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6th International Conference on Industry 4.0 and Smart Manufacturing, ISM 2024

作者： Putri Ardyanti, Anak Agung Ayu Xie, Zhiqiang Karnyoto, Andrea Stevens Pardamean, Bens Estiyanti, Ni Made School of Computer Science and Technology Harbin University of Science and Technology Harbin150000 China Faculty of Information Technology and Design Primakara University Bali 80226 Indonesia Bioinformatics and Data Science Research Center Bina Nusantara University Jakarta11480 Indonesia Computer Science Department BINUS Graduate Program Master of Computer Science Bina Nusantara University Jakarta 11480 Indonesia School of Management and Business University of Debrecen Debrecen Hungary

The industry is rapidly transitioning from the 4.0 era to the 5.0 era, prompting renewed interest among scholars in scheduling problems. They allow operations to process and assemble various components simultaneously. This bibliometric analysis provides a comprehensive understanding of the diverse research perspectives on the potential challenges of integrated scheduling within the framework. We identified 357 Scopus articles and analysed co-occurrence keyword (CNK) by VOSViewer tools and Global Citation Score (GCS) by Scopus tools. The research data obtained from 1993 to 2023 mainly in the subject areas of Engineering, computer science, Maths, and others. CNK identified six cluster keywords, and nine most cited articles based on normalised GCS. These results contribute to our understanding of the development of scheduling algorithms, shifting from an emphasis on manufacturing transfers to contemporary demand-centric research directions. Furthermore, this research provides a valuable perspective for policymakers, plant personnel, and manufacturing managers to make informed decisions. © 2025 The Authors. Published by Elsevier B.V.

关键词： Job shop scheduling

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Robust temporal knowledge inference via pathway snapshots with liquid neural network

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Methods 2025年 241卷 24-32页

作者： Han, Peifu Wang, Jianmin Liu, Dayan Liu, Lin Song, Tao College of Computer Science and Technology China University of Petroleum Qingdao 266580 China The Interdisciplinary Graduate Program in Integrative Biotechnology Yonsei University Incheon 21983 South Korea Department of Stomatology The First Medical Center Chinese PLA General Hospital Beijing 100853 China

Static graphs play a pivotal role in modeling and analyzing biological and biomedical data. However, many real-world scenarios—such as disease progression and drug pharmacokinetic processes—exhibit dynamic behaviors. Consequently, static graph methods often struggle to robustly address new environments characterized by complex and previously unseen relationship changes. Here, we propose a method for constructing temporal knowledge inference agents tailored to disease pathways, enabling effective relation reasoning beyond their training environment under complex shifts. To achieve this, we developed an imitation learning framework using liquid neural networks, a class of continuous-time neural models inspired by the brain function that are causal and adaptable to changing conditions. Our findings indicate that liquid agents can distill the essential tasks from knowledge graph inputs while accounting temporal evolution, thereby enabling the transfer of temporal skills to novel time nodes. Compared to state-of-the-art deep reinforcement learning agents, experiments demonstrate that temporal robustness in decision-making emerges uniquely in liquid networks. © 2025

关键词： Disease Pathways Liquid Neural Networks Relation Reasoning Robust Decision-Making Temporal Knowledge Inference

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Placement Refinement Strategies for Security Closure

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IEEE Transactions on computer-Aided Design of Integrated Circuits and Systems 2025年

作者： Danigno, Marcelo Fogaca, Mateus Schvittz, Rafael Butzen, Paulo Microelectronic Graduate Program Porto Alegre Brazil Cadence Design Systems Inc United States Computer Science Center Rio Grande Brazil

The security closure of integrated circuits (ICs) is an emerging area of research within the very large scale integration (VLSI) community. Malicious third parties, referred to as "attackers", can employ various techniques to leak, alter, or manipulate the logic of a circuit. When targeting a completed layout, their primary goal is often the insertion of hardware trojans. In this work, we present algorithms that strengthen placement solutions against hardware trojan attacks. While state-of-the-art methods rely on exhaustive placement algorithms, we propose a clustering-based placement approach that reduces the number of moved cells by up to 17%. Additionally, we introduce a cell movement heuristic aimed at preventing increases in wirelength. Our methods reduce vulnerable placement sites by up to 78% while maintaining minimal impact on design performance. Compared to other approaches, our solution decreases the amount of moved cells to an average of 8%, mitigating the impact on wirelength to an average of 0.5%. © 1982-2012 IEEE.

