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Measurement system of hand tapping capacity for quantitative diagnosis of Parkinson's disease

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World Congress on Medical Physics and biomedical engineering: Neuroengineering, Neural Systems, Rehabilitation and Prosthetics

作者： Kim, Sang Kyong Jeon, Hyo Seon Han, Jonghee Choi, Yoon Jae Jeon, Beom Seok Yi, Won Jin Park, Kwang Suk Interdisciplinary Program of Bioengineering Seoul National University Seoul Korea Republic of Dept. of Neurology Seoul National University Hospital Seoul Korea Republic of Dept. of Oral and Maxillofacial Radiology College of Dentistry Seoul National University Seoul Korea Republic of Dept. of Biomedical Engineering College of Medicine Seoul National University 110-799 28 Yeongeon-dong Jongno-gu Seoul Korea Republic of

ISBN: (纸本)9783642038884

The Unified Parkinson's Disease Rating Scale (UPDRS) is commonly used to measure the patients' disorder in clinical therapeutics. However, UPDRS scores can be somewhat variable and subjective. Especially, there are only 5 scales at each item. It is necessary to develop a quantitative measurement of movement ability in PD patients. Hand Tapping test system was developed in this purpose. Here, we present hand tapping test system and some test such as simple reaction test and random response test. Twelve PD patients (7 men and 5 women) were evaluated. The result of tests show us good correlation between movement time and UPDRS partIII score (0.84, 0.72). On the other hand, the reaction time and UPDRS partIII score was not related to each other. Thus, we conclude that movement time of hand tapping test can be one of the feasible quantitative measurement methods of PD patients' movement. © 2009 Springer-Verlag.

关键词： Diagnosis

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A survival prediction model of hemorrhagic shock in rats using a logistic regression equation

A survival prediction model of hemorrhagic shock in rats usi...

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31st Annual International Conference of the IEEE engineering in Medicine and Biology Society: engineering the Future of Biomedicine, EMBC 2009

作者： Lee, Tak Hyung Lee, Ju Hyung Chung, Sang Won Noh, Hyung Wook Shim, Young Woo Kim, Deok Won Graduate Program in Biomedical Engineering Yonsei University Seoul Korea Republic of Dept. of Emergency Medicine College of Medicine Kwandong University Koyang Korea Republic of Brain Korea 21 Project for Medical Science Yonsei University Seoul Korea Republic of Dept. of Medical Engineering College of Medicine Yonsei University Seoul Korea Republic of

ISBN: (纸本)9781424432967

Hemorrhagic shock is a common cause of death in emergency rooms. Since the symptoms of hemorrhagic shock occur after shock has considerably progressed, it is difficult to diagnose shock early. The purpose of this study was to improve early diagnosis of hemorrhagic shock using a survival prediction model in rats. We measured ECG, blood pressure, respiration and temperature in 45 Sprague-Dawley rats, and then obtained a logistic regression equation predicting survival rates. Area under the ROC curves was 0.99. The Hosmer-Lemeshow goodness-of-fit chi-square was 0.86 (degree of freedom=8, p=0.999). Applying the determined optimal boundary value of 0.25, the accuracy of survival prediction was 94.7%. ©2009 IEEE.

关键词： Rats

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Patient specific computerized phantoms to estimate dose in pediatric CT

Patient specific computerized phantoms to estimate dose in p...

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Medical Imaging 2009: Physics of Medical Imaging

作者： Segars, W.P. Sturgeon, G. Li, X. Cheng, L. Ceritoglu, C. Ratnanather, J.T. Miller, M.I. Tsui, B.M.W. Frush, D. Samei, E. Medical Physics Graduate Program Duke University Durham NC United States Carl E. Ravin Advanced Imaging Laboratories Duke University Durham NC United States Dept. of Radiology Duke University Durham NC United States Dept. of Biomedical Engineering Duke University Durham NC United States Dept. of Physics Duke University Durham NC United States Dept. of Biomedical Engineering University of North Carolina Chapel Hill NC United States Russell H. Morgan Dept. of Radiology The Johns Hopkins University Baltimore MD United States Center for Imaging Science The Johns Hopkins University Baltimore MD United States

