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14th International Conference on Bioscience, Biochemistry and Bioinformatics, ICBBB 2024

作者： Ito, Satoshi Ono, Kenji miyano, Satoru Department of Integrated Analysis M&D Data Science Center Tokyo Medical and Dental University Tokyo Japan Section of Applied Data Science Research Institute for Information Technology Kyushu University Fukuoka Japan

ISBN: (纸本)9798400716768

The remarkable improvement in the performance of next-generation sequencers has led to the analysis of large numbers of samples in recent years for whole-genome analysis. The computing capabilities required for the same have also increased dramatically;in particular, supercomputers and cloud services have become essential. However, few analyses have used TOP500 large-scale parallel computers because of the difference in the computational scientific properties of existing software for supercomputers and software for bioinformatics and the associated supercomputer resource management methods. In this study, we investigated the difference between bioinformatics pipelines and legacy supercomputer applications carefully and found that job management systems of TOP500-class supercomputers and distributed file systems have issues for bioinformatics pipelines. Based on the results, we developed some easy and efficient methods to overcome them, then we ported and optimized Genomon, a whole-genome analysis pipeline to Fugaku. We performed large-scale WGS analysis on Fugaku, and successfully analyzed over 1 thousand samples with 1,460 thousand node-hours, which is currently the largest analysis of the world’s. Availability: The ported and optimized Genomon is available at the following URL. https://***/genomon_wg/genomonpipeline/src/GPF_develop/ © 2024 Copyright held by the owner/author(s).

关键词： Supercomputers

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Acceleration of BAm I/O on distributed file systems

Acceleration of BAM I/O on distributed file systems

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2023 IEEE International Conference on Bioinformatics and Biomedicine, BIBm 2023

作者： Ito, Satoshi miyano, Satoru Ono, Kenji Tokyo Medical and Dental University Dept. of Integrated Analysis M&d Data Science Center Tokyo Japan Kyushu University Section of Applied Data Science Res. Inst. for Information Technology Fukuoka Japan

ISBN: (纸本)9798350337488

Rapid advances in high-throughput sequencers have made it possible to obtain large amounts of whole genome data quickly and inexpensively. As the amount of data increases, the increase in computation time has become a serious problem. One of the main causes of this problem is file I/O performance. most pipelines do not implement file I/O suitable for distributed file systems, which are common storage systems in parallel computers used for large-scale analysis. In this study, we developed an I/O system adapted to distributed file systems. In the proposed system, storage access frequency was suppressed by I/O buffers, and thread parallelization by OpenmP was employed. We tested the developed system and a high parallel speedup was achieved. Availability: The developed system is freely available from https://***/SatoshiITO/GAPS © 2023 IEEE.

关键词： distributed File System High performance computing Whole genome sequencing analysis

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Acceleration of BAm I/O on distributed file systems

Acceleration of BAM I/O on distributed file systems

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IEEE International Conference on Bioinformatics and Biomedicine (BIBm)

作者： Satoshi Ito Satoru miyano Kenji Ono Dept. of Integrated Analysis M&D Data Science Center Tokyo Medical and Dental University Tokyo Japan Section of Applied Data Science Res. Inst. for Information Technology Kyushu University Fukuoka Japan

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Prognostic Relevance of Genetic Abnormalities in Blastic Transformation of Chronic myeloid Leukemia

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BLOOd 2020年 136卷 3-4页

作者： md, Yotaro Ochi mdphd, Kenichi Yoshida Huang, Ying-Jung Kuo, ming-Chung Sasaki, Ko Hosoya, Noriko Hiramoto, Nobuhiro Bera, Rabindranath Nannya, Yasuhito Shiozawa, Yusuke Takeda, June Watatani, Yosaku makishima, Hideki Shiraishi, Yuichi Chiba, Kenichi Tanaka, Hiroko Sanada, masashi Ishikawa, Takayuki Takaori-Kondo, Akifumi miyano, Satoru mitani, Kinuko Ogawa, Seishi Shih, Lee-Yung Department of Pathology and Tumor Biology Graduate School of Medicine Kyoto University Kyoto Japan Department of Hematology and Oncology Graduate School of Medicine Kyoto University Kyoto Japan Division of Hematology-Oncology Department of Internal Medicine Chang Gung Memorial Hospital-Linkou Taoyuan Taiwan College of Medicine Chang Gung University Taoyuan Taiwan Department of Hematology and Oncology Dokkyo Medical University Tochigi Japan Laboratory of Molecular Radiology Center for Disease Biology and Integrative Medicine The University of Tokyo Tokyo Japan Department of Medical Genomics The University of Tokyo Tokyo Japan Department of Hematology Kobe City Medical Center General Hospital Kobe Japan Laboratory of DNA Information Analysis Human Genome Center Institute of Medical Science The University of Tokyo Tokyo Japan Department of Integrated Data Science M&D Data Science Center Tokyo Medical and Dental University Tokyo Japan Clinical Research Center National Hospital Organization Nagoya Medical Center Nagoya Japan

