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Human genome meeting 2016 : Houston, TX, USA. 28 February - 2 March 2016

Human genomics 2016年第1期10 Suppl 1卷 12页

作者： A. K. Srivastava Y. Wang R. Huang C. Skinner T. Thompson L. Pollard T. Wood F. Luo R. Stevenson R. Polimanti J. Gelernter X. Lin I. Y. Lim Y. Wu A. L. Teh L. Chen I. M. Aris S. E. Soh M. T. Tint J. L. MacIsaac F. Yap K. Kwek S. M. Saw M. S. Kobor M. J. Meaney K. M. Godfrey Y. S. Chong J. D. Holbrook Y. S. Lee P. D. Gluckman N. Karnani A. Kapoor D. Lee A. Chakravarti C. Maercker F. Graf M. Boutros G. Stamoulis F. Santoni P. Makrythanasis A. Letourneau M. Guipponi N. Panousis M. Garieri P. Ribaux E. Falconnet C. Borel S. E. Antonarakis S. Kumar J. Curran J. Blangero S. Chatterjee J. Akiyama D. Auer C. Berrios L. Pennacchio T. R. Donti G. Cappuccio M. Miller P. Atwal A. Kennedy A. Cardon C. Bacino L. Emrick J. Hertecant F. Baumer B. Porter M. Bainbridge P. Bonnen B. Graham R. Sutton Q. Sun S. Elsea Z. Hu P. Wang Y. Zhu J. Zhao M. Xiong David A. Bennett A. Hidalgo-Miranda S. Romero-Cordoba S. Rodriguez-Cuevas R. Rebollar-Vega E. Tagliabue M. Iorio E. D’Ippolito S. Baroni B. Kaczkowski Y. Tanaka H. Kawaji A. Sandelin R. Andersson M. Itoh T. Lassmann Y. Hayashizaki P. Carninci A. R. R. Forrest C. A. Semple E. A. Rosenthal B. Shirts L. Amendola C. Gallego M. Horike-Pyne A. Burt P. Robertson P. Beyers C. Nefcy D. Veenstra F. Hisama R. Bennett M. Dorschner D. Nickerson J. Smith K. Patterson D. Crosslin R. Nassir N. Zubair T. Harrison U. Peters G. Jarvik F. Menghi K. Inaki X. Woo P. Kumar K. Grzeda A. Malhotra H. Kim D. Ucar P. Shreckengast K. Karuturi J. Keck J. Chuang E. T. Liu B. Ji A. Tyler G. Ananda G. Carter H. Nikbakht M. Montagne M. Zeinieh A. Harutyunyan M. Mcconechy N. Jabado P. Lavigne J. Majewski J. B. Goldstein M. Overman G. Varadhachary R. Shroff R. Wolff M. Javle A. Futreal D. Fogelman L. Bravo W. Fajardo H. Gomez C. Castaneda C. Rolfo J. A. Pinto K. C. Akdemir L. Chin S. Patterson C. Statz S. Mockus S. N. Nikolaev X. I. Bonilla L. Parmentier B. King F. Bezrukov G. Kaya V. Zoete V. Seplyarskiy H. Sharpe T. McKee K. Popadin N. Basset-Seguin R. Ben Chaabene M. Andrianova C. Verdan K. Grosdemange O. Sumara M. E JCSRI Greenwood Genetic Center Greenwood USA School of Computing Clemson University Clemson USA Biochemical Genetics Laboratory Greenwood Genetic Center Greenwood USA Department Psychiatry Yale Sch Med and VA CT Healthcare Center West Haven USA Department Genetics Yale Sch Med and VA CT Healthcare Center West Haven USA Department Neurobiology Yale Sch Med and VA CT Healthcare Center West Haven USA Singapore Institute for Clinical Sciences Singapore Singapore National University of Singapore Singapore Singapore University of British Columbia Vancouver Canada KK Women’s and Children’s Hospital Singapore Singapore University of Southampton and University Hospital Southampton NHS Foundation Trust Southampton UK University of Auckland Auckland New Zealand McKusick-Nathans Institute of Genetic Medicine Johns Hopkins University School of Medicine Baltimore USA Esslingen University of Applied Sciences Esslingen Germany German Cancer Research Center Heidelberg Germany Department of Genetic Medicine and Development University of Geneva Medical School Geneva Switzerland Geneva University Hospitals-HUG Service of Genetic Medicine Geneva Switzerland GE3 Institute of Genetics and Genomics of Geneva University of Geneva Medical School Geneva Switzerland South Texas Diabetes and Obesity Institute School of Medicine University of Texas Rio-Grande Valley Edinburg USA South Texas Diabetes and Obesity Institute School of Medicine University of Texas Rio-Grande Valley Brownsville USA Institute of Genetic Medicine Johns Hopkins University Baltimore USA Genomics Division Lawrence Berkeley National Laboratory Berkeley USA Molecular and Human Genetics Baylor College of Medicine Houston USA Department of Translational Medical Sciences Federico II University Naples Italy Metabolon Inc Durham USA Section of Pediatric Neurology and Neuroscience Baylor College of Medicine Houston USA Tawam Hospital Abu Dhabi United Arab Emirates Stanford Medical School Stanford USA Sch

