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Author Correction: Why rankings of biomedical image analysis competitions should be interpreted with care

Nature communications 2019年第1期10卷 588页

作者： Lena Maier-Hein Matthias Eisenmann Annika Reinke Sinan Onogur Marko Stankovic Patrick Scholz Tal Arbel Hrvoje Bogunovic Andrew P Bradley Aaron Carass Carolin Feldmann Alejandro F Frangi Peter M Full Bram van Ginneken Allan Hanbury Katrin Honauer Michal Kozubek Bennett A Landman Keno März Oskar Maier Klaus Maier-Hein Bjoern H Menze Henning Müller Peter F Neher Wiro Niessen Nasir Rajpoot Gregory C Sharp Korsuk Sirinukunwattana Stefanie Speidel Christian Stock Danail Stoyanov Abdel Aziz Taha Fons van der Sommen Ching-Wei Wang Marc-André Weber Guoyan Zheng Pierre Jannin Annette Kopp-Schneider Division of Computer Assisted Medical Interventions (CAMI) German Cancer Research Center (DKFZ) 69120 Heidelberg Germany. l.maier-hein@dkfz.de. Division of Computer Assisted Medical Interventions (CAMI) German Cancer Research Center (DKFZ) 69120 Heidelberg Germany. Centre for Intelligent Machines McGill University Montreal QC H3A0G4 Canada. Christian Doppler Laboratory for Ophthalmic Image Analysis Department of Ophthalmology Medical University Vienna 1090 Vienna Austria. Science and Engineering Faculty Queensland University of Technology Brisbane QLD 4001 Australia. Department of Electrical and Computer Engineering Department of Computer Science Johns Hopkins University Baltimore MD 21218 USA. CISTIB - Center for Computational Imaging & Simulation Technologies in Biomedicine The University of Leeds Leeds Yorkshire LS2 9JT UK. Department of Radiology and Nuclear Medicine Medical Image Analysis Radboud University Center 6525 GA Nijmegen The Netherlands. Institute of Information Systems Engineering TU Wien 1040 Vienna Austria. Complexity Science Hub Vienna 1080 Vienna Austria. Heidelberg Collaboratory for Image Processing (HCI Heidelberg University 69120 Heidelberg Germany. Centre for Biomedical Image Analysis Masaryk University 60200 Brno Czech Republic. Electrical Engineering Vanderbilt University Nashville TN 37235-1679 USA. Institute of Medical Informatics Universität zu Lübeck 23562 Lübeck Germany. Division of Medical Image Computing (MIC) German Cancer Research Center (DKFZ) 69120 Heidelberg Germany. Institute for Advanced Studies Department of Informatics Technical University of Munich 80333 Munich Germany. Information System Institute HES-SO Sierre 3960 Switzerland. Departments of Radiology Nuclear Medicine and Medical Informatics Erasmus MC 3015 GD Rotterdam The Netherlands. Department of Computer Science University of Warwick Coventry CV4 7AL UK. Department of Radiation Oncology Massachusetts General Hospital Boston MA

In the original version of this Article the values in the rightmost column of Table 1 were inadvertently shifted relative to the other columns. This has now been corrected in the PDF and HTML versions of the Article.

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Publisher Correction: Brain charts for the human lifespan

