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Single-cell transcriptomics uncovers EGFR signaling-mediated gastric progenitor cell differentiation in stomach homeostasis (vol 14, 3750, 2023)

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NATURE COMMUNICATIONS 2023年第1期14卷 1-16页

作者： Takada, Hitomi Sasagawa, Yohei Yoshimura, Mika Tanaka, Kaori Iwayama, Yoshimi Hayashi, Tetsutaro Isomura-Matoba, Ayako Nikaido, Itoshi Kurisaki, Akira Laboratory of Stem Cell Technologies Graduate School of Science and Technology Nara Institute of Science and Technology Takayama-cho Ikoma Nara Japan Laboratory for Bioinformatics Research RIKEN Center for Biosystems Dynamics Research Wako Saitama Japan Department of Functional Genome Informatics Biological Data Science Medical Research Institute Tokyo Medical and Dental University Bunkyo Tokyo Japan Master’s/Doctoral Program in Life Science Innovation (Bioinformatics) Degree Programs in Systems and Information Engineering Graduate School of Science and Technology University of Tsukuba Tsukuba Ibaraki Japan

Defects in gastric progenitor cell differentiation are associated with various gastric disorders, including atrophic gastritis, intestinal metaplasia, and gastric cancer. However, the mechanisms underlying the multilineage differentiation of gastric progenitor cells during healthy homeostasis remain poorly understood. Here, using a single-cell RNA sequencing method, Quartz-Seq2, we analyzed the gene expression dynamics of progenitor cell differentiation toward pit cell, neck cell, and parietal cell lineages in healthy adult mouse corpus tissues. Enrichment analysis of pseudotime-dependent genes and a gastric organoid assay revealed that EGFR-ERK signaling promotes pit cell differentiation, whereas NF-κB signaling maintains gastric progenitor cells in an undifferentiated state. In addition, pharmacological inhibition of EGFR in vivo resulted in a decreased number of pit cells. Although activation of EGFR signaling in gastric progenitor cells has been suggested as one of the major inducers of gastric cancers, our findings unexpectedly identified that EGFR signaling exerts a differentiation-promoting function, not a mitogenic function, in normal gastric homeostasis.

关键词： Adult stem cells Stem-cell differentiation Stem-cell niche

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Activated carbon characteristics of tabah bamboo that physically activated under different activation time 1

Activated carbon characteristics of tabah bamboo that physic...

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1st International Conference on Design, Energy, Materials and Manufacture, ICDEMM 2018

作者： Negara, D.N.K.P. Nindhia, T.G.T. Surata, I.W. Sucipta, M. Hidajat, F. Doctoral Study Program of Engineering Science Faculty of Engineering Udayana University Kampus Sudirman Denpasar-Bali Indonesia Mechanical Engineering Department Udayana University Street of Bukit Jimbaran Bali Badung Indonesia PPPTMGB Lemigas Jl. Ciledug Raya Kav. 109 Jakarta Selatan12230 Indonesia

Activated carbon is a versatile porous material that widely applied to purify, deodorize, decolorize, remove or reduce some gases harmful constituents and storage of gas. For different application different characteristics of activated carbon is required. This paper concerns to find out the characteristics of activated carbons derived from tabah bamboo (Gigantochloc nigrociliata) that physically activated with different activation holding time. Prepared tabah bamboo was carbonized by heating up to the temperature of 800 °C for two hours. The char produced was powdered and then activated physically by heating up to 800 °C, soaked at that temperature during each 1, 1.5 and 2 hours under 100 mL/min N2 flow. Activated carbons manufactured were characterized by proximate and ultimate analyses and SEM observation. The results show that the highest fix carbon (82.52%) and lowest ash (5.91 %) was obtained at 1 hour soaking time with moisture and volatile contents were 3.56% and 8.00 % respectively;the highest carbon (C) content of 84.16 % was yielded at soaked time of 1.5 hours;SEM observation shows that there were significant differences of morphology structure between raw material and activated carbons for all of the soaking time variations. The pores structures have been formed in the activated carbons produced. © Published under licence by IOP Publishing Ltd.

关键词： Activated carbon

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Exploring Low Rate Dos Attack Detection Methods: A Bibliometric Analysis and Roadmap for Further Research

Exploring Low Rate Dos Attack Detection Methods: A Bibliomet...