ISBN: (纸本)9780819475091

We create a series of detailed computerized phantoms to estimate patient organ and effective dose in pediatric CT and investigate techniques for efficiently creating patient-specific phantoms based on imaging data. The initial anatomy of each phantom was previously developed based on manual segmentation of pediatric CT data. Each phantom was extended to include a more detailed anatomy based on morphing an existing adult phantom in our laboratory to match the framework (based on segmentation) defined for the target pediatric model. By morphing a template anatomy to match the patient data in the LDDMM framework, it was possible to create a patient specific phantom with many anatomical structures, some not visible in the CT data. The adult models contain thousands of defined structures that were transformed to define them in each pediatric anatomy. The accuracy of this method, under different conditions, was tested using a known voxelized phantom as the target. Errors were measured in terms of a distance map between the predicted organ surfaces and the known ones. We also compared calculated dose measurements to see the effect of different magnitudes of errors in morphing. Despite some variations in organ geometry, dose measurements from morphing predictions were found to agree with those calculated from the voxelized phantom thus demonstrating the feasibility of our methods. © 2009 SPIE.

关键词： Phantoms

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Breast tomosynthesis reconstruction with a multi-beam x-ray source

Breast tomosynthesis reconstruction with a multi-beam x-ray ...

引用

Medical Imaging 2009: Physics of Medical Imaging

作者： Chen, Ying Zhou, Weihua Yang, Guang Qian, Xin Lu, Jianping Zhou, Otto Dept. of Electrical and Computer Engineering Southern Illinois University Carbondale IL 62901 United States Biomedical Engineering Graduate Program Southern Illinois University Carbondale IL 62901 United States Dept. of Physics and Astronomy and Curriculum in Applied Sciences and Engineering University of North Carolina Chapel Hill NC 27599 United States Lineberger Comprehensive Cancer Center University of North Carolina Chapel Hill NC 27599 United States

ISBN: (纸本)9780819475091

As a new three-dimensional breast imaging technique, breast tomosynthesis allows the reconstruction of an arbitrary set of planes in the breast from a limited-angle series of x-ray projection images. The breast tomosynthesis technique has been demonstrated as promising to improve early breast cancer detection. This paper represents a preliminary phantom study and computer simulation results of different breast tomosynthesis reconstruction algorithms with a novel carbon nanotube based multi-beam x-ray source. Five representative tomosynthesis reconstruction algorithms, including back projection (BP), filtered back projection (FBP), matrix inversion tomosynthesis (MITS), maximum likelihood expectation maximization (MLEM), and simultaneous algebraic reconstruction technique (SART) were investigated. Tomosynthesis projection images of a phantom were acquired with the stationary multi-beam x-ray tomosynthesis system. Reconstruction results from different algorithms were studied. A computer simulation study was further done to investigate the sharpness of reconstructed in-plane structures and to see how effective each algorithm is at removing outof- plane blur with parallel-imaging geometries. Datasets with 9 and 25 projection images of a defined 3D spherical object were simulated with a total view angle of 50 degrees. Results showed that the multi-beam x-ray system is capable to generate 3D tomosynthesis images with faster speed compared with current commercial prototype systems. With simulated parallel-imaging geometry, MITS and FBP showed edge enhancement in-plane performance. BP, FBP and MLEM performed better at out-of-plane structure removal with larger number of projection images. © 2009 SPIE.

关键词： Carbon nanotubes

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The use of modified deconvolution averaging algorithm for the analysis of auditory evoked activity

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25th Southern biomedical engineering Conference 2009

作者： Presacco, A. Bohórquez, J. Yavuz, E. Özdamar, Ö. Dept. Biomedical Engineering University of Miami P.O. Box 248294 Coral Gables FL 33124 United States Dept. Otolaryngology Pediatrics and Neuroscience Program School of Medicine University of Miami United States Intelligent Hearing Systems Corp. 7356 SW 48th St. Miami FL 33155 United States

ISBN: (纸本)9783642016967

Continuous Loop Averaging Deconvolution (CLAD) is a recently developed mathematical theory and algorithm that allows to deconvolve averaged electrophysiological signals obtained at high stimulation (Delgado and Özdamar (2004) [1]). It assumes that the individual unit responses are linearly combined to form quasi-steady state responses. One limitation of this algorithm is related to the fact that the length of the recording window has to be equivalent to the duration of the response. In this study, we have developed a modified deconvolution averaging algorithm to derive deconvolved responses when the length of the recording is longer than the duration of the response. The algorithm uses the Least Mean Square (LMS) optimization method to find the deconvolved recording that best fits the acquired data. The method has been applied to study the evoked activity in 40 Hz auditory responses. © 2009 Springer Berlin Heidelberg.