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Nature 2022年第7931期610卷 E6页

作者： R A I Bethlehem J Seidlitz S R White J W Vogel K M Anderson C Adamson S Adler G S Alexopoulos E Anagnostou A Areces-Gonzalez D E Astle B Auyeung M Ayub J Bae G Ball S Baron-Cohen R Beare S A Bedford V Benegal F Beyer J Blangero M Blesa Cábez J P Boardman M Borzage J F Bosch-Bayard N Bourke V D Calhoun M M Chakravarty C Chen C Chertavian G Chetelat Y S Chong J H Cole A Corvin M Costantino E Courchesne F Crivello V L Cropley J Crosbie N Crossley M Delarue R Delorme S Desrivieres G A Devenyi M A Di Biase R Dolan K A Donald G Donohoe K Dunlop A D Edwards J T Elison C T Ellis J A Elman L Eyler D A Fair E Feczko P C Fletcher P Fonagy C E Franz L Galan-Garcia A Gholipour J Giedd J H Gilmore D C Glahn I M Goodyer P E Grant N A Groenewold F M Gunning R E Gur R C Gur C F Hammill O Hansson T Hedden A Heinz R N Henson K Heuer J Hoare B Holla A J Holmes R Holt H Huang K Im J Ipser C R Jack A P Jackowski T Jia K A Johnson P B Jones D T Jones R S Kahn H Karlsson L Karlsson R Kawashima E A Kelley S Kern K W Kim M G Kitzbichler W S Kremen F Lalonde B Landeau S Lee J Lerch J D Lewis J Li W Liao C Liston M V Lombardo J Lv C Lynch T T Mallard M Marcelis R D Markello S R Mathias B Mazoyer P McGuire M J Meaney A Mechelli N Medic B Misic S E Morgan D Mothersill J Nigg M Q W Ong C Ortinau R Ossenkoppele M Ouyang L Palaniyappan L Paly P M Pan C Pantelis M M Park T Paus Z Pausova D Paz-Linares A Pichet Binette K Pierce X Qian J Qiu A Qiu A Raznahan T Rittman A Rodrigue C K Rollins R Romero-Garcia L Ronan M D Rosenberg D H Rowitch G A Salum T D Satterthwaite H L Schaare R J Schachar A P Schultz G Schumann M Schöll D Sharp R T Shinohara I Skoog C D Smyser R A Sperling D J Stein A Stolicyn J Suckling G Sullivan Y Taki B Thyreau R Toro N Traut K A Tsvetanov N B Turk-Browne J J Tuulari C Tzourio É Vachon-Presseau M J Valdes-Sosa P A Valdes-Sosa S L Valk T van Amelsvoort S N Vandekar L Vasung L W Victoria S Villeneuve A Villringer P E Vértes K Wagstyl Y S Wang S K Warfield V Warrier E Westman M L Westwater H C Whalley A V Witte N Yang B Yeo H Y Autism Research Centre Department of Psychiatry University of Cambridge Cambridge UK. rb643@medschl.cam.ac.uk. Brain Mapping Unit Department of Psychiatry University of Cambridge Cambridge UK. rb643@medschl.cam.ac.uk. Department of Psychiatry University of Pennsylvania Philadelphia PA USA. jakob.seidlitz@pennmedicine.upenn.edu. Department of Child and Adolescent Psychiatry and Behavioral Science The Children's Hospital of Philadelphia Philadelphia PA USA. jakob.seidlitz@pennmedicine.upenn.edu. Lifespan Brain Institute The Children's Hospital of Philadelphia and Penn Medicine Philadelphia PA USA. jakob.seidlitz@pennmedicine.upenn.edu. Department of Psychiatry University of Cambridge Cambridge UK. MRC Biostatistics Unit University of Cambridge Cambridge UK. Department of Psychiatry University of Pennsylvania Philadelphia PA USA. Lifespan Informatics & Neuroimaging Center University of Pennsylvania Philadelphia PA USA. Department of Psychology Yale University New Haven CT USA. Developmental Imaging Murdoch Children's Research Institute Melbourne Victoria Australia. Department of Medicine Monash University Melbourne Victoria Australia. UCL Great Ormond Street Institute for Child Health London UK. Weill Cornell Institute of Geriatric Psychiatry Department of Psychiatry Weill Cornell Medicine New York USA. Department of Pediatrics University of Toronto Toronto Canada. Holland Bloorview Kids Rehabilitation Hospital Toronto Canada. The Clinical Hospital of Chengdu Brain Science Institute MOE Key Lab for NeuroInformation University of Electronic Science and Technology of China Chengdu China. University of Pinar del Río "Hermanos Saiz Montes de Oca" Pinar del Río Cuba. MRC Cognition and Brain Sciences Unit University of Cambridge Cambridge UK. Autism Research Centre Department of Psychiatry University of Cambridge Cambridge UK. Department of Psychology School of Philosophy Psychology and Language Sciences University of Edinburgh Edinburgh UK. Queen's

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Publisher Correction: Capturing variation impact on molecular interactions in the IMEx Consortium mutations data set

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Nature communications 2019年第1期10卷 1098页