关键词： Electronic design automation

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Mapping the Scientific Landscape of Integrated Scheduling Towards Industry 5.0 with A Bibliometric Analysis

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Procedia computer science 2025年 253卷 84-93页

作者： Anak Agung Ayu Putri Ardyanti Zhiqiang Xie Andrea Stevens Karnyoto Bens Pardamean Ni Made Estiyanti School of Computer Science and Technology Harbin University of Science and Technology Harbin 150000 China Faculty of Information Technology and Design Primakara University Bali 80226 Indonesia Bioinformatics and Data Science Research Center Bina Nusantara University Jakarta Indonesia 11480 Computer Science Department BINUS Graduate Program - Master of Computer Science Bina Nusantara University Jakarta Indonesia 11480 Doctoral School of Management and Business University of Debrecen Debrecen Hungary

关键词： integrated scheduling assembly job shop scheduling heuristic algorithm genetic algorithm bibliometric analysis

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Blockchain Developer Experience: A Multivocal Literature Review

arXiv

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arXiv 2025年

作者： Soares, Pamella Araújo, Allysson Allex Destefanis, Giuseppe Neykova, Rumyana Saraiva, Raphael Souza, Jerffeson Graduate Program in Computer Science State University of Ceará Fortaleza Brazil Science and Technology Center Federal University of Cariri Juazeiro do Norte Brazil Department of Computer Science Brunel University London United Kingdom

The rise of smart contracts has expanded blockchain’s capabilities, enabling the development of innovative decentralized applications (dApps). However, this advancement brings its own challenges, including the management of distributed architectures and immutable data. Addressing these complexities requires a specialized approach to software engineering, with blockchain-oriented practices emerging to support development in this domain. Developer Experience (DEx) is central to this effort, focusing on the usability, productivity, and overall satisfaction of tools and frameworks from the engineers’ perspective. Despite its importance, research on Blockchain Developer Experience (BcDEx) remains limited, with no systematic mapping of academic and industry efforts. To bridge this gap, we conducted a Multivocal Literature Review analyzing 62 to understand the distribution of BcDEx sources, practical implementations, and their impact. Our findings revealed that academic focus on BcDEx is limited compared to the coverage in gray literature, which primarily includes blogs (41.8%) and corporate sources (21.8%). Particularly, development efficiency, multi-network support, and usability are the most addressed aspects in tools and frameworks. In addition, we found that BcDEx is being shaped through five key perspectives: complexity abstraction, adoption facilitation, productivity enhancement, developer education, and BcDEx evaluation. © 2025, CC BY.

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Cryptotanshinone Suppresses the STAT3/BCL-2 Pathway to Provoke Human Bladder Urothelial Carcinoma Cell Death

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Environmental Toxicology 2025年第4期40卷 624-635页

作者： Tung, Min-Che Chang, Ge-Man Dai, Wen-Chyi Hsu, Chen-Hsuan Chang, Hsiang-Chun Yang, Wei-Ting Ho, Yann-Jen Lu, Chien-Hsing Chen, Yi-Hsin Chang, Chia-Che Division of Urology Department of Surgery Tungs' Taichung MetroHarbor Hospital Taichung Taiwan Graduate Institute of Biomedical Sciences National Chung Hsing University Taichung Taiwan Doctoral Program in Biotechnology Industrial Innovation and Management National Chung Hsing University Taichung Taiwan Department of Life Sciences National Chung Hsing University Taichung Taiwan Department of Obstetrics and Gynecology Taichung Veterans General Hospital Taichung Taiwan Doctoral Program in Translational Medicine National Chung Hsing University Taichung Taiwan Department of Nephrology Taichung Tzu Chi Hospital Buddhist Tzu chi Medical Foundation Taichung Taiwan School of Medicine Tzu Chi University Hualein Taiwan Department of Artificial Intelligence and Data Science National Chung Hsing University Taichung Taiwan Master Program in Precision Health Rong Hsing Research Center for Translational Medicine The iEGG and Animal Biotechnology Research Center National Chung Hsing University Taichung Taiwan Department of Medical Laboratory Science and Biotechnology Asia University Taichung Taiwan Department of Medical Research China Medical University Hospital Taichung Taiwan