关键词： Deconvolution

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Patient-specific dose estimation for pediatric abdomen-pelvisCT

Patient-specific dose estimation for pediatric abdomen-pelvi...

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Medical Imaging 2009: Physics of Medical Imaging

作者： Li, Xiang Samei, Ehsan Segars, W. Paul Sturgeon, Gregory M. Colsher, James G. Frush, Donald P. Medical Physics Graduate Program United States Carl E. Ravin Advanced Imaging Laboratories United States Dept. of Radiology United States Depts of Physics and Biomedical Engineering Duke University Durham NC 27705 United States GE Healthcare Waukesha WI 53188 United States

ISBN: (纸本)9780819475091

The purpose of this study is to develop a method for estimating patient-specific dose from abdomen-pelvis CT examinations and to investigate dose variation across patients in the same weight group. Our study consisted of seven pediatric patients in the same weight/protocol group, for whom full-body computer models were previously created based on the patients' CT data obtained for clinical indications. Organ and effective dose of these patients from an abdomen-pelvis scan protocol (LightSpeed VCT scanner, 120- kVp, 85-90 mA, 0.4-s gantry rotation period, 1.375-pitch, 40-mm beam collimation, and small body scan field-of-view) was calculated using a Monte Carlo program previously developed and validated for the same CT system. The seven patients had effective dose of 2.4-2.8 mSv, corresponding to normalized effective dose of 6.6-8.3 mSv/100mAs (coefficient of variation: 7.6%). Dose variations across the patients were small for large organs in the scan coverage (mean: 6.6%;range: 4.9%-9.2%), larger for small organs in the scan coverage (mean: 10.3%;range: 1.4%-15.6%), and the largest for organs partially or completely outside the scan coverage (mean: 14.8%;range: 5.7%-27.7%). Normalized effective dose correlated strongly with body weight (correlation coefficient: r = -0.94). Normalized dose to the kidney and the adrenal gland correlated strongly with mid-liver equivalent diameter (kidney: r = -0.97;adrenal glands: r = -0.98). Normalized dose to the small intestine correlated strongly with mid-intestine equivalent diameter (r = -0.97). These strong correlations suggest that patient-specific dose may be estimated for any other child in the same size group who undergoes the abdomen-pelvis scan. © 2009 SPIE.

关键词： Pediatrics

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Effects of citraconylation on enzymatic modification of human proinsulin using trypsin and carboxypeptidase B

Effects of citraconylation on enzymatic modification of huma...

引用

作者： Son, Young-Jin Kim, Chang-Kyu Kim, Young Bong Kweon, Dae-Hyuk Park, Yong-Cheol Seo, Jin-Ho Interdisciplinary Program for Bioengineering Seoul National University Seoul 151-742 Korea Republic of Dept. of Animal Biotechnology College of Animal Bioscience and Technology Konkuk University Seoul 143-701 Korea Republic of Department of Genetic Engineering Sungkyunkwan University Suwon 440-746 Korea Republic of Center for Agricultural Biomaterials Seoul National University Seoul 151-921 Korea Republic of

Insulin is a polypeptide hormone which is produced by the β-cell of pancreas and controls the blood glucose level in the human body. Enzymatic modification of human proinsulin using trypsin and carboxypeptidase B generally causes high accumulation of insulin derivatives, leading to more complicated purification processes. A simple method including citraconylation and decitraconylation in the enzymatic modification process was developed for the reduction of a major derivative, des-threonine human insulin. Addition of 3.0 g citraconic anhydride per g protein into the reaction solution led to the citraconylation of lysine residues in human proinsulin and reduction of relative des-threonine insulin content from 13.5 to 1.0%. After the enzymatic hydrolysis of the citraconylated proinsulin, 100% of lysine residues can be decitraconylated and restored by adjusting pH to 2-3 at 25 °C. Combination of hydrogen peroxide addition and citraconylation of proinsulin expressed in recombinant Escherichia coli remarkably improved the conversion yield of insulin from 52.7 to 77.7%. Consequently, citraconylation of lysine residues blocked the unexpected cleavage of human proinsulin by trypsin, minimized the formation of des-threonine insulin and hence increased the production yield of active insulin. © 2009 American Institute of Chemical Engineers.