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2023 IEEE International Conference on Data and Software engineering, ICoDSE 2023

作者： Widodo, Anteng Rochim, Adian Fatchur Warsito, Budi School of Postgraduated Studies Diponegoro University Doctoral Program of Information System Semarang Indonesia Muria Kudus University Faculty of Engineering Department of Information System Kudus Indonesia Diponegoro University Faculty of Engineering Department of Computer Engineering Semarang Indonesia Diponegoro University Faculty of Science and Mathematics Department of Statistics Semarang Indonesia

ISBN: (纸本)9798350381382

Low-Rate Denial of Service (LDoS) attacks, an emerging breed of DoS attacks, present a formidable challenge in terms of their detectability. Within the realm of network security, these attacks cast a substantial shadow over the availability and integrity of services. This study seeks to delve into the intricate mechanics of LDoS attacks and explore the landscape of developed detection methodologies. Employing bibliometric analysis, we employ a multifaceted approach to gather research insights pertaining to LDoS attack detection. This approach encompasses the examination of evolving research trends, scrutiny of widely cited scientific publications within the same domain, identification of prolific researchers shaping the field, and a judicious selection of reputable publishers for dependable information acquisition. Furthermore, our study undertakes a meticulous categorization and classification of previously proposed LDoS detection methods documented in well-established scientific literature. This endeavor not only provides a more profound comprehension of the evolutionary trajectory and thematic thrusts within LDoS attack detection research, but it also facilitates the identification of gaps and directions for future exploration. The culmination of these analytical efforts culminates in a comprehensive framework. This contribution manifests through structured categorization, classification, and a forward-looking research roadmap, which collectively serve as valuable tools for both current and aspiring researchers engaged in LDoS attack detection. In summary, this research not only delves into the complexities of LDoS attacks and their mechanisms but also augments the current understanding of detection capabilities. Through its nuanced contributions, this paper extends a helpful guide to the dynamic realm of LDoS attack detection, thus catalyzing advancements and insights for the future. copy;2023 IEEE. © 2023 IEEE.

关键词： Denial-of-service attack

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E-Translator Kawi to Bahasa 2

E-Translator Kawi to Bahasa

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2nd International Joint Conference on Advanced engineering and Technology, IJCAET 2017 and International Symposium on Advanced Mechanical and Power engineering, ISAMPE 2017

作者： Sudana, Oka Putra, Darma Sudarma, M. Hartati, Rukmi S. Pradnya Prastika, Ryan Wirdiani, Ayu Study Program of Doctoral Engineering Science Faculty of Engineering Udayana University Kabupaten Badung-Bali80361 Indonesia Information Technology Departement Faculty of Engineering Udayana University Kabupaten Badung-Bali80361 Indonesia Electrical and Computer EngineeringDepartement Faculty of Engineering Udayana University Jalan Raya Bukit Jimbaran Kabupaten Badung-Bali80361 Indonesia

Kawi Language is a kind of language which has developed in Java during the Hindu-Buddhist era in the ancient Indonesian archipelago. As the time passed, Kawi began to come to extinction. To overcome this, preservation of Kawi language can be done by enhancing the understanding of culture through the use of technology. Technology that can be used for cultural preservation is one of NLP based applications such as Kawi Language to Bahasa Translator Application which is developed in this research. The translator application is an application that translates from one language to another. The result of translation of the translator application is a language that is easy to understand by the people or commonly used language. This translator application is developed to processes Kawi Language text into bahasa based on search method which each word inserted. The stemming method used is Bobby Nazief & Mima Adriani Algorithm using Kawi Language rule. The translated Kawi Language text can be a word, sentence or paragraph with the result of the Text in Bahasa as well as words, sentences or paragraphs. © The Authors, published by EDP sciences, 2018.

关键词： Translation (languages)

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Inert effects on the flammability characteristics of methanol by nitrogen or carbon dioxide

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Journal of Thermal Analysis and Calorimetry 2009年第3期96卷 759-763页

作者： Chiang, C.-C. Lee, J.-C. Chang, Y.-M. Chuang, C.-F. Shu, C.-M. 1 Jin-De Rd. Changhua Changhua 50074 Taiwan Department of Electrical Engineering Hsiuping Institute of Technology 11 Gong-Ye Rd. Dali Taichung 41280 Taiwan Doctoral Program Graduate School of Engineering Science and Technology National Yunlin University of Science and Technology 123 University Rd. Sec. 3 Douliou Yunlin 64002 Taiwan Bao-Shan Campus 1 Jin-De Rd. Changhua Changhua 50074 Taiwan

Knowledge of material safety properties is critical for safe handing in the chemical process industries, especially for flammable chemicals that might result in serious fires and explosions. This study investigated the flammability characteristics of methanol under working conditions during the process. The targeted fire and explosion properties, like explosion limits (UEL and LEL), vapor deflagration index (K g), maximum explosion pressure (P max), and maximum explosion pressure rise [(dP dt -1) max], were deliberately obtained via a 20-L-Apparatus in 101 kPa (i.e., 760 mmHg/1 atm), 150 and 200 °C, along with various experimental arrangements containing nitrogen (N2) or carbon dioxide (CO 2) as inert component. Particularly, this study discussed and elucidated the inert influence on the above safety-related parameters by two different inerting gases of N2 and CO2. The results indicated that adding an inert component to fuel-inert gas mixtures determined the decrease of explosion range and flammability hazard degree. The results also demonstrated that CO2 possessed higher inerting capability than N2 in this study. © 2009 Akadémiai Kiadó, Budapest, Hungary.