Bladder cancer is one of the most common human malignancies worldwide. Aberrant activation of signal transducer and activator of transcription 3 (STAT3) is crucial to driving malignant progression and predicting poor prognosis of multiple human cancers, including bladder cancer, making STAT3 a promising target of cancer therapeutics. Cryptotanshinone (CTS) is an anticancer ingredient of Danshen (Salvia miltiorrhiza), a top-graded Chinese medicinal herb. However, whether CTS targets STAT3 to exert its cytotoxic effect on human bladder cancer remains unknown. Herein, we demonstrated that CTS is cytotoxic to multiple human urinary bladder transitional cell carcinoma (TCC) cell lines while sparing normal human urothelial cells. CTS provoked apoptosis-dependent bladder TCC cytotoxicity, as apoptosis blockage by z-VAD-fmk markedly rescued the clonogenicity of CTS-treated cells. Besides, CTS was found to suppress constitutive and interleukin 6-inducible activation of STAT3, evidenced by the downregulation of STAT3 tyrosine 705 phosphorylation and BCL2, a recognized STAT3 transcriptional target. Notably, ectopic expression of a dominant-active STAT3 mutant (STAT3-C) or BCL-2 alleviated CTS-induced apoptosis and clonogenicity inhibition, thus confirming STAT3 blockade as a pivotal mechanism of CTS's cytotoxic action on bladder TCC cells. Lastly, immunoblotting revealed that CTS lowered the levels of active JAK2, an upstream kinase that mediates STAT3 tyrosine 705 phosphorylation. Altogether, we conclude that the blockade of the JAK2/STAT3/BCL-2 antiapoptotic signaling axis is a vital mechanism whereby CTS provokes bladder cancer cytotoxicity. The current evidence implicates CTS's potential to be translated into a bladder cancer therapeutic agent. © 2024 Wiley Periodicals LLC.

关键词： Cell death

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Joint Source Decomposition of Concurrent EEG-FMRI Data in Epilepsy and Control Groups

Joint Source Decomposition of Concurrent EEG-FMRI Data in Ep...

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IEEE International Symposium on Biomedical Imaging

作者： J. Mason Harding Haatef Pourmotabbed Yamin Li Kimberly Rogge-Obando Kate Wang Sarah E. Goodale Shiyu Wang Camden Bibro Bergen Allee Caroline Martin Victoria L. Morgan Dario J. Englot Catie Chang Department of Electrical and Computer Engineering Vanderbilt University Department of Biomedical Engineering Vanderbilt University Department of Computer Science Vanderbilt University Neuroscience Graduate Program Vanderbilt University Vanderbilt Memory and Alzheimer's Center Vanderbilt University Medical Center Department of Neurological Surgery Vanderbilt University Medical Center Department of Radiology Vanderbilt University Medical Center

ISBN: (数字)9798331520526

ISBN: (纸本)9798331520533

EEG and fMRI are complementary, noninvasive technologies for investigating human brain function. These modalities have been used to uncover large-scale functional networks and their disruptions in clinical populations. Given the high temporal resolution of EEG and high spatial resolution of fMRI, integrating these modalities can provide a more holistic understanding of brain activity. This work explores a multimodal source decomposition technique for extracting shared modes of temporal variation between fMRI BOLD signals and EEG spectral power fluctuations in the resting state. The resulting components are then compared between patients with focal epilepsy and controls, revealing multimodal network differences between groups.

关键词： Neuroimaging Brain Fluctuations Epilepsy Functional magnetic resonance imaging Electroencephalography Pattern recognition Hemodynamics Spatial resolution Signal resolution

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Chiral exceptional point enhanced active tuning and non reciprocity in micro-resonators

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光：科学与应用（英文版） 2025年第2期14卷 401-410页

作者： Hwaseob Lee Lorry Chang Ali Kecebas Dun Mao Yahui Xiao Tiantian Li Andrea Alù Sahin K.Özdemir Tingyi Gu Department of Electrical and Computer Engineering University of DelawareNewarkDelaware 19716USA Department of Engineering Science and Mechanics Pennsylvania State UniversityUniversity ParkPA 16802USA Photonics Initiative Advanced Science Research CenterCity University of New YorkNew YorkNY 10031USA Physics Program Graduate CenterCity University of New YorkNew YorkNY 10016USA Department of Engineering Science and Mechanics Pennsylvania State UniversityUniversity ParkPA 16802USA Department of Electrical and Computer Engineering Saint Louis UniversitySaint LouisMO 63103USA

Exceptional points(EPs)have been extensively explored in mechanical,acoustic,plasmonic,and photonic ***,little is known about the role of EPs in tailoring the dynamic tunability of optical devices.A specific type of EPs known as chiral EPs has recently attracted much attention for controlling the flow of light and for building sensors with better responsivity.A recently demonstrated route to chiral EPs via lithographically defined symmetric Mie scatterers on the rim of resonators has not only provided the much-needed mechanical stability for studying chiral EPs,but also helped reduce losses originating from nanofabrication imperfections,facilitating the in-situ study of chiral EPs and their contribution to the dynamics and tunability of ***,we use asymmetric Mie scatterers to break the rotational symmetry of a microresonator,to demonstrate deterministic thermal tuning across a chiral EP,and to demonstrate EP-mediated chiral optical nonlinear response and efficient electro-optic *** results indicate asymmetric electro-optic modulation with up to 17 dB contrast at GHz and CMOS-compatible voltage *** wafer-scale nano-manufacturing of chiral electro-optic modulators and the chiral EP-tailored tunning may facilitate new micro-resonator functionalities in quantum information processing,electromagnetic wave control,and optical interconnects.