关键词： Insulin

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3D registration of micro-PET-CT for measurable correlates of dyspeptic symptoms in mice

3D registration of micro-PET-CT for measurable correlates of...

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Medical Imaging 2009: biomedical Applications in Molecular, Structural, and Functional Imaging

作者： Camp, Jon Simpson, Kathryn Bardsley, Michael R. Popko, Laura N. Young, David L. Kemp, Bradley J. Low, Val Ordog, Tamas Robb, Richard Biomedical Imaging Resource 200 1st ST. SW Rochester MN 55905 United States Enteric Neuroscience Program Miles and Shirley Fiterman Center for Digestive Diseases Department of Physiology and Biomedical Engineering 200 1st ST. SW Rochester MN 55905 United States Dept. of Nuclear Medicine Mayo Clinic/Foundation 200 1st ST. SW Rochester MN 55905 United States

ISBN: (纸本)9780819475138

Patients with chronic calorie insufficiency commonly suffer from upper gastrointestinal dysfunction and consequent dyspeptic symptoms, which may interfere with their nutritional rehabilitation. To investigate the relationship between gastric dysfunction and feeding behavior, we exposed mice to chronic caloric restriction and demonstrated gastric motor abnormalities in them. Gastric dysmotility is typically associated with dyspeptic symptoms but sensations cannot be directly assessed in animal models. Therefore, as an initial step toward establishing measurable correlates of postprandial symptoms in small animals, we have attempted to characterize central responses to food intake by positron emission tomography-computerized microtomography (PET-CT) in normal and calorically restricted mice. Animals consumed a standard test meal after an overnight fast before receiving 2-deoxy-2[18F]fluoro- D-glucose tracer. The same mice were also scanned in the fasting state on a separate day. We were able to bring the fed and fasting PET volume images into spatial registration with each other and with an MR-derived atlas of the mouse brain, so that the differences in uptake between the two states could be mapped quantitatively against the neuroanatomic regions of the atlas. Our approach is suitable for studying the effects of gastric dysmotilities on central responses to feeding. © 2009 SPIE.

关键词： Positron emission tomography

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Optical spectroscopy for clinical detection of pancreatic cancer

Optical spectroscopy for clinical detection of pancreatic ca...

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European Conference on biomedical Optics, ECBO 2009

作者： Chandra, Malavika Wilson, Robert H. Scheiman, James Simeone, Diane McKenna, Barbara Purdy, Julianne Mycek, Mary-Ann Applied Physics Program University of Michigan Ann Arbor MI 48109 United States Division of Gastroenterology University of Michigan Medical School Ann Arbor MI 48109 United States Comprehensive Cancer Center University of Michigan Medical School Ann Arbor MI 48109 United States Dept. of Surgery University of Michigan Medical School Ann Arbor MI 48109 United States Dept. of Pathology University of Michigan Medical School Ann Arbor MI 48109 United States Dept. of Biomedical Engineering University of Michigan Ann Arbor MI 48109 United States

A prototype clinical fluorescence and reflectance spectrometer was developed and employed to detect human pancreatic adenocarcinoma. For the first time, quantitative pancreatic tissue models and chemometric algorithms... 详细信息

ISBN: (纸本)9780819476432

关键词： Fluorescence spectroscopy

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Near-infrared In Vivo fluorescence sensor with integrated dielectric emission filter

Near-infrared In Vivo fluorescence sensor with integrated di...

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Conference on Lasers and Electro-Optics, CLEO 2009

作者： O'Sullivan, Thomas D. Munro, Elizabeth Conca, Christopher Parashurama, Natesh Zerda, Adam De La Gambhir, Sanjiv S. Harris, James S. Levi, Ofer Solid State and Photonics Laboratory Stanford University Stanford CA 94305 United States Inst. of Biomaterials and Biomedical Engineering Dept. of Electrical and ComputerEngineering University of Toronto Toronto ON Canada Chroma Technology Corp 10 Imtec Lane PO Box 489 Rockingham VT 05101 United States Molecular Imaging Program at Stanford Departments of Radiology and Bioengineering Stanford University Stanford CA 94305 United States

We present a monolithically integrated near-infrared fluorescence sensor incorporating a dielectric emission filter for in vivo applications. We successfully integrated a dielectric emission filter (OD3) onto a low-no... 详细信息

ISBN: (纸本)9781557528698

关键词： Infrared devices

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