作者： N Del-Toro M Duesbury M Koch L Perfetto A Shrivastava D Ochoa O Wagih J Piñero M Kotlyar C Pastrello P Beltrao L I Furlong I Jurisica H Hermjakob S Orchard P Porras European Bioinformatics Institute (EMBL-EBI) European Molecular Biology Laboratory Wellcome Genome Campus Hinxton CB10 1SD UK. Novartis Institutes for BioMedical Research (NIBR) Maulbeerstrasse 66 4058 Basel Canton of Basel-Stadt Switzerland. Deep Genomics MaRS Centre 661 University Ave Suite 480 Toronto ON M5G 1M1 Canada. Research Programme on Biomedical Informatics (GRIB) Department of Experimental and Health Sciences (DCEXS) Hospital del Mar Medical Research Institute (IMIM) Universitat Pompeu Fabra (UPF) 08003 Barcelona Spain. Krembil Research Institute Data Science Discovery Centre for Chronic Diseases University Health Network 5KD-407 60 Leonard Avenue Toronto ON M5T 0S8 Canada. Departments of Medical Biophysics and Computer Science University of Toronto Toronto M4B 1B5 Canada. State Key Laboratory of Proteomics Beijing Proteome Research Center National Center for Protein Sciences Beijing Institute of Life Omics 102206 Beijing China. European Bioinformatics Institute (EMBL-EBI) European Molecular Biology Laboratory Wellcome Genome Campus Hinxton CB10 1SD UK. pporras@ebi.ac.uk.

In the original HTML version of this Article, the order of authors within the author list was incorrect. The IMEx Consortium contributing authors were incorrectly listed as the last author and should have been listed as the first author. This error has been corrected in the HTML version of the Article; the PDF version was correct at the time of publication.

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Developing a framework for digital objects in the Big data to Knowledge (BD2K) commons: Report from the Commons Framework Pilots workshop

Developing a framework for digital objects in the Big Data t...

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作者： Jagodnik, Kathleen M. Koplev, Simon Jenkins, Sherry L. Ohno-Machado, Lucila Paten, Benedict Schurer, Stephan C. Dumontier, Michel Verborgh, Ruben Bui, Alex Ping, Peipei McKenna, Neil J. Madduri, Ravi Pillai, Ajay Ma'ayan, Avi Department of Pharmacological Sciences BD2K-LINCS Data Coordination and Integration Center Mount Sinai Center for Bioinformatics Icahn School of Medicine at Mount Sinai One Gustave L. Levy Place Box 1215 New YorkNY10029 United States Health System Department of Biomedical Informatics University of California San Diego 9500 Gilman Dr. La Jolla CA92083 United States Health Services Research San Diego Veterans Administration Health System San DiegoCA92083 United States UC Santa Cruz Genomics Institute University of California Santa Cruz 1156 High St. Santa CruzCA95060 United States MiamiFL33136 United States Institute for Data Science Universiteit Maastricht Minderbroedersberg 4-6 LK Maastricht6211 Netherlands Ghent University – iMinds Research Foundation Flanders St. Pietersnieuwstraat 33 Gent9000 Belgium Department of Radiological Sciences UCLA School of Medicine Los AngelesCA90095 United States Department of Bioengineering UCLA Henri Samueli School of Engineering Los AngelesCA90095 United States Departments of Physiology Medicine and Bioinformatics UCLA School of Medicine Los AngelesCA90095 United States Department of Molecular and Cellular Biology Baylor College of Medicine 1 Baylor Plaza HoustonTX77030 United States Department of Mathematics and Computer Science Argonne National Laboratory 9700 S. Cass Avenue ArgonneIL60439 United States Division of Genome Sciences National Human Genome Research Institute National Institutes of Health 31 Center Drive MSC 2152 9000 Rockville Pike Bethesda MD20892 United States

The volume and diversity of data in biomedical research have been rapidly increasing in recent years. While such data hold significant promise for accelerating discovery, their use entails many challenges including: the need for adequate computational infrastructure, secure processes for data sharing and access, tools that allow researchers to find and integrate diverse datasets, and standardized methods of analysis. These are just some elements of a complex ecosystem that needs to be built to support the rapid accumulation of these data. The NIH Big data to Knowledge (BD2K) initiative aims to facilitate digitally enabled biomedical research. Within the BD2K framework, the Commons initiative is intended to establish a virtual environment that will facilitate the use, interoperability, and discoverability of shared digital objects used for research. The BD2K Commons Framework Pilots Working Group (CFPWG) was established to clarify goals and work on pilot projects that address existing gaps toward realizing the vision of the BD2K Commons. This report reviews highlights from a two-day meeting involving the BD2K CFPWG to provide insights on trends and considerations in advancing Big data science for biomedical research in the United States. © 2017 Elsevier Inc.

