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Annual Conference on Neural Information Processing Systems

作者： Timothy X Brown Interdisciplinary Telecommunications Program Dept. of Electrical and Computer Engineering University of Colorado Boulder 80309-0530

We classify an input space according to the outputs of a real-valued function. The function is not given, but rather examples of the function. We contribute a consistent classifier that avoids the unnecessary complexi... 详细信息

ISBN: (纸本)0262122413

关键词： Taxonomy Output Mentoring Classifiers

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On the Perception of Transients: Applying Psychophysical Constraints to Improve Audio Analysis and Synthesis 26

On the Perception of Transients: Applying Psychophysical Con...

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26th International Computer Music Conference, ICMC 2000

作者： Wakefield, Gregory H. Heller, Laurie M. Carney, Laurel H. Mellody, Maureen Department of Electrical Engineering and Computer Science University of Michigan Ann ArborMI48109 United States Naval Submarine Medical Research Laboratory GrotonCT06359 United States Hearing Research Center Dept. of Biomedical Engineering Boston University BostonMA02215 United States Applied Physics Program University of Michigan United States

In a psychophysical experiment, a wideband, 4-ms noise is compared with spectrally smoothed versions of the noise. To isolate on the magnitude spectrum, the phase spectrum is controlled by assigning the same random phase spectrum to both the original and smoothed signals. Depending on the choice of phase spectrum, discrimination thresholds for spectral shape vary from a maximum spectral deviation of 2-3 dB to as much as 25 dB. The exact source of this effect remains an open question. However, it suggests that not all transients require the same signal fidelity. Given a proper characterization of the perceptual response, it may be possible to reduce the size of the codebook required to maintain acceptable perceptual results. © 2000 ICMC. All Rights Reserved.

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Custom report generator

Custom report generator

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Annual Northeast Bioengineering Conference

作者： A.A. AlAqeel N. Noyes J. Enderle Dept. of Electr. & Syst. Eng. Connecticut Univ. Storrs CT USA Clinical Engineering Department UCONN Health Center Farmington CT USA Department of Electrical & Systems Engineering Biomedical Engineering Program University of Connecticut Storrs CT USA

The tremendous advances in medical informatics are providing new software products for developing more powerful and user-friendly tools. At the same time, the clinical engineering role is shifting towards implementing quality systems approaches in managing medical technology. As a result there is a need for continuous upgrade or redesign of database management systems. Datastream MP2 is a computerized maintenance management system software application that controls maintenance operations and stores service data. The Clinical engineering Department at the University of Connecticut Health Center runs this software as their database. The thrust of this project is to develop a software tool that facilitates the retrieval of useful information from a computerized maintenance management database and provides custom reports that are not otherwise available.

关键词： Software tools Clinical diagnosis Power system management biomedical informatics Quality management Technology management engineering management Database systems Power engineering computing Software maintenance

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Optical-axis directional solidification stage for topographic imaging of ice growth

American Society of Mechanical Engineers, Bioengineering Div...

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American Society of Mechanical Engineers, Bioengineering Division (Publication) BED 1999年 42卷 599-600页

作者： Neils, Christopher M. Diller, Kenneth R. Biomedical Engineering Program Dept. Aerosp. Eng. Eng. Mechanics University of Texas at Austin Austin TX United States

A new directional solidification (DS) stage was configured to align the direction of ice growth vertically, along the optical axis of a confocal laser scanning microscope. The resultant setup allows to observe the fre... 详细信息

ISBN: (纸本)0791816117

关键词： biomedical engineering

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Voxel based nonlinear finite element modeling of trabeculated myocardium in the embryonic heart

American Society of Mechanical Engineers, Bioengineering Div...

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American Society of Mechanical Engineers, Bioengineering Division (Publication) BED 1999年 42卷 331-332页

作者： Xie, Wenjie Perucchio, Renato Thompson, Robert Dept. of Cell Biology and Anatomy Medical University of South Carolina Charleston SC United States Department of Mechanical Engineering Program of Biomedical Engineering University of Rochester Rochester NY United States

ISBN: (纸本)0791816117

The mechanical response of the trabeculated ventricle at stage 21 is modeled using nonlinear finite element analysis. The objective is to investigate how stresses and strains resulting from ventricular activation and blood pressure modulate the growth and remodeling of the trabeculated wall and of the ventricle. A multiscale approach, consisting of several local voxel meshes and global mesh derived from a smooth solid model of the ventricle, is established to address this objective.

