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Combination of curcumin or chitosan with photodynamic therapy as an effective alternative therapy for overcoming wound infection associated with multidrug-resistant Acinetobacter baumannii

Microbe (Netherlands)

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Microbe (Netherlands) 2025年 7卷

作者： Yonpiam, Manta Wannigama, Dhammika Leshan Shein, Aye Mya Sithu Liao, Tingting Hurst, Cameron Monk, Peter N. Amarasiri, Mohan Phattharapornjaroen, Phatthranit Ounjai, Puey Saethang, Thammakorn Badavath, Vishnu Nayak Luk-in, Sirirat Nilgate, Sumanee Rirerm, Ubolrat Srisakul, Sukrit Ngamwongsatit, Natharin Leelahavanichkul, Asada Ragupathi, Naveen Kumar Devanga Kanjanabuch, Talerngsak Narkban, Phurin Miyanaga, Kazuhiko Cui, Longzhu Boontaveeyuwat, Einapak Higgins, Paul G. Kicic, Anthony Hamamoto, Hiroshi Abe, Shuichi Hongsing, Parichart Chatsuwan, Tanittha Department of Microbiology Faculty of Medicine Chulalongkorn University King Chulalongkorn Memorial Hospital Thai Red Cross Society Bangkok Thailand Center of Excellence in Antimicrobial Resistance and Stewardship Research Faculty of Medicine Chulalongkorn University Bangkok Thailand Dual degree Medical Science program Faculty of Medicine Chulalongkorn University Bangkok 10330 Thailand Department of Infectious Diseases and Infection Control Yamagata Prefectural Central Hospital Yamagata Japan School of Medicine Faculty of Health and Medical Sciences The University of Western Australia Nedlands WA Australia Biofilms and Antimicrobial Resistance Consortium of ODA receiving countries The University of Sheffield Sheffield United Kingdom Pathogen Hunter's Research Team Department of Infectious Diseases and Infection Control Yamagata Prefectural Central Hospital Yamagata Japan Department of Infectious Diseases Faculty of Medicine Yamagata University Yamagata Japan Department of Clinical Epidemiology Faculty of Medicine Thammasat University Rangsit 10120 Thailand Department of Infection Immunity & Cardiovascular Disease University of Sheffield Medical School United Kingdom Department of Civil and Environmental Engineering Graduate School of Engineering Tohoku University Miyagi Japan Faculty of Health Science Technology Chulabhorn Royal Academy Bangkok 10210 Thailand HRH Princess Chulabhorn Disaster and Emergency Medicine Center Chulabhorn Royal Academy Bangkok 10210 Thailand Department of Biology Faculty of Science Mahidol University Bangkok Thailand Department of Computer Science Faculty of Science Kasetsart University Bangkok Thailand School of Pharmacy & Technology Management SVKM's Narsee Monjee Institute of Management Studies (NMIMS) Hyderabad 509301 India Department of Clinical Microbiology and Applied Technology Faculty of Medical Technology Mahidol University Bangkok Thailand Department of Clinical Sciences and Public Health Faculty of Veteri

The increasing prevalence of multidrug-resistant Acinetobacter baumannii as an opportunistic pathogen in wound infections raises significant concerns due to its antibiotic resistance and biofilm-mediated antibiotic tolerance. This underscores the urgent need to explore an alternative approach to effectively managing wound infections caused by MDR A. baumannii. In this study, combining subinhibitory concentrations of curcumin (25 µg/ml) or chitosan (156 µg/ml) with photodynamic therapy-PDT (10 J/cm²) resulted in a significant reduction of planktonic viabilities and biofilm biovolume of MDR A. baumannii clinical isolates in vitro. In murine A. baumannii-associated wound infection, a combination of curcumin (25 µg/ml) or chitosan (156 µg/ml) with PDT (10 J/cm²) resulted in complete bacterial eradication with wound healing at Day 15 of post-treatments with these combination therapies. Our study demonstrated that combining curcumin or chitosan with PDT at their subinhibitory concentrations represents a promising alternative strategy as localized therapy for effectively managing A. baumannii-associated wound infection. © 2025 The Authors

关键词： Acinetobacter baumannii Alternative therapy Biofilm eradication Chitosan Curcumin Multidrug-resistant (MDR) Photodynamic therapy (PDT) Wound infection

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Closure relations during the plateau emission of Swift GRBs and the fundamental plane

arXiv

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arXiv 2021年

作者： Dainotti, M.G. Lenart, Aleksander L. Fraija, N. Nagataki, S. Warren, D.C. De Simone, B. Srinivasaragavan, G. Mata, A. National Astronomical Observatory of Japan 2 Chome-21-1 Osawa Mitaka Tokyo181-8588 Japan Astronomical Observatory Jagiellonian University ul. Orla 171 Kraków31-501 Poland The Graduate University for Advanced Studies SOKENDAI Shonankokusaimura Hayama Miura District Kanagawa240-0193 Japan Space Science Institute 4765 Walnut St STE B BoulderCO80301 United States 2-1 Hirosawa Wako Saitama351-0198 Japan Program Wako Saitama351-0198 Japan Università degli Studi di Salerno Dipartimento di Fisica 'E. R. Caianiello' Salerno Via Giovanni Paolo II 132 Fisciano84084 Italy Cahill Center for Astrophysics California Institute of Technology 1200 E. California Blvd PasadenaCA91125 United States

