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Mussel-inspired sulfated hyaluronan cryogel patch with antioxidant, anti-inflammatory, and drug-loading properties for multifunctional wound adhesives

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Bioactive Materials 2024年第10期40卷 582-596页

作者： Wonmoon Song Young Hwan Choi Young Gi Moon Changyub Lee M.Nivedhitha Sundaram Nathaniel S.Hwang School of Chemical and Biological Engineering Institute for Chemical ProcessesSeoul National UniversitySeoul08826Republic of Korea Interdisciplinary Program in Bioengineering Seoul National UniversitySeoul08826Republic of Korea Bio-MAX/N-Bio Institute Institute of BioEngineeringSeoul National UniversitySeoul08826Republic of Korea Division of Pediatric Cardiac Surgery Department of SurgeryJohns Hopkins School of MedicineBaltimoreMDUSA Institute of Engineering Research Seoul National UniversitySeoul08826Republic of Korea

Wounds, characterized by the disruption of the continuity of body tissues resulting from external trauma,manifest in diverse types and locations. Although numerous wound dressings are available for various woundscenarios, it remains challenging to find an integrative wound dressing capable of addressing diverse woundsituations. We focused on utilizing sulfated hyaluronan (sHA), known for its anti-inflammatory properties andcapacity to load cationic drugs. By conjugating catechol groups to sHA (sHA-CA), we achieved several advantagesin wound healing: 1) Fabrication of patches through crosslinking with catechol-modified high-molecularweighthyaluronan (HA(HMW)-CA), 2) Adhesiveness that enabled stable localization, 3) Radical scavenging thatcould synergize with the immunomodulation of sHA. The sHA-CA patches demonstrated therapeutic efficacy inthree distinct murine wound models: diabetic wound, hepatic hemorrhage, and post-surgical adhesion. Collectively,these findings underscore the potential of the sHA-CA patch as a promising candidate for the nextgenerationwound dressing.

关键词： Adhesive patch Anti-inflammation Sulfated hyaluronic acid Post-surgical adhesion Diabetic wound Hemostasis

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Fused-ring induced end-on orientation in conjugated molecular dyads toward efficient single-component organic solar cells

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Aggregate 2023年第2期4卷 291-299页

作者： Dongdong Xia Shengxi Zhou Wen Liang Tan Safakath Karuthedath Chengyi Xiao Chaowei Zhao Frédéric Laquai Christopher R.McNeill Weiwei Li Institute of Applied Chemistry Jiangxi Academy of SciencesNanchangChina Beijing Advanced Innovation Center for Soft Matter Science and Engineering&State Key Laboratory of Organic-Inorganic Composites Beijing University of Chemical TechnologyBeijingChina Department of Materials Science and Engineering Monash UniversityClaytonAustralia KAUST Solar Center(KSC) Physical Sciences and Engineering Division(PSE)Material Science and Engineering Program(MSE)King Abdullah University of Science and Technology(KAUST)ThuwalSaudi Arabia

The molecular orientations of conjugated materials on the substrate mainly include edge-on,face-on,and ***-on and face-on orientations have been widely observed,while end-on orientation has been rarely *** in organic solar cells(OSCs)charge transport is along the vertical direction,end-on orientation with conjugated backbones perpendicular to the substrate is recognized as the ideal microstructure for *** this work,we for the first time obtained the preferential end-on orientation in a conjugated molecular dyad that contains a conjugated backbone as donor and perylene bisimide side units as *** was realized by introducing a fused-ring structure to replace linear terthiophenes with conjugated backbones,yielding F-MDPBI and L-MDPBI ***,a shifting trend of the molecular orientation from dominating edge-on in L-MDPBI to preferential end-on in F-MDPBI was *** a consequence,vertical charge carrier mobilities in F-MDPBI are one order of magnitude higher than those with preferential edge-on orientation,so single-component OSCs based on this molecular dyad as a single photoactive layer provided a power conversion efficiency of 4.89% compared to 1.70% based on L-MDPBI with preferential edge-on orientation.