Background Chronic myeloid leukemia (CmL) is characterized by the BCR - ABL1 fusion gene. despite the use of tyrosine kinase inhibitors (TKIs), a minority of chronic phase (CP) CmL patients fail TKI therapies and progress to blast crisis (BC), showing dismal outcomes. Although genetic studies have revealed that CmL-BC frequently carries not only ABL1 mutations but other driver mutations, our knowledge about the mechanism of TKI resistance and progression to BC is still limited by a relatively small number of patients and/or genes analyzed in each study. moreover, it remains elusive whether mutations can predict clinical outcomes of BC patients, in which few biomarkers are known. Here, we investigated a large cohort of CmL patients to reveal the landscape of genetic lesions and those predicting clinical outcomes in CmL. methods We performed whole-exome sequencing (WES) of paired CP and BC samples from 52 patients and targeted-capture sequencing that covered myeloid driver genes in 32 BC and 19 CP samples. Combined with public WES data for 24 BC and 77 CP, we analyzed a total of 108 BC and 148 CP samples. Results In WES analysis of paired CP and BC samples, an average of 5.3 nonsynonymous mutations were acquired during disease progression from CP to BC. Notably, a Poisson regression model revealed that the number of acquired mutations was positively correlated with time to progression from CP to BC ( P < 0.001) and negatively with TKI therapy after CP diagnosis ( P = 0.0093), although the correlation of the number of driver mutations in CmL-BC with time to progression was not clear. These results suggest that the use of TKI effectively reduces the size of tumor populations at risk for clonal evolution by acquiring random mutations, by which prevents BC. In CmL-BC, we found frequent mutations not only in known mutational targets in other hematological malignancies, such as RUNX1 , ABL1 , ASXL1 , BCOR / BCORL1 , TP53 , and WT1 , but also in other genes recently reported

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KRAS mutations Frequently Coexist with High-Risk mLL Fusions and Are Independent Adverse Prognostic Factors in mLL-Rearranged Acute myeloid Leukemia

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BLOOd 2020年 136卷 28-29页

作者： matsuo, Hidemasa Yoshida, Kenichi Nakatani, Kana Harata, Yutarou Higashitani, moe Ito, Yuri Kamikubo, Yasuhiko Shiozawa, Yusuke Shiraishi, Yuichi Chiba, Kenichi Tanaka, Hiroko Okada, Ai Nannya, Yasuhito Takeda, June Ueno, Hiroo Kiyokawa, Nobutaka Tomizawa, daisuke Taga, Takashi Tawa, Akio miyano, Satoru meggendorfer, manja Haferlach, Claudia Ogawa, Seishi Adachi, Souichi Department of Human Health Sciences Kyoto University Kizugawa Japan Kyoto Univeristy Kyoto Japan Department of Human Health Sciences Kyoto University Kyoto-Shi Japan Department of Human Health Sciences Graduate School of Medicine Kyoto University Kyoto Japan Department of Human Health Sciences Graduate School of Medicine Kyoto University Kyoto JPN Kyoto University Kyoto Japan Department of Pediatrics The University of Tokyo Tokyo Japan Center for Cancer Genomics and Advanced Therapeutics National Cancer Center Research Institute Tokyo Japan Division of Cellular Signaling National Cancer Center Research Institute Tokyo Japan Laboratory of DNA Information Analysis Human Genome Center The University of Tokyo Tokyo Japan Laboratory of DNA Information Science Institute of Medical Science The University of Tokyo Tokyo Japan Department of Pathology and Tumor Biology Kyoto University Kyoto City Japan Department of Pathology and Tumor Biology Kyoto University Kyoto Japan Department of Pediatric Hematology and Oncology Research National Center for Child Health and Development Tokyo Japan Children's Cancer Center National Center for Child Health and Development Tokyo Japan Department of Pediatrics Shiga University of Medical Science Ohtsu Japan Higashiosaka Aramoto Hiewa Clinic Higashiosaka Japan Department of Integrated Data Science M&D Data Science Center Tokyo Medical and Dental University Tokyo Japan