The Neil Gehrels Swift observatory observe Gamma-Ray bursts (GRBs) plateaus in X-rays. We test the reliability of the closure relations through the fireball model when dealing with the GRB plateau emission. We analyze 455 X-ray lightcurves (LCs) collected by Swift from 2005 (January) until 2019 (August) for which the redshift is both known and unknown using the phenomenological Willingale 2007 model. Using these fits, we analyze the emission mechanisms and astrophysical environments of these GRBs through the closure relations within the time interval of the plateau emission. Finally, we test the 3D fundamental plane relation (Dainotti relation) which connects the prompt peak luminosity, the time at the end of the plateau (rest-frame), and the luminosity at that time, on the GRBs with redshift, concerning groups determined by the closure relations. This allows us to check if the intrinsic scatter σintof any of these groups is reduced compared to previous literature. The most fulfilled environments for the electron spectral distribution, p>2, are Wind Slow Cooling (SC) and ISM Slow Cooling for cases in which the parameter q, which indicates the flatness of the plateau emission and accounts for the energy injection, is =0 and =0.5, respectively, both in the cases with known and unknown redshifts. We also find that for the sGRBs All ISM Environments with q=0 have the smallest σint=0.04 ± 0.15 in terms of the fundamental plane relation holding a probability of occurring by chance of p=0.005. We have shown that the majority of GRBs presenting the plateau emission fulfil the closure relations, including the energy injection, with a particular preference for the Wind SC environment. The subsample of GRBs that fulfil given relations can be used as possible standard candles and can suggest a way to reduce the intrinsic scatter of these studied relationships. Copyright © 2021, The Authors. All rights reserved.

关键词： Stars

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Key issues for stakeholder engagement in the development of health and healthcare guidelines

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Research Involvement and Engagement 2023年第1期9卷 27页

作者： Petkovic, Jennifer Magwood, Olivia Lytvyn, Lyubov Khabsa, Joanne Concannon, Thomas W. Welch, Vivian Todhunter-Brown, Alex Palm, Marisha E. Akl, Elie A. Mbuagbaw, Lawrence Arayssi, Thurayya Avey, Marc T. Marusic, Ana Morley, Richard Saginur, Michael Slingers, Nevilene Texeira, Ligia Ben Brahem, Asma Bhaumik, Soumyadeep Bou Akl, Imad Crowe, Sally Dormer, Laura Ekanem, Comfort Lang, Eddy Kianzad, Behrang Kuchenmüller, Tanja Moja, Lorenzo Pottie, Kevin Schünemann, Holger Tugwell, Peter Bruyère Research Institute Ottawa Canada Faculty of Medicine University of Ottawa Ottawa Canada Interdisciplinary School of Health Sciences University of Ottawa Ottawa Canada McMaster University Hamilton Canada Clinical Research Institute American University of Beirut Medical Center Beirut Lebanon The RAND Corporation and Tufts University School of Medicine Boston MA United States School of Epidemiology and Public Health University of Ottawa Ottawa Canada Nursing Midwifery and Allied Health Professions (NMAHP) Research Unit Glasgow Caledonian University Glasgow United Kingdom Tufts Medical Center Tufts Clinical and Translational Science Institute Boston MA United States Tufts Medical Center Institute for Clinical Research and Health Policy Studies Boston MA United States Department of Internal Medicine American University of Beirut Beirut Lebanon Department of Health Research Methods Evidence and Impact (HEI) McMaster University Hamilton ON Canada Department of Health Research Methods Evidence and Impact McMaster University Hamilton ON Canada Department of Anesthesia McMaster University Hamilton ON Canada Department of Pediatrics McMaster University Hamilton ON Canada Biostatistics Unit Father Sean O’Sullivan Research Centre St Joseph’s Healthcare Hamilton ON Canada Centre for Development of Best Practices in Health (CDBPH) Yaoundé Central Hospital Yaoundé Cameroon Division of Epidemiology and Biostatistics Department of Global Health Stellenbosch University Cape Town South Africa Weill Cornell Medicine –Qatar Doha Qatar Ministry of Health Cross River State Calabar Nigeria Cumming School of Medicine University of Calgary Alberta Health Services Calgary Zone Canada Canadian Council on Animal Care Ottawa Canada Department of Research in Biomedicine and Health Center for Evidence-Based Medicine University of Split School of Medicine Split Croatia Cochrane St Albans House Haymarket London 57-59 United Kingdom Hôpital Montfort Ottawa

Established in 2015, the Multi-Stakeholder Engagement (MuSE) Consortium is an international network of over 120 individuals interested in stakeholder engagement in research and guidelines. The MuSE group is developing guidance for stakeholder engagement in the development of health and healthcare guideline development. The development of this guidance has included multiple meetings with stakeholders, including patients, payers/purchasers of health services, peer review editors, policymakers, program managers, providers, principal investigators, product makers, the public, and purchasers of health services and has identified a number of key issues. These include: (1) Definitions, roles, and settings (2) Stakeholder identification and selection (3) Levels of engagement, (4) Evaluation of engagement, (5) Documentation and transparency, and (6) Conflict of interest management. In this paper, we discuss these issues and our plan to develop guidance to facilitate stakeholder engagement in all stages of the development of health and healthcare guideline development. © 2023, The Author(s).

