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IEEE International Conference on Bioinformatics and Biomedicine (BIBM)

作者： Nicholas A. Furlotte Lijing Xu Robert W. Williams Ramin Homayouni Computer Science department University of California Los Angeles Los Angeles USA Bioinformatics Program University of Memphis Memphis USA Dept. of department and Neurobiology University of Tennessee HSC Memphis USA

Normalization procedures attempt to remove non- biological variance within microarray datasets. The choice of normalization procedure is important, as it has a dramatic effect on downstream data analysis. Although many normalization procedures have been developed, comparison and evaluation of their performance is difficult. We present a method to evaluate normalization procedures by utilizing gene- gene associations derived from the biomedical literature via Latent Semantic Indexing. The functional coherence of co- regulated genes obtained from different normalized data sets is calculated in order to evaluate the effectiveness of each normalization procedure. The method was tested on three popular normalization procedures (MAS5, PDNN and RMA) applied to gene expression data across 71 recombinant inbred mouse brain samples. Results show that, on average, MAS5 outperforms both PDNN and RMA by producing a higher number of functionally cohesive gene sets. These results demonstrate that our literature-based cohesion analysis can provide an objective method for evaluation of normalization procedures.

关键词： Probes Bioinformatics Correlation Indexes Mice Arrays Strain

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Problem solving by english learners and english primary students in an algebra-readiness ITS

Problem solving by english learners and english primary stud...

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作者： Cirett, Federico Beal, Carole R. University of Arizona Computer Science Dept. Cognitive Science Program Tucson AZ 85721 United States

ISBN: (纸本)9781577354475

Problem solving was compared for English Learners and English Primary students who had used Animal Watch, an algebra-readiness ITS. Data records for word problems solved by students in both language groups were located and compared. Results indicated that English Learners were less likely to answer correctly, had more incorrect answer attempts, took longer on each problem, and were more likely to use multimedia help features in the ITS. Differences between English Learners and English Primary students were most apparent on word problems with challenging English text. Copyright © 2010, Association for the Advancement of Artificial Intelligence (***). All rights reserved.

关键词： Students

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Using co-evolved RTS opponents to teach spatial tactics

Using co-evolved RTS opponents to teach spatial tactics

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2010 IEEE Conference on Computational Intelligence and Games, CIG2010

作者： Smith, Greg Avery, Phillipa Houmanfar, Ramona Louis, Sushil Behavior Analysis Program Dept. of Psychology United States Evolutionary Computing Systems Laboratory Dept. of Computer Science and Engineering University of Nevada Reno NE United States

ISBN: (纸本)9781424462971

This paper describes a co-evolutionary algorithm for generating simple spatially oriented tactics and considers whether students can learn better by playing against co-evolved opponents or by playing against an expert system or other similar hard-coded opponent. Although a number of artificially intelligent tutoring and e-learning systems exist, our work looks at using co-evolution to generate competent opponents for human students to learn from. This paper describes and discusses early results on using computationally intelligent opponents for tactical training of human students. Initial results indicate that the learning environment for human players, measured by game difficulty and transfer of training, is comparable across co-evolved and hard-coded computer opponents. © 2010 IEEE.

关键词： Students

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Recommender system based on user information

Recommender system based on user information

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7th International Conference on Service Systems and Service Management, ICSSSM'10

作者： Yun, So-Young Youn, Sung-Dae Dept. of Interdisciplinary Program of Electronic Commerce Pukyong National University Pusan 608-737 Korea Republic of Dept. of Computer Science Pukyong National University Pusan 608-737 Korea Republic of

ISBN: (纸本)9781424464876

One of the most successful recommender system, collaborative filtering (CF) still has problems: sparsity deteriorating the accuracy of recommendation and scalability making it difficult to expand data smoothly. In particular, sparsity can reduce the accuracy of recommendation, causing a serious problem in terms of reliability. In this paper, in order to reduce sparsity and raise the accuracy of recommendation, we propose a method that combines an item-based CF with user-based CF using weight of user information. The proposed method computes user similarity on the basis of weight of user information and thereby makes a prediction, once non-rated items pre-filled in the user-item rating matrix in the item-based CF. The result of the experiment shows that the proposed method can improve the extreme sparsity of rating data, and provide better recommendation results than traditional collaborative filtering. ©2010 IEEE.

