In this paper we present the fundamental concept, as well as, the objectives and the architecture of HarmonicSS EU project. The proposed architecture envisages to address (i) the lack of patient stratification in larg...
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This paper presents the first deep reinforcement learning (DRL) framework to estimate the optimal Dynamic Treatment Regimes from observational medical data. This framework is more flexible and adaptive for high dimens...
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Automatic clinical diagnosis of retinal diseases has emerged as a promising approach to facilitate discovery in areas with limited access to specialists. Based on the fact that fundus structure and vascular disorders ...
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Diffuse intrinsic pontine glioma (DIPG) is a poor-prognosis pediatric brain tumor with a median survival of less than one year. No effective therapy is currently available, and no therapeutic advances have been made i...
Diffuse intrinsic pontine glioma (DIPG) is a poor-prognosis pediatric brain tumor with a median survival of less than one year. No effective therapy is currently available, and no therapeutic advances have been made in several decades. BMI-1 is a member of the multimeric protein complex Polycomb repressor complex 1 (PRC1). It has been implicated in self-renewal of normal and cancer cells, and in DNA damage signaling. We have previously identified BMI-1 as a potential therapeutic target in DIPG and have shown that BMI-1 is highly expressed in DIPG tumors regardless of histone 3 subtype. In the present study, we show that the modulation of BMI-1 leads to DNA damage, M phase cell cycle arrest, chromosome abnormalities and cell death. Furthermore, modulation of BMI-1 sensitizes DIPG patient-derived stem-like cells to ionizing radiation (IR). Treatment of DIPG stem-like cells with PTC596, a BMI-1 modulator, and IR, impairs the kinetics of DNA damage response (DDR). Both DDR foci formation and resolution were delayed, resulting in further reduction in cell viability compared with either treatment alone.
In vivo
, treatment of mice bearing DIPG xenografts with PTC596 leads to decreased tumor volume and growth kinetics, increased in-tumor apoptosis and sustained animal survival benefit. Gene expression analysis indicates that
BMI-1
expression correlates positively with DIPG stemness and BMI-1 signature. Together our findings indicate that BMI-1 modulation is associated with mitotic abnormalities, impaired DDR and cell death, supporting the combination of BMI-1 modulation and radiation as a promising novel therapy to treat children with DIPG.
Helicity indicates the in-plane magnetic-moment swirling direction of a skyrmionic configuration. The ability to reverse the helicity of a skyrmionic bubble via purely electrical means has been predicted in frustrated...
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In this letter, we propose an acoustic distance rendering (ADR) algorithm that can efficiently create the proximity effect in virtual reality (VR) systems. By observing the variation of acoustic cues caused by the mov...
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In the current study, we focus on the development of a numerical algorithm for the Laplace equation-based image inpainting problem. A software program to implement the proposed algorithm is also developed. In experime...
In the current study, we focus on the development of a numerical algorithm for the Laplace equation-based image inpainting problem. A software program to implement the proposed algorithm is also developed. In experiments, the proposed method recovered corrupted images effectively. It can also remove defects as well as unnecessary objects successfully. The program provides an effective, convenient, and easy solution to perform the image inpainting in practical tasks. It also provides a useful feature to assess image quality after processing with both full reference and blind image quality assessment.
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