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Global and risk-group stratified well-being and mental health during the COVID-19 pandemic in adults: Results from the international COH-FIT Study

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Psychiatry Research 2024年 342卷 115972-115972页

作者： Solmi, Marco Thompson, Trevor Estradé, Andrés Agorastos, Agorastos Radua, Joaquim Cortese, Samuele Dragioti, Elena Vancampfort, Davy Thygesen, Lau Caspar Aschauer, Harald Schlögelhofer, Monika Aschauer, Elena Schneeberger, Andres Huber, Christian G. Hasler, Gregor Conus, Philippe Cuénod, Kim Q. Do von Känel, Roland Arrondo, Gonzalo Fusar-Poli, Paolo Gorwood, Philip Llorca, Pierre-Michel Krebs, Marie-Odile Scanferla, Elisabetta Kishimoto, Taishiro Rabbani, Golam Skonieczna-Żydecka, Karolina Brambilla, Paolo Favaro, Angela Takamiya, Akihiro Zoccante, Leonardo Colizzi, Marco Bourgin, Julie Kamiński, Karol Moghadasin, Maryam Seedat, Soraya Matthews, Evan Wells, John Vassilopoulou, Emilia Gadelha, Ary Su, Kuan-Pin Kwon, Jun Soo Kim, Minah Lee, Tae Young Papsuev, Oleg Manková, Denisa Boscutti, Andrea Gerunda, Cristiano Saccon, Diego Righi, Elena Monaco, Francesco Croatto, Giovanni Cereda, Guido Demurtas, Jacopo Brondino, Natascia Veronese, Nicola Enrico, Paolo Politi, Pierluigi Ciappolino, Valentina Pfennig, Andrea Bechdolf, Andreas Meyer-Lindenberg, Andreas Kahl, Kai G. Domschke, Katharina Bauer, Michael Koutsouleris, Nikolaos Winter, Sibylle Borgwardt, Stefan Bitter, Istvan Balazs, Judit Czobor, Pál Unoka, Zsolt Mavridis, Dimitris Tsamakis, Konstantinos Bozikas, Vasilios P. Tunvirachaisakul, Chavit Maes, Michael Rungnirundorn, Teerayuth Supasitthumrong, Thitiporn Haque, Ariful Brunoni, Andre R. Costardi, Carlos Gustavo Schuch, Felipe Barreto Polanczyk, Guilherme Luiz, Jhoanne Merlyn Fonseca, Lais Aparicio, Luana V. Valvassori, Samira S. Nordentoft, Merete Vendsborg, Per Hoffmann, Sofie Have Sehli, Jihed Sartorius, Norman Heuss, Sabina Guinart, Daniel Hamilton, Jane Kane, John Rubio, Jose Sand, Michael Koyanagi, Ai Solanes, Aleix Andreu-Bernabeu, Alvaro Cáceres, Antonia San José Arango, Celso Díaz-Caneja, Covadonga M. Hidalgo-Mazzei, Diego Vieta, Eduard Gonzalez-Peñas, Javier Fortea, Lydia Parellada, Mara Fullana, Miquel A. Verdolini, Norma Andrlíková, Eva Janků, Karolina Millan, Mark J. Honciuc, Mihaela Moniuszko-Mal University of Ottawa Department of Psychiatry ON Canada The Ottawa Hospital Department of Mental Health ON Canada Ottawa Hospital Research Institute (OHRI) Neurosciences Program Ottawa Ontario Canada Early Psychosis: Interventions and Clinical-detection (EPIC) Lab Department of Psychosis Studies Institute of Psychiatry Psychology & Neuroscience King's College London London United Kingdom Centre for Innovation in Mental Health-Developmental Lab School of Psychology University of Southampton and NHS Trust Southampton United Kingdom Charité Universitätsmedizin Berlin Department of Child and Adolescent Psychiatry Berlin Germany Centre for Chronic Illness and Ageing University of Greenwich London United Kingdom University of Southampton Centre for Innovation in Mental Health Southampton United Kingdom Universidad Católica Department of Psychology Montevideo Uruguay Aristotle University of Thessaloniki II. Dept. of Psychiatry Division of Neurosciences Medical School Faculty of Health Sciences Greece Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS) Imaging of Mood- and Anxiety-Related Disorders (IMARD) University of Barcelona CIBERSAM Instituto de Salud Carlos III Barcelona Spain Karolinska Institutet Centre for Psychiatric Research and Education Department of Clinical Neuroscience Stockholm Sweden Linköping University Pain and Rehabilitation Centre and Department of Health Medicine and Caring Sciences Linköping Sweden University of Ioannina Research Laboratory Psychology of Patients Families & Health Professionals Department of Nursing School of Health Sciences Ioannina Greece Katholieke Universiteit Leuven (KU Leuven) Department of Rehabilitation Sciences Leuven Belgium National Institute of Public Health University of Southern Denmark Denmark BioPsyC - Biopsychosocial Corporation Non-profit association for Research Funding Ltd. Vienna Austria University of California San Diego California United States University of Basel Universitä

