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arXiv 2019年

作者： Al-Radhawi, M. Ali Sontag, Eduardo D. Departments of Bioengineering and Electrical and Computer Engineering Northeastern University 360 Huntington Avenue BostonMA02115 United States Laboratory of Systems Pharmacology Program in Therapeutic Science Harvard Medical School BostonMA02115

Tumor metastasis is one of the main factors responsible for the high fatality rate of cancer. Metastasis can occur after malignant cells transition from the epithelial phenotype to the mesenchymal phenotype. This transformation allows cells to migrate via the circulatory system and subsequently settle in distant organs after undergoing the reverse transition. The core gene regulatory network controlling these transitions consists of a system made up of coupled SNAIL/miRNA-34 and ZEB1/miRNA-200 subsystems. In this work, we formulate a mathematical model and analyze its long-term behavior. We start by developing a detailed reaction network with 24 state variables. Assuming fast promoter and mRNA kinetics, we then show how to reduce our model to a monotone four-dimensional system. For the reduced system, monotone dynamical systems theory can be used to prove generic convergence to the set of equilibria for all bounded trajectories. The theory does not apply to the full model, which is not monotone, but we briefly discuss results for singularly-perturbed monotone systems that provide a tool to extend convergence results from reduced to full systems, under appropriate time separation assumptions. Copyright © 2019, The Authors. All rights reserved.

关键词： Diseases

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Self-triggered Adaptive Planning and Scheduling of UAV Operations

Self-triggered Adaptive Planning and Scheduling of UAV Opera...

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IEEE International Conference on Robotics and Automation (ICRA)

作者： Esen Yel Tony X. Lin Nicola Bezzo Departments of Systems and Information Engineering and Electrical and Computer Engineering University of Virginia Charlottesville VA USA

Modern unmanned aerial vehicles (UAVs) rely on constant periodic sensor measurements to detect and avoid obstacles. However, constant checking and replanning are time and energy consuming and are often not necessary especially in situations in which the UAV can safely fly in uncluttered environments without entering unsafe states. Thus, in this paper, we propose a self-triggered framework that leverages reachability analysis to schedule the next time to check sensor measurements and perform replanning while guaranteeing safety under noise and disturbance effects. Further, we relax sensor checking and motion replanning operations by leveraging a risk-based analysis that determines the likelihood to reach undesired states over a certain time horizon. We also propose an online speed adaptation policy based on the planned trajectory curvature to minimize drift from the desired path due to the system dynamics. Finally, we validate the proposed approach with simulations and experiments for a quadrotor UAV motion planning case study in a cluttered environment.

关键词： Trajectory Robot sensing systems Safety Unmanned aerial vehicles Reachability analysis Schedules

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High Charge Transport in Tio2-Rgo Heterostructure Field-Effect Biosensors: Ultra-Low Detection Limits for Sars-Cov-2

SSRN

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SSRN 2025年

作者： Zaidan, Liena Tadele, Debela T. Azer, Bersu Bastug Ozyigit, Dogu Abdelrahman, Rana Xu, Alex Takaloo, Saeed Pennings, Joel Almoabadi, Afaf Azadinia, Mohsen Karimi, Reza Sanderson, Joe Pope, Michael Mekonnen, Tizazu H. Bajcsy, Michal Yavuz, Mustafa Department of Electrical and Computer Engineering University of Waterloo 200 University Avenue West WaterlooONN2L 3G1 Canada Department of Chemical Engineering Institute of Polymer Research University of Waterloo WaterlooONN2L 3G1 Canada Waterloo Institute for Nanotechnology University of Waterloo 200 University Avenue West WaterlooONN2L 3G1 Canada Mechanical and Mechatronics Engineering University of Waterloo 200 University Avenue West WaterlooONN2L 3G1 Canada Systems Design Engineering University of Waterloo 200 University Ave W WaterlooONN2L 3G1 Canada Department of Physics and Astronomy University of Waterloo 200 University Ave W WaterlooONN2L 3G1 Canada Department of Chemical Engineering University of Waterloo WaterlooONN2L 3G1 Canada Institute for Quantum Computing University of Waterloo 200 University Ave W WaterlooONN2L 3G1 Canada University of Waterloo Canada

