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2005 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2005

作者： Heller, M.J. Sullivan, B. Dehlinger, D. University of California San Diego Departments of Bioengineering/Electrical and Computer Engineering PFBE Bldg. Rm 429 9500 Gilman Dr. San Diego CA 92093-0412

ISBN: (纸本)0976798506

The fabrication of viable linear DNA photonic/electronic transfer nanostructures is an important prerequisite for the subsequent self-assembly into higher-order 2D/3D devices, structures and materials (high density memory, photonic antennas, nanoscale "fiber optics", nanocomputers, nano-sensors etc.). Unfortunately, it is very difficult to maintain the self-assembling and self-recognition properties of derivatized molecules such as biotin functionalized DNA sequences, when attempting to further derivatize the structure with multiply functionalized nanoparticles (streptavidin-quantum dots, gold nanoparticles, fluorescent polymer nanoparticles). Generally, overwhelming intra- and intermolecular crosslinking reactions prevent the formation of viable linear structures. Our goal is the development of nanofabrication techniques which will allow quantum dot functionalized linear DNA chains to be constructed without the need for complex chemical blocking group procedures.

关键词： Nanostructured materials

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Data Integration for Medical Information Management

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Journal of VLSI signal processing systems for signal, image and video technology 2005年第3期41卷 319-328页

作者： Sun, Mingui Shi, Yun Q. Liu, Qiang Sclabassi, Robert J. Departments of Neurosurgery Electrical Engineering and Bioengineering Laboratory for Computational Neuroscience University of Pittsburgh Pittsburg USA Departments of Neurosurgery and Electrical Engineering University of Pittsburgh Pittsburg USA Department of Electrical and Computer Engineering New Jersey Institute of Technology Newyork USA

We present a new method for data integration and security by mixing medical waveforms and images with encrypted patient identifiers and unencrypted ancillary information, such as acquisition parameters, diagnostic comments and notes in textual, pictorial, and voice forms. We vary the sampling rate according to the instantaneous frequency of the signal. Redundant samples (or pixels) are eliminated and replaced by associative data which are labeled using a status string encoded based on the Huffman and run-length techniques. This method achieves both data compression and integration simultaneously, allows synchronized presentation of information from different sources by using multimedia technology, and provides data security features.

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3D Multiwavelet-based Motion Residual Compression for Neurosurgical Monitoring Videos

3D Multiwavelet-based Motion Residual Compression for Neuros...

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IEEE Workshop on Multimedia Signal Processing

作者： Jong-chih Chien C.c. Li Mingui Sun Department of Electrical and Computer Engineering University of Pittsburgh Pittsburgh PA USA Departments of Neurosurgery Electrical and Computer Engineering and Bioengineering University of Pittsburgh Pittsburgh PA USA

Neurophysical interoperative monitoring (OIM) video is an important tool in biomedical applications and telemedicine and it is essential to maintain high fidelity of the frames even in low bit-rate environment. Toward this end, we studied a spatio-temporal 3D multiwavelet-based OIM video compression system that is capable of high quality output even under the demands of high compression ratios

关键词： Neurosurgery Video compression Layout Surgery Cameras Biomedical monitoring computerized monitoring Biomedical engineering Central nervous system Quantization

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Micromachined tacks for retinal implant applications

Micromachined tacks for retinal implant applications

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International Conference on Microtechnologies in Medicine and Biology

作者： S.D. Cambron J.R. Franco-Sarabia K.M. Walsh R.S. Keynton Departments of Bioengineering University of Louisville KY USA Electrical and Computer Engineering University of Louisville KY USA

To fasten an artificial retinal implant onto the epiretinal surface of the eye, our group has designed retinal microtacks. The microtacks were fabricated using two different micromachining techniques: 1) deep reactive ion etching (DRIE) and 2) ultra-high-precision micromilling. Metrology was performed on each microtack design following fabrication, measuring all critical and overall dimensions. Force measurement experiments were performed to determine the loads required to insert and remove each microtack design in a synthetic material. This was carried out to verify the validity of the new geometric features added to the microtack. Each experiment consisted of three programmed zones: Insertion, Hold, and Removal. The required displacement and velocity were determined for each zone dependent upon microtack design.