International studies measuring wellbeing/multidimensional mental health before/ during the COVID-19 pandemic, including representative samples for >2 years, identifying risk groups and coping strategies are lacking. COH-FIT is an online, international, anonymous survey measuring changes in well-being (WHO-5) and a composite psychopathology P-score, and their associations with COVID-19 deaths/restrictions, 12 a-priori defined risk individual/cumulative factors, and coping strategies during COVID-19 pandemic (26/04/2020-26/06/2022) in 30 languages (representative, weighted non-representative, adults). T-test, χ², penalized cubic splines, linear regression, correlation analyses were conducted. Analyzing 121,066/142,364 initiated surveys, WHO-5/P-score worsened intra-pandemic by 11.1±21.1/13.2±17.9 points (effect size d=0.50/0.60) (comparable results in representative/weighted non-probability samples). Persons with WHO-5 scores indicative of depression screening (<50, 13% to 32%) and major depression (<29, 3% to 12%) significantly increased. WHO-5 worsened from those with mental disorders, female sex, COVID-19-related loss, low-income country location, physical disorders, healthcare worker occupations, large city location, COVID-19 infection, unemployment, first-generation immigration, to age=18-29 with a cumulative effect. Similar findings emerged for P-score. Changes were significantly but minimally related to COVID-19 deaths, returning to near-pre-pandemic values after >2 years. The most subjectively effective coping strategies were exercise and walking, internet use, social contacts. Identified risk groups, coping strategies and outcome trajectories can inform global public health strategies. © 2024 The Authors

关键词： Covid-19 Mental health P-factor Pandemic Psychiatry Psychopathology Survey Well-being WHO-5

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26th Annual Computational Neuroscience Meeting (CNS*2017) of the Organization for Computational Neuroscience Antwerp, Belgium, July 15-20, 2017

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BMC NEUROscience 2017年第SUPPL 1期18卷 59-59页