关键词： conjugated molecular dyads crystallinity edge-on end-on single-component organic solar cells

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Deciphering DNA variant-associated aberrant splicing with the aid of RNA sequencing (vol 55, pg 732, 2023)

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NATURE GENETICS 2023年第7期55卷 1251-1251页

作者： Zhang, Bin Gao, Xin Computer Science Program Computer Electrical and Mathematical Sciences and Engineering Division King Abdullah University of Science and Technology (KAUST) Thuwal Saudi Arabia KAUST Computational Bioscience Research Center King Abdullah University of Science and Technology Thuwal Saudi Arabia

Aberrant RNA splicing events resulting from DNA variations are common causes of genetic disorders. Two studies published in Nature Genetics independently describe methods to decipher DNA-variant-associated aberrant sp... 详细信息

关键词： Data mining High-throughput screening

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Amination of biochar surface from watermelon peel for toxic chromium removal enhancement

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Chinese Journal of Chemical engineering 2021年第8期34卷 199-222页

作者： Mohamed A.El-Nemr Ibrahim M.A.Ismail Nabil M.Abdelmonem Ahmed El Nemr Safaa Ragab Department of Chemical Engineering Faculty of EngineeringCairo UniversityGizaEgypt Renewable Energy Program Zewail City of Science and TechnologyEgypt Environmental Division National Institute of Oceanography and FisheriesKayet BeyEl-AnfoushyAlexandriaEgypt

Watermelon peel residues were used to produce a new biochar by dehydration *** new biochar has undergone two methods of chemical modification and the effect of this chemical modification on its ability to adsorb Cr(VI)ions from aqueous solution has been *** biochars,Melon-B,Melon-BO-NH_(2) and Melon-BO-TETA,were made from watermelon peel via dehydration with 50%sulfuric acid to give Melon-B followed by oxidation with ozone and amination using ammonium hydroxide to give Melon-BO-NH_(2) or Triethylenetetramine(TETA)to give *** prepared biochars were characterized by BET,BJH,SEM,FT-IR,TGA,DSC and EDAX *** highest removal percentage of Cr(VI)ions was 69%for Melon-B,98%for Melon-BO-NH_(2) and 99%for Melon-BO-TETA biochars of 100 mg·L^(−1) Cr(VI)ions initial concentration and 1.0 g·L^(−1) adsorbents *** unmodified biochar(Melon-B)and modified biochars(Melon-BO-NH_(2) and Melon-BO-TETA)had maximum adsorption capacities(Q_(m))of 72.46,123.46,and 333.33 mg·g^(−1),*** amination of biochar reduced the pore size of modified biochar,whereas the surface area was *** obtained data of isotherm models were tested using different error function *** Freundlich,Tempkin and Langmuir isotherm models were best fitted to the experimental data of Melon-B,Melon-BO-NH_(2) and Melon-BO-TETA,*** adsorption rate was primarily controlled by pseudo-second–order rate ***,the functional groups interactions are important for adsorption mechanisms and expected to control the adsorption *** adsorption for the Melon-B,Melon-BO-NH_(2) and Melon-BO-TETA could be explained for acid–base interaction and hydrogen bonding interaction.

关键词： Waste treatment Powder technology Citrullus lanatus Hexavalent chromium Biochar amination Adsorption

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Updating Clinical Risk Stratification Models Using Rank-Based Compatibility: Approaches for Evaluating and Optimizing Clinician-Model Team Performance 8

Updating Clinical Risk Stratification Models Using Rank-Base...

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8th Machine Learning for Healthcare Conference, MLHC 2023

作者： Ötles, Erkin Denton, Brian T. Wiens, Jenna Medical Scientist Training Program University of Michigan Ann ArborMI United States Department of Industrial and Operations Engineering University of Michigan Ann ArborMI United States Division of Computer Science and Engineering University of Michigan Ann ArborMI United States

As data shift or new data become available, updating clinical machine learning models may be necessary to maintain or improve performance over time. However, updating a model can introduce compatibility issues when the behavior of the updated model does not align with user expectations, resulting in poor user-model team performance. Existing compatibility measures depend on model decision thresholds, limiting their applicability in settings where models are used to generate rankings based on estimated risk. To address this limitation, we propose a novel rank-based compatibility measure, CR, and a new loss function that aims to optimize discriminative performance while encouraging good compatibility. Applied to a case study in mortality risk stratification leveraging data from MIMIC, our approach yields more compatible models while maintaining discriminative performance compared to existing model selection techniques, with an increase in CR of 0.019 (95% confidence interval: 0.005, 0.035). This work provides new tools to analyze and update risk stratification models used in clinical care. © 2023 E. Ötles., B.T. Denton & J. Wiens.