关键词： Guideline development Patient and public involvement Stakeholder engagement

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JCMT 850 µm continuum observations of density structures in the G35 molecular complex

arXiv

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arXiv 2024年

作者： Shen, Xianjin Liu, Hong-Li Ren, Zhiyuan Tej, Anandmayee Li, Di Liu, Hauyu Baobab Fuller, Gary A. Xie, Jinjin Jiao, Sihan Yang, Aiyuan Koch, Patrick M. Xu, Fengwei Sanhueza, Patricio Diep, Pham Ngoc Peretto, Nicolas Yadav, Ram K. Kramer, Busaba H. Sugiyama, Koichiro Rawlings, Mark G. Lee, Chang Won Tatematsu, Kenichi Harsono, Daniel Eden, David Kwon, Woojin Tsai, Chao-Wei White, Glenn J. Kim, Kee-Tae Liu, Tie Wang, Ke Zhang, Siju Jiao, Wenyu Yang, Dongting Swagat, R. Das Wu, Jingwen Wang, Chen School of Physics and Astronomy Yunnan University Kunming650091 China National Astronomical Observatories Chinese Academy of Sciences Datun Road A20 Beijing China CAS Key Laboratory of FAST NAOC Chinese Academy of Sciences Beijing China University of Chinese Academy of Sciences Beijing China Indian Institute of Space Science and Technology Kerala Thiruvananthapuram695 547 India University of KwaZulu-Natal Durban4000 South Africa Department of Physics National Sun Yat-Sen University No. 70 Lien-Hai Road Kaohsiung City80424 Taiwan Center of Astronomy and Gravitation National Taiwan Normal University Taipei116 Taiwan Jodrell Bank Centre for Astrophysics School of Physics and Astronomy University of Manchester Oxford Road ManchesterM13 9PL United Kingdom Physikalisches Institut University of Cologne Zülpicher Str. 77 KölnD-50937 Germany Key Laboratory of Radio Astronomy and Technology Chinese Academy of Sciences A20 Datun Road Datun Road A20 Beijing China Max-Plank-Institut für Radioastronomie Auf dem Hügel 69 BonnD-53121 Germany Academia Sinica Institute of Astronomy and Astrophysics No. 1 Sec. 4 Roosevelt Road Taipei10617 Taiwan Kavli Institute for Astronomy and Astrophysics Peking University 5 Yiheyuan Road Haidian District Beijing100871 China Department of Astronomy School of Physics Peking University Beijing100871 China National Astronomical Observatory of Japan National Institutes of Natural Sciences 2-21-1 Osawa Mitaka Tokyo181-8588 Japan Astronomical Science Program The Graduate University for Advanced Studies SOKENDAI 2-21-1 Osawa Mitaka Tokyo181-8588 Japan Vietnam National Space Center Vietnam Academy of Science and Technology 18 Hoang Quoc Viet Hanoi Viet Nam Cardiff Hub for Astrophysics Research & Technology School of Physics & Astronomy Cardiff University Queens Buildings The Parade CardiffCF24 3AA United Kingdom Sirindhorn AstroPark 260 Moo 4 T. Donkaew A. Maerim Chiangmai50180 Thailand Gemini Observato

Filaments are believed to play a key role in high-mass star formation. We present a systematic study of the filaments and their hosting clumps in the G35 molecular complex using JCMT SCUBA-2 850 µm continuum data. We identified five clouds in the complex and 91 filaments within them, some of which form 10 hub-filament systems (HFSs), each with at least 3 hub-composing filaments. We also compiled a catalogue of 350 dense clumps, 183 of which are associated with the filaments. We investigated the physical properties of the filaments and clumps, such as mass, density, and size, and their relation to star formation. We find that the global mass-length trend of the filaments is consistent with a turbulent origin, while the hub-composing filaments of high line masses (ml > 230 M☉ pc−1) in HFSs deviate from this relation, possibly due to feedback from massive star formation. We also find that the most massive and densest clumps (R > 0.2 pc, M > 35 M☉, Σ > 0.05 g cm−2) are located in the filaments and in the hubs of HFS with the latter bearing a higher probability of occurrence of high-mass star-forming signatures, highlighting the preferential sites of HFSs for high-mass star formation. We do not find significant variation in the clump mass surface density across different evolutionary environments of the clouds, which may reflect the balance between mass accretion and stellar feedback. Copyright © 2024, The Authors. All rights reserved.

关键词： Giant stars

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A Fourth Planet in the Kepler-51 System Revealed by Transit Timing Variations