作者： [Anonymous] Indiana University Purdue University Indianapolis Indianapolis IN 46032 USA Stark Neurosciences Research Institute Indiana University School of Medicine Indianapolis IN 46032 USA Department of Mathematics East Carolina University Greenville NC 27858 USA Jülich Supercomputing Centre Forschungszentrum Jülich 52425 Jülich Germany Future Systems Swiss National Supercomputing Centre 8092 Zurich Switzerland User Engagement and Support Swiss National Supercomputing Centre 6900 Lugano Switzerland Institut de Neurosciences des Systèmes Aix Marseille Univ 13005 Marseille France Simulation Lab Neuroscience Forschungszentrum Jülich Jülich Germany Department of Experimental Psychology Ghent University 9000 Ghent Belgium Donders Center for Cognitive Neuroimaging Radboud University 6525HR Nijmegen The Netherlands Department of Electrical Computer and Energy Engineering University of Colorado Boulder CO 80309 USA Department of Neurosurgery Johns Hopkins School of Medicine Baltimore MD 21287 USA Department of Neurology Johns Hopkins School of Medicine Baltimore MD 21287 USA Department of Otolaryngology Johns Hopkins School of Medicine Baltimore MD 21287 USA INSERM U968 Paris France Sorbonne Universités UPMC University Paris 06 UMR_S 968 Institut de la Vision Paris France CNRS UMR_7210 Paris France Department of Computer Architecture and Technology University of Granada (CITIC) Granada Spain Sorbonne Universités UPMC Univ Paris 06 INSERM CNRS Institut de la Vision Paris France Department of Adaptive Machine Systems Osaka University Osaka Japan Department of Computer Science University of Cergy-Pontoise Cergy-Pontoise France Department of Physics and Astronomy College of Charleston Charleston SC 29424 USA School of Physics Faculty of Science University of Sydney Sydney NSW 2006 Australia Center of Excellence for Integrative Brain Function Australian Research Council Sydney Australia Max Planck Institute for Human Cognitive and Brain Sciences Saxony Lei

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Poster abstracts

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Sleep and Biological Rhythms 2016年第1期5卷 A1-A189页

作者： J. Ferrie M. Shipley F. Cappuccio E. Brunner M. Miller M. Kumari M. Marmot A. Coenen J. L. Castillo F. Araya G. Bustamante L. Montecino C. Torres S. Oporto J. Gronli E. Fiske R. Murison B. Bjorvatn E. Sorensen R. Ursin C. M. Portas S. Rajaraman A. Gribok N. Wesensten T. Balkin J. Reifman N. Dursunoglu S. Ozkurt S. Baser O. Delen S. Sarikaya P. Sadler P. Mitchell D. Françon M. Decobert B. Herve A. Richard G. Griebel P. Avenet B. Scatton G. L. Fur D. Eckert A. Jordan A. Wellman S. Smith A. Malhotra D. White D. Bruck I. Thomas A. Kritikos W. Oertel K. Stiasny-Kolster D. Garcia-Borreguero W. Poewe B. Hoegl R. Kohnen E. Schollmayer J. Keffel C. Trenkwalder A. Valle S. Roizenblatt F. Fregni P. Boggio S. Tufik K. Ward L. Robertson L. Palmer P. Eastwood D. Hillman J. Lee S. Mukherjee V. de Padova G. Barbato G. Ficca I. Zilli P. Salzarulo M. Veldi T. Hion V. Vasar M. Kull L. Nowak J. Davis Y. Latzer O. Tzischinsky S. Crowley M. Carskadon M. Anca-Herschkovitsch D. Frey J. Ortega C. Wiseman C. Farley K. Wright A. Campbell A. Neill K. Spiegel R. Leproult E. Tasali N. Scherberg E. van Cauter A. T. Noradina N. A. Karim I. Norlinah A. A. Raymond R. Sahathevan B. Hamidon E. Werth R. Poryazova R. Khatami C. Bassetti R. G. Beran L. Ainley G. Holand J. Duncan H. Kinney B. Davis B. Hood S. Frey C. Schmidt M. Hofstetter P. Peigneux C. Cajochen W.-P. Hu J.-D. Li C. Zhang L. Boehmer J. Siegel Q.-Y. Zhou Y. Sagawa H. Kondo T. Takemura H. Kanayama Y. Kaneko M. Sato T. Kanbayashi Y. Hishikawa T. Shimizu A. Viola L. James L. Schlangen D.-J. Dijk R. Andretic Y.-C. Kim K.-A. Han F. Jones R. Greenspan L. Sanford L. Yang X. Tang K. Dieter E. Uta H. Sven M. Richard N. Oyane S. Pallesen F. Holsten Y. Inoue M. Fujita N. Emura K. Kuroda N. Uchimura A. Johnston J. Astbury G. Kennedy K. Hoedlmoser M. Schabus T. Pecherstorfer S. Moser G. Gruber P. Anderer W. Klimesch N. Naidoo M. Ferber A. Pack D. Neu O. Mairesse G. Hoffmann A. Dris L. Lambrecht P. Linkowski P. Verbanck O. Le Bon N. Matsuura M. Yamao N. Adachi R. Aritomi Y. Komada H. Tanaka S. Shirak University College London London UK University College London London USA Warwick Medical School London UK Warwick Medical School Coventry USA Radboud University Nijmegen Nijmegen Netherlands Department of Neurology University of Chile Santiago Chile Neurology Service Hospital del Salvador Santiago Chile Family Health Center Juan Pablo II Santiago Chile Department of Biomedicine Section on Physiology Univeristy of Bergen Bergen Norway Department of Public Health and Primary Health Care Univeristy of Bergen Bergen Norway Department of Public Health and Primary Health Care University of Bergen Bergen Norway Norwegian Competence Center for Sleep Disorders Haukeland University Hospital Bergen Norway Department of Child and Adolescent Psychiatry Haukeland University Hospital Univeristy of Bergen Bergen Norway Department of Biomedicine University of Bergen Bergen Norway US Army Medical Research and Materiel Command Fort Detrick Frederick USA Walter Reed Army Institute of Research Silver Spring USA Department of Behavioral Biology Walter Reed Army Institute of Research Silver Spring USA Faculty Department of Pulmonology Pamukkale University Medical Denizli Turkey University of Ballarat Ballarat Australia Sanofi-Aventis Recherche et Developpement Paris France Brigham and Women’s Hospital Harvard Medical School Boston USA The University of Queensland Adelaide Australia School of Psychology University of Queensland Brisbane Australia The University of Queensland Brisbane Australia Victoria University Melbourne Australia Department of Psychology Victoria University Melbourne Australia School of Psychology Victoria University Melbourne Australia Philips-Universität Marburg Germany Philips-Universitaet-Marburg Marburg Germany Instituto de Investigaciones del Sueno Madrid Spain Universitätsklinik für Neurologie Innsbruck Austria Universitaetsklinik fuer Neurologie Innsbruck Austria IMEREM GmbH Nuernberg Germany Schwarz Pharma AG Monheim Germany

