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Rapid breast cancer gene detection in picoliter droplet

Rapid breast cancer gene detection in picoliter droplet

引用

9th International Conference on Miniaturized Systems for Chemistry and Life sciences, MicroTAS 2005

作者： Hsieh, Albert Tsung-Hsi Hung, Lung-Hsin Lee, Abraham P. Dept. of Chemical Engineering and Materials Science University of California 204 Rockwell Engineering Center Irvine CA 92697 United States Dept. of Biomedical Engineering University of California 204 Rockwell Engineering Center Irvine CA 92697 United States Dept. Mechanical and Aerospace Engineering University of California 204 Rockwell Engineering Center Irvine CA 92697 United States

ISBN: (纸本)0974361119

We report a preliminary results of employing molecular beacon in picoliter droplets for breast cancer gene (BRCA1) detection. Experiments are carried out comparing the detection with control samples, verifying signal-to-noise levels and rate of hybridization. The sensing system is rapid, simple, highly selective, stable, reproducible, and only a few micro liters of samples are required. Copyright © 2005 by the Transducer Research Foundation, Inc.

关键词： Drops

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Electromagnetic containerless processing of single-waled nanotube reinforced metal-matrix composites

Electromagnetic containerless processing of single-waled nan...

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2005 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2005

作者： Wilson, K. Zeng, Q. Barrera, E. Bayazitoglu, Y. Rice University Mechanical Engineering and Materials Science Dept. MS 321 6100 Main St. Houston TX 77251-5423 United States

ISBN: (纸本)0976798514

Single-walled carbon nanotube (SWNT) reinforced copper (Cu) matrix composites were produced by powder metallurgy (PM) and electromagnetic levitation methods. The nanotubes were first decorated with a nickel coating and then dispersed by ball milling. The optimization of factors such as cold pressing pressure, powder grain size and sintering temperature for full densification were essential in the preform stage of PM in order to produce a sample suitable for levitation. Scanning electron microscopy (SEM) observations have shown that the well-dispersed nanotubes in the composites are not damaged during the high-temperature composite preparation. The preforms were then melted by electromagnetic levitation in an argon environment. SEM observations showed that the nanotubes survived the high-temperature melting. Hardness testing demonstrated that the strength of the composites is increased with increasing volume fraction of SWNTs.

关键词： Carbon nanotubes

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Design and tuning of a vacuum microplasma spray system: Particle entrainment

引用

2005 TMS Annual Meeting

作者： Crawford, W.Scott Cappelli, Mark A. Prinz, Friedrich B. Stanford University Mechanical Engineering Dept. Bldg. 520 Stanford CA 94305-3032 United States Stanford University Mechanical Engineering and Materials Science and Engineering Depts. Bldg. 530 Stanford CA 94305-3030 United States

ISBN: (纸本)0873395905

A vacuum microplasma spray system, operating on gross power levels of 1-3 kW, with powder feed rates below 1 g/min and using plasma gas mixtures of argon and hydrogen, was built and tested. In order to improve the deposition efficiency and quality of coatings, the system was analyzed and the matter of particle entrainment into the plasma jet core was identified as a critical sub-process. Particle entrainment is a strong fimction of carrier gas flow rate. Best carrier gas flow rates for entrainment of stainless steel, titanium, and tungsten powders, particle trajectories were determined by quantitative imaging with planar laser Mie scattering. It was found that particle distributions with greater average mass were less likely to overshoot the plasma jet core. This may be attributed to the particle accelerations within the particle injector.

关键词： Plasma spraying

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Fabrication of surface nitridation mask on GaAs substrate for nano-lithography

Fabrication of surface nitridation mask on GaAs substrate fo...

引用

Surface engineering 2004 - Fundamentals and Applications

作者： Yamamoto, Yo Saito, Kohji Kondo, Toshiyuki Maruyama, Takahiro Naritsuka, Shigeya Meijo Univ. 21St Century COE Program Nagoya Japan Dept. of Materials Science and Engineering Meijo University Nagoya Japan

The surface nitridation of GaAs substrate under various conditions were performed and its surface morphology was studied by using atomic force microscope. The RMS roughness of the surfaces was closely related to formation of the particles which was formed by As evaporation and subsequent Ga migration, which was enhanced by higher substrate temperature. © 2005 materials Research Society.