关键词： Tissue

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Effect of spinal instrumentation on fatigue of juxtafused discs

American Society of Mechanical Engineers, Bioengineering Div...

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American Society of Mechanical Engineers, Bioengineering Division (Publication) BED 1999年 42卷 181-182页

作者： Rapoff, Andrew J. Deguchi, Masao Heisey, Dennis M. Zdeblick, Thomas A. Vanderby Jr., Ray Dept. Aerosp. Eng. Mechanics E. Biomedical Engineering Program University of Florida Gainesville FL United States Department of Orthopedic Surgery Nagano Red Cross Hospital Nagano Japan Division of Orthopedic Surgery University of Wisconsin Madison WI United States

ISBN: (纸本)0791816117

The effect of instrumentation rigidity on the tensile fatigue behavior of juxtafused intervertebral discs was investigated. Cyclic loading was performed with the load amplitude set at predetermined fractions of static strengths of related specimens. Overall, the juxtafused discs exhibited a macroscopically degenerated appearance, characteristic of dehydration embrittlement and accelerated aging.

关键词： Implants (surgical)

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Ontology and metadata creation for the Poseidon distributed Coastal Zone Management System

Ontology and metadata creation for the Poseidon distributed ...

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International Forum on Research and Technology Advances in Digital Libraries (ADL)

作者： P.C.H. Wariyapola S.L. Abrams A.R. Robinson K. Streitlien N.M. Patrikalakis P. Elisseeff H. Schmidt Dept. of Ocean Eng. MIT Cambridge MA USA Department of Ocean Engineering Design Labor Massachusetts Institute of Technology USA Physical-Interdisciplinary Ocean Science Group Harvard University USA Sea Grant College Program Autonomous Underwater Vehicles Laboratory Massachusetts Institute of Technology USA Department of Ocean Engineering Design Laboratory Massachusetts Institute of Technology Cambridge MA USA Department of Ocean Engineering Acoustics Group Massachusetts Institute of Technology USA

The objective of the Poseidon Coastal Zone Management System project is to develop a distributed data and software architecture to locate, retrieve, utilize, and visualize information about the coastal ocean environment. The article focuses on the issues related to efficiently identifying and creating the data needed for a given task. Since scientific data sets often do not contain information about the environment in which the data was obtained, we need a method of distinguishing data based on external information, or metadata. This metadata needs to be standardized in order to facilitate searching. While many metadata standards exist, none of them are adequate for representing all the information needed for coastal zone management. We have therefore implemented existing metadata standards in an expandable object oriented structure known as the Warwick Framework. Furthermore, since metadata is expensive and tedious to produce, we have developed a Web based software tool that simplifies the process and reduces the storage of redundant information. While we can search the metadata for the information we need, we still need a common vocabulary, or ontology, to ensure that we can identify data unambiguously. Since no existing vocabulary encapsulates all aspects of the ocean sciences and ocean systems management, we have facilitated the production of such a resource by creating a Web based tool that will allow specialists with the requisite domain knowledge to populate the ontology independently. The tool handles all the logistical issues of storage, maintenance and distribution.

关键词： Ontologies Sea measurements Oceans Vocabulary Environmental management Project management Software development management Software architecture Information retrieval Data visualization

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Contributory presentations/posters

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Journal of Biosciences 1999年第1期24卷 33-198页