关键词： Reusability

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Author Correction: The power of genetic diversity in genome-wide association studies of lipids

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Nature 2023年第7965期618卷 E19-E20页

作者： Sarah E Graham Shoa L Clarke Kuan-Han H Wu Stavroula Kanoni Greg J M Zajac Shweta Ramdas Ida Surakka Ioanna Ntalla Sailaja Vedantam Thomas W Winkler Adam E Locke Eirini Marouli Mi Yeong Hwang Sohee Han Akira Narita Ananyo Choudhury Amy R Bentley Kenneth Ekoru Anurag Verma Bhavi Trivedi Hilary C Martin Karen A Hunt Qin Hui Derek Klarin Xiang Zhu Gudmar Thorleifsson Anna Helgadottir Daniel F Gudbjartsson Hilma Holm Isleifur Olafsson Masato Akiyama Saori Sakaue Chikashi Terao Masahiro Kanai Wei Zhou Ben M Brumpton Humaira Rasheed Sanni E Ruotsalainen Aki S Havulinna Yogasudha Veturi QiPing Feng Elisabeth A Rosenthal Todd Lingren Jennifer Allen Pacheco Sarah A Pendergrass Jeffrey Haessler Franco Giulianini Yuki Bradford Jason E Miller Archie Campbell Kuang Lin Iona Y Millwood George Hindy Asif Rasheed Jessica D Faul Wei Zhao David R Weir Constance Turman Hongyan Huang Mariaelisa Graff Anubha Mahajan Michael R Brown Weihua Zhang Ketian Yu Ellen M Schmidt Anita Pandit Stefan Gustafsson Xianyong Yin Jian'an Luan Jing-Hua Zhao Fumihiko Matsuda Hye-Mi Jang Kyungheon Yoon Carolina Medina-Gomez Achilleas Pitsillides Jouke Jan Hottenga Gonneke Willemsen Andrew R Wood Yingji Ji Zishan Gao Simon Haworth Ruth E Mitchell Jin Fang Chai Mette Aadahl Jie Yao Ani Manichaikul Helen R Warren Julia Ramirez Jette Bork-Jensen Line L Kårhus Anuj Goel Maria Sabater-Lleal Raymond Noordam Carlo Sidore Edoardo Fiorillo Aaron F McDaid Pedro Marques-Vidal Matthias Wielscher Stella Trompet Naveed Sattar Line T Møllehave Betina H Thuesen Matthias Munz Lingyao Zeng Jianfeng Huang Bin Yang Alaitz Poveda Azra Kurbasic Claudia Lamina Lukas Forer Markus Scholz Tessel E Galesloot Jonathan P Bradfield E Warwick Daw Joseph M Zmuda Jonathan S Mitchell Christian Fuchsberger Henry Christensen Jennifer A Brody Mary F Feitosa Mary K Wojczynski Michael Preuss Massimo Mangino Paraskevi Christofidou Niek Verweij Jan W Benjamins Jorgen Engmann Rachel L Kember Roderick C Slieker Ken Sin Lo Nuno R Zilhao Phuong Le Marcus E Kleber Graciela E Delgado Shaofeng Huo Dai Department of Internal Medicine Division of Cardiology University of Michigan Ann Arbor MI USA. VA Palo Alto Health Care System Palo Alto CA USA. Department of Medicine Division of Cardiovascular Medicine Stanford University School of Medicine Stanford CA USA. Department of Computational Medicine and Bioinformatics University of Michigan Ann Arbor MI USA. William Harvey Research Institute Barts and the London School of Medicine and Dentistry Queen Mary University of London London UK. Department of Biostatistics and Center for Statistics Genetics University of Michigan Ann Arbor MI USA. Department of Genetics Perelman School of Medicine University of Pennsylvania Philadelphia PA USA. Clinical Pharmacology William Harvey Research Institute Barts and The London School of Medicine and Dentistry Queen Mary University of London London UK. Endocrinology Boston Children's Hospital Boston MA USA. Medical and Population Genetics Broad Institute Cambridge MA USA. Department of Genetic Epidemiology University of Regensburg Regensburg Germany. McDonnell Genome Institute and Department of Medicine Washington University St Louis MO USA. Department of Precision Medicine Division of Genome Science National Institute of Health Cheongju-si South Korea. Tohoku Medical Megabank Organization Tohoku University Sendai Japan. Sydney Brenner Institute for Molecular Bioscience Faculty of Health Sciences University of the Witwatersrand Johannesburg South Africa. Center for Research on Genomics and Global Health National Human Genome Research Institute National Institutes of Health Bethesda MD USA. Blizard Institute Barts and the London School of Medicine and Dentistry Queen Mary University of London London UK. Wellcome Sanger Institute Hinxton UK. Department of Epidemiology Emory University Rollins School of Public Health Atlanta GA USA. Atlanta VA Health Care System Decatur GA USA. Malcolm Randall VA Medical Center Gainesville FL USA. Division of Vascular Sur