关键词： Risk assessment

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Connectivity of LEO Satellite Mega Constellations: An Application of Percolation Theory on a Sphere

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IEEE Transactions on Aerospace and Electronic Systems 2025年

作者： Lin, Hao Kishk, Mustafa A. Alouini, Mohamed-Slim Electrical and Computer Engineering Program CEMSE Division Thuwal23955-6900 Saudi Arabia Maynooth University Department of Electronic Engineering MaynoothW23 F2H6 Ireland CEMSE Division Thuwal23955-6900 Saudi Arabia

With the advent of the 6G era, global connectivity has become a common goal in the evolution of communications, aiming to bring Internet services to more unconnected regions. Additionally, the rise of applications such as the Internet of Everything and remote education also requires global connectivity. Non-terrestrial networks (NTN), particularly low earth orbit (LEO) satellites, play a crucial role in this future vision. Although some literature already analyze the coverage performance using stochastic geometry, the ability of generating large-scale continuous service area is still expected to analyze. Therefore, in this paper, we mainly investigate the necessary conditions of LEO satellite deployment for large-scale continuous service coverage on the earth. Firstly, we apply percolation theory to a closed spherical surface and define the percolation on a sphere for the first time. We introduce the sub-critical and super-critical cases to prove the existence of the phase transition of percolation probability. Then, through stereographic projection, we introduce the tight bounds and closed-form expression of the critical number of LEO satellites on the same constellation. In addition, we also investigate how the altitude and maximum slant range of LEO satellites affect percolation probability, and derive the critical values of them. Based on our findings, we provide useful recommendations for companies planning to deploy LEO satellite networks to enhance connectivity. © 1965-2011 IEEE.

关键词： Spheres

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A Stable Discontinuous Galerkin Time-Domain Method for Simulation of Thin Conductive Layers

A Stable Discontinuous Galerkin Time-Domain Method for Simul...

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2022 IEEE International Symposium on Antennas and Propagation and USNC-URSI Radio Science Meeting, AP-S/URSI 2022

作者： Özakin, M. Burak Chen, Liang Ahmed, Shehab Bagci, Hakan Electrical and Computer Engineering Program Computer Electrical and Mathematical Science and Engineering Division Thuwal23955 Saudi Arabia Ali I. Al-Naimi Petroleum Engineering Research Center Thuwal23955 Saudi Arabia

ISBN: (数字)9781665496582

ISBN: (纸本)9781665496582

A conductive layer that is much thinner than the skin depth is often incorporated into electromagnetic solvers as a resistive boundary condition (RBC) to avoid fine meshes (and consequently small time steps for time-domain methods). When the discontinuous Galerkin time-domain (DGTD) method, which relies on an explicit Runge-Kutta (RK) scheme for time integration, is used in a simulation involving an RBC surface with high conductivity, the solution becomes unstable. In this work, to circumvent this bottleneck, a locally-implicit time marching scheme is developed. The proposed method uses implicit Euler backward and explicit Euler forward schemes to discretize the time derivatives in local DG equations associated with the elements that "touch"and do not "touch"the RBC surface, respectively. This yields a locally-implicit Euler (LIME) time marching scheme that maintains its stability in the presence of a highly conductive layer. Indeed, numerical results demonstrate that LIME-DGTD is more stable than RK-DGTD for a transmission problem involving a thin metal sheet. © 2022 IEEE.