mLL(KmT2A) rearrangements are among the most frequent chromosomal abnormalities in acute myeloid leukemia (AmL). mLL fusion patterns are associated with patient prognosis; however, little is known about the distribution and prognostic significance of driver mutations according to specific mLL fusion partner genes. In this study, we conducted sequence analysis of 338 genes in pediatric patients with mLL -rearranged ( mLL -r) AmL (n = 56; JPLSG AmL-05 study) alongside data from TARGET cohort pediatric mLL -r AmL (n = 104) and non- mLL -r AmL (n = 581). In addition, mutation data and clinical information from adult mLL -r AmL patients (n=81), collected at the mLL munich Leukemia Laboratory, were also analyzed. The frequencies of driver mutations differed according to mLL fusion partner genes in pediatric mLL -r AmL patients (JPLSG AmL-05 study + TARGET cohort, n = 160). FLT3 mutations or internal tandem duplications were more frequent in patients with mLL-mLLT3 (27/63, 42.9%) and mLL-mLLT1 (4/11, 36.4%). RAS pathway genes were more frequently mutated in specific groups, such as KRAS in those with mLL-mLLT10 (17/37, 45.9%), mLL-mLLT4(AFdN) (5/12, 41.7%), mLL-mLLT1 (3/11, 27.3%), and other (4/14, 28.6%) fusions, and NRAS in those with mLL-ELL (10/23, 43.5%) and mLL-mLLT4 (4/12, 33.3%) fusions. Other pathway mutations also coexisted with specific partner genes; SETd2 mutations were frequent in patients with mLL-mLLT4 fusions (4/12, 33.3%), and STAG2 mutations were frequent in those with mLL-ELL (6/23, 26.1%). Next, we examined the prognostic significance of each driver mutation. In pediatric mLL -r AmL patients (n = 160), among eight frequently mutated genes (≥ 5%: ≥ 8 patients with mutations) and one copy number change (trisomy 8), only KRAS mutations were significantly associated with adverse prognoses, in terms of both event-free survival (EFS) and overall survival (OS). Compared with patients without KRAS mutations (n = 118, KRAS -WT), those with KRAS mutations (n = 4

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Post-Treatment Clone Size Predicts Survival Independently of IPSS-R and Response after Azacitidine Therapy for mdS

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BLOOd 2020年 136卷 12-13页

作者： Nannya, Yasuhito Tobiasson, magnus Sato, Shinya Bernard, Elsa Creignou, maria Zhao, Lanying Takeda, June Shiraishi, Yuichi Chiba, Kenichi Tanaka, Hiroko Tsurumi, Hisashi Kasahara, Senji Taguchi, masataka Takaori, Akifumi Kondo Ohyashiki, Kazuma makishima, Hideki Yoshida, Kenichi Naoe, Tomoki miyano, Satoru miyazaki, Yasushi Papaemmanuil, Elli Lindberg, Eva Hellstrom Ogawa, Seishi Department of Pathology and Tumor Biology Graduate School of Medicine Kyoto University Kyoto Japan Karolinska University Hospital Stockholm Sweden Department of Hematology Atomic Bomb Disease and Hibakusha Medicine Unit Atomic Bomb Disease Institute Nagasaki University Nagasaki Japan Center for Molecular Oncology Center for Heme Malignancies and Department of Epidemiology and Biostatistics Memorial Sloan Kettering Cancer Center New York NY 10065 USA New York NY Karolinska University Hospital Stockholm Sweden Karolinska Institutet Linköping SWE Department of Pathology and Tumor Biology Kyoto University Kyoto Japan Center for Cancer Genomics and Advanced Therapeutics National Cancer Center Research Institute Tokyo Japan Laboratory of DNA Information Analysis Human Genome Center Institute of Medical Science The University of Tokyo Tokyo Japan Division of Cellular Signaling National Cancer Center Research Institute Tokyo Japan Department of Integrated Data Science M&D Data Science Center Tokyo Medical and Dental University Tokyo Japan Hematology Gifu University Graduate School of Medicine Gifu Japan Hematology Gifu Municipal Hospital Gifu Japan Atomic Bomb Disease Institute Department of Hematology Nagasaki University Graduate School of Biomedical Sciences Nagasaki Japan Department of Hematology and Oncology Graduate School of Medicine Kyoto University Kyoto Japan Department of Advanced Cellular Therapy Tokyo Medical University Tokyo Japan Kyoto Univeristy Kyoto Japan National Hospital Organization Nagoya Medical Center Nagoya Japan Atomic Bomb Disease Institute Nagasaki University Hospital Nagasaki Japan Department of Medicine Center for Haematology and Regenerative Medicine Karolinska Institutet Stockholm Sweden Institute for the Advanced Study of Human Biology (WPI-ASHBi) Kyoto University Kyoto Japan