arXiv

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arXiv 2024年

作者： Masuda, Kento Libby-Roberts, Jessica E. Livingston, John H. Stevenson, Kevin B. Gao, Peter Vissapragada, Shreyas Fu, Guangwei Han, Te Greklek-McKeon, Michael Mahadevan, Suvrath Agol, Eric Bello-Arufe, Aaron Berta-Thompson, Zachory Cañas, Caleb I. Chachan, Yayaati Hebb, Leslie Hu, Renyu Kawashima, Yui Knutson, Heather A. Morley, Caroline V. Murray, Catriona A. Ohno, Kazumasa Tokadjian, Armen Zhang, Xi Welbanks, Luis Nixon, Matthew C. Freedman, Richard Narita, Norio Fukui, Akihiko de Leon, Jerome P. Mori, Mayuko Palle, Enric Murgas, Felipe Parviainen, Hannu Esparza-Borges, Emma Jontof-Hutter, Daniel Collins, Karen A. Benni, Paul Barkaoui, Khalid Pozuelos, Francisco J. Gillon, Michaël Jehin, Emmanuël Benkhaldoun, Zouhair Hawley, Suzanne Lin, Andrea S.J. Stefánsson, Guðmundur Bieryla, Allyson Yilmaz, Mesut Senavci, Hakan Volkan Girardin, Eric Marino, Giuseppe Wang, Gavin Department of Earth and Space Science Osaka University Osaka560-0043 Japan Department of Astronomy & Astrophysics 525 Davey Laboratory The Pennsylvania State University University ParkPA16802 United States Center for Exoplanets and Habitable Worlds 525 Davey Laboratory The Pennsylvania State University University ParkPA16802 United States Astrobiology Center 2-21-1 Osawa Mitaka Tokyo181-8588 Japan National Astronomical Observatory of Japan 2-21-1 Osawa Mitaka Tokyo181-8588 Japan Astronomical Science Program Graduate University for Advanced Studies SOKENDAI 2-21-1 Osawa Mitaka Tokyo181-8588 Japan JHU Applied Physics Laboratory 11100 Johns Hopkins Rd LaurelMD20723 United States Carnegie Science Earth and Planets Laboratory 5241 Broad Branch Road NW WashingtonDC20015 United States Carnegie Science Observatories 813 Santa Barbara Street PasadenaCA91101 United States Department of Physics and Astronomy Johns Hopkins University BaltimoreMD United States Department of Physics & Astronomy The University of California Irvine IrvineCA92697 United States Division of Geological and Planetary Sciences California Institute of Technology PasadenaCA91125 United States Department of Astronomy University of Washington SeattleWA98195 United States Jet Propulsion Laboratory California Institute of Technology PasadenaCA91011 United States Department of Astrophysical and Planetary Sciences University of Colorado Boulder BoulderCO80309 United States NASA Goddard Space Flight Center 8800 Greenbelt Road GreenbeltMD20771 United States Department of Physics Trottier Space Institute McGill University 3600 rue University MontréalQCH3A 2T8 Canada Université de Montréal Quebec Canada Hobart and William Smith Colleges GenevaNY14456 United States Cornell University IthacaNY14853 United States Frontier Research Institute for Interdisciplinary Sciences Tohoku University 6-3 Aramaki aza Aoba Aoba-ku Sendai Miyagi980-8578 Japan Department o

Kepler-51 is a 1 Gyr-old Sun-like star hosting three transiting planets with radii ≈ 6–9 R and orbital periods ≈ 45–130 days. Transit timing variations (TTVs) measured with past Kepler and Hubble Space Telescope (HST) observations have been successfully modeled by considering gravitational interactions between the three transiting planets, yielding low masses and low mean densities ( 0.1 g/cm3) for all three planets. However, the transit time of the outermost transiting planet Kepler-51d recently measured by the James Webb Space Telescope (JWST) 10 years after the Kepler observations is significantly discrepant from the prediction made by the three-planet TTV model, which we confirmed with ground-based and follow-up HST observations. We show that the departure from the three-planet model is explained by including a fourth outer planet, Kepler-51e, in the TTV model. A wide range of masses ( MJup) and orbital periods ( 10 yr) are possible for Kepler-51e. Nevertheless, all the coplanar solutions found from our brute-force search imply masses 10 M for the inner transiting planets. Thus their densities remain low, though with larger uncertainties than previously estimated. Unlike other possible solutions, the one in which Kepler-51e is around the 2: 1 mean motion resonance with Kepler-51d implies low orbital eccentricities ( 0.05) and comparable masses (∼ 5 M) for all four planets, as is seen in other compact multi-planet systems. This work demonstrates the importance of long-term follow-up of TTV systems for probing longer period planets in a system. © 2024, CC BY.

关键词： Space telescopes

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Three short-period Earth-sized planets around M dwarfs discovered by TESS: TOI-5720 b, TOI-6008 b, and TOI-6086 b