关键词： Semiconducting gallium arsenide

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Beam induced lateral epitaxy of GaAs on a GaAs/Si template

Beam induced lateral epitaxy of GaAs on a GaAs/Si template

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Progress in Compound Semiconductor materials IV - Electronic and Optoelectronic Applications

作者： Naritsuka, Shigeya Saitoh, Koji Kondo, Toshiyuki Maruyama, Takahiro Meijo University Dept. of Materials Science and Engineering Nagoya 468-8502 Japan Meijo University 21st century COE program NANO FACTORY

Beam induced lateral epitaxy (BILE) on truncated ridges was applied to the heteroepitaxial growth of GaAs on a Si substrate. A GaAs buffer layer was formed on the Si substrate, and then this GaAs/Si template was used as a substrate for the BILE process. As a result, overgrown regions of GaAs of widths as large as 6.5 μm were grown laterally from the sides of the truncated ridges. The growth regions had a flat, smooth top surface consisting of a (111) facet. Although stacking faults from the GaAs/Si template remained in the growth region, which are unfavorable for device applications, the lateral grown region has no dislocations. Thus, the BILE method is useful for reducing dislocations in heteroepitaxy. © 2005 materials Research Society.

关键词： Semiconducting gallium arsenide

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Electrode design for magnetohydrodynamic power panels on reentering space vehicles

Electrode design for magnetohydrodynamic power panels on ree...

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43rd AIAA Aerospace sciences Meeting and Exhibit

作者： Steeves, Craig A. Shneider, Mikhail N. Macheret, Sergey O. Wadley, Haydn N. G. Miles, Richard B. Evans, Anthony G. Princeton University Dept. of Mechanical and Aerospace Engineering Engineering Quad. Olden St. Princeton NJ 08544 United States AIAA United States University of Virginia Dept. of Materials Science and Engineering 116 Engineer's Way Charlottesville VA 22904 United States University of California Santa Barbara Dept. of Mechanical Engineering Engr. II Santa Barbara CA 93106 United States

Power can be extracted from the ionized fluid surrounding a re-entering space vehicle using magnetohydrodynamic (MHD) principles, provided an appropriate system of magnetic fields, thermal protection, and current collection electrodes can be designed and manufactured. Given computational fluid dynamics results for a re-entering spacecraft presented elsewhere (1), this paper examines possible electrode configurations and the implications that these will have for power generation. For practical electrode designs and realistic magnetic fields it is shown that current recirculation, which is detrimental to power generation and to thermal management, will generally arise. The necessity for fully-coupled CFD-MHD calculations is also demonstrated. Copyright © 2005 by Princeton University.

关键词： Aerospace engineering

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Model for time-to-fracture determination of low-alloyed steel under creep conditions

Model for time-to-fracture determination of low-alloyed stee...

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11th International Conference on Fracture 2005, ICF11

作者： Bakic, G. Zeravcic, Sijacki V. Djukic, M. Milanovic, D. Andjelic, B. Faculty of Mechanical Engineering Department of Material Science University of Belgrade Serbia Vectram Belgrade Serbia Techical Faculty Dept. of Physics and Materials University of Kragujevac Cacak Serbia

ISBN: (纸本)9781617820632

Structural integrity of power plant component is usually estimate by its residual service life. Input data for component residual life estimation exposed to high-temperature creep is the creep strength of material (time dependent strength), after particular service period. Creep strength is usually obtained by statistical treatment of experimental data, and it decreases during service time due to degradation of microstructure. Since the creep resistance decreases with time due to microstructure degradation, it is essential for practice to use microstructural parameters in order to define statistically the changes in the creep resistance, which in turn enables to follow the physical significance of these changes. Due to a considerable scatter in the creep data, treatment by statistical analysis of the physically significant parameters is a problem that, to date has not been satisfactorily solved. One of attempt to overcome the lack of all data, which were required for previous analyses and estimation of service resources/service life, is done in this paper. Kinetic process has to be defined by the rate of process or by time for which such process will cause the rupture, instead of creep strength. Thus, the time to fracture of the component subjected to a high-temperature creep is determined due the kinetic theory of strength (model Zurkov) and using the microstructural parameters as an input data.

关键词： Fracture

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Effect of electromigration on mechanical behavior of solder joints

Effect of electromigration on mechanical behavior of solder ...