O1 The metabolomics approach to autism: identification of biomarkers for early detection of autism spectrum disorder A. K. Srivastava, Y. Wang, R. Huang, C. Skinner, T. Thompson, L. Pollard, T. Wood, F. Luo, R. Stevenson O2 Phenome-wide association study for smoking- and drinking-associated genes in 26,394 American women with African, Asian, European, and Hispanic descents R. Polimanti, J. Gelernter O3 Effects of prenatal environment, genotype and DNA methylation on birth weight and subsequent postnatal outcomes: findings from GUSTO, an Asian birth cohort X. Lin, I. Y. Lim, Y. Wu, A. L. Teh, L. Chen, I. M. Aris, S. E. Soh, M. T. Tint, J. L. MacIsaac, F. Yap, K. Kwek, S. M. Saw, M. S. Kobor, M. J. Meaney, K. M. Godfrey, Y. S. Chong, J. D. Holbrook, Y. S. Lee, P. D. Gluckman, N. Karnani, GUSTO study group O4 High-throughput identification of specific qt interval modulating enhancers at the SCN5A locus A. Kapoor, D. Lee, A. Chakravarti O5 Identification of extracellular matrix components inducing cancer cell migration in the supernatant of cultivated mesenchymal stem cells C. Maercker, F. Graf, M. Boutros O6 Single cell allele specific expression (ASE) IN T21 and common trisomies: a novel approach to understand DOWN syndrome and other aneuploidies G. Stamoulis, F. Santoni, P. Makrythanasis, A. Letourneau, M. Guipponi, N. Panousis, M. Garieri, P. Ribaux, E. Falconnet, C. Borel, S. E. Antonarakis O7 Role of microRNA in LCL to IPSC reprogramming S. Kumar, J. Curran, J. Blangero O8 Multiple enhancer variants disrupt gene regulatory network in Hirschsprung disease S. Chatterjee, A. Kapoor, J. Akiyama, D. Auer, C. Berrios, L. Pennacchio, A. Chakravarti O9 Metabolomic profiling for the diagnosis of neurometabolic disorders T. R. Donti, G. Cappuccio, M. Miller, P. Atwal, A. Kennedy, A. Cardon, C. Bacino, L. Emrick, J. Hertecant, F. Baumer, B. Porter, M. Bainbridge, P. Bonnen, B. Graham, R. Sutton, Q. Sun, S. Elsea O10 A novel causal methylation network approach to Alzheimer’s

关键词： Pulmonary Arterial Hypertension Oral Squamous Cell Carcinoma Deep Neural Network Autosomal Recessive Polycystic Kidney Disease Whole Genome Bisulfite Sequencing

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Proceedings of the 3rd IPLeiria's International Health Congress Abstracts

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BMC HEALTH SERVICES RESEARCH 2016年第3期16卷 111-242页

作者： [Anonymous] Health Sciences Research Unit: Nursing Collegue of College of Health Technology of Coimbra Coimbra Portugal Sisters Hospitallers of the Sacred Heart of Jesus Casa de Saúde Rainha Santa Isabel Coimbra Portugal Research Unit for Sport and Physical Activity Faculty of Sport Sciences and Physical Education University of Coimbra Coimbra Portugal Complementary Sciences- INESCC Coimbra Portugal CUF Hospitals Lisbon Portugal Breast Unit Champalimaud Clinical Center Lisbon Portugal Swiss Centre for Medical Simulation & Swiss Association of Simulation in Healthcare Basel Switzerland Basel University Hospital Basel Switzerland HELPO Association Cascais Portugal Centro de Linguística Universidade de Lisboa Lisboa Portugal Centro Superior de Estudios Universitarios La Salle Madrid Spain Universidade da Madeira Funchal Portugal Serviço de Saúde da Região Autónoma da Madeira E.P.E. Funchal Portugal Escola Superior de Enfermagem de Lisboa Lisboa Portugal Instituto Superior Miguel Torga Coimbra Portugal Centro de Investigação do Núcleo de Estudos e Intervenção Cognitivo Comportamental Universidade de Coimbra Coimbra Portugal Escola Superior de Saúde de Leiria & Unidade de Investigação em Saúde Instituto Politécnico de Leiria Leiria Portugal National School of Public Health & Centro de Investigação em Saúde Pública Universidade Nova de Lisboa Lisboa Portugal Agrarian Superior School Polytechnic Institute of Viseu Viseu Portugal Laboratory of Microbiology Department of Biological Sciences Faculty of Pharmacy University of Porto Porto Portugal Unit for Multidisciplinary Biomedical Research Institute of Biomedical Sciences Abel Salazar University of Porto Porto Portugal Agrupamento de Centros de Saúde (ACES) Baixo Mondego Figueira da Foz Portugal Universidade de Trás-os-Montes e Alto Douro Vila Real Portugal Centro de Salud La Paz Badajoz España Centro de Salud San Fernando Badajoz España Complejo Hospitalario Universitario de Badajoz Badajoz España Hospital Don Beni