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Altered information transfer in neuronal networks marks pathology

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BMC Neuroscience 2010年第1期11卷 1-2页

作者： Samuel A Neymotin Heekyung Lee Eunhye Park Andre A Fenton William W Lytton SUNY Downstate/Polytechnic Joint Biomedical Engineering Program Brooklyn NY 11203 USA Neural and Behavioral Sciences Program SUNY Downstate USA Dept. Physiology & Pharmacology SUNY Downstate USA Center for Neural Science New York University New York NY 10003 USA Neurology SUNY Downstate USA Biomedical Engineering Brooklyn NY 11203 USA

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Three-dimensional optical tomographic brain imaging in small animals

Three-dimensional optical tomographic brain imaging in small...

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Biomedical Topical Meeting, BIOMED 2002

作者： Bluestone, A.Y. Abdoulaev, G.S. Lasker, J.M. Stewart, M. Hielscher, A.H. Depts. of Biomedical Engineering and Radiology Columbia University 530 West 120th Street MC 8904 New YorkNY11203 United States Dept. of Pathology and Program in Neural and Behavioral Science State University of New York - Downstate Medical Center 450 Clarkson Avenue BrooklynNY11203 United States

ISBN: (纸本)1557527024

We have developed a brain imaging system that uses continuous back-reflected light intensities to obtain spatially resolved, volumetric maps of oxy- and deoxy-hemoglobin in small animals. We report on numerical results as well as experimental studies performed on rats. The numerical study verified the ability to spatially localize changes in the optical properties. The preliminary experimental results focused on visualizing the three-dimensional hemodynamic changes in a rat brain in response to perturbations in the inspired CO2 concentration. © 2002 Optical Society of America.

关键词： Animals

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Volumetric vascular bain imaging in small animals with near-infrared optical tomography

Volumetric vascular bain imaging in small animals with near-...