Background dNA hypomethylating agents (HmAs), including azacytidine (AZA) have been established as key drugs for higher-risk myelodysplastic syndromes (mdS). We and others have explored the role of mutation profile before AZA administration on predicting outcomes. Actually, we have previously identified mutated- TP53 as a marker associated with higher rate of achieving complete remission (CR). In addition, mutations in TP53 and ddX41 predicted reduced and prolonged survival after treatment, respectively. However, the clinical significance of evaluating clone size changes early after treatment has not been determined. In this study, we explored the role of post-treatment clone size in predicting outcomes of AZA treatment for mdS and related diseases. methods We enrolled 290 AZA-treated cases, including 88 from a Japanese prospective study (JALSG mdS-212 trial), 149 from Karolinska Institute, and 53 from a retrospectively collected Japanese cases. The diagnoses were mdS (n=242), mdS/mPN (n=25), and AmL-mRC (n=23). For all patients, tumor samples were collected both before and after AZA administration and were analyzed for mutations in 66 genes implicated in myeloid neoplasms using targeted-capture sequencing. The median cycles of AZA treatment before sampling was 4 (range 1-7). Clone size was calculated from variant allele frequency adjusted for ploidy or allelic *** was calculated with a Cox regression model. Results In post-treatment samples, we identified 870 mutations in 51 genes in 255 (88%) patients with a median of 3 mutations per sample, while 943 mutations were seen in 279 (96%) patients in the pre-treatment samples. most frequently detected mutations in post-treatment samples were seen in TET2, TP53, RUNX1, and ASXL1 . Germline ddX41 mutations were excluded from clone size evaluation. median clone sizes were 0.63 and 0.54 for pre-treatment and post-treatment samples ( P =.011), respectively. The largest clone sizes (max(VAF)) in post-treatmen

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Ten-year survival of neoadjuvant dual HER2 blockade in patients with HER2-positive breast cancer

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European journal of cancer (Oxford, England : 1990) 2023年 181卷 92-101页

作者： Paolo Nuciforo John Townend martine J Piccart Shona Fielding Panagiota Gkolfi Sarra El-Abed Evandro de Azambuja Gustavo Werutsky Judith Bliss Volker moebus marco Colleoni Alvaro moreno Aspitia Henry Gomez Andrea Gombos maria A Coccia-Portugal Ling-ming Tseng Georg Kunz Guillermo Lerzo Joohyuk Sohn Vladimir Semiglazov Cristina Saura Judith Kroep Antonella Ferro david Cameron Richard Gelber Jens Huober Serena di Cosimo Vall d'Hebron Institute of Oncology Barcelona Spain. SOLTI Barcelona Spain. Electronic address: pnuciforo@***. Frontier Science (Scotland) Ltd Kincraig Kingussie UK. Institut Jules Bordet Université Libre de Bruxelles (ULB) Brussels Belgium. Global Drug Development Novartis Basel Switzerland. Breast International Group Brussels Belgium. Latin American Cooperative Oncology Group (LACOG) Porto Alegre Brazil. The Institute of Cancer Research ICR-CTSU London UK. Dept. of Medicine II Hematology & Oncology University of Frankfurt Frankfurt Germany. Division of Medical Senology IEO European Institute of Oncology IRCCS Milan Italy. Jacoby Center for Breast Health Mayo Clinic Jacksonville FL USA. National Institute of Neoplastic Diseases Ricardo Palma University Lima Peru. Coccia-Portugal M Eastleigh Breast Care Centre Pretoria South Africa. Taipei-Veterans General Hospital National Yang Ming Chiao Tung University Taipei Taiwan. Dept. Obstet./Gyn. St.-Johannes-Hospital Dortmund Germany. Fundación CENIT Para La Investigación Ciudad Autónoma de Buenos Aires Argentina. Yonsei Cancer Center Yonsei University College of Medicine Seoul South Korea. Breast Cancer Department N.N. Petrov National Medical Research Center of Oncology St. Petersburg Russian Federation. Vall d'Hebron Institute of Oncology Barcelona Spain. SOLTI Barcelona Spain. Department Medical Oncology Leiden University Medical Center Leiden The Netherlands. Dutch Breast Cancer Oncology Group (BOOG) the Netherlands. Department of Medical Oncology Rete Clinica Senologica- Santa Chiara Hospital Trento Italy. Edinburgh Cancer Research The University of Edinburgh Institute of Genetics and Cancer Crewe Road South Edinburgh UK. Department of Data Science Dana-Farber Cancer Institute Harvard Medical School Harvard TH Chan School of Public Health Frontier Science Foundation Boston MA USA. Cantonal Hospital St.Gallen | Breast Center | St.Gallen Switzerland. University of Ulm Breast Center Ulm Germany. I