关键词： Retina Implants Silicon Etching Design engineering Micromachining Performance evaluation Fabrication Force measurement Blindness

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Dual capillary electrophoresis devices with electrochemical detection on a single platform

Dual capillary electrophoresis devices with electrochemical ...

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International Conference on Microtechnologies in Medicine and Biology

作者： R. Dorairaj T.J. Roussel M.M. Crain D.J. Jackson D. Franco K.M. Walsh R.P. Baldwin J.F. Naber R.S. Keynton Departments of Electrical & Computer Engineering University of Louisville Louisville KY USA Department of Bioengineering University of Louisville Louisville KY USA Department of Chemistry University of Louisville Louisville KY USA

The purpose of this paper is to demonstrate the feasibility of developing a single lab-on-a-chip (LOC) platform capable of performing dual, simultaneous separation and detection of multiple analytes. Computational modeling was performed to determine optimum device geometry and performance. The soda-lime glass-based device was fabricated using traditional microtechnology processes, including UV photolithography, buffered oxide etch (BOE), electrode deposition and compression thermal bonding. The device was characterized with a mixture of dopamine (2mM) and catechol (2mM) in a phosphate buffer (20mM, 6.5 pH). Modeling results yielded migration velocities of 0.6 mm/s and 0.42 mm/s for dopamine (electrokinetic (EK) mobility=60,000 /spl mu/m/sup 2//V/spl middot/s) and catechol (EK mobility=42,000 /spl mu/m/sup 2//V/spl middot/s), respectively. Experimental results obtained from microchips exhibiting the same EK mobilities demonstrated identical electropherograms in both detection channels with migration velocities of 0.58 mm/s for dopamine and 0.41 mm/s for catechol.

关键词： Electrokinetics Lab-on-a-chip Computational modeling Reservoirs Computational geometry Electrodes Biochemical analysis Plugs Voltage Glass

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Comment on “Inability of Lyapunov Exponents to Predict Epileptic Seizures”

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Physical Review Letters 2005年第1期94卷 019801-019801页

作者： Leonidas D. Iasemidis Konstantinos Tsakalis J. Chris Sackellares Panos M. Pardalos The Harrington Department of Bioengineering Arizona State University Tempe Arizona 85287 USA Department of Electrical Engineering Arizona State University Tempe Arizona 85287 USA Departments of Neurology Neuroscience Pediatrics Psychiatry and Biomedical Engineering University of Florida Gainesville Florida 32611 USA Departments of Industrial and Systems Engineering Computer Science and Biomedical Engineering University of Florida Gainesville Florida 32611 USA

A Comment on the Letter by Ying-Cheng Lai et al., Phys. Rev. Lett. 91, 068102 (2003). The authors of the Letter offer a Reply.

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Integrated neural interfaces arrays for neuroprosthetics applications

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Nanomedicine: Nanotechnology, Biology and Medicine 2005年第3期1卷 250-251页

作者： F. Solzbacher R.R. Harrison R.A. Normann H. Oppermann M. Klein K.P. Koch Departments of Electrical and Computer Engineering Materials Science Bioengineering University of Utah Salt Lake City UT USA Fraunhofer Institute for Reliability and Microintegration IZM Berlin Germany Neuroprosthetics Fraunhofer Institute for Biomedical Technology St. Ingbert Germany

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A multimedia system for remote neurosurgical monitoring

A multimedia system for remote neurosurgical monitoring

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Proceedings of 2004 International Symposium on Intelligent Signal Processing and Communication Systems, ISPACS 2004