arXiv

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arXiv 2024年

作者： Barkaoui, K. Schwarz, R.P. Narita, N. Mistry, P. Magliano, C. Hirano, T. Maity, M. Burgasser, A.J. Rackham, B.V. Murgas, F. Pozuelos, F.J. Stassun, K.G. Everett, M.E. Ciardi, D.R. Lamman, C. Pass, E.K. Bieryla, A. Aganze, C. Esparza-Borges, E. Collins, K.A. Covone, G. de Leon, J. Dévora-Pajares, M. de Wit, J. Fukuda, Izuru Fukui, A. Gerasimov, R. Gillon, M. Hayashi, Y. Howell, S.B. Ikoma, M. Ikuta, K. Jenkins, J.M. Karpoor, P.R. Kawai, Y. Kimura, T. Kotani, T. Latham, D.W. Mori, M. Pallé, E. Parviainen, H. Patel, Y.G. Ricker, G. Relles, H.M. Shporer, A. Seager, S. Softich, E. Srdoc, G. Tamura, M. Theissen, C.A. Twicken, J.D. Vanderspek, R. Watanabe, N. Watkins, C.N. Winn, J.N. Wohler, B. Astrobiology Research Unit Université de Liège Allée du 6 Août 19C LiègeB-4000 Belgium Department of Earth Atmospheric and Planetary Science Massachusetts Institute of Technology 77 Massachusetts Avenue CambridgeMA02139 United States Calle Vía Láctea s/n Tenerife La Laguna38200 Spain Center for Astrophysics Harvard & Smithsonian 60 Garden St CambridgeMA02138 United States Komaba Institute for Science The University of Tokyo 3-8-1 Komaba Meguro Tokyo153-8902 Japan Astrobiology Center 2-21-1 Osawa Mitaka Tokyo181-8588 Japan Department of Physics Sardar Vallabhbhai National Institute of Technology Gujarat Surat395007 India Dipartimento di Fisica "Ettore Pancini" Università di Napoli Federico II Napoli Italy INFN Sezione di Napoli Complesso Universitario di Monte S. Angelo Via Cintia Edificio 6 Napoli80126 Italy INAF - Osservatorio Astronomico di Capodimonte via Moiariello 16 Napoli80131 Italy National Astronomical Observatory 2-21-1 Osawa Mitaka-shi Tokyo181-8588 Japan Department of Physics Presidency University West Bengal Kolkata700073 India Department of Astronomy & Astrophysics University of California San Diego La Jolla CA92093 United States Department of Physics Kavli Institute for Astrophysics and Space Research Massachusetts Institute of Technology CambridgeMA02139 United States Tenerife La LagunaE-38206 Spain Glorieta de la Astronomía s/n Granada18008 Spain Department of Physics and Astronomy Vanderbilt University NashvilleTN37235 United States NSF’s National Optical-Infrared Astronomy Research Laboratory 950 N. Cherry Ave. TucsonAZ85719 United States NASA Exoplanet Science Institute-Caltech/IPAC PasadenaCA91125 United States Department of Physics Center for Astrophysics & Space Sciences University of California San Diego La Jolla CA92093 United States Department of Physics & Astronomy Stanford University StanfordCA94305 United States Department of Multi-Disciplinary Sciences Graduate School of Arts

One of the main goals of the NASA Transiting Exoplanet Survey Satellite (TESS) mission is the discovery of Earth-like planets around nearby M-dwarf stars. We present the discovery and validation of three new short-period Earth-sized planets orbiting nearby M dwarfs: TOI-5720 b, TOI-6008 b, and TOI-6086 b. We combined TESS data, ground-based multicolor light curves, ground-based optical and near-infrared spectroscopy, and Subaru/IRD radial velocity data to validate the planetary candidates and constrain the physical parameters of the systems. In addition, we used archival images, high-resolution imaging, and statistical validation techniques to support the planetary validation. TOI-5720 b is an Earth-sized planet with a radius of Rp = 1.09 ± 0.07 R☉. It orbits a nearby (36 pc) M2.5 host with an orbital period of P = 1.4344555 ± 0.0000036 days. It has an equilibrium temperature of Teq = 708 ± 19 K (assuming a null albedo) and an incident flux of S p = 41.7 ± 4.5 S☉. TOI-6008 b is a short-period planet of P = 0.8574347 ± 0.0000424 day. It has a radius of Rp = 1.03 ± 0.05 R☉, an equilibrium temperature of Teq = 707 ± 19 K, and an incident flux of S p = 41.5 ± 4.5 S☉. The host star (TOI-6008) is a nearby (23 pc) M5 with an effective temperature of Teff = 3075 ± 75 K. Based on the radial velocity measurements collected with Subaru/IRD, we set a 3σ upper limit of Mp ☉, thus ruling out a star or brown dwarf as the transiting companion. TOI-6086 b orbits its nearby (32 pc) M3 host star (Teff = 3200 ± 75 K) every 1.3888725 ± 0.0000827 days and has a radius of Rp = 1.18 ± 0.07 R☉, an equilibrium temperature of Teq = 634 ± 16 K, and an incident flux of S p = 26.8 ± 2.7 S☉. Additional high-precision radial velocity measurements are needed to derive the planetary masses and bulk densities and to search for additional planets in the systems. Moreover, short-period Earth-sized planets orbiting around nearby M dwarfs are suitable targets for an atmospheric characterization with the

关键词： Stars

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Direct Imaging Discovery and Dynamical Mass of a Substellar Companion Orbiting an Accelerating Hyades Sun-like Star with SCExAO/CHARIS