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IEEE International Symposium on Biomedical Imaging, ISBI 2002

作者： Bluestone, A.Y. Stewart, M. Lasher, J. Abdoulaev, G. Hielscher, A.H. Depts. of Biomedical Engineering and Radiology Columbia University 500 West 120th Street MC 8904 New YorkNY10027 United States Dept. of Pathology Program in Neural and Behavioral Science State University of New York Downstate Medical Center 450 Ciarkson Avenue BrooklynNY11203 United States

ISBN: (纸本)078037584X

We performed three-dimensional optical tomographic brain imaging studies on small animals. Using near-infrared continuous light to probe rat brains, we were able to test our diffuse optical tomographic reconstruction algorithm. The preliminary experimental results focused on visualizing the hemodynamics in the rat head in response to perturbations in the inspired CO2 concentration. Good agreement with observed and known physiological phenomena was obtained. © 2002 IEEE.

关键词： Rats

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Volumetric imaging of hemodynamic effects in the human brain by three-dimensional diffuse optical tomography

Volumetric imaging of hemodynamic effects in the human brain...

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Biomedical Topical Meeting, BIOMED 2002

作者： Hielscher, A.H. Bluestone, A. Schmitz, C. Barbour, R.L. Abdoulaev, G. Dept. of Biomedical Engineering Columbia University 530 West 120th Street MC8904 New YorkNY10027 United States Dept. of Radiology College of Physicians and Surgeons Columbia University 622 West 168th Street New YorkNY10032 United States Dept. of Pathology Program in Neural and Behavioral Science State University of New York - Downstate Medical Center 450 Clarkson Avenue BrooklynNY11203 United States

We report on the first three dimensional tomographic localization of hemodynamic effects in the brain with diffuse optical tomography. Using a model-based iterative image reconstruction algorithms we localize spatial ... 详细信息

ISBN: (纸本)1557527024

关键词： Iterative methods

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Abstracts

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Canadian Journal of Anaesthesia 1992年第1期39卷 A3-A151页