作者： Sun, Mingui Liu, Qiang Xu, Jian Liu, Bing Hu, Chengquan Kassam, Amin Sclabassi, Robert J. Departments of Neurosurgery Pittsburgh PA 15261 United States Departments of Electrical and Computer Engineering Pittsburgh PA 15261 United States Departments of Bioengineering University of Pittsburgh Pittsburgh PA 15261 United States

ISBN: (纸本)0780386396

Neurophysiological intraoperative monitoring (IOM) is an important tool aimed at reducing iatrogenic injury to the central nervous system during complex surgical procedures. We utilize multimedia techniques involving digital video to perform remote IOM. A video camera mounted on a microscope records the same surgical scene as the one observed by the neurosurgeon. The recorded video along with a variety of physiological data are processed, compressed, and transmitted through networks to be monitored by neurophysiologists at remote sites. In order to reduce bandwidth without degenerating video quality in critical areas of surgical field, we utilized a novel method based on the wavelet transform to decompose each video frame into subframes and encode them in different resolutions. Our experimental results have demonstrated the effectiveness of this method. © 2004 IEEE.

关键词： Neurosurgery

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Tunable optical properties of colloidal quantum dots in electrolytic environments

Tunable optical properties of colloidal quantum dots in elec...

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2004 10th International Workshop on Computational Electronics: The Field of Computational Electronics - Looking Back and Looking Ahead, IEEE IWCE-10 2004, Abstracts

作者： Stroscio, Michael A. Dutta, Mitra Ramadurai, Dinakar Kohanpour, Babak Dimitri, Alexson Shi, Peng Sethuraman, Akil Li, Yang Saini, Vikas Departments of Bioengineering University of Illinois Chicago United States Department of Electrical and Computer Engineering University of Illinois Chicago United States Department of Physics University of Illinois Chicago United States

ISBN: (纸本)0780386493

The threshold of the absorption spectra of colloidal cadmium sulfide (CdS) quantum dots in electrolytic solutions is shown to shift as the concentration of the electrolyte is varied. The shift in the absorption threshold as a function of the electrolytic concentration is given by electrolytic screening of the field caused by the intrinsic spontaneous polarization of these wurtzite quantum dots. These electrolyte-dependent absorption properties will be compared with Fermi-level tuning in carbon nanotubes in electrolytic environments. Moreover, concepts for integrating such colloidal quantum dots in high density networks with biomolecular links will be discussed. MAS is grateful for the support and guidance of Dr. Dwight Woolard of the ARO, and MD gratefully acknowledges the support of NSF and SRC. Copyright 2004 IEEE.

关键词： Semiconductor quantum dots

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Tunable optical properties of colloidal quantum dots in electrolytic environments

Tunable optical properties of colloidal quantum dots in elec...

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International Workshop on Computational Electronics

作者： Stroscio Dutta Ramadurai Kohanpour Alexson Peng Shi Sethuraman Yang Li Saini Departments of Bioengineering Department of Electrical and Computer Engineering Department of Physics University of Illinois Chicago USA Department of Electrical and Computer Engineering Department of Physics University of Illinois Chicago USA Departments of Bioengineering University of Illinois Chicago USA Department of Electrical and Computer Engineering University of Illinois Chicago USA

Summary form only given. The threshold of the absorption spectra of colloidal cadmium sulfide (CdS) quantum dots in electrolytic solutions is shown to shift as the concentration of the electrolyte is varied. The shift in the absorption threshold as a function of the electrolytic concentration is given by electrolytic screening of the field caused by the intrinsic spontaneous polarization of these wurtzite quantum dots. These electrolyte-dependent absorption properties will be compared with Fermi-level tuning in carbon nanotubes in electrolytic environments. Moreover, concepts for integrating such colloidal quantum dots in high density networks with biomolecular links will be discussed.

关键词： Quantum dots Electrochemical processes Cadmium compounds Molecular electronics

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