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2005 10th International Symposium on Advanced Packaging materials: Processes, Properties and Interfaces

作者： Ren, F. Nah, J.W. Suh, J.O. Tu, K.N. Xiong, B.S. Xu, L.H. Pang, J.H.L. Dept. Materials Science Engineering UCLA Box 951595 405 Hilgard Ave. Los Angeles CA 90095-1595 School Mechanical Production and Engineering NTU Nanyang Ave. Singapore 639798 Singapore

ISBN: (纸本)0780390857

The combination of electromigration effect and stress effect was investigated in lead free solder joints with a diameter of 300μm. One dimensional structures, metal(wire)-solder(ball)-metal(wire) was developed. mechanical force and current could be applied serially or simultaneously. The current density of electromigration was 1-5×103 A/cm 2. The working temperature was 100-150°C. Tensile test and shear test were taken before and after electromigration to make the comparison. The tensile strain rate was 3μm/min. The experiment results show that, the samples broke at the middle of solder without applying current. However, after applying current of electromigration for 1 day, 2 days or longer, the failure always occurred at cathode interface. And the tensile strength was lower with longer electromigration time or higher current density. Shear test also illustrates the electromigration effect on mechanical property in composite solder joints. © 2005 IEEE.

关键词： Soldered joints

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Modeling nutrient transport coupled with mechanics in collagen

Modeling nutrient transport coupled with mechanics in collag...

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2005 Summer Bioengineering Conference

作者： Klein, Patrick A. Holdych, David J. Garikipati, Krishna Noble, David R. Science-based Materials Modeling Sandia National Laboratories Livermore CA Microscale Science and Technology Sandia National Laboratories Albuquerque NM Dept. of Mechanical Engineering University of Michigan Ann Arbor MI

ISBN: (纸本)0974249211

Self-assembly is a promising avenue toward the development of new materials. engineering principles for micro- and nano-fabrication can be discovered from the study of self-assembly phenomena in nature. Biological tissues serve as model factories for the production of macromolecular structures, where the processes of molecular self-assembly and macroscopic growth are integrated in robust systems, which display self-healing and adaptivity. Growth occurs as nutrients, amino acids, and enzymes undergo mass transport and react to increase tissue mass. At the molecular scale, there is considerable understanding of the reactions for self-assembly of tissue components such as collagen. There is less understanding of the thermodynamic driving forces and of how these interact with growth processes to form multicellular tissue. These processes are also influenced by mechanics at the continuum scale. In this work, we simulate processes of growth in collagen at the continuum scale. The mathematical description of growth constitutes a highly complex system that requires mixture theory with coupled diffusion-reaction and mechanics, and differs significantly from classical continuum formulations of closed systems. Following thermodynamic arguments, we have derived constitutive relations for the flux of the fluid and the species dissolved within it. The relations account for driving forces due to inertial forces, gradients in pressure, and gradients in chemical potential. We relate species mobilities that arise in the formulation to classic mixture-theory transport parameters, the permeability coefficient and the dispersion tensor, and calculate these parameters from simulations of flow through a fiber network. The accuracy of the modeling approach will be demonstrated by comparing predictions of multi-species flow from the continuum formulation with direct simulations of flow through a collagen-like network.

关键词： Biomechanics

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Environmentally benign materials for electronics;A review of current developments and emerging technologies

Environmentally benign materials for electronics;A review of...

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materials science and Technology 2005 Conference

作者： Lincoln, John D. Ogunseitan, Oladele A. Saphores, Jean-Daniel M. Schoenung, Julie M. Nixon, Hilary Shapiro, Andrew A. Dept. of Chemical Engineering and Materials Science University of California Irvine HSSOE Irvine CA 92697 Program in Industrial Ecology Dept. of Environmental Health Science and Policy UCI 92697-7070 Dept. of Planning Policy and Design UCI 218D SEI 92697-7075 Dept. of Chemical Engineering and Materials Science University of California 2017 Kemper Hall Davis 95616-5294 Jet Propulsion Laboratory 4800 Oak Grove Dr. Pasadena CA 91109

ISBN: (纸本)0873396456

materials used in handheld consumer electronic devices (CEDs), such as cell phones or PDAs, create environmental risks both during procurement and disposal. The increasing global demand for CEDs and recent legislative pressure motivate our review of alternative materials that could make CEDs more environmentally friendly. Hazardous materials considered include brominated flame retardants, lead-based solders, hexavalent chromium, copper, and ceramic materials. We survey recent research in the development of environmentally benign replacement materials, provide a brief assessment of the potential environmental, industrial, and economic consequences of their substitution, and assess progress in their industrial application. Identifying appropriate environmentally benign replacement materials provides a starting point for developing environmentally friendly CED prototypes.

关键词： Electronic equipment

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