraCO80045 United States Semanticly Athens Greece Yale School of Medicine New HavenCT06510 United States HealthLinc ValparaisoIN46383 United States Intelligent Systems Program University of Pittsburgh PittsburghPA15260 United States Department of Family Medicine University of Colorado Anschutz School of Medicine AuroraCO80045 United States Translational and Integrative Sciences Lab University of Colorado Anschutz Medical Campus AuroraCO80045 United States Tufts Institute for Clinical Research and Health Policy Studies Tufts University Bos

Background: Common data models solve many challenges of standardizing electronic health record (EHR) data, but are unable to semantically integrate all the resources needed for deep phenotyping. Open Biological and Biomedical Ontology (OBO) Foundry ontologies provide computable representations of biological knowledge and enable the integration of heterogeneous data. However, mapping EHR data to OBO ontologies requires significant manual curation and domain expertise. Objective: We introduce OMOP2OBO, an algorithm for mapping Observational Medical Outcomes Partnership (OMOP) vocabularies to OBO ontologies. Results: Using OMOP2OBO, we produced mappings for 92,367 conditions, 8611 drug ingredients, and 10,673 measurement results, which covered 68-99% of concepts used in clinical practice when examined across 24 hospitals. When used to phenotype rare disease patients, the mappings helped systematically identify undiagnosed patients who might benefit from genetic testing. Conclusions: By aligning OMOP vocabularies to OBO ontologies our algorithm presents new opportunities to advance EHR-based deep phenotyping. © 2022, CC BY.

关键词： Ontology

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A computational approach to measure the linguistic characteristics of psychotherapy timing, responsiveness, and consistency

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npj Mental Health Research 2022年第1期1卷 1-12页

作者： Miner, Adam S. Fleming, Scott L. Haque, Albert Fries, Jason A. Althoff, Tim Wilfley, Denise E. Agras, W. Stewart Milstein, Arnold Hancock, Jeff Asch, Steven M. Stirman, Shannon Wiltsey Arnow, Bruce A. Shah, Nigam H. Department of Psychiatry and Behavioral Sciences Stanford University Stanford CA United States Center for Biomedical Informatics Research Stanford University Stanford CA United States Department of Biomedical Data Science Stanford University Stanford CA United States Department of Computer Science Stanford University Stanford CA United States Allen School of Computer Science & Engineering University of Washington Seattle WA United States Departments of Psychiatry Medicine Pediatrics and Psychological & Brain Sciences Washington University in St. Louis St. Louis MO United States Clinical Excellence Research Center Stanford University Stanford CA United States Department of Communication Stanford University Stanford CA United States VA Palo Alto Health Care System Palo Alto CA United States Division of Primary Care and Population Health Stanford University School of Medicine Stanford CA United States National Center for Posttraumatic Stress Disorders Dissemination and Training Division VA Palo Alto Healthcare System Menlo Park CA United States Technology and Digital Solutions Stanford Healthcare Stanford CA United States

Although individual psychotherapy is generally effective for a range of mental health conditions, little is known about the moment-to-moment language use of effective therapists. Increased access to computational power, coupled with a rise in computer-mediated communication (telehealth), makes feasible the large-scale analyses of language use during psychotherapy. Transparent methodological approaches are lacking, however. Here we present novel methods to increase the efficiency of efforts to examine language use in psychotherapy. We evaluate three important aspects of therapist language use - timing, responsiveness, and consistency - across five clinically relevant language domains: pronouns, time orientation, emotional polarity, therapist tactics, and paralinguistic style. We find therapist language is dynamic within sessions, responds to patient language, and relates to patient symptom diagnosis but not symptom severity. Our results demonstrate that analyzing therapist language at scale is feasible and may help answer longstanding questions about specific behaviors of effective therapists. © The Author(s) 2022.