S1 Health literacy and health education in adolescence Catarina Cardoso Tomás S2 The effect of a walking program on the quality of life and well-being of people with schizophrenia Emanuel Oliveira, D. Sousa, M. Uba-Chupel, G. Furtado, C. Rocha, A. Teixeira, P. Ferreira S3 Diagnosis and innovative treatments - the way to a better medical practice Celeste Alves S4 Simulation-based learning and how it is a high contribution Stefan Gisin S5 Formative research about acceptability, utilization and promotion of a home fortification programme with micronutrient powders (MNP) in the Autonomous Region of Príncipe, São Tomé and Príncipe Elisabete Catarino, Nelma Carvalho, Tiago Coucelo, Luís Bonfim, Carina Silva S6 Safety culture of the patient: a reflexion about the therapeutic approach on the patient with vocal pathology Débora Franco S7 About wine, fortune cookies and patient experience Jesús Alcoba González O1 The psychological impact on the emergency crews after the disaster event on February 20, 2010 Helena G. Jardim, Rita Silva O2 Musculoskeletal disorders in midwives Cristina L. Baixinho, Mª Helena Presado, Mª Fátima Marques, Mário E. Cardoso O3 Negative childhood experiences and fears of compassion: Implications for psychological difficulties in adolescence Marina Cunha, Joana Mendes, Ana Xavier, Ana Galhardo, Margarida Couto O4 Optimal age to give the first dose of measles vaccine in Portugal João G. Frade, Carla Nunes, João R. Mesquita, Maria S. Nascimento, Guilherme Gonçalves O5 Functional assessment of elderly in primary care Conceição Castro, Alice Mártires, Mª João Monteiro, Conceição Rainho O6 Smoking and coronary events in a population of Spanish health-care centre: An observational study Francisco P. Caballero, Fatima M. Monago, Jose T. Guerrero, Rocio M. Monago, Africa P. Trigo, Milagros L. Gutierrez, Gemma M. Milanés, Mercedes G. Reina, Ana G. Villanueva, Ana S. Piñero, Isabel R. Aliseda, Francisco B. Ramirez O7 Prevalence of musculoskeletal injuries in Por

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Poster abstracts

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Sleep and Biological Rhythms 2016年第1期5卷 A1-A189页