关键词： active point micro chiral enhanced exceptional reciprocity resonators tuning

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Enhanced Performance and Data Privacy in Lung Nodule Classification via Federated Deep Learning Approach 24

Enhanced Performance and Data Privacy in Lung Nodule Classif...

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2024 7th International Conference on Healthcare Service Management, ICHSM 2024

作者： Nguyen, Duc-Khanh Li, Ai-Hsien Adam Lai, Yen-Jun Chiu, Yen-Ling Phan, Dinh-Van Chien, Ting-Ying Chan, Chien-Lung Department of Information Management Yuan Ze University Taoyuan Taiwan Department of Statistics and Informatics University of Economics The University of Danang Danang Viet Nam Division of Cardiology Far Eastern Memorial Hospital New Taipei Taiwan Graduate Program in Biomedical Informatics Yuan Ze University Taoyuan Taiwan Department of Radiology Far Eastern Memorial Hospital New Taipei Taiwan Graduate Institute of Medicine and Graduate Program in Biomedical Informatics Yuan Ze University Taoyuan Taiwan Department of Medical Research Far Eastern Memorial Hospital New Taipei Taiwan Department of Computer Science and Engineering Yuan Ze University Taoyuan Taiwan ZDT Group- YZU Joint Research and Development Center for Big Data Taoyuan Taiwan Yuan Ze University Taoyuan Taiwan

ISBN: (纸本)9798400710162

This study explores the feasibility of deep learning for classifying nodule neoplasms, analyzing their performance on two openly available datasets, LUNGx SPIE, and LIDC-IDRI. These datasets offer valuable diversity in image quantity, quality, and malignancy annotation methodologies, posing a real-world challenge for effective model development. To handle the disparities in these diverse datasets, we aim to develop a robust classification model trained using federated learning. This decentralized approach allows model training across datasets without sharing patient data, preserving privacy and overcoming data fragmentation. Our experiments demonstrate that federated learning enables the development of a robust and superior deep learning model compared to individual models trained on limited data. This combination of deep learning, and federated learning holds immense promise for nodule neoplasm classification and can significantly improve patient care and outcomes. © 2024 Copyright held by the owner/author(s).

关键词： Federated learning

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FDAM: Filter-Dedicated Approximate Multiplier Design for Real-Time CNN Acceleration

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IEEE Transactions on computer-Aided Design of Integrated Circuits and Systems 2025年

作者： Nguyen, Kihwan Kim Xuan Truong Jeon, Dongsuk Lee, Hyuk-Jae Korea Republic of program Department of Electrical Engineering Seoul08826 Korea Republic of Inter-University Semiconductor Research Center Seoul National University Graduate School of Convergence Science and Technology Research Institute for Convergence Science Seoul08826 Korea Republic of Department of Electrical and Computer Engineering Seoul08826 Korea Republic of

Video super-resolution (VSR) is widely used in various high-definition applications, such as HDTVs and smartphones, requiring a dedicated upscaling technique for realtime full-HD generation. To reduce on-chip buffers for largesize output feature maps, a streaming VSR accelerator may employ an output stationary dataflow, leading to a large energy consumption caused by frequent filter switching. To mitigate this, we introduce a new filter-dedicated multiplier design for realtime VSR acceleration. We replace costly multipliers with adders, shifters, and multiplexers (MUXes), referred to as unified multiple constant multiplications (UMCM). The conventional UMCM, however, may incur considerable area/power overhead due to the unified topology constraint among different filter sets. To address this problem, we propose a new approximated MCM (AMCM) problem to relax the constraint and an approximate compatible graph synthesis (A-CGS) framework to efficiently solve AMCM by jointly searching for approximated filters and constructing a unified graph. Additionally, we suggest a lightweight finetuning method by freezing approximated filters and only finetuning biases, which can recover the original model’s accuracy within a few epochs. Experimental results with synthetic data demonstrate that AMCM reduces the area by up to 49.8%, 44.8%, and 40.3% when considering constant sets of 2, 4, and 8, respectively. Our designs with SR application achieve up to a 73.3% reduction in energy consumption. Experiments with the Set5 and Set14 datasets show that our model with bias correction achieves similar restoration performance compared to the eightbit models. © 1982-2012 IEEE.

关键词： Acceleration

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