关键词： Translational research Human behaviour

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Deep learning for LiDAR point clouds in autonomous driving: A review

arXiv

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arXiv 2020年

作者： Li, Ying Ma, Lingfei Zhong, Zilong Liu, Fei Cao, Dongpu Li, Jonathan Chapman, Michael A. Department of Geography and Environmental Management University of Waterloo 200 University Avenue West WaterlooN2L 3G1 Canada School of Data and Computer Science Sun Yat-Sen University Guangzhou510006 China Xilinx Technology Beijing Limited Beijing100083 China Waterloo Cognitive Autonomous Driving Lab University of Waterloo N2L 3G1 Canada Departments of System Design Engineering University of Waterloo WaterlooONN2L 3G1 Canada Department of Civil Engineering Ryerson University TorontoONM5B 2K3 Canada

Recently, the advancement of deep learning in discriminative feature learning from 3D LiDAR data has led to rapid development in the field of autonomous driving. However, automated processing uneven, unstructured, noisy, and massive 3D point clouds is a challenging and tedious task. In this paper, we provide a systematic review of existing compelling deep learning architectures applied in LiDAR point clouds, detailing for specific tasks in autonomous driving such as segmentation, detection, and classification. Although several published research papers focus on specific topics in computer vision for autonomous vehicles, to date, no general survey on deep learning applied in LiDAR point clouds for autonomous vehicles exists. Thus, the goal of this paper is to narrow the gap in this topic. More than 140 key contributions in the recent five years are summarized in this survey, including the milestone 3D deep architectures, the remarkable deep learning applications in 3D semantic segmentation, object detection, and classification;specific datasets, evaluation metrics, and the state of the art performance. Finally, we conclude the remaining challenges and future researches. Copyright © 2020, The Authors. All rights reserved.

关键词： Object detection

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DpMood: Exploiting local and periodic typing dynamics for personalized mood prediction

arXiv

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arXiv 2018年

作者： Huang, He Cao, Bokai Yu, Philip S. Wang, Chang Dong Leow, Alex D. Department of Computer Science University of Illinois ChicagoIL United States Facebook Inc. Menlo ParkCA United States School of Data and Computer Science Sun Yat-sen University Guangzhou China Departments of Psychiatry and Bioengineering University of Illinois ChicagoIL United States

Mood disorders are common and associated with significant morbidity and mortality. Early diagnosis has the potential to greatly alleviate the burden of mental illness and the ever increasing costs to families and society. Mobile devices provide us a promising opportunity to detect the users' mood in an unobtrusive manner. In this study, we use a custom keyboard which collects keystrokes' meta-data and accelerometer values. Based on the collected time series data in multiple modalities, we propose a deep personalized mood prediction approach, called dpMood, by integrating convolutional and recurrent deep architectures as well as exploring each individual's circadian rhythm. Experimental results not only demonstrate the feasibility and effectiveness of using smart-phone meta-data to predict the presence and severity of mood disturbances in bipolar subjects, but also show the potential of personalized medical treatment for mood disorders. Copyright © 2018, The Authors. All rights reserved.

关键词： Forecasting

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From FAIR to CURE: Guidelines for Computational Models of Biological Systems