关键词： Collaborative filtering

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A novel way to conduct human studies and do some good

A novel way to conduct human studies and do some good

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28th Annual CHI Conference on Human Factors in Computing Systems, CHI 2010

作者： Buddharaju, Pradeep Fujiki, Yuichi Pavlidis, Ioannis Akleman, Ergun Dept. of Computer Science University of Houston Houston TX 77204 United States Visualization Sciences Program Texas A and M University College Station TX 77843 United States

ISBN: (纸本)9781605589312

In this paper the authors describe a novel way to conduct large-scale human studies achieving the maximum outreach and impact with the minimum cost. An iPhone health application, 'Walk n' Play', was developed and released for free in the App Store. The application measures calories spent due to walking activities through the iPhone's accelerometer. It is a real-time awareness tool that helps people to keep their sedentariness in check. Furthermore, it uses motivational mechanisms based on buddy support/competition and social networking to increase daily physical activity. The anonymous data gathered from thousands of users around the world, reveal patterns of human behavior at a resolution and scale not feasible before. © 2010 Copyright is held by the author/owner(s).

关键词： Smartphones

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How local is the local field potential?

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BMC neuroscience 2011年第1期12卷 1-1页

作者： Henrik Lindén Tom Tetzlaff Klas H Pettersen Gaute T Einevoll Tobias C Potjans Sonja Grün Markus Diesmann Dept. of Mathematical Sciences and Technology Norwegian University of Life Sciences Ås 1432 Norway Computational and Systems Neuroscience (INM-6) Research Center Jülich Institute of Neuroscience and Medicine Jülich 52425 Germany Brain and Neural Systems Team RIKEN Computational Science Research Program Wakoshi Saitama 351-0198 Japan RIKEN Brain Science Institute Wakoshi Saitama 351-0198 Japan

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Efficient clustering with limited distance information

Efficient clustering with limited distance information

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作者： Voevodski, Konstantin Balcan, Maria-Florina Röglin, Heiko Teng, Shang-Hua Xia, Yu Dept. of Computer Science Boston University Boston MA 02215 United States College of Computing Georgia Institute of Technology Atlanta GA 30332 United States Dept. of Quantitative Economics Maastricht University Maastricht Netherlands Computer Science Dept. University of Southern California Los Angeles CA 90089 United States Bioinformatics Program Dept. of Chemistry Boston University Boston MA 02215 United States

ISBN: (纸本)9780974903965

Given a point set S and an unknown metric d on S, we study the problem of efficiently partitioning S into k clusters while querying few distances between the points. In our model we assume that we have access to one versus all queries that given a point s Ε S return the distances between s and all other points. We show that given a natural assumption about the structure of the instance, we can efficiently find an accurate clustering using only O(k) distance queries. We use our algorithm to cluster proteins by sequence similarity. This setting nicely fits our model because we can use a fast sequence database search program to query a sequence against an entire dataset. We conduct an empirical study that shows that even though we query a small fraction of the distances between the points, we produce clusterings that are close to a desired clustering given by manual classification.

关键词： Search engines

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Cartouche: Conventions for tangibles bridging diverse interactive systems

Cartouche: Conventions for tangibles bridging diverse intera...

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4th International Conference on Tangible, Embedded, and Embodied Interaction, TEI'10

作者： Ullmer, Brygg Dever, Zachary Sankaran, Rajesh Toole Jr., Cornelius Freeman, Chase Cassady, Brooke Wiley, Cole Diabi, Mohamed Wallace Jr., Alvin DeLatin, Michael Tregre, Blake Liu, Kexi Jandhyala, Srikanth Kooima, Robert Branton, Chris Parker, Rod Louisiana State University Dept. of Computer Science United States United States Louisiana State University Dept. of Electrical Engineering United States Louisiana State University Graphic Design Program United States Louisiana State University Ceramics Area United States

ISBN: (纸本)9781605588414

We describe an approach for a class of tangible interaction elements that are applicable across a broad variety of interactive systems. These tangibles share certain physical, visual, tagging, and software conventions, while fostering diversity in many aspects of design and function. Building on related techniques using paper and graspable artifacts as interactive embodiments of digital information, we propose several fixed and free parameters, present illustrative examples and applications, and discuss the resulting design space. Copyright 2010 ACM.

关键词： Interactive computer systems

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Support for flight trajectories and video capture: Initial results using a free open source flight simulator

Support for flight trajectories and video capture: Initial r...