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A data Mining Analysis of Asthma Risk Factors

A Data Mining Analysis of Asthma Risk Factors

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International Conference on Applied Computing and Information Technology/International Conference on Computational science and Intelligence (ACIT-CSI)

作者： Alma Pochini Ben M. Williams Hasanboy M. Isomitdinov Gongzhu Hu Departments of Finance Law & Departments of Mathematics Data Mining Graduate Certificate Program Department of Economics Department of Computer Science Central Michigan University Michigan USA

Asthma is a chronic inflammatory disease of the airways. Although causes of asthma may directly related to environment factors such as dust mites, pollens, cold air, etc.,we would like to find out if demographic, social and behavior factors also play a role. In this paper, we present a study of the behavioral rick factors in relation to people getting asthma. This study applies data mining techniques to the 2013 Behavioral Risk Factor Surveillance System (BRFSS) dataset of over 490,000 observations with 336 variables. The results reveal some relationships between some of these variables and asthma that may help asthma prevention.

关键词： Logistics Diseases data mining Neural networks Regression tree analysis

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Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits (vol 50, pg 1412, 2018)

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NATURE GENETICS 2018年第12期50卷 1755-1755页

作者： Evangelou, Evangelos Warren, Helen R. Mosen-Ansorena, David Mifsud, Borbala Pazoki, Raha Gao, He Ntritsos, Georgios Dimou, Niki Cabrera, Claudia P. Karaman, Ibrahim Fu Liang Ng Evangelou, Marina Witkowska, Katarzyna Tzanis, Evan Hellwege, Jacklyn N. Giri, Ayush Edwards, Digna R. Velez Sun, Yan V. Cho, Kelly Gaziano, J. Michael Wilson, Peter W. F. Tsao, Philip S. Kovesdy, Csaba P. Esko, Tonu Magi, Reedik Milani, Lili Almgren, Peter Boutin, Thibaud Debette, Stephanie Ding, Jun Giulianini, Franco Holliday, Elizabeth G. Jackson, Anne U. Li-Gao, Ruifang Lin, Wei-Yu Luan, Jian'an Mangino, Massimo Oldmeadow, Christopher Prins, Bram Peter Qian, Yong Sargurupremraj, Muralidharan Shah, Nabi Surendran, Praveen Theriault, Sebastien Verweij, Niek Willems, Sara M. Zhao, Jing-Hua Amouyel, Philippe Connell, John de Mutsert, Renee Doney, Alex S. F. Farrall, Martin Menni, Cristina Morris, Andrew D. Noordam, Raymond Pare, Guillaume Poulter, Neil R. Shields, Denis C. Stanton, Alice Thom, Simon Abecasis, Goncalo Amin, Najaf Arking, Dan E. Ayers, Kristin L. Barbieri, Caterina M. Batini, Chiara Bis, Joshua C. Blake, Tineka Bochud, Murielle Boehnke, Michael Boerwinkle, Eric Boomsma, Dorret I. Bottinger, Erwin P. Braund, Peter S. Brumat, Marco Campbell, Archie Campbell, Harry Chakravarti, Aravinda Chambers, John C. Chauhan, Ganesh Ciullo, Marina Cocca, Massimiliano Collins, Francis Cordell, Heather J. Davies, Gail de Borst, Martin H. de Geus, Eco J. Deary, Ian J. Deelen, Joris Del Greco, Fabiola M. Demirkale, Cumhur Yusuf Dorr, Marcus Ehret, Georg B. Elosua, Roberto Enroth, Stefan Erzurumluoglu, A. Mesut Ferreira, Teresa Franberg, Mattias Franco, Oscar H. Gandin, Ilaria Gasparini, Paolo Giedraitis, Vilmantas Gieger, Christian Girotto, Giorgia Goel, Anuj Gow, Alan J. Gudnason, Vilmundur Guo, Xiuqing Gyllensten, Ulf Hamsten, Anders Harris, Tamara B. Harris, Sarah E. Hartman, Catharina A. Havulinna, Aki S. Hicks, Andrew A. Hofer, Edith Hofman, Albert Hottenga, Jouke-Jan Huffman, Jennifer E. Hwang, Shih-Jen Ingelsson, Erik James, Alan Jansen Department of Epidemiology and Biostatistics Imperial College London London UK Department of Hygiene and Epidemiology University of Ioannina Medical School Ioannina Greece William Harvey Research Institute Barts and The London School of Medicine and Dentistry Queen Mary University of London London UK National Institute for Health Research Barts Cardiovascular Biomedical Research Center Queen Mary University of London London UK MRC-PHE Centre for Environment and Health Imperial College London London UK Department of Mathematics Imperial College London London UK Division of Epidemiology Department of Medicine Institute for Medicine and Public Health Vanderbilt Genetics Institute Vanderbilt University Medical Center Tennessee Valley Healthcare System (626)/Vanderbilt University Nashville TN USA Vanderbilt Genetics Institute Vanderbilt Epidemiology Center Department of Obstetrics and Gynecology Vanderbilt University Medical Center Tennessee Valley Health Systems VA Nashville TN USA Department of Epidemiology Emory University Rollins School of Public Health Atlanta GA USA Department of Biomedical Informatics Emory University School of Medicine Atlanta GA USA Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC) VA Boston Healthcare System Boston MA USA Division of Aging Department of Medicine Brigham and Women’s Hospital Department of Medicine Harvard Medical School Boston MA USA Atlanta VAMC and Emory Clinical Cardiovascular Research Institute Atlanta GA USA VA Palo Alto Health Care System Division of Cardiovascular Medicine Stanford University School of Medicine Stanford CA USA Nephrology Section Memphis VA Medical Center and University of Tennessee Health Science Center Memphis TN USA Estonian Genome Center University of Tartu Tartu Estonia Program in Medical and Population Genetics Broad Institute of Harvard and MIT Cambridge MA USA Department Clinical Sciences Malmö Lund University Malmö Sweden MRC Human Genetics Un