arXiv

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arXiv 2025年

作者： Sauro, Herbert M. Agmon, Eran Blinov, Michael L. Gennari, John H. Hellerstein, Joe Heydarabadipour, Adel Hunter, Peter Jardine, Bartholomew E. May, Elebeoba Nickerson, David P. Smith, Lucian P. Bader, Gary D. Bergmann, Frank Boyle, Patrick M. Dräger, Andreas Faeder, James R. Feng, Song Freire, Juliana Fröhlich, Fabian Glazier, James A. Gorochowski, Thomas E. Helikar, Tomas Hoops, Stefan Imoukhuede, Princess Keating, Sarah M. Konig, Matthias Laubenbacher, Reinhard Loew, Leslie M. Lopez, Carlos F. Lytton, William W. McCulloch, Andrew Mendes, Pedro Myers, Chris J. Myers, Jerry G. Mulugeta, Lealem Niarakis, Anna van Niekerk, David D. Olivier, Brett G. Patrie, Alexander A. Quardokus, Ellen M. Radde, Nicole Rohwer, Johann M. Sahle, Sven Schaff, James C. Sego, T.J. Shin, Janis Snoep, Jacky L. Vadigepalli, Rajanikanth Wiley, H. Steve Waltemath, Dagmar Moraru, Ion Department of Bioengineering University of Washington SeattleWA98195-5061 United States Intelligent Systems Engineering and Biocomplexity Institute Indiana University Street BloomingtonIN47408 United States Center for Cardiovascular Biology University of Washington SeattleWA98195-5061 United States eScience Institute University of Washington SeattleWA98195-5061 United States Institute for Stem Cell and Regenerative Medicine University of Washington SeattleWA98195-5061 United States School of Biological Sciences University of Bristol 24 Tyndall Avenue BristolBS8 1TQ United Kingdom Departments of Physiology & Pharmacology Neurology Downstate Health Science University BrooklynNY11203 United States Department of Neurology Kings County Hospital BrooklynNY11203 United States NASA-John H. Glenn Research Center MS 110-3 21000 Brookpark Road ClevelandOH44135 United States Center for Cell Analysis and Modeling UConn Health 263 Farmington Avenue FarmingtonCT06030-6406 United States Amsterdam Institute for Life and Environment Vrije Universiteit Amsterdam De Boelelaan 1108 Amsterdam1081 HZ Netherlands Department of Pathology and Genomic Medicine Thomas Jefferson University 1020 Locust St PhiladelphiaPA19107 United States Biological Sciences Division Pacific Northwest National Laboratory 902 Battelle Blvd RichlandWA99354 United States Auckland Bioengineering Institute University of Auckland Auckland1010 New Zealand Center of Integrative Biology University of Toulouse III-Paul Sabatier 165 Rue Marianne Grunberg-Manago Toulouse31400 France Lifeware Group Inria Building Alan Turing 1 Rue Honoré d’Estienne d’Orves Palaiseau91120 France Multiscale Modeling Group Altos Labs Redwood CityCA94065 United States partner site Tübingen Tübingen Germany Ottfried-Müller-Str. 37 Tübingen72076 Germany 06120 Germany Department of Computer Science Center for Data Science New York University New YorkNY11201 United States Department of Bi

Guidelines for managing scientific data have been established under the FAIR principles requiring that data be Findable, Accessible, Interoperable, and Reusable. In many scientific disciplines, especially computational biology, both data and models are key to progress. For this reason, and recognizing that such models are a very special type of "data", we argue that computational models, especially mechanistic models prevalent in medicine, physiology and systems biology, deserve a complementary set of guidelines. We propose the CURE principles, emphasizing that models should be Credible, Understandable, Reproducible, and Extensible. We delve into each principle, discussing verification, validation, and uncertainty quantification for model credibility;the clarity of model descriptions and annotations for understandability;adherence to standards and open science practices for reproducibility;and the use of open standards and modular code for extensibility and reuse. We outline recommended and baseline requirements for each aspect of CURE, aiming to enhance the impact and trustworthiness of computational models, particularly in biomedical applications where credibility is paramount. Our perspective underscores the need for a more disciplined approach to modeling, aligning with emerging trends such as Digital Twins and emphasizing the importance of data and modeling standards for interoperability and reuse. Finally, we emphasize that given the non-trivial effort required to implement the guidelines, the community moves to automate as many of the guidelines as possible. © 2025, CC BY.

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The importance of transparency and reproducibility in artificial intelligence research