关键词： Lime

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Optical tissue clearing enables rapid,precise and comprehensive assessment of three-dimensional morphology in experimental nerve regeneration research

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Neural Regeneration Research 2022年第6期17卷 1348-1356页

作者： Simeon C.Daeschler Jennifer Zhang Tessa Gordon Gregory H.Borschel SickKids Research Institute Neuroscience and Mental Health ProgramTorontoONCanada Institute of Biomaterials and Biomedical Engineering University of TorontoTorontoONCanada Division of Plastic and Reconstructive Surgery the Hospital for Sick ChildrenTorontoONCanada Indiana University School of Medicine IndianapolisINUSA

Morphological analyses are key outcome assessments for nerve regeneration studies but are historically limited to tissue *** optical tissue clearing techniques enabling three-dimensional imaging of entire organs at a subcellular resolution have revolutionized morphological studies of the *** extend their applicability to experimental nerve repair studies we adapted these techniques to nerves and their motor and sensory targets in *** solvent-based protocols rendered harvested peripheral nerves and their target organs transparent within 24 hours while preserving tissue architecture and *** optical clearing was compatible with conventional laboratory techniques,including retrograde labeling studies,and computational image segmentation,providing fast and precise cell ***,optically cleared organs enabled three-dimensional morphometry at an unprecedented scale including dermatome-wide innervation studies,tracing of intramuscular nerve branches or mapping of neurovascular *** their wide-ranging applicability,rapid processing times,and low costs,tissue clearing techniques are likely to be a key technology for next-generation nerve repair *** procedures were approved by the Hospital for Sick Children’s Laboratory Animal Services Committee(49871/9)on November 9,2019.

关键词： histology image segmentation morphometry nerve regeneration outcome assessment peripheral nerve three-dimensional imaging tissue clearing

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Uranium Oxide Production Pathway Classification Using Quantified Particle Morphology

Uranium Oxide Production Pathway Classification Using Quanti...

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2024 Annual Conference on Transactions of the American Nuclear Society, ANS 2024

作者： Goodell, Edward Sjoden, Glenn McDonald, Luther Sentz, Kari University of Utah Nuclear Engineering Program Department of Civil & Environmental Engineering 110 Central Campus Drive Suite 2000 Salt Lake CityUT84112 United States Information Sciences-3 CCS Division Los Alamos National Laboratory Bikini Atoll Rd Los AlamosNM87545 United States

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Thermal Management of Photovoltaic Module Using Affordable Organic Phase Change Material Combined with Nano Metal Oxide Particles Enhancer

SSRN

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SSRN 2024年

作者： Phukaokaew, Wisanu Suksri, Amnart Wongwuttanasatian, Tanakorn Energy Engineering Program Faculty of Engineering Khon Kaen University Thailand Electrical Engineering Division Faculty of Engineering Khon Kaen University Thailand Mechanical Engineering Division Faculty of Engineering Khon Kaen University Thailand Centre for Alternative Energy Research and Development Khon Kaen University Thailand

The utilisation of cooling systems based on phase change materials has experienced a surge in popularity due to their ability to effectively reduce the temperature of photovoltaic (PV) modules. Phase change materials (PCMs) have been widely recognised as a highly efficient medium for thermal energy storage due to their ability to harness latent heat capacity. The low thermal conductivity of the material has been identified in many studies. In the current investigation, we have blended PCM with nanoparticles to enhance its thermal conductivity and electrical efficiency. We produce nanoparticle composited phase change materials (nc-PCMs) by combining lauric acid (LA) with three different nanoparticles: aluminum oxide (Al2O3), copper oxide (CuO), and magnesium oxide (MgO), in an optimal weight proportion of 94: 6. Lauric acid and these nanoparticles are chosen based on their ability to provide a significantly lower cost compared to commercial nanoparticles. Research has demonstrated that the incorporation of nanoparticles increases thermal conductivity, resulting in a decrease in the PV module's temperature. The findings indicate that a combination of LA and MgO in a proportion of 94: 6 constitutes the optimal nc-PCM. This composition demonstrated a 5.2 °C reduction in PV module temperature, which resulted in a notable enhancement in the average electrical efficiency of 14.11%. Furthermore, the power output increased significantly to 14.18%. © 2024, The Authors. All rights reserved.

关键词： Phase change materials

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