Medical imaging has become a major tool in clinical experiments due to its ability in rapid diagnosis with visualization and quantitative assessment. Fractal and texture analysis are the computer techniques used to di...
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The purpose of the activity here described is the morphological and subsequently the geometrical and topological analysis of the active sites in protein surfaces for protein-ligand docking. The approach follows a sequ...
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ISBN:
(纸本)9789898425362
The purpose of the activity here described is the morphological and subsequently the geometrical and topological analysis of the active sites in protein surfaces for protein-ligand docking. The approach follows a sequence of three steps: i) the solvent-excluded-surface is analyzed and segmented in a number of pockets and tunnels;ii) the candidate binding sites are detected through a structural matching of pockets and ligand, both represented through a suitable Extended Gaussian Image modality;iii) the loci of compatible positions of the ligand is identified through mathematical morphology. This representation of ligand and candidate binding pockets, the comparison of the morphological similarity and the identification of potential ligand docking are the novelties of this proposal.
The study of the 3D structure of proteins supports the investigation of their functions and represents an initial step towards protein based drug design. The goal of this paper is to define a technique, based on the g...
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ISBN:
(纸本)9789898425362
The study of the 3D structure of proteins supports the investigation of their functions and represents an initial step towards protein based drug design. The goal of this paper is to define a technique, based on the geometrical and topological structure of protein surfaces, for the detection and the analysis of sites of possible protein-protein and protein-ligand interactions. In particular, the aims is to identify concave and convex regions which constitute 'pockets' and 'protuberance' that can make up the interactions 'active sites'. A segmentation process is applied to the solvent-excluded- surface (SES) through a sequence of propagation steps applied to the region between the protein convex-hull and the SES: the first phase generates the pockets (and tunnels) set, meanwhile the second (backwards) produces the protrusions set.
In this work, we discuss the analytical modeling of single and cascaded plasmonic metasurfaces excited by normally incident plane waves using a transmission-line shunt admittance model. We derive an analytical model t...
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Traditionally, members of communities of practice collaborated through traditional means: word of mouth, conferences, lectures and hand written notes. However, the emergence of online environments, have led to the use...
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Agile Project Management (APM) must adopt dynamic project plans to better handle the uncertainty and unpredictability associated with the Agile software Development (ASD) methodologies. For these dynamic project plans...
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In this paper, we propose a novel method for real-time three-dimensional (3-D) object tracking based on integration of 3-D range and color information. To get 3D range and color information simultaneously, our method ...
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Ubiquitous revolution is widely implemented around the world, innovative changes in mobile information environment provides high quality to meet many different users' demanding requirements. In particular, as comp...
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The design of portable low cost systems for remote monitoring of patients with chronic diseases is one of the most important fields in telemedicine and telecare. Using Bluetooth communication technology, which can be ...
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News articles have always been a prominent force in the formation of a company's financial image in the minds of the general public, especially the investors. Given the large amount of news being generated these d...
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