The recent COVID-19 pandemic has shown that emerging infectious diseases impose a heavy burden on public health and economic development, highlighting the critical need for early and accurate diagnostic tools. During this time, graphene-based materials field effect transistor (FET) biosensors functionalized with bioreceptors emerged as a novel biosensing technology with minute-scale detection time. For sensors relying on doped reduced graphene oxide (rGO) as channel material, the reported sensitivity often approaches the ultimate standard of polymerase chain reaction (PCR), at least under laboratory conditions. Here, we present a FET-biosensor with a channel formed by TiO2-rGO heterostructure produced with Femtosecond Laser (FL) irradiation. Compared to the rGO-FET biosensor, TiO2-rGO FET biosensor has significantly increased charge transportation rate, the biosensor limit of detection (LOD) was improved 20-fold to 0.5 ag/mL (10 zM) when detecting SARS-CoV-2 nucleocapsid proteins, and the TiO2-rGO heterostructure supports visible-light-induced photocatalysis that enables sensor regeneration and reuse. Structural and chemical analyses confirm heterojunction formation with a narrowed bandgap and optimized properties tailored for biosensing. © 2025, The Authors. All rights reserved.

关键词： Enzyme sensors

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Geometric Filterless Photodetectors for Mid-infrared Spin Light

arXiv

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arXiv 2022年

作者： Wei, Jingxuan Chen, Yang Li, Ying Li, Wei Xie, Junsheng Lee, Chengkuo Novoselov, Kostya S. Qiu, Cheng-Wei Department of Electrical and Computer Engineering National University of Singapore Singapore117583 Singapore CAS Key Laboratory of Mechanical Behaviour and Design of Materials Department of Precision Machinery and Precision Instrumentation University of Science and Technology of China Hefei230026 China Interdisciplinary Center for Quantum Information State Key Laboratory of Modern Optical Instrumentation ZJU-Hangzhou Global Scientific and Technological Innovation Center Zhejiang University Hangzhou310027 China International Joint Innovation Center Key Lab of Advanced Micro/Nano Electronic Devices & Smart Systems of Zhejiang Zhejiang University Haining314400 China GPL Photonics Lab State Key Laboratory of Applied Optics Changchun Institute of Optics Fine Mechanics and Physics Chinese Academy of Sciences Changchun130033 China Center for Intelligent Sensors and MEMS National University of Singapore Singapore117608 Singapore Institute for Functional Intelligent Materials National University of Singapore Singapore117544 Singapore

Free-space circularly polarized light (CPL) detection, requiring polarizers and waveplates, has been well established, while such spatial degree of freedom is unfortunately absent in integrated on-chip optoelectronics. So far, those reported filterless CPL photodetectors suffer from the intrinsic small discrimination ratio, vulnerability to the non-CPL field components, and low responsivity. Here, we report a distinct paradigm of geometric photodetectors in mid-infrared exhibiting colossal discrimination ratio, close-to-perfect CPL-specific response, a zero-bias responsivity of 392 V/W at room temperature, and a detectivity of ellipticity down to 0.03o Hz−1/2. Our approach employs plasmonic nanostructures array with judiciously designed symmetry, assisted by graphene ribbons to electrically read their near-field optical information. This geometry-empowered recipe for infrared photodetectors provides a robust, direct, strict, and high-quality solution to on-chip filterless CPL detection and unlocks new opportunities for integrated functional optoelectronic devices. Copyright © 2022, The Authors. All rights reserved.

关键词： Photodetectors

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MrDP: Multiple-Row Detailed Placement of Heterogeneous-Sized Cells for Advanced Nodes

MrDP: Multiple-Row Detailed Placement of Heterogeneous-Sized...

