Key processes in biological and chemical systems are described by networks of chemical reactions. From molecular biology to biotechnology applications, computational models of reaction networks are used extensively to...
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Key processes in biological and chemical systems are described by networks of chemical reactions. From molecular biology to biotechnology applications, computational models of reaction networks are used extensively to elucidate their non-linear dynamics. Model dynamics are crucially dependent on parameter values which are often estimated from observations. Over past decade, the interest in parameter and state estimation in models of (bio-) chemical reaction networks (BRNs) grew considerably. Statistical inference problems are also encountered in many other tasks including model calibration, discrimination, identifiability and checking as well as optimum experiment design, sensitivity analysis, bifurcation analysis and other. The aim of this review paper is to explore developments of past decade to understand what BRN models are commonly used in literature, and for what inference tasks and inference methods. Initial collection of about 700 publications excluding books in computational biology and chemistry were screened to select over 260 research papers and 20 graduate theses concerning estimation problems in BRNs. The paper selection was performed as text mining using scripts to automate search for relevant keywords and terms. The outcome are tables revealing the level of interest in different inference tasks and methods for given models in literature as well as recent trends. In addition, a brief survey of general estimation strategies is provided to facilitate understanding of estimation methods which are used for BRNs. Our findings indicate that many combinations of models, tasks and methods are still relatively sparse representing new research opportunities to explore those that have not been considered - perhaps for a good reason. The most common models of BRNs in literature involve differential equations, Markov processes, mass action kinetics and state space representations whereas the most common tasks in cited papers are parameter inference and model ident
Smart meters enable improvements in electricity distribution system efficiency at some cost in customer privacy. Users with home batteries can mitigate this privacy loss by applying charging policies that mask their u...
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Smart meters enable improvements in electricity distribution system efficiency at some cost in customer privacy. Users with home batteries can mitigate this privacy loss by applying charging policies that mask their underlying energy use. A battery charging policy is proposed and shown to provide universal privacy guarantees subject to a constraint on energy cost. The guarantee bounds our strategy's maximal information leakage from the user to the utility provider under general stochastic models of user energy consumption. The policy construction adapts coding strategies for non-probabilistic permuting channels to this privacy problem.
The patients with cardiovascular diseases undergo complex medical procedures, including medical imaging, blood biochemistry analysis, physical examination, etc. The digitization of information is an intensive process ...
The patients with cardiovascular diseases undergo complex medical procedures, including medical imaging, blood biochemistry analysis, physical examination, etc. The digitization of information is an intensive process in e-health therefore, in this paper there are presented some methods to extract important data from medical records of patients suffering from coronary artery diseases organized in PDF files.
Machine and reinforcement learning (RL) are increasingly being applied to plan and control the behavior of autonomous systems interacting with the physical world. Examples include self-driving vehicles, distributed se...
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ISBN:
(数字)9781728113982
ISBN:
(纸本)9781728113999
Machine and reinforcement learning (RL) are increasingly being applied to plan and control the behavior of autonomous systems interacting with the physical world. Examples include self-driving vehicles, distributed sensor networks, and agile robots. However, when machine learning is to be applied in these new settings, the algorithms had better come with the same type of reliability, robustness, and safety bounds that are hallmarks of control theory, or failures could be catastrophic. Thus, as learning algorithms are increasingly and more aggressively deployed in safety critical settings, it is imperative that control theorists join the conversation. The goal of this tutorial paper is to provide a starting point for control theorists wishing to work on learning related problems, by covering recent advances bridging learning and control theory, and by placing these results within an appropriate historical context of system identification and adaptive control.
Laboratories are a core part of any engineering degree, but access to laboratories is typically limited due to a combination of timetable, space and equipment restrictions [1]. In more recent years that has been a sig...
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Laboratories are a core part of any engineering degree, but access to laboratories is typically limited due to a combination of timetable, space and equipment restrictions [1]. In more recent years that has been a significant growth in so-called virtual laboratories (VL), that is laboratory like activities that can be accessed via software or even a web interface, e.g. [2], [3], [5]. The advantage of VL is that the accessibility can potentially be improved to 24/7 and often these may be available on a student's own computing device thus also giving no space restrictions. Improvements in accessibility mean that staff can integrate VL far more easily into the curriculum and student independent study schedule with the consequence that, in principle, students can learn more effectively.
Mathematical modelling of vehicle dynamics is essential for the development of autonomous cars. Many of the vehicle models that are used for control design in cars are based on nonlinear physical models. However, it i...
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Mathematical modelling of vehicle dynamics is essential for the development of autonomous cars. Many of the vehicle models that are used for control design in cars are based on nonlinear physical models. However, it is not clear, especially for the case of longitudinal dynamics, whether such nonlinear models are necessary or simpler models can be used. In this paper, we identify a linear data-driven model of longitudinal vehicle dynamics and compare it to a nonlinear physically derived model. The linear model was identified in continuous-time state-space form using a prediction error method. The identification data were obtained from a Lancia Delta car, over 53 km of normal driving on public roads. The selected linear model was first order with requested torque, brake and road gradient as inputs and car velocity as output. The key results were that 1. the linear model was accurate, with a variance accounted for (VAF) metric of VAF=96.5%, and 2. the identified linear model was also superior in accuracy to the nonlinear physical model, VAF=77.4%. The implication of these results, therefore, is that for longitudinal dynamics, in normal driving conditions, a first order linear model is sufficient to describe the vehicle dynamics. This is advantageous for control design, state estimation and real-time implementation, e.g. in predictive control.
Traffic prediction approaches face challenges when presented with sparse or missing data. This can be caused by numerous factors such as: i) sensors not being operational; ii) communication issues; iii) cost prohibiti...
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Traffic prediction approaches face challenges when presented with sparse or missing data. This can be caused by numerous factors such as: i) sensors not being operational; ii) communication issues; iii) cost prohibiting full monitoring of a road network. This present work adds to existing body of knowledge by proposing a particle based framework for dealing with these challenges. An expression of the likelihood function is derived for the case when the missing value is calculated based on Kriging interpolation. With the Kriging interpolation, the missing values of the measurements are predicted, which are subsequently used in the computation of likelihood terms in the particle filter algorithm. The results show 23% to 36.34% improvement in RMSE values for the synthetic data used.
Smart meters enable improvements in electricity distribution system efficiency at some cost in customer privacy. Users with home batteries can mitigate this privacy loss by applying charging policies that mask their u...
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Estimating hidden processes from non-linear noisy observations is particularly difficult when the parameters of these processes are not known. This paper adopts a machine learning approach to devise variational Bayesi...
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