作者： J. Ferrie M. Shipley F. Cappuccio E. Brunner M. Miller M. Kumari M. Marmot A. Coenen J. L. Castillo F. Araya G. Bustamante L. Montecino C. Torres S. Oporto J. Gronli E. Fiske R. Murison B. Bjorvatn E. Sorensen R. Ursin C. M. Portas S. Rajaraman A. Gribok N. Wesensten T. Balkin J. Reifman N. Dursunoglu S. Ozkurt S. Baser O. Delen S. Sarikaya P. Sadler P. Mitchell D. Françon M. Decobert B. Herve A. Richard G. Griebel P. Avenet B. Scatton G. L. Fur D. Eckert A. Jordan A. Wellman S. Smith A. Malhotra D. White D. Bruck I. Thomas A. Kritikos W. Oertel K. Stiasny-Kolster D. Garcia-Borreguero W. Poewe B. Hoegl R. Kohnen E. Schollmayer J. Keffel C. Trenkwalder A. Valle S. Roizenblatt F. Fregni P. Boggio S. Tufik K. Ward L. Robertson L. Palmer P. Eastwood D. Hillman J. Lee S. Mukherjee V. de Padova G. Barbato G. Ficca I. Zilli P. Salzarulo M. Veldi T. Hion V. Vasar M. Kull L. Nowak J. Davis Y. Latzer O. Tzischinsky S. Crowley M. Carskadon M. Anca-Herschkovitsch D. Frey J. Ortega C. Wiseman C. Farley K. Wright A. Campbell A. Neill K. Spiegel R. Leproult E. Tasali N. Scherberg E. van Cauter A. T. Noradina N. A. Karim I. Norlinah A. A. Raymond R. Sahathevan B. Hamidon E. Werth R. Poryazova R. Khatami C. Bassetti R. G. Beran L. Ainley G. Holand J. Duncan H. Kinney B. Davis B. Hood S. Frey C. Schmidt M. Hofstetter P. Peigneux C. Cajochen W.-P. Hu J.-D. Li C. Zhang L. Boehmer J. Siegel Q.-Y. Zhou Y. Sagawa H. Kondo T. Takemura H. Kanayama Y. Kaneko M. Sato T. Kanbayashi Y. Hishikawa T. Shimizu A. Viola L. James L. Schlangen D.-J. Dijk R. Andretic Y.-C. Kim K.-A. Han F. Jones R. Greenspan L. Sanford L. Yang X. Tang K. Dieter E. Uta H. Sven M. Richard N. Oyane S. Pallesen F. Holsten Y. Inoue M. Fujita N. Emura K. Kuroda N. Uchimura A. Johnston J. Astbury G. Kennedy K. Hoedlmoser M. Schabus T. Pecherstorfer S. Moser G. Gruber P. Anderer W. Klimesch N. Naidoo M. Ferber A. Pack D. Neu O. Mairesse G. Hoffmann A. Dris L. Lambrecht P. Linkowski P. Verbanck O. Le Bon N. Matsuura M. Yamao N. Adachi R. Aritomi Y. Komada H. Tanaka S. Shirak University College London London UK University College London London USA Warwick Medical School London UK Warwick Medical School Coventry USA Radboud University Nijmegen Nijmegen Netherlands Department of Neurology University of Chile Santiago Chile Neurology Service Hospital del Salvador Santiago Chile Family Health Center Juan Pablo II Santiago Chile Department of Biomedicine Section on Physiology Univeristy of Bergen Bergen Norway Department of Public Health and Primary Health Care Univeristy of Bergen Bergen Norway Department of Public Health and Primary Health Care University of Bergen Bergen Norway Norwegian Competence Center for Sleep Disorders Haukeland University Hospital Bergen Norway Department of Child and Adolescent Psychiatry Haukeland University Hospital Univeristy of Bergen Bergen Norway Department of Biomedicine University of Bergen Bergen Norway US Army Medical Research and Materiel Command Fort Detrick Frederick USA Walter Reed Army Institute of Research Silver Spring USA Department of Behavioral Biology Walter Reed Army Institute of Research Silver Spring USA Faculty Department of Pulmonology Pamukkale University Medical Denizli Turkey University of Ballarat Ballarat Australia Sanofi-Aventis Recherche et Developpement Paris France Brigham and Women’s Hospital Harvard Medical School Boston USA The University of Queensland Adelaide Australia School of Psychology University of Queensland Brisbane Australia The University of Queensland Brisbane Australia Victoria University Melbourne Australia Department of Psychology Victoria University Melbourne Australia School of Psychology Victoria University Melbourne Australia Philips-Universität Marburg Germany Philips-Universitaet-Marburg Marburg Germany Instituto de Investigaciones del Sueno Madrid Spain Universitätsklinik für Neurologie Innsbruck Austria Universitaetsklinik fuer Neurologie Innsbruck Austria IMEREM GmbH Nuernberg Germany Schwarz Pharma AG Monheim Germany

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SU-E-J-140: Dual-Gated Radiotherapy with PTV Partition Technique: A Feasibility Study

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Medical Physics 2013年第6PART8期40卷 183-183页

作者： H Kim K Choi S Ye Interdisciplinary Program in Radiation Applied Life Science Seoul National University College of Medicine Seoul Korea Biomedical Research Institute Seoul National University Hospital Seoul Korea Institute of Radiation Medicine Seoul National University Medical Research Center Seoul Korea Program in Biomedical Radiation Sciences Department of Transdisciplinary Studies Graduate School of Convergence Science and Technology Seoul National University Suwon Korea Department of Radiation Oncology Seoul National University Hospital Seoul Korea