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作者： Lin, Yibo Yu, Bei Xu, Xiaoqing Gao, Jhih-Rong Viswanathan, Natarajan Liu, Wen-Hao Li, Zhuo Alpert, Charles J. Pan, David Z. Department of Electrical and Computer Engineering University of Texas at Austin AustinTX78741 United States Department of Computer Science and Engineering Chinese University of Hong Kong Hong Kong Hong Kong Cadence Design Systems Inc. AustinTX78759 United States

As very large-scale integration technology shrinks to fewer tracks per standard cell, e.g., from 10 to 7.5-track libraries (and lesser for 7 nm), there has been a rapid increase in the usage of multiple-row cells like two- and three-row flip-flops, buffers, etc., for design closure. Additionally, the usage of multibit flip-flops or flop trays to save power creates large cells that further complicate critical design tasks, such as placement. Detailed placement happens to be a key optimization transform, which is repeatedly invoked during the design closure flow to improve design parameters, such as wirelength, timing, and local wiring congestion. Advanced node designs, with hundreds of thousands of multiple-row cells, require a paradigm change for this critical design closure transform. The traditional approach of fixing multiple-row cells during detailed placement and only optimizing the locations of single-row standard cells can no longer obtain appreciable quality of results. It is imperative to have new techniques that can simultaneously optimize both multiple- and single-row height cell locations during detailed placement. In this paper, we propose a new density-aware detailed placer for heterogeneous-sized netlists. Our approach consists of a chain move scheme that generalizes the movement of heterogeneous-sized cells, a nested dynamic programming-based approach for ordered double-row placement and a network flow-based formulation to solve ordered multiple-row placement for wirelength and density optimization. Experimental results demonstrate the effectiveness of these techniques in wirelength minimization and density smoothing compared with the most recent detailed placers for designs with heterogeneous-sized cells. © 1982-2012 IEEE.

关键词： Cells

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Energetic electron precipitation driven by electromagnetic ion cyclotron waves from ELFIN’s low altitude perspective

arXiv

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arXiv 2022年

作者： Angelopoulos, V. Zhang, X.-J. Artemyev, A.V. Mourenas, D. Tsai, E. Wilkins, C. Runov, A. Liu, J. Turner, D.L. Li, W. Khurana, K. Wirz, R.E. Sergeev, V.A. Meng, X. Wu, J. Hartinger, M.D. Raita, T. Shen, Y. An, X. Shi, X. Bashir, M.F. Shen, X. Gan, L. Qin, M. Capannolo, L. Ma, Q. Russell, C.L. Masongsong, E.V. Caron, R. He, I. Iglesias, L. Jha, S. King, J. Kumar, S. Le, K. Mao, J. McDermott, A. Nguyen, K. Norris, A. Palla, A. Roosnovo Tam, J. Xie, E. Yap, R.C. Ye, S. Young, C. Adair, L.A. Shaffer, C. Chung, M. Cruce, P. Lawson, M. Leneman, D. Allen, M. Anderson, M. Arreola-Zamora, M. Artinger, J. Asher, J. Branchevsky, D. Cliffe, M. Colton, K. Costello, C. Depe, D. Domae, B.W. Eldin, S. Fitzgibbon, L. Flemming, A. Frederick, D.M. Gilbert, A. Hesford, B. Krieger, R. Lian, K. McKinney, E. Miller, J.P. Pedersen, C. Qu, Z. Rozario, R. Rubly, M. Seaton, R. Subramanian, A. Sundin, S.R. Tan, A. Thomlinson, D. Turner, W. Wing, G. Wong, C. Zarifian, A. Earth Planetary and Space Sciences Department Institute of Geophysics and Planetary Physics University of California Los Angeles Los AngelesCA90095 United States University of Texas at Dallas RichardsonTX75080 United States CEA DAM DIF Arpajon France Atmospheric and Oceanic Sciences Departments University of California Los AngelesCA United States Johns Hopkins University Applied Physics Laboratory LaurelMD United States Department of Astronomy Center for Space Physics Boston University BostonMA United States Mechanical and Aerospace Engineering Department Henry Samueli School of Engineering University of California Los AngelesCA90095 United States School of Mechanical Industrial Manufacturing Engineering Oregon State University CorvallisOR97331 United States University of St. Petersburg St. Petersburg Russia Jet Propulsion Laboratory California Institute of Technology PasadenaCA91109 United States Space Science Institute BoulderCO80301 United States Sodankylä Geophysical Observatory University of Oulu Sodankylä Finland Materials Science and Engineering Department Henry Samueli School of Engineering University of California Los AngelesCA90095 United States Deloitte Consulting New YorkNY10112 United States Computer Science Department Henry Samueli School of Engineering University of California Los AngelesCA90095 United States Microsoft RedmondWA98052 United States Physics and Astronomy Department University of California Los AngelesCA90095 United States Department of Astronomy and Astrophysics The University of Chicago ChicagoIL60637 United States Raybeam Inc. Mountain ViewCA94041 United States SpaceX HawthorneCA90250 United States Reliable Robotics Corporation Mountain ViewCA94043 United States Los Alamos National Laboratory Los AlamosNM87545 United States Mathematics Department University of California Los AngelesCA90095 United States Planet Labs PBC San FranciscoCA94107 United States KSAT Inc. De