High blood pressure is a highly heritable and modifiable risk factor for cardiovascular disease. We report the largest genetic association study of blood pressure traits (systolic, diastolic and pulse pressure) to date in over 1 million people of European ancestry. We identify 535 novel blood pressure loci that not only offer new biological insights into blood pressure regulation but also highlight shared genetic architecture between blood pressure and lifestyle exposures. Our findings identify new biological pathways for blood pressure regulation with potential for improved cardiovascular disease prevention in the future.

关键词： Cardiovascular diseases Genome informatics Genome-wide association studies

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26th Annual Computational Neuroscience Meeting (CNS*2017): Part 3 Antwerp, Belgium. 15-20 July 2017 Abstracts

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BMC NEUROscience 2017年第SUPPL 1期18卷 95-176页

作者： [Anonymous] Department of Neuroscience Yale University New Haven CT 06520 USA Department Physiology & Pharmacology SUNY Downstate Brooklyn NY 11203 USA NYU School of Engineering 6 MetroTech Center Brooklyn NY 11201 USA Departament de Matemàtica Aplicada Universitat Politècnica de Catalunya Barcelona 08028 Spain Institut de Neurobiologie de la Méditerrannée (INMED) INSERM UMR901 Aix-Marseille Univ Marseille France Center of Neural Science New York University New York NY USA Aix-Marseille Univ INSERM INS Inst Neurosci Syst Marseille France Laboratoire de Physique Théorique et Modélisation CNRS UMR 8089 Université de Cergy-Pontoise 95300 Cergy-Pontoise Cedex France Department of Mathematics and Computer Science ENSAT Abdelmalek Essaadi’s University Tangier Morocco Laboratory of Natural Computation Department of Information and Electrical Engineering and Applied Mathematics University of Salerno 84084 Fisciano SA Italy Department of Medicine University of Salerno 84083 Lancusi SA Italy Dipartimento di Fisica Università degli Studi Aldo Moro Bari and INFN Sezione Di Bari Italy Data Analysis Department Ghent University Ghent Belgium Coma Science Group University of Liège Liège Belgium Cruces Hospital and Ikerbasque Research Center Bilbao Spain BIOtech Department of Industrial Engineering University of Trento and IRCS-PAT FBK 38010 Trento Italy Department of Data Analysis Ghent University Ghent 9000 Belgium The Wellcome Trust Centre for Neuroimaging University College London London WC1N 3BG UK Department of Electronic Engineering NED University of Engineering and Technology Karachi Pakistan Blue Brain Project École Polytechnique Fédérale de Lausanne Lausanne Switzerland Departement of Mathematics Swansea University Swansea Wales UK Laboratory for Topology and Neuroscience at the Brain Mind Institute École polytechnique fédérale de Lausanne Lausanne Switzerland Institute of Mathematics University of Aberdeen Aberdeen Scotland UK Department of Integrativ