BACKGROUNd:dual anti-HER2-targeted therapy in breast cancer (BC) significantly increased the rate of pathological complete response (pCR) compared to single blockade when added to chemotherapy. However, limited data exist on the long-term impact on survival of the additional increase in pCR. mETHOdS:Neoadjuvant lapatinib and/or trastuzumab treatment optimisation (NCT00553358) is an international, randomised, open-label, phase III study investigating the addition of lapatinib to chemotherapy plus trastuzumab in HER2-positive early BC. Ten-year event-free survival (EFS), overall survival (OS) and safety were assessed on intention-to-treat population. The association between pCR and EFS or OS was investigated in landmark population. RESULTS:A total of 455 patients were randomised to receive lapatinib (154), trastuzumab (149) or the combination (152). Ten-year EFS estimates were 63% (95% confidence interval [CI], 54%-71%) in the lapatinib group, 64% (95% CI, 55%-72%) in the trastuzumab group and 67% (95% CI, 58%-74%) in the combination group. Ten-year OS rates were 76% (95% CI, 67%-83%), 75% (95% CI, 66%-82%) and 80% (95% CI, 73%-86%) in the lapatinib, trastuzumab and combination groups, respectively. Women who achieved a pCR had improved EFS (hazard ratio 0.48, 95% CI, 0.31-0.73) and OS (hazard ratio 0.37, 95% CI, 0.20-0.63) compared with those who did not. The numerical difference in survival according to pCR status was greater in women treated with the combination and those with hormone-receptor-negative tumours. There were no new or long-term safety concerns. CONCLUSIONS:Patients with HER2-positive BC showed a durable survival benefit of neoadjuvant anti-HER2, irrespective of treatment arm. Patients who achieve pCR have significantly better outcomes than patients without pCR.

关键词： Breast cancer dual anti-HER2 blockade HER2-Positive Long-term survival Neoadjuvant Pathological complete response

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GASKAP-HI Pilot Survey science I: ASKAP Zoom Observations of Hi Emission in the Small magellanic Cloud