We review comprehensive observations of electromagnetic ion cyclotron (EMIC) wave-driven energetic electron precipitation using data from the energetic electron detector on the Electron Losses and Fields InvestigatioN (ELFIN) mission, two polar-orbiting low-altitude spinning CubeSats, measuring 50-5000 keV electrons with good pitch-angle and energy resolution. EMIC wave-driven precipitation exhibits a distinct signature in energy-spectrograms of the precipitating-to-trapped flux ratio: peaks at >0.5 MeV which are abrupt (bursty) (lasting ∼17s, or ∆L ∼ 0.56) with significant substructure (occasionally down to sub-second timescale). We attribute the bursty nature of the precipitation to the spatial extent and structuredness of the wave field at the equator. Multiple ELFIN passes over the same MLT sector allow us to study the spatial and temporal evolution of the EMIC wave - electron interaction region. Case studies employing conjugate ground-based or equatorial observations of the EMIC waves reveal that the energy of moderate and strong precipitation at ELFIN approximately agrees with theoretical expectations for cyclotron resonant interactions in a cold plasma. Using 2 years of ELFIN data uniformly distributed in local time, we assemble a statistical database of ∼50 events of strong EMIC wave-driven precipitation. Most reside at L ∼ 5 − 7 at dusk, while a smaller subset exists at L ∼ 8 − 12 at post-midnight. The energies of the peak-precipitation ratio and of the half-peak precipitation ratio (our proxy for the minimum resonance energy) exhibit an L-shell dependence in good agreement with theoretical estimates based on prior statistical observations of EMIC wave power spectra. The precipitation ratio’s spectral shape for the most intense events has an exponential falloff away from the peak (i.e., on either side of ∼ 1.45 MeV). It too agrees well with quasi-linear diffusion theory based on prior statistics of wave spectra. It should be noted though that this diffusive

关键词： Radiation belts

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EFFECTS OF VASCULAR BURDEN ON COGNITION ARE MEDIATED BY ATROPHY, AMYLOID, AND GLUCOSE METABOLISM: A MULTI-CENTRE MIXED COHORT OF SMALL VESSEL DISEASE AND ALZHEIMER'S PATHOLOGY

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Cerebral Circulation - Cognition and Behavior 2024年 6卷 100105-100105页