作者： Saiah Michèle Borgeat Alain Wilder-Smith Oliver Orlando R. Hung Charles E. Hope Geoffrey Laney Sara C. Whynot Thomas J. Coonan David S. Malloy S. Patterson A. Gelb P. Manninen D. Strum B. Glosten M. J. Spellman E. I. Eger R. A. Craen A. W. Gelb J. M. Murkin K. Y. Chong D. H. Penning H. El-Behairy J. F. Brien J. W. Coh R. Arellano J. Correa L. Fedorko Z. Liu J. F. Boylan A. N. Sandler H. Nierenberg P. A. Sheiner P. D. Greig G. M. O’Leary S. J. Teasdale M. F. X. Glynn B. A. Orser L. -Y. Wang J. F. MacDonald C. W. Loomis K. D. Arunachalam D. Vyas B. Milne Daniel Gagnon Josée Lavoie Jean-Yves Dupuis D. R. Miller R. J. Martineau D. Greenway L. Olivaris K. Hull R. N. M. Tierney J. E. Wynands R. Martineau B. St-Jean J. Kitts D. Miller P. Lindsay M. Curran G. C. Allen M. L. Crossan Richard Wise François Donati David R. Bevan J. F. Hardy J. Desroches J. Perrault M. Carrier D. Robitaille D. M. Ansley J. P. O’Connor J. Dolman G. E. Townsend D. Ricci D. J. Liepert P. M. Browne T. Hertz M. Rooney R. W. Yip W. Code A. A. Phillips R. F. McLean J. H. Devitt E. M. Harrington R. J. Byrick P. Y. Wong D. Wigglesworth J. C. Kay L. A. Sinclair J. P. Koch K. A. Deemar G. K. Christakis S. Belo P. Angle D. Cheng J. Boylan A. Sandler C. Feindel F. Carmichael P. Boylen L. G. R. DeLima H. J. Nathan M. S. Hynes M. E. Bourke G. N. Russell C. Seyone F. Chung Daniel Chartrand Lucie Roux S. L. Dain B. D. Smith A. C. Webster D. F. Wigglesworth D. K. Rose G. Caskennette C. Mechetuk D. John Doyle Wilfred DeMajo Frank van den Bosch Mark Lee K. M. McClenaghan C. D. Mazer R. Preston E. T. Crosby D. Kotarba H. Dudas R. D. Elliott J. Enns P. H. Manninen J. K. Farrar David L. Huzyka L. Philip Lin Susan Fossey Brendan T. Finucane M. Stockwell S. Lozanoff S. Lang J. Hyssen D. C. Campbell M. J. Douglas T. J. G. Pavy M. L. Flanagan G. H. McMorland Colin Bands Ch. B. Ffaracs Catherine Lipsett David Drover Mark Stafford-Smith Sarah Stevens Kate Shields Michael J. MacSween J. D. McAllister P. K. Morley-Forster A. K. White M. D. Taylor H. M. Vandenberghe D. Knop Department of Anesthesiology University Hospital of Geneva Genève 4 Switzerland Departments of Anaesthesia and Neurosurgery Dalhousie University and Victoria General Hospital Halifax Departments of Anaesthesia and Medicine Dalhousie University Halifax Department of Anaesthesia Victoria General Hospital Dalhousie University Halifax Department of Anaesthesia Dalhousie University and Victoria General Hospital Halifax Department of Anaesthesia University Hospital London Departments of Anesthesia at U of Pittsburgh UC San Francisco U of Chicago USA Departments of Physiology and Anaesthesia The University of Western Ontario and The John. P. Roberts Research Institute London Department of Anaesthesia and Program in Critical Care University Hospital London Department of Anaesthesia/Critical Care University Hospital University of Western Ontario London Department of Anaesthesia Queen’s University Kingston Canada Department of Pharmacology & Toxicology Queen’s University Kingston Canada Department of Anaesthesia University of Toronto Toronto Departments of Anaesthesia Surgery and Haematology The Toronto Hospital Toronto The Acute Pain Research Unit Department of Anaesthesia and The Department of Psychology The Toronto Hospital (General Division) Toronto Departments of Anaesthesia and Psychology Toronto General Division The Toronto Hospital University of Toronto Toronto Departments of Anaesthesia and Behavioral Science University of Toronto Toronto The Toronto Hospital General Division University of Toronto Toronto Dept. Anaesthesia Sunnybrook Health Science Center Canada Dept. Physiology University of Toronto Toronto School of Pharmacy Memorial University of Newfoundland St. John’s Department of Anaesthesia Faculty of Medicine The University of British Columbia & Grace Hospital Vancouver Centre Hospitalier Universitaire de Sherbrooke N. Fleurimont Department of Anesthesia University of Ottawa Heart Institute Ottawa Civic Hospital Ottawa Department of Anaesthesia

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Erratum

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Canadian Journal of Anaesthesia 1992年第7期39卷 749-749页