作者： N. Manoj V. R. Srinivas A. Surolia M. Vijayan K. Suguna R. Ravishankar R. Schwarzenbacher K. Zeth Diederichs G. M. Kostner A. Gries P. Laggner R. Prassl Madhusudan Pearl Akamine Nguyen-huu Xuong Susan S. Taylor M. Bidva Sagar K. Saikrishnan S. Roy K. Purnapatre P. Handa U. Varshney B. K. Biswal N. Sukumar J. K. Mohana Rao A. Johnson Vasantha Pattabhi S. Sri Krishna Mira Sastri H. S. Savithri M. R. N. Murthy Bindu Pillai Kannan M. V. Hosur Mukesh Kumar Swati Patwardhan K. K. Kannan B. Padmanabhaa S. Sasaki-Sugio M. Nukaga T. Matsuzaki S. Karthikevan S. Sharma A. K. Sharma M. Paramasivam P. Kumar J. A. Khan S. Yadav A. Srinivasan T. P. Singh S. Gourinath Neelima Alam A. Srintvasan Vikas Chandra Punit Kaur Ch. Betzel S. Ghosh A. K. Bera S. Bhattacharya S. Chakraborty A. K. Pal B. P. Mukhopadhyay I. Dey U. Haldar Asok Baneriee Jozef Sevcik Adriana Solovicova K. Sekar M. Sundaralingam N. Genov Dong-cai Liang Tao Jiang Ji-ping Zhang Wen-rui Chang Wolfgang Jahnke Marcel Blommers S. C. Panchal R. V. Hosur Bindu Pillay Puniti Mathur S. Srivatsun Ratan Mani Joshi N. R. Jaganathan V. S. Chauhan H. S. Atreya S. C. Sahu K. V. R. Chary Girjesh Govil Elisabeth Adjadj Éric Quinjou Nadia Izadi-Pruneyre Yves Blouquit Joël Mispelter Bernadette Heyd Guilhem Lerat Philippe Milnard Michel Desmadreil Y. Lin B. D. Nageswara Rao Vidva Raghunathan Mei H. Chau Prashant Pesais Sudha Srivastava Evans Coutinho Anil Saran Leizl F. Sapico Jayson Gesme Herbert Lijima Raymond Paxton Thamarapu Srikrishnan C. R. Grace G. Nagenagowda A. M. Lynn Sudha M. Cowsik Sarata C. Sahu S. Chauhan A. Bhattacharya G. Govil Anil Kumar Maurizio Pellecchia Erik R. P. Zuiderweg Keiichi Kawano Tomoyasu Aizawa Naoki Fujitani Yoichi Hayakawa Atsushi Ohnishi Tadayasu Ohkubo Yasuhiro Kumaki Kunio Hikichi Katsutoshi Nitta V. Rani Parvathy R. M. Kini Takumi Koshiba Yoshihiro Kobashigawa Min Yao Makoto Demura Astushi Nakagawa Isao Tanaka Kunihiro Kuwajima Jens Linge Seán O. Donoghue Michael Nilges G. Chakshusmathi Girish S. Ratnaparkhi P. K. Madhu R. Varadarajan C. Tetreau Molecular Biophysics Unit Indian Institute of Science Bangalore India Austrian Academy of Sciences Institute of Biophysics and X-ray Structure Research Graz Austria Faculty of Biology University of Konstanz Germany Institute of Medical Biochemistry University of Graz Austria Howard Huges Medical Institute Department of Chemistry & Biochemistry University of California La Jolla USA Department of Chemistry & Biochemistry University of California San Diego La Jolla USA Molecular Biophysics Unit India Department of Microbiology &Cell Biology Indian Institute of Science Bangalore India Macromolecular Structure Laboratory NCI - Frederick Cancer Research and Development Center ABL - Basic Research Program Frederick USA Department of Crystallography and Biophysics University of Madras Chennai Biochemistry Department Indian Institute of Science Bangalore India Condensed Matter Physics Division B.A.R.C. Trombay Mumbai Condensed Matter Physics Division Bhabha Atomic Research Centre Trombay Mumbai IMCB The University of Tokyo Tokyo Japan Mitsubishi Chemical Corporation Yokohama Research Center Yokohama Japan Faculty of Pharmaceutical Sciences Chiba University Chiba Japan Department of Biophysics All India Institute of Medical Sciences New Delhi India Department of Biophysics All India Institute of Medical sciences New Delhi India Institüt Physiologische Chemie Hamburg Germany Biophysics Department Bose Institute Calcutta India Slovak Academy of Sciences Institute of Molecular Biology Bratislava Slovakia Indian Institute of Science Bioinformatics Centre Bangalore Departments of Chemistry and Biochemistry Biological Macromolecular Structure Center USA Bulgarian Academy of Sciences Institute of Organic Chemistry Sofia Bulgaria Chinese Academy of Sciences Institute of Biophysics Beijing China Novartis Pharma AG Preclinical Research Basel Switzerland Department of Chemical Sciences Tata Institute of Fundamental Research Mumbai India Solid State Physics Div