作者： Julie Ottoy Miracle Ozzoude Katherine Zukotynski Sabrina Adamo Christopher Scott Vincent Gaudet Joel Ramirez Walter Swardfager Hugo Cogo-Moreira Benjamin Lam Aparna Bhan Parisa Mojiri Min Su Kang Jennifer Rabin Alex Kiss Stephen Strother Christian Bocti Michael Borrie Howard Chertkow Richard Frayne Maged Goubran Cognitive Neurology Unit Hurvitz Brain Sciences Program Sunnybrook Research Institute University of Toronto Toronto ON Canada Departments of Medicine and Radiology McMaster University Hamilton ON Canada Department of Electrical and Computer Engineering University of Waterloo Waterloo ON Canada Department of Pharmacology & Toxicology University of Toronto ON Canada Montreal Neurological Institute McGill University Montreal QC Canada Department of Research Design and Biostatistics Sunnybrook Research Institute University of Toronto Toronto ON Canada The Rotman Research Institute Baycrest University of Toronto Toronto ON Canada Département de médecine Université de Sherbrooke Sherbrooke QC Canada Lawson Health Research Institute Western University London ON Canada Jewish General Hospital McGill University Montreal QC Canada Departments of Radiology and Clinical Neuroscience University of Calgary Calgary AB Canada Department of Medical Biophysics University of Toronto Toronto ON Canada

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Bilevel Arbitrage Potential Evaluation for Grid-Scale Energy Storage Considering Wind Power and LMP Smoothing Effect

Bilevel Arbitrage Potential Evaluation for Grid-Scale Energy...

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IEEE General Meeting Power& Energy Society

作者： Hantao Cui Fangxing Li Xin Fang Hao Chen Honggang Wang Electrical Engineering and Computer Science University of Tennessee Knoxville Power Systems Design & Studies Group National Renewable Energy Laboratory Protection and Relay Group Jiangsu Electric Power Supply Company Rutgers Energy Institute Rutgers University

This paper deals with extended-term energy storage (ES) arbitrage problems to maximize the annual revenue in deregulated power systems with high-penetration wind power. The conventional ES arbitrage model takes the locational marginal prices (LMP) as an input and is unable to account for the impacts of ES operations on system LMPs. This paper proposes a bilevel ES arbitrage model, where the upper level maximizes the ES arbitrage revenue and the lower level simulates the market clearing process considering wind power and ES. The bilevel model is formulated as a mathematical program with equilibrium constraints) and then recast into a mixed-integer linear programming using strong duality theory. Wind power fluctuations are characterized by the GARCH forecast model and the forecast error is modeled by forecast-bin-based Beta distributions. Case studies are performed on a modified PJM 5-bus system and an IEEE 118-bus system with a weekly time horizon over an annual term to show the validity of the proposed bilevel model. The results from the conventional model and the bilevel model are compared under different ES power and energy ratings, and also various load and wind penetration levels.

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A Gd@C82-based single molecular electret device

arXiv

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arXiv 2020年

作者： Zhang, Kangkang Wang, Cong Zhang, Minhao Bai, Zhanbin Xie, Fangfang Tan, Yuanzhi Guo, Yilv Hu, Kuo-Juei Cao, Lu Zhang, Shuai Tu, Xuecou Kang, Lin Chen, Jian Wu, Peiheng Wang, Xuefeng Wang, Jinlan Liu, Junming Wang, Baigeng Wang, Guanghou Xie, Suyuan Ji, Wei Shi, Su-Fei Reed, M.A. Song, Fengqi National Laboratory of Solid State Microstructures Collaborative Innovation Center of Advanced Microstructures School of Physics Nanjing University Nanjing210093 China Beijing Key Laboratory of Optoelectronic Functional Materials & Micro-Nano Devices Department of Physics Renmin University of China Beijing100872 China State Key Laboratory of Physical Chemistry of Solid Surfaces Department of Chemistry College of Chemistry and Chemical Engineering Xiamen University Xiamen361005 China School of Physics Southeast University Nanjing211189 China School of Electronic Science and Engineering and Collaborative Innovation Center of Advanced Microstructures Nanjing University Nanjing210023 China Department of Chemical and Biological Engineering Rensselaer Polytechnic Institute TroyNY12180 United States Department of Electrical Computer and Systems Engineering Rensselaer Polytechnic Institute TroyNY12180 United States Departments of Applied Physics and Electrical Engineering Yale University New HavenCT06520 United States Nanjing211805 China