arXiv

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arXiv 2020年

作者： Haibe-Kains, Benjamin Adam, George Alexandru Hosny, Ahmed Khodakarami, Farnoosh Waldron, Levi Wang, Bo McIntosh, Chris Kundaje, Anshul Greene, Casey S. Hoffman, Michael M. Leek, Jeffrey T. Huber, Wolfgang Brazma, Alvis Pineau, Joelle Tibshirani, Robert Hastie, Trevor Ioannidis, John P.A. Quackenbush, John Aerts, Hugo J.W.L. Princess Margaret Cancer Centre University Health Network TorontoON Canada Department of Medical Biophysics University of Toronto TorontoON Canada Department of Computer Science University of Toronto TorontoON Canada Ontario Institute for Cancer Research TorontoON Canada Vector Institute for Artificial Intelligence TorontoON Canada Program Brigham and Women's Hospital Harvard Medical School BostonMA United States Radiation Oncology and Radiology Dana-Farber Cancer Institute Brigham and Women's Department of Epidemiology and Biostatistics Institute for Implementation Science in Population Health CUNY Graduate School of Public Health and Health Policy New YorkNY United States Peter Munk Cardiac Centre University Health Network TorontoON Canada Hospital Harvard Medical School BostonMA United States Department of Genetics Stanford University School of Medicine StanfordCA United States Dept. of Systems Pharmacology and Translational Therapeutics Perelman School of Medicine University of Pennsylvania PhiladelphiaPA United States Childhood Cancer Data Lab Alex's Lemonade Stand Foundation PhiladelphiaPA United States Department of Biostatistics Johns Hopkins Bloomberg School of Public Health BaltimoreMD United States European Molecular Biology Laboratory Genome Biology Unit Heidelberg Germany European Molecular Biology Laboratory European Bioinformatics Institute EMBL-EBI Hinxton United Kingdom McGill University MontrealQC Canada Montreal Institute for Learning Algorithms QC Canada StanfordCA United States Department of Biomedical Data Science Stanford University School of Medicine StanfordCA United States Departments of Medicine of Health Research and Policy and of Biomedical Data Science Stanford University School of Medicine StanfordCA United States Department of Statistics Stanford University School of Humanities and Sciences StanfordCA United States Department of Biostatistics Harvard T.H Chan School of Public Health BostonMA Un

In their study, McKinney et al. showed the high potential of artificial intelligence for breast cancer screening. However, the lack of detailed methods and computer code undermines its scientific value. We identify obstacles hindering transparent and reproducible AI research as faced by McKinney et al and provide solutions with implications for the broader field. Copyright © 2020, The Authors. All rights reserved.

关键词： Artificial intelligence

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Corrigendum to "Dissemination in time and space in presymptomatic granulin mutation carriers: A spatial chronnectome study" [Neurobiology of Aging Volume 108, December 2021, Pages 155-167]

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Neurobiology of aging 2022年 119卷 140-144页

作者： Enrico Premi Marcello Giunta Armin Iraji Srinivas Rachakonda VinceD Calhoun Stefano Gazzina Alberto Benussi Roberto Gasparotti Silvana Archetti Martina Bocchetta Dave Cash Emily Todd Georgia Peakman Rhian Convery John C van Swieten Lize Jiskoot Raquel Sanchez-Valle Fermin Moreno Robert Laforce Caroline Graff Matthis Synofzik Daniela Galimberti JamesB Rowe Mario Masellis Carmela Tartaglia Elizabeth Finger Rik Vandenberghe Alexandre de Mendonça Fabrizio Tagliavini Chris R Butler Isabel Santana Alexander Gerhard Isabelle Le Ber Florence Pasquier Simon Ducharme Johannes Levin Adrian Danek Sandro Sorbi Markus Otto Jonathan D Rohrer Barbara Borroni Stroke Unit Azienda Socio Sanitaria Territoriale Spedali Civili Brescia Brescia Italy. Centre for Neurodegenerative Disorders Department of Clinical and Experimental Sciences University of Brescia Brescia Italy. Tri-institutional Center for Translational Research in Neuroimaging and Data Science (TReNDS) Georgia State University Georgia Institute of Technology Emory University Atlanta GA USA. Tri-institutional Center for Translational Research in Neuroimaging and Data Science (TReNDS) Georgia State University Georgia Institute of Technology Emory University Atlanta GA USA Departments of Psychology and Computer Science Georgia State University Atlanta GA USA Department of Electrical and Computer Engineering Georgia Institute of Technology Atlanta GA USA. Neurophysiology Unit Azienda Socio Sanitaria Territoriale Spedali Civili Brescia Brescia Italy. Neuroradiology Unit University of Brescia Brescia Italy. Laboratory Unit Azienda Socio Sanitaria Territoriale Spedali Civili Brescia Brescia Italy. Department of Neurodegenerative Disease Dementia Research Centre UCL Institute of Neurology Queen Square London UK. Department of Neurology Erasmus Medical Centre Rotterdam the Netherlands. Alzheimer's disease and Other Cognitive Disorders Unit Neurology Service Hospital Clinic University of Barcelona Barcelona Spain. Cognitive Disorders Unit Department of Neurology Donostia University Hospital San Sebastian Gipuzkoa Spain. Clinique Interdisciplinaire de Memoire Department des Sciences Neurologiques CHU de Quebec and Faculte de Medecine Universite Laval Quebec Canada. Center for Alzheimer Research Division of Neurogeriatrics Department of Neurobiology Care Sciences and Society Bioclinicum Karolinska Institutet Solna Sweden. Department of Neurodegenerative Diseases Hertie-Institute for Clinical Brain Research and Center of Neurology University of Tubingen Tubingen Germany. Fondazione Ca' Granda IRCCS Ospedale Policlinico Milan Italy University of Milan