arXiv

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arXiv 2022年

作者： Kuzuhara, Masayuki Currie, Thayne Takarada, Takuya Brandt, Timothy D. Sato, Bun'ei Uyama, Taichi Janson, Markus Chilcote, Jeffrey Tobin, Taylor Lawson, Kellen Hori, Yasunori Guyon, Olivier Groff, Tyler D. Lozi, Julien Vievard, Sebastien Sahoo, Ananya Deo, Vincent Jovanovic, Nemanja Ahn, Kyohoon Martinache, Frantz Skaf, Nour Akiyama, Eiji Norris, Barnaby R. Bonnefoy, Mickaël Helminiak, Krzysztof G. Kudo, Tomoyuki McElwain, Michael W. Samland, Matthias Wagner, Kevin Wisniewski, John Knapp, Gillian R. Kwon, Jungmi Nishikawa, Jun Serabyn, Eugene Hayashi, Masahiko Tamura, Motohide Astrobiology Center of NINS 2-21-1 Osawa Mitaka Tokyo181-8588 Japan National Astronomical Observatory of Japan 2-21-2 Osawa Mitaka Tokyo181-8588 Japan Subaru Telescope National Astronomical Observatory of Japan 650 North A'ohōkū Place HiloHI96720 United States NASA-Ames Research Center Moffett Blvd. Moffett Field CA United States Eureka Scientific 2452 Delmer Street Suite 100 OaklandCA United States Department of Physics University of California Santa Barbara Santa BarbaraCA United States Department of Earth and Planetary Sciences School of Science Tokyo Institute of Technology 2-12-1 Ookayama Meguro-ku Tokyo152-8551 Japan Infrared Processing and Analysis Center California Institute of Technology PasadenaCA91125 United States Department of Astronomy Stockholm University Stockholm Sweden Department of Physics University of Notre Dame Notre DameIN United States Homer S Dodge Department of Physics and Astronomy University of Oklahoma NormanOK United States Department of Astronomical Science The Graduate University for Advanced Studies SOKENDAI 2-21-1 Osawa Mitaka Tokyo181-8588 Japan Steward Observatory The University of Arizona TucsonAZ85721 United States College of Optical Sciences University of Arizona TucsonAZ85721 United States NASA-Goddard Space Flight Center GreenbeltMD United States Department of Astronomy California Institute of Technology 1200 E. California Blvd. PasadenaCA91125 United States Université Côte d'Azur Observatoire de la Côte d'Azur CNRS Laboratoire Lagrange France LESIA Observatoire de Paris Univ. PSL CNRS Sorbonne Univ. Univ. de Paris 5 pl. Jules Janssen Meudon92195 France Division of Fundamental Education and Liberal Arts Department of Engineering Niigata Institute of Technology 1719 Fujihashi Niigata Kashiwazaki945-1195 Japan Sydney Institute for Astronomy School of Physics University of Sydney SydneyNSW Australia Institut de Planétologie et d'Astrophysique de Grenoble CNRS IPAG Franc

We present the direct-imaging discovery of a substellar companion in orbit around a Sun-like star member of the Hyades open cluster. So far, no other substellar companions have been unambiguously confirmed via direct imaging around main-sequence stars in Hyades. The star HIP 21152 is an accelerating star as identified by the astrometry from the Gaia and Hipparcos satellites. We have detected the companion, HIP 21152 B, in multi-epoch using the high-contrast imaging from SCExAO/CHARIS and Keck/NIRC2. We have also obtained the stellar radial-velocity data from the Okayama 188cm telescope. The CHARIS spectroscopy reveals that HIP 21152 B's spectrum is consistent with the L/T transition, best fit by an early T dwarf. Our orbit modeling determines the semi-major axis and the dynamical mass of HIP 21152 B to be (Equation presented) au and (Equation presented) MJup, respectively. The mass ratio of HIP 21152 B relative to its host is ≈2%, near the planet/brown dwarf boundary suggested from recent surveys. Mass estimates inferred from luminosity evolution models are slightly higher (33-42 MJup). With a dynamical mass and a well-constrained age due to the system's Hyades membership, HIP 21152 B will become a critical benchmark in understanding the formation, evolution, and atmosphere of a substellar object as a function of mass and age. Our discovery is yet another key proof-of-concept for using precision astrometry to select direct imaging targets. Copyright © 2022, The Authors. All rights reserved.

关键词： Stars

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"So what if ChatGPT wrote it?" Multidisciplinary perspectives on opportunities, challenges and implications of generative conversational AI for research, practice and policy

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International Journal of Information Management 2023年 71卷

作者： Dwivedi, Yogesh K. Kshetri, Nir Hughes, Laurie Slade, Emma Louise Jeyaraj, Anand Kar, Arpan Kumar Baabdullah, Abdullah M. Koohang, Alex Raghavan, Vishnupriya Ahuja, Manju Albanna, Hanaa Albashrawi, Mousa Ahmad Al-Busaidi, Adil S. Balakrishnan, Janarthanan Barlette, Yves Basu, Sriparna Bose, Indranil Brooks, Laurence Buhalis, Dimitrios Carter, Lemuria Chowdhury, Soumyadeb Crick, Tom Cunningham, Scott W. Davies, Gareth H. Davison, Robert M. Dé, Rahul Dennehy, Denis Duan, Yanqing Dubey, Rameshwar Dwivedi, Rohita Edwards, John S. Flavián, Carlos Gauld, Robin Grover, Varun Hu, Mei-Chih Janssen, Marijn Jones, Paul Junglas, Iris Khorana, Sangeeta Kraus, Sascha Larsen, Kai R. Latreille, Paul Laumer, Sven Malik, F. Tegwen Mardani, Abbas Mariani, Marcello Mithas, Sunil Mogaji, Emmanuel Nord, Jeretta Horn O'Connor, Siobhan Okumus, Fevzi Pagani, Margherita Pandey, Neeraj Papagiannidis, Savvas Pappas, Ilias O. Pathak, Nishith Pries-Heje, Jan Raman, Ramakrishnan Rana, Nripendra P. Rehm, Sven-Volker Ribeiro-Navarrete, Samuel Richter, Alexander Rowe, Frantz Sarker, Suprateek Stahl, Bernd Carsten Tiwari, Manoj Kumar van der Aalst, Wil Venkatesh, Viswanath Viglia, Giampaolo Wade, Michael Walton, Paul Wirtz, Jochen Wright, Ryan Digital Futures for Sustainable Business & Society Research Group School of Management Swansea University Bay Campus Fabian Bay Wales Swansea United Kingdom Maharashtra Pune India Bryan School of Business and Economics University of North Carolina at Greensboro United States University of Bristol Business School University of Bristol BS8 1SD United Kingdom Professor of Information Systems Raj Soin College of Business Wright State University 3640 Colonel Glenn Highway DaytonOH45435 United States School of Artificial Intelligence Indian Institute of Technology Delhi Hauz Khas New Delhi India Department of Management Studies Indian Institute of Technology Delhi Hauz Khas New Delhi India Department of Management Information Systems Faculty of Economics and Administration King Abdulaziz University Jeddah Saudi Arabia School of Computing Middle Georgia State University MaconGA United States Client Advisory and Transformation Stackroute NIIT Limited India Department of Information Systems Analytics and Operations College of Business University of Louisville United States Northumbria University London United Kingdom IRC-FDE KFUPM Saudi Arabia ISOM KFUPM Business School KFUPM Saudi Arabia Innovation and Technology Transfer Center Sultan Qaboos University Oman Department of Business Communication Sultan Qaboos University Oman Department of Management Studies National Institute of Technology Tiruchirappalli India Montpellier France FORE School of Management New Delhi India Indian Institute of Management Ahmedabad Vastrapur Ahmedabad380015 India Information School University of Sheffield United Kingdom Bournemouth University Business School Poole United Kingdom School of Information Systems and Technology Management University of New South Wales Sydney Australia Information Operations and Management Sciences Department TBS Business School 1 Place Alphonse Jourdain Toulouse31068 France Department of Education & Childhood Studies Swansea Univers