Purpose: Dual-gated radiotherapy is a promising method to reduce overall treatment time in which a dose is delivered at inhale and exhale phases. However, problems still remain associated with the phase shift and the target motion artifact. Dual-gated method deals with both phases — inhale and exhale, hence the delivered dose uncertainties due to the residual motion may be doubled. In order to account for these uncertainties, we applied PTV partition technique to dual-gated radiotherapy method. Methods: An IMRT plan for a lung cancer patient was optimized in Eclipse TPS at exhale phase. The PTV on the exhale CT was partitioned into three regions along the superior-inferior axis; head, mid, and tail region. The dose distribution on PTV was reformed as follows: a) no dose is given to the head region, b) a gradient dose (zero to the prescription dose) is given to the mid region, and c) a hundred percent of prescription dose is given to the tail region. The reformed exhale phase dose distribution and structures were deformed to the inhale phase CT using MIM software. Thereafter the dose distribution on PTV at inhale phase was reformed in order that complement of the prescription dose is given to each region. Results: The dose-volume histogram for PTV in the dual-gated plan with partitioned PTV was comparable to that in the conventional gating plan while the presented technique gives robustness to the residual motion. Conclusion: The proposed method using the PTV partition technique is promising to assess dose uncertainties due to the phase shift and the target motion artifact. Further assessment of the robustness to the residual motion by experiments using thorax phantom is warranted in this regard.

关键词： Dosimetry Radiation therapy Cancer Intensity modulated radiation therapy Lungs

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SU-E-J-99: Utilizing CT Dual DFOV in Treatment Planning System

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Medical Physics 2013年第6PART8期40卷 173-173页

作者： HyunSeok Lee Jung-in Kim Wonmo Sung Jong In Park Sung-Joon Ye Program in Biomedical Radiation Sciences Department of Transdisciplinary Studies Graduate School of Convergence Science and Technology Seoul National University Seoul Korea Biomedical Research Institute Seoul National University Hospital Seoul Korea Institute of Radiation Medicine Seoul National University Medical Research Center Seoul Korea Interdisciplinary Program in Radiation Applied Life Science Seoul National University College of Medicine Seoul Korea Department of Radiation Oncology Seoul National University Hospital Seoul Korea

Purpose: Typically, a Display Field of View (DFOV) parameter is set to accommodate the wide part of anatomy in the scan, which is the shoulder in head and neck (HN) cases. The dual DFOV can make use of two image resolutions in one CT set. However, the Eclipse™ treatment planning system (TPS) accepts only the larger DFOV when reconstructing the body volume and thus particularly reduces in-plane resolution of the head region. In this study, we developed a method to preserve the original resolution of head CT images. Methods: The anthromorphic phantom was scanned from head to shoulder using the GE LightSpeed RT16 CT by applying small and large DFOV to head and shoulder region, respectively. Our in-house software enables dual DFOV CT images to be entered into Eclipse™ TPS. Basically, the software converts the pixel size of head CT images from 512 × 512 to 1024 × 1024 by expanding the DFOV outside. Results: The original and processed CT sets were loaded by Eclipse™ TPS and the differences were analyzed. Processed CT images showed two times better resolution than original CT images in head region. Distinguishing target and OAR in processed CT images is also clearer than before. We also confirmed that the mean percentage difference of CT numbers before and after processing was negligible for total phantom volume of the head region except steep gradient region which CT number changes drastically. Conclusion: The advantage of dual DFOV images was fully taken in the Eclipse™ TPS. In treatment planning, defining target and organ at risk which is the most important part for accurate treatment can be improved using high resolution dual DFOV CT images.

关键词： Computed tomography Medical imaging Medical treatment planning Anatomy Germanium

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SU-D-105-05: Independent Evaluation of Respiratory-Gated Treatments Using In-House Quality Assurance Tool

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Medical Physics 2013年第6PART3期40卷 101-101页

作者： J Park Y Park J Lee H Kim Ye Interdisciplinary Program in Radiation Applied Life Science Seoul National University College of Medicine Seoul Korea Biomedical Research Institute Seoul National University Hospital Seoul Korea Institute of Radiation Medicine Seoul National University Medical Research Center Seoul Korea Department of Radiation Oncology Massachusetts General Hospital Boston MA Program in Biomedical Radiation Sciences Department of Transdisciplinary Studies Graduate School of Convergence Science and Technology Seoul National University Department of Radiation Oncology Seoul National University Hospital Seoul Korea