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Correction: Investigation of common, low-frequency and rare genome-wide variation in anorexia nervosa

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Molecular psychiatry 2018年第9期23卷 1969页

作者： L M Huckins K Hatzikotoulas L Southam L M Thornton J Steinberg F Aguilera-McKay J Treasure U Schmidt C Gunasinghe A Romero C Curtis D Rhodes J Moens G Kalsi D Dempster R Leung A Keohane R Burghardt S Ehrlich J Hebebrand A Hinney A Ludolph E Walton P Deloukas A Hofman A Palotie P Palta F J A van Rooij K Stirrups R Adan C Boni R Cone G Dedoussis E van Furth F Gonidakis P Gorwood J Hudson J Kaprio M Kas A Keski-Rahonen K Kiezebrink G-P Knudsen M Maj A M Monteleone P Monteleone A H Raevuori T Reichborn-Kjennerud F Tozzi A Tsitsika A van Elburg D A Collier P F Sullivan G Breen C M Bulik E Zeggini Department of Human Genetics Wellcome Trust Sanger Institute Wellcome Trust Genome Campus Hinxton Cambridge UK. laura.huckins@mssm.edu. Division of Psychiatric Genomics Icahn School of Medicine at Mount Sinai New York NY USA. laura.huckins@mssm.edu. Department of Human Genetics Wellcome Trust Sanger Institute Wellcome Trust Genome Campus Hinxton Cambridge UK. Department of Psychiatry and Nutrition University of North Carolina at Chapel Hill Chapel Hill NC USA. Section of Eating Disorders Institute of Psychiatry Psychology and Neuroscience King's College London London UK. NIHR BRC SLaM BioResource for Mental Health SGDP Centre & Centre for Neuroimaging Sciences Section of Eating Disorders Institute of Psychiatry Psychology and Neuroscience King's College London London UK. Klinik für Kinder- und Jugendpsychiatrie Psychotherapie und Psychosomatik Klinikum Frankfurt Frankfurt Germany. Division of Psychological and Social Medicine and Developmental Neurosciences Faculty of Medicine TU Dresden Dresden Germany. Eating Disorders Research and Treatment Center Department of Child and Adolescent Psychiatry Faculty of Medicine TU Dresden Dresden Germany. Department of Child and Adolescent Psychiatry and Psychotherapy University Hospital Essen University of Duisburg-Essen Essen Germany. Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt Neuherberg Germany. Division of Psychological & Social Medicine and Developmental Neurosciences Technische Universität Dresden Faculty of Medicine University Hospital C.G. Carus Dresden Germany. Department of Psychology Georgia State University Atlanta GA USA. Erasmus University Medical Center Rotterdam The Netherlands. Center for Human Genome Research at the Massachusetts General Hospital Boston USA MA. Department of Public Health & Institute for Molecular Medicine FIMM University of Helsinki Helsinki Finland. Brain Center Rudolf Magnus Department of Neuroscience and Pharmacology University Medica

The fortieth author's name was listed incorrectly. The correct presentation is A Keski-Rahkonen.

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Sequence data and association statistics from 12,940 type 2 diabetes cases and controls

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Scientific data 2017年第1期4卷 170179页