Transformative artificially intelligent tools, such as ChatGPT, designed to generate sophisticated text indistinguishable from that produced by a human, are applicable across a wide range of contexts. The technology presents opportunities as well as, often ethical and legal, challenges, and has the potential for both positive and negative impacts for organisations, society, and individuals. Offering multi-disciplinary insight into some of these, this article brings together 43 contributions from experts in fields such as computer science, marketing, information systems, education, policy, hospitality and tourism, management, publishing, and nursing. The contributors acknowledge ChatGPT's capabilities to enhance productivity and suggest that it is likely to offer significant gains in the banking, hospitality and tourism, and information technology industries, and enhance business activities, such as management and marketing. Nevertheless, they also consider its limitations, disruptions to practices, threats to privacy and security, and consequences of biases, misuse, and misinformation. However, opinion is split on whether ChatGPT's use should be restricted or legislated. Drawing on these contributions, the article identifies questions requiring further research across three thematic areas: knowledge, transparency, and ethics;digital transformation of organisations and societies;and teaching, learning, and scholarly research. The avenues for further research include: identifying skills, resources, and capabilities needed to handle generative AI;examining biases of generative AI attributable to training datasets and processes;exploring business and societal contexts best suited for generative AI implementation;determining optimal combinations of human and generative AI for various tasks;identifying ways to assess accuracy of text produced by generative AI;and uncovering the ethical and legal issues in using generative AI across different contexts. © 2023 The Authors

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ALMA Survey of Orion Planck Galactic Cold Clumps (ALMASOP): A Forming Quadruple System with Continuum "ribbons" and Intricate Outflows

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Astrophysical Journal Letters 2023年第1期952卷 L2-L2页

作者： Luo, Qiu-Yi Liu, Tie Lee, Aaron T. Offner, Stella S. R. Di Francesco, James Johnstone, Doug Juvela, Mika Goldsmith, Paul F. Qin, Sheng-Li Mai, Xiaofeng Liu, Xun-Chuan Sanhueza, Patricio Xu, Feng-Wei Tatematsu, Ken'Ichi Dutta, Somnath Chen, Huei-Ru Vivien Li, Shanghuo Yang, Aiyuan Liu, Sheng-Yuan Lee, Chin-Fei Hirano, Naomi Lee, Chang Won Sahu, Dipen Shang, Hsien Hsu, Shih-Ying Bronfman, Leonardo Kwon, Woojin Rawlings, M.G. Eden, David Lu, Xing Gu, Qi-Lao Ren, Zhiyuan Ward-Thompson, D. Shen, Zhi-Qiang Shanghai Astronomical Observatory Chinese Academy of Sciences 80 Nandan Road Shanghai 200030 China School of Astronomy and Space Sciences University of Chinese Academy of Sciences No. 19A Yuquan Road Beijing 100049 China Department of Physics and Astronomy Saint Mary's College of California 1928 Saint Mary's Road Moraga 94575 CA United States Department of Astronomy University of Texas Austin Austin 78712 TX United States NRC Herzberg Astronomy and Astrophysics 5071 West Saanich Road Victoria V9E 2E7 BC Canada Department of Physics and Astronomy University of Victoria 3800 Finnerty Road Elliot Building Victoria V8P 5C2 BC Canada Department of Physics University of Helsinki P.O. Box 64 FI-00014 Finland Jet Propulsion Laboratory California Institute of Technology Pasadena 91109 CA United States Department of Astronomy Yunnan University Kunming 650091 China National Astronomical Observatory of Japan National Institutes of Natural Sciences 2-21-1 Osawa Mitaka Tokyo 181-8588 Japan Department of Astronomical Science SOKENDAI (The Graduate University for Advanced Studies) 2-21-1 Osawa Mitaka Tokyo 181-8588 Japan Department of Astronomy School of Physics Peking University Beijing 100871 China Kavli Institute for Astronomy and Astrophysics Peking University Haidian District Beijing 100871 China Nobeyama Radio Observatory National Astronomical Observatory of Japan National Institutes of Natural Sciences Nobeyama Minamimaki Minamisaku Nagano 384-1305 Japan Astronomical Science Program Graduate Institute for Advanced Studies SOKENDAI 2-21-1 Osawa Mitaka Tokyo 181-8588 Japan Academia Sinica Institute of Astronomy and Astrophysics 11F of AS/NTU Astronomy-Mathematics Building No.1 Sec. 4 Roosevelt Rd Taipei 10617 Taiwan Institute of Astronomy Department of Physics National Tsing Hua University Hsinchu Taiwan Max Planck Institute for Astronomy Königstuhl 17 Heidelberg D-69117 Germany National Astronomical Observatories Chinese Acad