Purpose: To quantitatively evaluate the reproducibility of patient breathing between the calculated phase from respiratory signal and RPM (real-time position management system, Varian Medical Systems, Palo Alto, CA) within treatment. We developed an independent retrospective verification system (RVS) for gated-radiotherapy using full signal and gating window in RPM system. Methods: RVS was programmed by LabVIEW 2009 with wavelet-based multi-resolution analysis, which is a useful and accurate technique for identifying peaks and valleys of noisy signals. The respiratory signal and real-time calculated phase information from RPM was exported to RVS as a text file. Using this text file, several respiratory parameters were calculated by RVS, and were compared with the generated parameters from RPM. The evaluated parameters included phase-shift, total displacement, residual motion, baseline shift, and so forth. The analysis was conducted for both in-gate and full respiratory signal separately. The analysis report was automatically generated in Excel file format. Eleven patients of abdominal cancer were retrospectively analyzed for the evaluation. Results: The mean phase error of gated signal and full signal between RPM and our software ranged from 1.50% to 3.08% and 1.52% to 3.08%, respectively. Average phase shift was not significant but in-gate phase difference between RVS and RPM was found to be higher than 4% in two cases. At times, real-time phase calculation from RPM caused the beam to be turned on at incorrect time of the breathing cycle when the patient breathing was not regular. The total displacement varied from 0.672 cm to 1.732 cm, which showed patient-specific baseline shift during treatment. Conclusion: The developed software demonstrated competency in analyzing RPM signal and evaluating patient-specific respiratory parameters of radiotherapy. Thus, it can be used as an independent quality assurance tool for RPM phase-based gating treatment.

关键词： Quality assurance Computer software Radiation therapy Cancer Acoustic noise measurement

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ESICM LIVES 2016: part two

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Intensive Care Medicine Experimental 2016年第1期4卷 205-404页

作者： S. Sivakumar F. S. Taccone K. A. Desai C. Lazaridis M. Skarzynski M. Sekhon W. Henderson D. Griesdale L. Chapple A. Deane L. Williams R. Strickland K. Lange D. Heyland M. Chapman M. J. Rowland P. Garry J. Westbrook R. Corkill C. A. Antoniades K. T. Pattinson G. Fatania A. J. Strong R. B. Myers C. M. Jermaine C. S. Robertson C. G. Rusin J. Hofmeijer L. Sondag M. C. Tjepkema-Cloostermans A. Beishuizen F. H. Bosch M. J. A. M. van Putten L. Carteron C. Patet D. Solari M. Oddo M. A. Ali C. Dias R. Almeida A. Vaz-Ferreira J. Silva E. Monteiro A. Cerejo A. P. Rocha A. A. Elsayed A. M. Abougabal B. N. Beshey K. M. Alzahaby S. Pozzebon A. Blandino Ortiz S. Cristallini O. Lheureux A. Brasseur J. L. Vincent J. Creteur M. Hravnak K. Yousef Y. Chang E. Crago R. M. Friedlander S. A. Abdelmonem S. A. Tahon T. A. Helmy H. S. Meligy F. Puig I. Dunn-Siegrist J. Pugin S. Gupta D. Govil S. Srinivasan S. J. Patel J. K. N A. Gupta D. S. Tomar M. Shafi R. Harne D. P. Arora N. Talwar S. Mazumdar E. E. Papakrivou D. Makris E. Manoulakas B. Tsolaki B. Karadodas E. Zakynthinos I. Palacios Garcia A. Diaz Martin V. Sanchez Encinares M. Pachón Ibañez J. Garnacho Montero G. Labrador T. Cebrero Cangueiro V. Poulose J. Koh J. W. Kam H. Yeter A. Kara O. Aktepe A. Topeli I. Tsolakoglou G. Intas P. Stergiannis A. A. Kolaros E. Chalari E. Athanasiadou A. Martika G. Fildisis V. Faivre C. Mengelle B. Favier D. Payen A. Poppe M. S. Winkler E. Mudersbach J. Schreiber M. L. Wruck E. Schwedhelm S. Kluge C. Zöllner T. Tavladaki A. M. Spanaki H. Dimitriou E. Kondili C. Choulaki E. Meleti D. Kafetzopoulos D. Georgopoulos G. Briassoulis A. García-de la Torre M. V. de la Torre-Prados T. Tsvetanova-Spasova P. Nuevo-Ortega C. Rueda-Molina A. Fernández-Porcel E. Camara-Sola L. Salido-Díaz A. García-Alcántara D. E. Meleti B. Suberviola J. Riera L. Rellan M. Sanchez J. C. Robles E. Lopez R. Vicente E. Miñambres M. Santibañez M. Le Guen J. Moore N. Mason M. Windpassinger O. Plattner E. Mascha D. I. Sessler Outcomes Research U. Melia J. Fontanet J. P. van den Berg M. Baylor College of Medicine Neurology/Neurocritical Care Houston USA Erasmus Hospital Intensive Care Medicine Brussels Belgium Centre Hospitalier Régional Orléans Réaimation Médicale Orléans France University of British Columbia Vancouver Canada University of Adelaide Discipline of Acute Care Medicine Adelaide Australia Royal Adelaide Hospital Intensive Care Adelaide Australia Griffith University Menzies Health Institute of Queensland Gold Coast Australia University of Adelaide Discipline of Medicine Adelaide Australia Kingston General Hospital Clinical Evaluation Research Unit Kingston Canada University of Oxford Nuffield Department of Clinical Neurosciences Oxford UK Oxford University Hospitals NHS Foundation Trust Neurosciences Intensive Care Unit Oxford UK King’s College Hospital Department of Neurosurgery London UK King’ College London Institute of Psychiatry Psychology and Neuroscience Department of Clinical Neuroscience London UK Rice University Computer Science Houston USA Baylor College of Medicine Neurosurgery Houston USA Baylor College of Medicine Pediatric Cardiology Houston USA University of Twente Clinical Neurophysiology Enschede Netherlands Rijnstate Hospital Neurology Arnhem Netherlands Medical Spectrum Twente Clinical Neurophysiology Enschede Netherlands Medical Spectrum Twente Intensive Care Enschede Netherlands Rijnstate Hospital Intensive Care Arnhem Netherlands CHUV Department of Intensive Care Medicine Neuroscience Critical Care Research Group Lausanne Switzerland Aga Khan University Hospital Anaesthesiology Karachi Pakistan Centro Hospitalar São João Intensive Care Porto Portugal Faculty of Medicine University of Porto Medicine Porto Portugal Faculdade de Ciências Universidade do Porto Departamento de Matemática Porto Portugal Centro de Matemática Universidade do Porto Porto Portugal The Biomedical Research Networking Center in Bioengineering Biomaterials and Nanomedicine Zaragoza Spain Centro Hospitalar