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Proximity variational inference

arXiv

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arXiv 2017年

作者： Altosaar, Jaan Ranganath, Rajesh Blei, David M. Department of Physics Princeton University Department of Computer Science Princeton University Data Science Institute Departments of Computer Science and Statistics Columbia University

Variational inference is a powerful approach for approximate posterior inference. However, it is sensitive to initialization and can be subject to poor local optima. In this paper, we develop proximity variational inference (pvi). pvi is a new method for optimizing the variational objective that constrains subsequent iterates of the variational parameters to robustify the optimization path. Consequently, pvi is less sensitive to initialization and optimization quirks and finds better local optima. We demonstrate our method on three proximity statistics. We study pvi on a Bernoulli factor model and sigmoid belief network with both real and synthetic data and compare to deterministic annealing (Katahira et al., 2008). We highlight the flexibility of pvi by designing a proximity statistic for Bayesian deep learning models such as the variational autoencoder (Kingma and Welling, 2014;Rezende et al., 2014). Empirically, we show that pvi consistently finds better local optima and gives better predictive *** Codes 68T10 Copyright © 2017, The Authors. All rights reserved.

关键词： Deep learning

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PCL: Proposal cluster learning for weakly supervised object detection

arXiv

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arXiv 2018年

作者： Tang, Peng Wang, Xinggang Bai, Song Shen, Wei Bai, Xiang Liu, Wenyu Yuille, Alan School of Electronic Information and Communications Huazhong University of Science and Technology Wuhan430074 China Department of Engineering Science University of Oxford OxfordOX1 3PJ United Kingdom Key Laboratory of Specialty Fiber Optics and Optical Access Networks Shanghai Institute for Advanced Communication and Data Science School of Communication and Information Engineering Shanghai University Shanghai200444 China Departments of Cognitive Science and Computer Science Johns Hopkins University BaltimoreMD21218-2608 United States

Weakly Supervised Object Detection (WSOD), using only image-level annotations to train object detectors, is of growing importance in object recognition. In this paper, we propose a novel deep network for WSOD. Unlike previous networks that transfer the object detection problem to an image classification problem using Multiple Instance Learning (MIL), our strategy generates proposal clusters to learn refined instance classifiers by an iterative process. The proposals in the same cluster are spatially adjacent and associated with the same object. This prevents the network from concentrating too much on parts of objects instead of whole objects. We first show that instances can be assigned object or background labels directly based on proposal clusters for instance classifier refinement, and then show that treating each cluster as a small new bag yields fewer ambiguities than the directly assigning label method. The iterative instance classifier refinement is implemented online using multiple streams in convolutional neural networks, where the first is an MIL network and the others are for instance classifier refinement supervised by the preceding one. Experiments are conducted on the PASCAL VOC, ImageNet detection, and MS-COCO benchmarks for WSOD. Results show that our method outperforms the previous state of the art significantly. Copyright © 2018, The Authors. All rights reserved.

关键词： Object detection

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