arXiv

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arXiv 2021年

作者： Pingel, Nickolas m. dempsey, J. mcClure-Griffiths, N.m. dickey, J.m. Jameson, K.E. Arce, H. Anglada, G. Bland-Hawthorn, J. Breen, S.L. Buckland-Willis, F. Clark, S.E. dawson, J.R. dénes, H. di Teodoro, E.m. For, B.-Q. Foster, Tyler J. Gómez, J.F. Imai, H. Joncas, G. Kim, C.-G. Lee, m.-Y. Lynn, C. Leahy, d. ma, Y.K. marchal, A. mcConnell, d. miville-deschênes, m.-A. moss, V.A. murray, C.E. Nidever, d. Peek, J. Stanimirović, S. Staveley-Smith, L. Tepper-Garcia, T. Tremblay, C.d. Uscanga, L. van Loon, J.Th. Vázquez-Semadeni, E. Allison, J.R. Anderson, C.S. Ball, Lewis Bell, m. Bock, d.C.-J. Bunton, J. Cooray, F.R. Cornwell, T. Koribalski, B.S. Gupta, N. Hayman, d.B. Harvey-Smith, L. Lee-Waddell, K. Ng, A. Phillips, C.J. Voronkov, m. Westmeier, T. Whiting, m.T. Research School of Astronomy and Astrophysics The Australian National University CanberraACT2611 Australia CSIRO Information Management and Technology GPO Box 1700 CanberraACT2601 Australia School of Natural Sciences University of Tasmania HobartTAS7001 Australia CSIRO Space and Astronomy PO Box 1130 BentleyWA6102 Australia Department of Astronomy Yale University New HavenCT06520 United States Instituto de Astrofísica de Andalucía CSIC Glorieta de la Astronomía s/n Granada18008 Spain Department of Physics University of Sydney SydneyNSW2006 Australia SKA Observatory Jodrell Bank Lower Withington Macclesfield CheshireSK11 9FT United Kingdom AIM CEA CNRS Université Paris-Saclay Université Paris Diderot Sorbonne Paris Cité Gif-sur-YvetteF-91191 France Department of Physics Stanford University 382 Via Pueblo Mall StanfordCA94305 United States Kavli Institute for Particle Astrophysics & Cosmology Stanford University P.O. Box 2450 StanfordCA94305 United States Department of Physics and Astronomy and MQ Research Centre in Astronomy Astrophysics and Astrophotonics Macquarie University NSW2109 Australia Australia Telescope National Facility CSIRO Space and Astronomy PO Box 76 EppingNSW1710 Australia ASTRON - The Netherlands Institute for Radio Astronomy Dwingeloo7991 PD Netherlands Department of Physics & Astronomy Johns Hopkins University 3400 N. Charles Street BaltimoreMD21218 United States The University of Western Australia 35 Stirling Hwy CrawleyWA6009 Australia Department of Physics & Astronomy Brandon University 270-18 Street BrandonMB Canada Center for General Education Comprehensive Institute of Education 1-21-30 Korimoto Kagoshima890-0065 Japan Amanogawa Galaxy Astronomy Research Center Graduate School of Science and Engineering 1-21-30 Korimoto Kagoshima890-0065 Japan Université Laval Pavillon Alexandre-Vachon 1045 Avenue de la Medecine Canada Department of Astrophysical Sciences Princeton University Pri

We present the most sensitive and detailed view of the neutral hydrogen (Hi) emission associated with the Small magellanic Cloud (SmC), through the combination of data from the Australian Square Kilometre Array Pathfinder (ASKAP) and Parkes (murriyang), as part of the Galactic Australian Square Kilometre Array Pathfinder (GASKAP) pilot survey. These GASKAP-HI pilot observations, for the first time, reveal Hi in the SmC on similar physical scales as other important tracers of the interstellar medium, such as molecular gas and dust. The resultant image cube possesses an rms noise level of 1.1 K (1.6 mJy/beam) per 0.98 km s−1 spectral channel with an angular resolution of 3000 (∼10 pc). We discuss the calibration scheme and the custom imaging pipeline that utilizes a joint deconvolution approach, efficiently distributed across a computing cluster, to accurately recover the emission extending across the entire ∼25 deg2 field-of-view. We provide an overview of the data products and characterize several aspects including the noise properties as a function of angular resolution and the represented spatial scales by deriving the global transfer function over the full spectral range. A preliminary spatial power spectrum analysis on individual spectral channels reveals that the power-law nature of the density distribution extends down to scales of 10 pc. We highlight the scientific potential of these data by comparing the properties of an outflowing high velocity cloud with previous ASKAP+Parkes Hi test observations. © 2021, CC BY.

关键词： Galaxies

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A giant planet candidate transiting a white dwarf