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Water scarcity and drought in WANA countries

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Procedia Engineering 2012年 33卷 14-29页

作者： Jauad El Kharraz Alaa El-Sadek Noreddine Ghaffour Eric Mino Euro-Mediterranean Information System on know-how in the Water sector (EMWIS) BP 23 Sophia Antipolis 06901 France Water Resources Management Program College of Graduate Studies Arabian Gulf University Kingdom of Bahrain Water Desalination and Reuse Center King Abdullah University of Science and Technology (KAUST) KSA

Water Security was a central theme of WANA Forum 2010, where regional experts warned that the wars of the 21st century will be fought over water. Climate change will only exacerbate problems in a region already stressed by lack of water, food and political and social unrest. Across the Arc of Crisis, from Somalia, Sudan and Egypt in Africa to Yemen, Iraq, Pakistan, and Afghanistan in West Asia, water scarcity in the region has already lead to drought and famine, loss of livelihood, the spread of water-borne diseases, forced migrations and open conflict. Water scarcity is closely linked to food and health security, making better water management a key stepping stone for poverty reduction and economic growth. If nothing changes, most of the WANA countries will encounter, in less than a generation, serious problems in managing inland freshwater, the availability of which, in sufficient quantity and quality, may become, as it is already the case in several of these countries, a main challenge for economic and social development. Wastage and pollution will then be such that « water stress » will affect, in a way or another, most of the populations of WANA countries and the poorest first of all. The effects of global warming will increase current trends. On the other hand, water scarcity in the WANA region is an issue of growing concern. With heavy demand from agriculture, growing populations and virtually no remaining untapped water sources, the need to establish water-management strategies in the region is of vital importance. WANA countries can be divided into three major agro-ecologies, each facing slightly different challenges. Rain-fed areas are dependent on a low and extremely variable rainfall, resulting in minimal yields, a problem exacerbated by frequent drought. Rainfall occurs in the form of intense and unpredictable storms, and as a result, the crusting soils are unable to absorb the moisture, which rapidly becomes lost through evaporation or runoff. Irrigate

关键词： water scarcity drought WANA region water demand water supply climate change

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SU-E-J-98: Evaluating Commercial Orthopedic Metal Artifact Reduction Tool (OMAR) for CT Simulation in Radiotherapy for Head-And-Neck Cases

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Medical Physics 2013年第6PART8期40卷 173-173页

作者： H Kwon J Kim K Kim Y Chun J Park S Ye Interdisciplinary program in Radiation Applied Life Science Seoul National University College of Medicine Seoul Korea Biomedical Research Institute Seoul National University Hospital Seoul Korea Institute of Radiation Medicine Seoul National University Medical Research Center Seoul Korea Department of Radiation Oncology Seoul National University Hospital Seoul Korea Department of Radiation Oncology Seoul National University College of Medicine Seoul Korea Philips Healthcare Korea Seoul Korea Program in Biomedical Radiation Sciences Department of Transdisciplinary Studies Graduate School of Convergence Science and Technology Seoul National University Seoul Korea