作者： Michèle, Saiah Alain, Borgeat Oliver, Wilder-Smith Hung, Orlando R. Hope, Charles E. Laney, Geoffrey Whynot, Sara C. Coonan, Thomas J. Malloy, David S. Patterson, S. Gelb, A. Manninen, P. Strum, D. Glosten, B. Spellman, M. J. Eger, E. I. Craen, R. A. Gelb, A. W. Murkin, J. M. Chong, K. Y. Penning, D. H. El-Behairy, H. Brien, J. F. Coh, J. W. Arellano, R. Correa, J. Fedorko, L. Liu, Z. Boylan, J. F. Sandler, A. N. Nierenberg, H. Sheiner, P. A. Greig, P. D. O’Leary, G. M. Teasdale, S. J. Glynn, M. F. X. Orser, B. A. Wang, L. -Y. MacDonald, J. F. Loomis, C. W. Arunachalam, K. D. Vyas, D. Milne, B. Gagnon, Daniel Lavoie, Josée Dupuis, Jean-Yves Miller, D. R. Martineau, R. J. Greenway, D. Olivaris, L. Hull, K. Tierney, R. N. M. Wynands, J. E. Martineau, R. St-Jean, B. Kitts, J. Miller, D. Lindsay, P. Curran, M. Allen, G. C. Crossan, M. L. Wise, Richard Donati, François Bevan, David R. Hardy, J. F. Desroches, J. Perrault, J. Carrier, M. Robitaille, D. Ansley, D. M. O’Connor, J. P. Dolman, J. Townsend, G. E. Ricci, D. Liepert, D. J. Browne, P. M. Hertz, T. Rooney, M. Yip, R. W. Code, W. Phillips, A. A. McLean, R. F. Devitt, J. H. Harrington, E. M. Byrick, R. J. Wong, P. Y. Wigglesworth, D. Kay, J. C. Sinclair, L. A. Koch, J. P. Deemar, K. A. Christakis, G. K. Belo, S. Angle, P. Cheng, D. Boylan, J. Sandler, A. Feindel, C. Carmichael, F. Boylen, P. DeLima, L. G. R. Nathan, H. J. Hynes, M. S. Bourke, M. E. Russell, G. N. Seyone, C. Chung, F. Chartrand, Daniel Roux, Lucie Dain, S. L. Smith, B. D. Webster, A. C. Wigglesworth, D. F. Rose, D. K. Caskennette, G. Mechetuk, C. Doyle, D. John DeMajo, Wilfred van den Bosch, Frank Lee, Mark McClenaghan, K. M. Mazer, C. D. Preston, R. Crosby, E. T. Kotarba, D. Dudas, H. Elliott, R. D. Enns, J. Manninen, P. H. Farrar, J. K. Huzyka, David L. Lin, L. Philip Fossey, Susan Finucane, Brendan T. Stockwell, M. Lozanoff, S. Lang, S. Hyssen, J. Campbell, D. C. Douglas, M. J. Pavy, T. J. G. Flanagan, M. L. McMorland, G. H. Bands, Colin Ffaracs, Ch. B. Lipsett, Catherine Drover, David Stafford- Department of Anesthesiology University Hospital of Geneva Genève 4 Switzerland Departments of Anaesthesia and Neurosurgery Dalhousie University and Victoria General Hospital Halifax Departments of Anaesthesia and Medicine Dalhousie University Halifax Department of Anaesthesia Victoria General Hospital Dalhousie University Halifax Department of Anaesthesia Dalhousie University and Victoria General Hospital Halifax Department of Anaesthesia University Hospital London Departments of Anesthesia at U of Pittsburgh UC San Francisco U of Chicago USA Departments of Physiology and Anaesthesia The University of Western Ontario and The John. P. Roberts Research Institute London Department of Anaesthesia and Program in Critical Care University Hospital London Department of Anaesthesia/Critical Care University Hospital University of Western Ontario London Department of Anaesthesia Queen’s University Kingston Canada Department of Pharmacology & Toxicology Queen’s University Kingston Canada Department of Anaesthesia University of Toronto Toronto Departments of Anaesthesia Surgery and Haematology The Toronto Hospital Toronto The Acute Pain Research Unit Department of Anaesthesia and The Department of Psychology The Toronto Hospital (General Division) Toronto Departments of Anaesthesia and Psychology Toronto General Division The Toronto Hospital University of Toronto Toronto Departments of Anaesthesia and Behavioral Science University of Toronto Toronto The Toronto Hospital General Division University of Toronto Toronto Dept. Anaesthesia Sunnybrook Health Science Center Canada Dept. Physiology University of Toronto Toronto School of Pharmacy Memorial University of Newfoundland St. John’s Department of Anaesthesia Faculty of Medicine The University of British Columbia & Grace Hospital Vancouver Centre Hospitalier Universitaire de Sherbrooke N. Fleurimont Department of Anesthesia University of Ottawa Heart Institute Ottawa Civic Hospital Ottawa Department of Anaesthesia

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