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12th International Conference on Engineering, science, Construction, and Operations in Challenging Environments - Earth and Space 2010

作者： Durham, Jayson Mehrubeoglu, Mehrube McLauchlan, Lifford Carter, David McBee, Ross Capabilities Branch SPA WAR Systems Center - Pacific United States Dept. of Computing Sciences Engineering Technology Program Texas A and M University Corpus Christi TX United States Dept. of Electrical Engineering and Computer Science Texas A and M University Kingsville TX United States University of Texas Austin TX United States Regents School of Austin United States

ISBN: (纸本)9780784410967

Micro Aerial Vehicles (MAVs) and larger Unmanned Aerial Vehicles (UAVs) constitute a powerful tool for the modern warfighter and first responder. However, every developing technology must first be tested before being exported to the battlefield or hot spot to assure predictable behaviors. In today's digital age, computers give designers and testers unprecedented ability to quickly and easily test virtual models before physical prototypes are created and field tested. We have utilized emerging Free Open Source Software (FOSS) simulators and workbenches (e.g. FlightGear and AUV Workbench) to improve mission-driven MAV/UAV video and imagery capture and analysis capabilities. In this project, use of FlightGear to analyze flight trajectories and video capture capabilities of different UAVs is presented. FlightGear allows the free implementation of changeable flight dynamic models, weather, autopilot, GPS, and multiplayer to be included in the analysis of simulated flights. Another attractive aspect of FlightGear is its extensible and easy-to-modify implementation. Modifications are accomplished by changing or adding human readable XML files in the FlightGear subdirectories. In this effort, existing aerial vehicle models are incorporated into FlightGear to create flight trajectories and analyze video capture capabilities to determine the necessary toolset for analyzing imagery data to meet the mission needs. The limitations of the existing camera systems as well as effects of various flight parameters on mosaicking and georegistration are presented here. Sample analysis of the effect of aerial vehicle speed on the overlap of frames captured at the typical 30 frames/second frame rate, which provides a base for comparison of flight attributes, are demonstrated together with other parameters that affect mission performance. © 2010 ASCE.

关键词： Flight simulators

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Computational and biological approach to understand the 3′ UTR-mediated posttranscriptional regulation of alfalfa cytosolic glutamine synthetase genes

Computational and biological approach to understand the 3′ ...

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2nd International Conference on Bioinformatics and Computational Biology 2010, BICoB 2010

作者： Simon, Bindu Sengupta-Gopalan, Champa Yelavarthi, Pavan K. Ranjan, Desh Graduate Program in Molecular Biology New Mexico State University Las Cruces NM 88003 United States Dept. of Plant and Environmental Sciences New Mexico State University Las Cruces NM 88003 United States Department of Computer Science New Mexico State University Las Cruces NM 88003 United States Department of Computer Science Old Dominion University Norfolk VA 23529 United States

ISBN: (纸本)9781617381119

Glutamine synthetase (GS) is a key enzyme in nitrogen metabolism in plants. One of the GS isoforms in plants, GS1, is transcriptionally regulated. Our recent studies show that a soybean GS1, Gmglnβ 1, gene is posttranscriptionally regulated by its 3′UTR. It is of interest to know if the 3′UTR-mediated posttranscriptional regulation of GS1 genes is a universal phenomenon or is it limited to Gmglnβ 1 gene only. The 3′UTR-mediated posttranscriptional regulation of alfalfa GS1 genes (MsGS100 and MsGS13) was investigated using both computational and biological approaches. For our first set of study, we used CisFind, a software tool that identifies unextendable common patterns among sequences, to analyze the 3′UTRs of GS1 genes. CisFind analysis of the 3′UTRs showed that the 3′UTR of MsGS100 shared common putative cis-element motifs with the Gmglnβ 1 3′UTR whereas these elements were absent in the 3′UTR of MsGS13 gene. The computational results were verified using transgenic approach, and the results confirmed the computational analysis. The 3′UTR of MsGS 100 plays a similar role as the 3′UTR of Gmglnβ 1 gene in posttranscriptional regulation of a reporter gene while the 3′UTR of the MsGS13 does not. CisFind, was also used in analyzing the region in the 3′UTR of MsGS13 that could be responsible for its nodule enhanced expression (by detecting putative cis-elements that are overrepresented in the 3′UTR of nodule-enhanced GS1 genes).

关键词： Amino acids

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