arXiv

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arXiv 2020年

作者： Vanderburg, Andrew Rappaport, Saul A. Xu, Siyi Crossfield, Ian Becker, Juliette C. Gary, Bruce murgas, Felipe Blouin, Simon Kaye, Thomas G. Palle, Enric melis, Carl morris, Brett m. Kreidberg, Laura Gorjian, Varoujan morley, Caroline V. mann, Andrew W. Parviainen, Hannu Pearce, Logan A. Newton, Elisabeth R. Carrillo, Andreia Zuckerman, Ben Nelson, Lorne Zeimann, Greg Brown, Warren R. Tronsgaard, René Klein, Beth Ricker, George R. Vanderspek, Roland K. Latham, david W. Seager, Sara Winn, Joshua N. Jenkins, Jon m. Adams, Fred C. Benneke, Björn Berardo, david Buchhave, Lars A. Caldwell, douglas A. Christiansen, Jessie L. Collins, Karen A. Colón, Knicole d. daylan, Tansu doty, John doyle, Alexandra E. dragomir, diana dressing, Courtney dufour, Patrick Fukui, Akihiko Glidden, Ana Guerrero, Natalia m. Guo, Xueying Heng, Kevin Henriksen, Andreea I. Huang, Chelsea X. Kaltenegger, Lisa Kane, Stephen R. Lewis, John A. Lissauer, Jack J. morales, Farisa Narita, Norio Pepper, Joshua Rose, mark E. Smith, Jeffrey C. Stassun, Keivan G. Yu, Liang Department of Astronomy University of Wisconsin-Madison MadisonWI53706 United States Department of Astronomy University of Texas at Austin AustinTX78712 United States Department of Physics Kavli Institute for Astrophysics and Space Research Massachusetts Institute of Technology CambridgeMA02139 United States NSFs NOIRLab/Gemini Observatory 670 N. Aohoku Place HiloHI96720 United States Dept. of Physics and Astronomy University of Kansas 1251 Wescoe Hall Dr. LawrenceKS66045 United States Division of Geological and Planetary Sciences California Institute of Technology PasadenaCA91125 United States Hereford Arizona Observatory HerefordAZ85615 United States La Laguna TenerifeE-38200 Spain La Laguna TenerifeE-38206 Spain Los Alamos National Laboratory P.O. Box 1663 Mail Stop P365 Los AlamosNM87545 United States Raemor Vista Observatory 7023 E. Alhambra Dr. Sierra VistaAZ85650 United States Laboratory for Space Research University of Hong Kong Pokfulam Hong Kong Center for Astrophysics and Space Sciences UCSD CA92093-0424 United States Center for Space and Habitability University of Bern Gesellschaftsstrasse 6 BernCH-3012 Switzerland Max Planck Institute for Astronomy Königstuhl 17 Heidelberg69117 Germany Center for Astrophysics | Harvard & Smithsonian CambridgeMA02138 United States NASA Jet Propulsion Laboratory 4800 Oak Grove Dr PasadenaCA91109 United States Department of Physics and Astronomy University of North Carolina at Chapel Hill Chapel HillNC27599 United States Steward Observatory University of Arizona TucsonAZ85721 United States Department of Physics and Astronomy Dartmouth College HanoverNH03755 United States Large Synoptic Survey Telescope Corporation Data Science Fellow Department of Physics and Astronomy University of California Los AngelesCA90095-1562 United States Department of Physics and Astronomy Bishops University SherbrookeQCJ1M 1Z7 Canada Hobby Eberly Telescope University of Texas Austin A

Astronomers have discovered thousands of planets outside the solar system1, most of which orbit stars that will eventually evolve into red giants and then into white dwarfs. during the red giant phase, any close-orbiting planets will be engulfed by the star2, but more distant planets can survive this phase and remain in orbit around the white dwarf3, 4. Some white dwarfs show evidence for rocky material floating in their atmospheres5, in warm debris disks6–9, or orbiting very closely10–12, which has been interpreted as the debris of rocky planets that were scattered inward and tidally disrupted13. Recently, the discovery of a gaseous debris disk with a composition similar to ice giant planets14 demonstrated that massive planets might also find their way into tight orbits around white dwarfs, but it is unclear whether the planets can survive the journey. So far, the detection of intact planets in close orbits around white dwarfs has remained elusive. Here, we report the discovery of a giant planet candidate transiting the white dwarf Wd 1856+534 (TIC 267574918) every 1.4 days. The planet candidate is roughly the same size as Jupiter and is no more than 14 times as massive (with 95% confidence). Other cases of white dwarfs with close brown dwarf or stellar companions are explained as the consequence of common-envelope evolution, wherein the original orbit is enveloped during the red-giant phase and shrinks due to friction. In this case, though, the low mass and relatively long orbital period of the planet candidate make common-envelope evolution less likely. Instead, the Wd 1856+534 system seems to demonstrate that giant planets can be scattered into tight orbits without being tidally disrupted, and motivates searches for smaller transiting planets around white dwarfs. Copyright © 2020, The Authors. All rights reserved.