作者： Jason Flannick Christian Fuchsberger Anubha Mahajan Tanya M Teslovich Vineeta Agarwala Kyle J Gaulton Lizz Caulkins Ryan Koesterer Clement Ma Loukas Moutsianas Davis J McCarthy Manuel A Rivas John R B Perry Xueling Sim Thomas W Blackwell Neil R Robertson N William Rayner Pablo Cingolani Adam E Locke Juan Fernandez Tajes Heather M Highland Josee Dupuis Peter S Chines Cecilia M Lindgren Christopher Hartl Anne U Jackson Han Chen Jeroen R Huyghe Martijn van de Bunt Richard D Pearson Ashish Kumar Martina Müller-Nurasyid Niels Grarup Heather M Stringham Eric R Gamazon Jaehoon Lee Yuhui Chen Robert A Scott Jennifer E Below Peng Chen Jinyan Huang Min Jin Go Michael L Stitzel Dorota Pasko Stephen C J Parker Tibor V Varga Todd Green Nicola L Beer Aaron G Day-Williams Teresa Ferreira Tasha Fingerlin Momoko Horikoshi Cheng Hu Iksoo Huh Mohammad Kamran Ikram Bong-Jo Kim Yongkang Kim Young Jin Kim Min-Seok Kwon Juyoung Lee Selyeong Lee Keng-Han Lin Taylor J Maxwell Yoshihiko Nagai Xu Wang Ryan P Welch Joon Yoon Weihua Zhang Nir Barzilai Benjamin F Voight Bok-Ghee Han Christopher P Jenkinson Teemu Kuulasmaa Johanna Kuusisto Alisa Manning Maggie C Y Ng Nicholette D Palmer Beverley Balkau Alena Stančáková Hanna E Abboud Heiner Boeing Vilmantas Giedraitis Dorairaj Prabhakaran Omri Gottesman James Scott Jason Carey Phoenix Kwan George Grant Joshua D Smith Benjamin M Neale Shaun Purcell Adam S Butterworth Joanna M M Howson Heung Man Lee Yingchang Lu Soo-Heon Kwak Wei Zhao John Danesh Vincent K L Lam Kyong Soo Park Danish Saleheen Wing Yee So Claudia H T Tam Uzma Afzal David Aguilar Rector Arya Tin Aung Edmund Chan Carmen Navarro Ching-Yu Cheng Domenico Palli Adolfo Correa Joanne E Curran Dennis Rybin Vidya S Farook Sharon P Fowler Barry I Freedman Michael Griswold Daniel Esten Hale Pamela J Hicks Chiea-Chuen Khor Satish Kumar Benjamin Lehne Dorothée Thuillier Wei Yen Lim Jianjun Liu Marie Loh Solomon K Musani Sobha Puppala William R Scott Loïc Yengo Sian-Tsung Tan Herman A Taylor Farook Thameem Gregory Wilson Tien Yin Wong Pål Rasmu Department of Molecular Biology Massachusetts General Hospital Boston Massachusetts USA. Program in Medical and Population Genetics Broad Institute Cambridge Massachusetts USA. Department of Biostatistics and Center for Statistical Genetics University of Michigan Ann Arbor Michigan USA. Wellcome Trust Centre for Human Genetics Nuffield Department of Medicine University of Oxford Oxford UK. Harvard-MIT Division of Health Sciences and Technology Massachusetts Institute of Technology Cambridge Massachusetts USA. Department of Statistics University of Oxford Oxford UK. Genetics of Complex Traits University of Exeter Medical School University of Exeter Exeter UK. MRC Epidemiology Unit Institute of Metabolic Science University of Cambridge Cambridge UK. Department of Twin Research and Genetic Epidemiology King's College London London UK. Oxford Centre for Diabetes Endocrinology and Metabolism Radcliffe Department of Medicine University of Oxford Oxford UK. Department of Human Genetics Wellcome Trust Sanger Institute Hinxton Cambridgeshire UK. School of Computer Science McGill University Montreal Quebec Canada. McGill University and Génome Québec Innovation Centre Montreal Quebec Canada. Human Genetics Center The University of Texas Graduate School of Biomedical Sciences at Houston The University of Texas Health Science Center at Houston Houston Texas USA. Department of Biostatistics Boston University School of Public Health Boston Massachusetts USA. National Heart Lung and Blood Institute's Framingham Heart Study Framingham Massachusetts USA. Medical Genomics and Metabolic Genetics Branch National Human Genome Research Institute National Institutes of Health Bethesda Maryland USA. Department of Biostatistics Harvard School of Public Health Boston Massachusetts USA. Chronic Disease Epidemiology Swiss Tropical and Public Health Institute University of Basel Basel Switzerland. Institute of Genetic Epidemiology Helmholtz Zentrum München German R

To investigate the genetic basis of type 2 diabetes (T2D) to high resolution, the GoT2D and T2D-GENES consortia catalogued variation from whole-genome sequencing of 2,657 European individuals and exome sequencing of 12,940 individuals of multiple ancestries. Over 27M SNPs, indels, and structural variants were identified, including 99% of low-frequency (minor allele frequency [MAF] 0.1-5%) non-coding variants in the whole-genome sequenced individuals and 99.7% of low-frequency coding variants in the whole-exome sequenced individuals. Each variant was tested for association with T2D in the sequenced individuals, and, to increase power, most were tested in larger numbers of individuals (>80% of low-frequency coding variants in ~82 K Europeans via the exome chip, and ~90% of low-frequency non-coding variants in ~44 K Europeans via genotype imputation). The variants, genotypes, and association statistics from these analyses provide the largest reference to date of human genetic information relevant to T2D, for use in activities such as T2D-focused genotype imputation, functional characterization of variants or genes, and other novel analyses to detect associations between sequence variation and T2D.

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