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Effect of electrostatic interactions in recognition of acetylcholine by acetylcholinesterase

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Journal of Molecular Structure: THEOCHEM 1998年第1-2期425卷 81-85页

作者： Linaras, Charilaos E. Singh, Kamalendra Kristol, David Ritter, Arthur B. Department of Chemical Engineering New Jersey Institute of Technology Newark NJ 07102 United States Department of Opthalmology UMD-New Jersey Medical School Newark NJ 07103 United States Biomedical Engineering Program New Jersey Institute of Technology Newark NJ 07102 United States Dept. of Pharmacology and Physiology UMD-New Jersey Medical School Newark NJ 07103 United States

The role of electrostatic interactions in the steering of acetylcholine to the active site of acetylcholinesterase is investigated in this study. The results obtained suggest that acetylcholinesterase's catalytic processes involve more than two steps, one of which appears to be diffusion-controlled, while the others are influenced by electrostatic interactions. The results also support the concept that the electrostatic field contributes to the guidance of the ligand upon its close proximity to the entrance of the active site gorge. On the basis of the data obtained, a prehydrolysis (pre-transition state) structure for this catalytic reaction is also proposed. The root mean square deviation of the Ca atoms of the amino acid residues of the active site between the proposed transition state and a recently proposed transition state based on experimental data is 0.379 Å. © 1998 Elsevier Science B.V.

关键词： Acetylcholinesterase Catalytic reactions Electrostatic interactions Molecular model Transition state

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Decision support system to assist mechanical ventilation in the adult respiratory distress syndrome

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INTERNATIONAL JOURNAL OF CLINICAL MONITORING AND COMPUTING 1997年第2期14卷 73-81页

作者： Bottino, DA GiannellaNeto, A David, CMN Melo, MFV Biomedical Engineering Program Federal University of Rio de Janeiro Coppe/UFRJ Rio de Janeiro Brazil Dept. of Anesthesiology and Pain Management University of Texas Southwestern Medical Center Dallas USA

This paper presents a knowledge-based decision support system to assist mechanical ventilation in patients with the Adult Respiratory Distress Syndrome (DSSARDS). The knowledge base uses clinical algorithms developed from interviews and seminars with experts. The system contains 140 rules, applies backward chaining and was built on an IBM-PC compatible microcomputer. Clinical and physiological data and ventilator settings were used for suggestions of ventilatory support mode (VSMODE) and settings (MVSET) and for hemodynamic evaluation and therapy (HEMO). Success rates (s) and kappa coefficient (k) were used to measure agreement between DSSARDS and physicians at 4 decision steps related to: beginning of mechanical ventilation (FIRSTSET), VSMODE, MVSET and HEMO. DSSARDS prototype was evaluated in a development phase with 6 patients aged 48.6 +/- 15.9 years. Agreement results for 142 decision steps were: FIRSTSET k = 0.90, s = 0.93;VSMODE k = 0.76, s = 0.92;HEMO k = 0.58, s = 0.70, MVSET k = 0.86, s = 0.92 (p < 0.05 for all k). Improvements in the knowledge base were performed mainly in HEMO and VSMODE modules. The subsequent test phase studied 5 patients aged 54.8 +/- 11.0 years in a total of 900 decision steps. Results were: FIRSTSET k = 0.93, s = 0.95;VSMODE k = 0.93, s = 0.96;HEMO k = 0.97, s = 0.99, MVSET k = 0.96, s = 0.97 (p < 0.05 for all k). The results indicate significant agreement between DSSARDS and physicians for all decision steps. This suggests that DSSARDS may be used as a support for decision making and a training tool for mechanical ventilation in patients with the adult respiratory distress syndrome.

关键词： adult respiratory distress syndrome mechanical ventilators computer assisted decision making expert system

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