Single molecular electrets exhibiting single‐molecule electric polarization switching have been long desired as a platform for extremely small non-volatile storage devices, although it is controversial because of the poor stability of single molecular electric dipoles. Here we study the single molecular device of Gd@C82, where the encapsulated Gd atom forms a charge center, and we have observed a gate-controlled switching behavior between two sets of single-electron-transport stability diagrams. The switching is operated in a hysteresis loop with a coercive gate field of around 0.5 V/nm. Theoretical calculations have assigned the two conductance diagrams to corresponding energy levels of two states that the Gd atom is trapped at two different sites of the C82 cage, which possess two different permanent electrical dipole orientations. The two dipole states are stabilized by the anisotropic energy and separated by a transition energy barrier of 70 meV. Such switching is then accessed to the electric field driven reorientation of individual dipole while overcoming the barriers by the coercive gate field, and demonstrates the creation of a single molecular electret. Copyright © 2020, The Authors. All rights reserved.

关键词： Switching

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Editor-in-Chief

引用

IEEE Access 2024年 12卷 i-xi页

作者： Derek Abbott Sonia Aissa Anuradha Annaswamy Nirwan Ansari Jun Cai Kun-Shan Chen Yixin Chen J.-C. Chiao Ayman El-Baz Shaikh Fattah Hoay Gooi Maya Gokhale Chih-Lin Ⅰ Giuseppe Iannaccone Yumi Iwashita Bruce Jacob Abbas Jamalipour Bahram Javidi Weihua Jiang Okyay Kaynak Hulya Kirkici Germano Lambert-Torres Shengtao Li Michal Mrozowski Michele Nappi Dalma Novak Hugo Proença Yi Qian Zhihua Qu Susanto Rahardja Mehrdad Saif Ali Serpengüzel Peter H. Siegel Ashitey Trebi-Ollennu Daniela Tuninetti Ge Wang Keith A. Wear Andreas Weisshaar C. Patrick Yue Enrico Zio School of Electrical and Electronic Engineering University of Adelaide Adelaide SA Australia Institut National de la Recherche Scientifique (INRS) Québec City Canada Department of Mechanical Engineering Massachusetts Institute of Technology Cambridge MA USA Department of Electrical and Computer Engineering New Jersey Institute of Technology Newark NJ USA Concordia University Montreal Canada Guilin University of Technology Guilin China Washington University St. Louis MO USA Southern Methodist University Dallas TX USA University of Louisville/Bioengineering Department Louisville KY USA Department of Electrical and Electronic Engineering Bangladesh University of Engineering and Technology Dhaka Bangladesh Nanyang Technological University Jurong West Singapore Lawrence Livermore National Laboratory Livermore CA USA China Mobile Research Institute Beijing China University of Pisa Pisa Italy NASA-JPL California Institute of Technology Pasadena CA USA Florida Polytechnic University Lakeland FL USA The University of Sydney Sydney NSW Australia University of Connecticut Storrs CT USA Nagaoka University of Technology Nagaoka Niigata Japan Department of Electrical and Electronic Engineering Boğaziçi University Istanbul Turkey University of South Alabama Mobile AL USA Gnarus Institute Itajuba Brazil Xi’an Jiaotong University Xi’an China Gdansk University of Technology Gdansk Poland University of Salerno Fisciano Italy Octane Wireless Hanover MD USA University of Beira Interior Covilhã Portugal Department of Electrical and Computer Engineering University of NebraskaLincoln Lincoln NE USA University of Central Florida Orlando Florida USA Singapore Institute of Technology 10 Dover Dr Singapore Infocomm Technology Cluster 10 Dover Dr Singapore University of Windsor Windsor Canada Department of Physics Koç University Istanbul Turkey California Institute of Technology (CalTech) Pasadena California USA NASA-JPL Mobility and Robotics Systems S

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