关键词： Planets

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Author Correction: The FLUXNET2015 dataset and the ONEFlux processing pipeline for eddy covariance data

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Scientific data 2021年第1期8卷 72页

作者： Gilberto Pastorello Carlo Trotta Eleonora Canfora Housen Chu danielle Christianson You-Wei Cheah Cristina Poindexter Jiquan Chen Abdelrahman Elbashandy marty Humphrey Peter Isaac diego Polidori markus Reichstein Alessio Ribeca Catharine van Ingen Nicolas Vuichard Leiming Zhang Brian Amiro Christof Ammann m Altaf Arain Jonas Ardö Timothy Arkebauer Stefan K Arndt Nicola Arriga marc Aubinet mika Aurela dennis Baldocchi Alan Barr Eric Beamesderfer Luca Belelli marchesini Onil Bergeron Jason Beringer Christian Bernhofer daniel Berveiller dave Billesbach Thomas Andrew Black Peter d Blanken Gil Bohrer Julia Boike Paul V Bolstad damien Bonal Jean-marc Bonnefond david R Bowling Rosvel Bracho Jason Brodeur Christian Brümmer Nina Buchmann Benoit Burban Sean P Burns Pauline Buysse Peter Cale mauro Cavagna Pierre Cellier Shiping Chen Isaac Chini Torben R Christensen James Cleverly Alessio Collalti Claudia Consalvo Bruce d Cook david Cook Carole Coursolle Edoardo Cremonese Peter S Curtis Ettore d'Andrea Humberto da Rocha Xiaoqin dai Kenneth J davis Bruno de Cinti Agnes de Grandcourt Anne de Ligne Raimundo C de Oliveira Nicolas delpierre Ankur R desai Carlos marcelo di Bella Paul di Tommasi Han dolman Francisco domingo Gang dong Sabina dore Pierpaolo duce Eric dufrêne Allison dunn Jiří dušek derek Eamus Uwe Eichelmann Hatim Abdalla m ElKhidir Werner Eugster Cacilia m Ewenz Brent Ewers daniela Famulari Silvano Fares Iris Feigenwinter Andrew Feitz Rasmus Fensholt Gianluca Filippa marc Fischer John Frank marta Galvagno mana Gharun damiano Gianelle Bert Gielen Beniamino Gioli Anatoly Gitelson Ignacio Goded mathias Goeckede Allen H Goldstein Christopher m Gough michael L Goulden Alexander Graf Anne Griebel Carsten Gruening Thomas Grünwald Albin Hammerle Shijie Han Xingguo Han Birger Ulf Hansen Chad Hanson Juha Hatakka Yongtao He markus Hehn Bernard Heinesch Nina Hinko-Najera Lukas Hörtnagl Lindsay Hutley Andreas Ibrom Hiroki Ikawa marcin Jackowicz-Korczynski dalibor Janouš Wilma Jans Rachhpal Jassal Shicheng Jiang Tomomichi Kato myr Computational Research Division Lawrence Berkeley National Laboratory Berkeley CA 94720 USA. gzpastorello@lbl.gov. DIBAF University of Tuscia Viterbo 01100 Italy. Euro-Mediterranean Centre on Climate Change Foundation (CMCC) Lecce 73100 Italy. Climate & Ecosystem Sciences Division Lawrence Berkeley National Laboratory Berkeley CA 94720 USA. Computational Research Division Lawrence Berkeley National Laboratory Berkeley CA 94720 USA. Department of Civil Engineering California State University Sacramento CA 95819 USA. Department of Geography Environment and Spatial Sciences Michigan State University East Lansing MI 48823 USA. Department of Computer Science University of Virginia Charlottesville VA 22904 USA. TERN Ecosystem Processes Menzies Creek VIC3159 Australia. Max Planck Institute for Biogeochemistry Jena 07701 Germany. Laboratoire des Sciences du Climat et de l'Environnement (LSCE) CEA CNRS UVSQ UPSACLAY Gif sur Yvette 91190 France. Key Laboratory of Ecosystem Network Observation and Modeling Institute of Geographic Sciences and Natural Resources Research Chinese Academy of Sciences Beijing 100101 China. Department of Soil Science University of Manitoba Winnipeg MB R3T2N2 Canada. Department of Agroecology and Environment Agroscope Research Institute Zürich 8046 Switzerland. School of Geography and Earth Sciences McMaster University L8S4K1 Hamilton ON Canada. Department of Physical Geography and Ecosystem Science Lund University Lund 22362 Sweden. Department of Agronomy and Horticulture University of Nebraska-Lincoln Lincoln NE 68583 USA. School of Ecosystem and Forest Sciences The University of Melbourne Richmond VIC3121 Australia. Department of Biology Research Group PLECO University of Antwerp Antwerp 2610 Belgium. Joint Research Centre European Commission Ispra 21027 Italy. TERRA Teaching and Research Center University of Liege Gembloux B-5030 Belgium. Finnish Meteorological Institute Helsinki 00560 Finland. ES

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