We present ICE-TIDE, a method for cryogenic electron tomography (cryo-ET) that simultaneously aligns observations and reconstructs a high-resolution volume. The alignment of tilt series in cryo-ET is a major problem l...
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Point-of-care sensors are pivotal for early disease diagnosis, significantly advancing global health. Surface plasmons, the collective oscillations of free electrons under electromagnetic excitation, have been widely ...
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Point-of-care sensors are pivotal for early disease diagnosis, significantly advancing global health. Surface plasmons, the collective oscillations of free electrons under electromagnetic excitation, have been widely studied for biosensing due to their electromagnetic field enhancements at sub-wavelength scales. We introduce a plasmonic biosensor on a compact photonic integrated circuit (PIC) enhanced by exceptional points (EPs). EPs, singularities in non-Hermitian optical systems, provide extreme sensitivity to external perturbations. They emerge when two or more complex resonating modes merge into a single degenerate mode. We demonstrate an EP in a single coupled nanoantenna particle positioned in a uniquely designed silicon nitride slot-waveguide, which we call a junction-waveguide. By laterally shifting two optically coupled gold nanobars of different lengths, we achieve a single particle EP. The junction-waveguide enables efficient coupling of the plasmonic nanoantenna to the waveguide mode. The system integrates a four-port Mach–Zehnder interferometer (MZI), allowing for simultaneous measurements of the amplitude and phase of EP, facilitating highly accurate real-time eigenvalue extraction. For biosensing, we encapsulated the detection zone with a microchannel, enabling low-volume and simple sample handling. Our single particle integrated EP sensor demonstrates superior sensitivity compared to the corresponding linear diabolic point (DP) system under both local and bulk sensing schemes, even at large perturbations. Our studies revealed that the integrated EP sensor can detect a single molecule captured by the nanobars with the average size ranging from 10 to 100 nm. The proposed EP biosensor, with its extreme sensitivity,compact form, and real-time phase sensing capabilities, provides an approach for detecting and quantifying various biomarkers such as proteins and nucleic acids, offering a unique platform for early disease diagnosis.
The wholly wholesale transition into remote and hybrid workspaces is characteristic of modern-day work settings. As more and more firms adopt such flexible models, it is important to note, their implications on employ...
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ISBN:
(数字)9798350357509
ISBN:
(纸本)9798350357516
The wholly wholesale transition into remote and hybrid workspaces is characteristic of modern-day work settings. As more and more firms adopt such flexible models, it is important to note, their implications on employee wellness and productivity. This paper uses machine learning techniques in order to understand the effects of mental distancing and hybridization on various key results such as the mental state of the employees, balance between their work and private life, separation from the society, as well as productivity levels. With a sample size of 5000 employees collect from kaggle, we determine the advantages and disadvantages these work models present. In other regards, geographical larger shifts create practical benefits including greater flexibility and autonomy plus productivity. However, such dramatic shifts create higher work-related stress, greater social tension and isolation, as well as challenges with workplace culture. AI, or more precisely machine learning, uncovers concepts in relation to work models in this paper, fico that enable firms to better personate their constituents and the workforce. Reasonable conclusions could be drawn so as flexible working arrangements benefit in reducing work-life conflict however improved organizational structure within the companies is needed to have such benefits due. Mental health as one of the resources, alongside technology will assist in such transition. This paper is a step forward for HR practitioners.
This article presents a new family of transformerless buck-boost voltage-source inverter topologies for photovoltaic systems. Due to variations in irradiance, temperature, and shading effects, the terminal voltages of...
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In our study, we explore methods for detecting unwanted content lurking in visual datasets. We provide a theoretical analysis demonstrating that a model capable of successfully partitioning visual data can be obtained...
We report, for the first time, electric field periodic poling of single-crystal thin film barium titanate grown using pulsed-laser-deposition on dysprosium scandate substrate. Uniform domains with periods 5-7 μm are ...
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The circular economy represents a critical pathway toward achieving sustainable development goals through responsible resource production and consumption. Monitoring progress toward implementing a circular economy in ...
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Supervisory Control and Data Acquisition (SCADA) systems are utilized extensively in critical power grid infrastructures. Modern SCADA systems have been proven to be susceptible to cyber-security attacks and require i...
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Fantasy Sports has a current market size of ${\$}$27B and is expected to grow more than ${\$}$84B in less than a decade. The intent is to create virtual teams that somehow reflect what would happen if the constituent ...
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A comprehensive understanding of the topology of the electric power transmission network (EPTN) is essential for reliable and robust control of power systems. While existing research primarily relies on domain-specifi...
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