One of the most poorly understood aspects of low-mass star formation is how multiple-star systems are formed. Here we present the results of Atacama Large Millimeter/submillimeter Array (ALMA) Band 6 observations toward a forming quadruple protostellar system, G206.93-16.61E2, in the Orion B molecular cloud. ALMA 1.3 mm continuum emission reveals four compact objects, of which two are Class I young stellar objects and the other two are likely in prestellar phase. The 1.3 mm continuum emission also shows three asymmetric ribbon-like structures that are connected to the four objects, with lengths ranging from ∼500 to ∼2200 au. By comparing our data with magnetohydrodynamic simulations, we suggest that these ribbons trace accretion flows and also function as gas bridges connecting the member protostars. Additionally, ALMA CO J = 2-1 line emission reveals a complicated molecular outflow associated with G206.93-16.61E2, with arc-like structures suggestive of an outflow cavity viewed pole-on. © 2023. The Author(s). Published by the American Astronomical Society.

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Direct observational evidence of multi-epoch massive star formation in G24.47+0.49

arXiv

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arXiv 2024年

作者： Saha, Anindya Tej, Anandmayee Liu, Hong-Li Liu, Tie Garay, Guido Goldsmith, Paul F. Lee, Chang Won He, Jinhua Juvela, Mika Bronfman, Leonardo Baug, Tapas Vázquez-Semadeni, Enrique Sanhueza, Patricio Li, Shanghuo Chibueze, James O. Bhadari, N.K. Dewangan, Lokesh K. Das, Swagat Ranjan Xu, Feng-Wei Issac, Namitha Hwang, Jihye Tóth, L. Viktor Indian Institute of Space Science and Technology Kerala Thiruvananthapuram695 547 India Department of Astronomy Yunnan University Kunming650091 China Shanghai Astronomical Observatory Chinese Academy of Sciences 80 Nandan Road Shanghai200030 China Key Laboratory for Research in Galaxies and Cosmology Shanghai Astronomical Observatory Chinese Academy of Sciences 80 Nandan Road Shanghai200030 China Departamento de Astronomía Universidad de Chile Las Condes Santiago7550000 Chile Jet Propulsion Laboratory California Institute of Technology 4800 Oak Grove Drive PasadenaCA91109 United States 217 Gajeong-ro Yuseong-gu Daejeon34113 Korea Republic of Korea Astronomy and Space Science Institute 776 Daedeokdae-ro Yuseong-gu Daejeon34055 Korea Republic of Yunnan Observatories Chinese Academy of Sciences Phoenix Mountain East Suburb of Kunming Yunnan650216 China at Cerro Calán Camino El Observatorio #1515 Las Condes Santiago Chile Department of Physics University of Helsinki P.O. box 64 FI- 00014 Finland Satyendra Nath Bose National Centre for Basic Sciences Block-JD Sector-III Kolkata Salt Lake700 106 India Instituto de Radioastronomía y Astrofísica Universidad Nacional Autónoma de México Antigua Carretera a Pátzcuaro 8701 Ex-Hda. San José de la Huerta Michoacán Morelia58089 Mexico National Astronomical Observatory of Japan National Institutes of Natural Sciences 2-21-1 Osawa Mitaka Tokyo181-8588 Japan Astronomical Science Program The Graduate University for Advanced Studies SOKENDAI 2-21-1 Osawa Mitaka Tokyo181-8588 Japan Max Planck Institute for Astronomy Königstuhl 17 HeidelbergD-69117 Germany Department of Mathematical Sciences University of South Africa Cnr Christian de Wet Rd and Pioneer Avenue Florida Park Roodepoort1709 South Africa Department of Physics and Astronomy Faculty of Physical Sciences University of Nigeria Carver Building 1 University Road Nsukka410001 Nigeria Physical Research Laboratory Navrangpura Ahm

Using new continuum and molecular line data from the ALMA Three-millimeter Observations of Massive Star-forming Regions (ATOMS) survey and archival VLA, 4.86 GHz data, we present direct observational evidence of hierarchical triggering relating three epochs of massive star formation in a ring-like H II region, G24.47+0.49. We find from radio flux analysis that it is excited by a massive star(s) of spectral type O8.5V–O8V from the first epoch of star formation. The swept-up ionized ring structure shows evidence of secondary collapse, and within this ring a burst of massive star formation is observed in different evolutionary phases, which constitutes the second epoch. ATOMS spectral line (e.g., HCO+(1–0)) observations reveal an outer concentric molecular gas ring expanding at a velocity of ~ 9 km s−1, constituting the direct and unambiguous detection of an expanding molecular ring. It harbors twelve dense molecular cores with surface mass density greater than 0.05 g cm−2, a threshold typical of massive star formation. Half of them are found to be subvirial, and thus in gravitational collapse, making them third epoch of potential massive star-forming sites. Copyright © 2024, The Authors. All rights reserved.

关键词： Stars

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