检索结果-内蒙古大学图书馆

Biomedical Imaging and Sensing Conference 2023

作者： Kato, Daisuke Quan, Xiangyu Matoba, Osamu Wake, Hiroaki Department of Anatomy and Molecular Cell Biology Nagoya University Graduate School of Medicine Nagoya Japan Division of Multicellular Circuit Dynamics National Institute for Physiological Sciences National Institutes of Natural Sciences Okazaki Japan Department of System Science Kobe UniversityGraduate School of System Informatics Kobe Japan Center of Optical Scattering Image Science Kobe University Kobe Japan

ISBN: (纸本)9781510663435

Optical bioimaging and optogenetics have recently made it possible to control brain functions. However, these methods have limitations, such as the inability to regulate neural activity with a high spatiotemporal resolution. To address this limitation, we have developed microscope for biological applications by integrating optogenetics and digital holographic technology. This provides precise spatiotemporal information about neural activity. © 2023 SPIE.

关键词： Microscopes

来源：评论

学校读者我要写书评

暂无评论

A dopamine D1-like receptor-specific agonist improves the survival of septic mice

引用

iScience 2024年第4期27卷 109587页

作者： Tanaka, Koichi Choudhury, Mohammed E. Kikuchi, Satoshi Takeda, Ikuko Umakoshi, Kensuke Miyaue, Noriyuki Mikami, Kanta Takenaga, Ayane Yagi, Harumichi Shinabe, Rintaro Matsumoto, Hironori Yano, Hajime Nagai, Masahiro Takeba, Jun Tanaka, Junya Advanced Emergency and Critical Care Center Ehime Prefectural Central Hospital Kasugamachi Ehime Matsuyama 790-0024 Japan Department of Aeromedical Services for Emergency and Trauma Care Ehime University Graduate School of Medicine Shitsukawa Ehime Toon 791-0295 Japan Department of Molecular and Cellular Physiology Ehime University Graduate School of Medicine Shitsukawa Ehime Toon 791-0295 Japan Department of Emergency Medicine Ehime University Graduate School of Medicine Shitsukawa Ehime Toon 791-0295 Japan Department of Anatomy and Molecular Cell Biology Nagoya University Graduate School of Medicine Aichi Nagoya 466-8550 Japan Division of Multicellular Circuit Dynamics National Institute for Physiological Sciences Aichi Okazaki 444-8585 Japan Department of Clinical Pharmacology and Therapeutics Ehime University Graduate School of Medicine Shitsukawa Ehime Toon 791-0295 Japan

In this study, a murine sepsis model was developed using the cecum ligation and puncture (CLP) technique. The expression of the proinflammatory cytokines tumor necrosis factor alpha (TNF-α) and interleukin-1β (IL-1β) in the brain increased 6 h after CLP but decreased 24 h later when elevated endogenous dopamine levels in the brain were sustained. Methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride reduced dopamine levels in the striatum and increased mortality in septic mice. Dopamine D1-like receptors were significantly expressed in the brain, but not in the lungs. Intraperitoneally administered SKF-81297 (SKF), a blood-brain barrier-permeable D1-like receptor agonist, prevented CLP-induced death of septic mice with ameliorated acute lung injury and cognitive dysfunction and suppressed TNF-α and IL-1β expression. The D1-like receptor antagonist SCH-23390 abolished the anti-inflammatory effects of SKF. These data suggest that D1-like receptor-mediated signals in the brain prevent CLP-induced inflammation in both the brain and the periphery. © 2024 The Authors

关键词： Behavioral neuroscience Biological sciences Immunology Natural sciences Neuroscience Pathophysiology Pharmacology Physiology

来源：评论

学校读者我要写书评

暂无评论

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案：

请选择收藏分类：

通借通还

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：