Purpose: Many head-and-neck (H&N) patients have dental implants which can induce severe metal artifacts in CT images. This study assessed the performance and the effectiveness of the commercial orthopedic metal artifact reduction function (O-MAR) for radiotherapy of H&N patients. Methods: 20 H&N images scanned by Philips Brilliance Big Bore CT were used for the assessment. After O-MAR correction, the CT Hounsfield number and noise were measured and compared between the original and OMAR corrected images. Structures were contoured by a radiation oncologist on each of the two image sets. These contoured structure volumes on the original CT image were compared with those on O-MAR corrected CT image by radiation therapy planning system. After volumetric-modulated arc therapy (VMAT) planning was performed on the original CT image, this plan was translated and calculated on O-MAR corrected images. Each DVH was compared and the gamma passing rate was calculated for comparing dose distributions. Results: CT Hounsfield numbers became closer to the reference values after O-MAR correction. The standard deviations of the selected ROIs were reduced from 323.9 HU to 195.6 HU in air and from 43.5 HU to 24.7 HU in tissue. The volumes of contoured structure showed minute change. The difference between two DVH was less than 0.5%. The gamma pass rates of dose distributions calculated on the original and OMAR corrected images were higher than 99.9% in the case of closed-mouth-images but were about 80% in the case of opened-mouth-images when using 1mm and 1% distance-to-agreement criterion. Conclusion: The O-MAR algorithm is suitable for the entire radiation treatment planning process by increasing the accuracy of CT Hounsfield numbers and reducing noises. Although there was no significant difference in dose distribution for most cases, the O-MAR correction was shown to have an impact on opened-mouth-images.

关键词： Medical imaging Computed tomography Dosimetry Radiation therapy Medical image noise Tissues Medical image artifacts Radiation treatment Cancer

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0SU-E-T-326: Assessment of 2D / 3D Intra-Fractional Tumor Motion for Respiratory-Gated Radiotherapy

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Medical Physics 2013年第6PART15期40卷 279-279页

作者： J Lee Y Park K Choi S Ye Program in Biomedical Radiation Sciences Department of Transdisciplinary Studies Graduate School of Convergence Science and Technology Seoul National University Suwon Korea Biomedical Research Institute Seoul National University Hospital Seoul Korea Institute of Radiation Medicine Seoul National University Medical Research Center Seoul Korea Department of Radiation Oncology Massachusetts General Hospital Boston MA Department of Radiation Oncology Seoul National University Hospital Seoul Korea

Purpose: This study aims to develop and evaluate the effectiveness of full 3-dimensional motion platform in respiratory-gated radiotherapy (RGRT) quality assurance (QA). For this study, a motion platform had been developed to simulate the patient specific QA in RGRT. Commercial motion platforms have the limited freedom of movement : lateral-longitudinal or vertical movement for tumor motion, and vertical movement for the external marker motion. Addition to these, the developed platform has the freedom of full 3-dimensional movement: simultaneous lateral, longitudinal as well as vertical motion for tumor motion. Methods: 3-dimensional tumor motions of ten abdomen cancer patients treated RGRT with no-motion, 2-dimensional 0motion, and 3-dimensional motion were extracted in phase sorted 4D-CT images. After deformable registration based on contoured image in 50% respiratory phase, the center of voxel was defined as the tumor position to trace its motion. Varian RPM log files were used to trace external markers. 3-dimensional tumor motions were simulated using the developed motion platform. On its polycarbonate panel, a radio-chromic film attached on 10 cm solid water slabs was placed for the dose verification. 2-dimensional and 3-dimensional tumor motions were performed with gated beam delivery to compare their dosimetric differences. The gating window was 35-65%. Gamma-index method was adopted to compare dose distributions of the measurement using radio-chromic film with those of treatment planning system. Results: The average gamma pass rates (2%/2 mm) were 96.11%, 89.69%, and 88.86% for static-continuous, 2D-gated, and 3D-gated, respectively. Excepting one case, static-continuous showed results over 94%. Some of 3D-gated resulted in pass rates larger than those of 2D-gated. Conclusion: 3-dimensional tumor motions showed lower gamma pass rates than those of 2-dimensional tumor motions during treatment. These imply the requirement of tools that provide the 3-dimensiona

关键词： Cancer Dosimetry Radiation therapy Medical imaging Therapeutics Medical treatment planning Quality assurance

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