关键词： Carbon dioxide

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Path Planning for an Autonomous Vehicle based on the Ant Colony Algorithm: A Review

Path Planning for an Autonomous Vehicle based on the Ant Col...

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Artificial Intelligence and Image Processing (IWAIIP), International Workshop on

作者： Desi Windi Sari Suci Dwijayanti Bhakti Yudho Suprapto Department of Electrical Engineering Faculty of Engineering Universitas Sriwijaya Palembang Indonesia Doctoral Program in Engineering Science Faculty of Engineering Universitas Sriwijaya Palembang Indonesia

Efficient path planning technology for autonomous vehicles not only yields significant time savings but also contributes to reducing fuel usage. Various methodologies have been introduced and documented in the literature concerning the path planning of autonomous vehicles. While these methodologies may not ensure an optimal solution, they have demonstrated successful applications in their respective contexts, especially the ant colony algorithm. Nevertheless, not many papers discuss the literature review from the viewpoint of ant colony-based path planning. This paper aims to provide a comprehensive review encompassing the modeling, optimization criteria, and solution algorithms related to the ant colony for path planning. In this study, the review of the ant colony algorithm is divided into global and local path planning. Based on the review results, the ant colony algorithm appears suitable for global path planning. To achieve better performance, it can be combined with other algorithms such as artificial potential field (APF), genetic algorithm, and particle swarm algorithm. These studies are conducted solely in simulations. Therefore, further research should be carried out to ensure the performance of combining the ant colony and APF for autonomous vehicles for both global and local path planning.

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Electrolysis results in a comparison of metformin using aluminum, zinc, and iron (as the anode) as well as used carbon (as the cathode) 9

Electrolysis results in a comparison of metformin using alum...

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9th International Seminar on New Paradigm and Innovation of Natural sciences and Its Application, ISNPINSA 2019

作者： Suhartana, S. Purwanto, P. Darmawan, A. Doctoral Program in Environmental Science School of Postgraduate Studies Universitas Diponegoro Semarang Indonesia Departement of Chemistry Faculty of Engineering Universitas Diponegoro Semarang Indonesia Inorganic Chemistry Laboratory Departement of Chemistry Faculty of Sciences and Mathematics Universitas Diponegoro Semarang Indonesia

Metformin is an antidiabetic drug that can be obtained easily in pharmacies/on the market, because it is traded freely, so people can easily buy and consume it. Ferrous metal, aluminum metal, and zinc metals are metal quite easy to find and are often used by the public. Metformin and Ferrous metal, aluminum metal and zinc metals are metal are quite familiar in the community. This research aims to deconcentrate metformin which can be obtained easily in pharmacies / on the market by electrolysis method, using ferrous metal, aluminum metal, and zinc metals are as an anode and carbon as the cathode. Electrolysis of metformin has been carried out using ferrous metal, aluminum metal, and zinc metal as an anode. The success of the electrolysis process was seen with a decrease in the sample COD index. In the case without the addition of electrolytes using ferrous metals, the COD index of the sample reduction was very low (9-17%). This research aims to increase the success of the electrolysis process, by adding various kinds of electrolytes, such as acetic acid (weak electrolytes), hydrochloric acid (strong electrolytes), sodium chloride and Fenton reagents. The addition of electrolytes can increase electrolysis yield significantly. The interaction between metformin during electrolysis is traced to the possibility of changes in the chromophore group (with UV-Visible spectra) and the functional group (with FTIR spectra) of the sample. From the research data obtained information that there is a decrease and shift in UV-Visible spectra and changes in functional groups after the electrolysis process occurs. The best electrolysis percentage is obtained, after adding NaCl solution and Fenton's reagent in the range of 50 -66%. © Published under licence by IOP Publishing Ltd.

关键词： Electrolytes

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Real-time Vehicular Sensing System Design for Integrated Sensing as Service and IoT Platform in Smart Cities 11

Real-time Vehicular Sensing System Design for Integrated Sen...

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11th International Conference on ICT for Smart Society, ICISS 2024

作者： Eriyadi, Mindit Lubis, Fetty Fitriyanti Supangkat, Suhono Harso Hidayat, Fadhil Doctoral Program of Instiut Teknologi Bandung Indonesia School of Applied Science Universitas Telkom Bandung Indonesia School of Electrical Engineering and Informatics Instiut Teknologi Bandung Indonesia Institut Teknologi Bandung Smart City and Community Innovation Center Bandung Indonesia

ISBN: (纸本)9798350389654

This study focuses on the design and implementation of a Real-time Vehicular Sensing System (RVSS) aimed at enhancing air quality monitoring in smart cities. By integrating advanced sensors into moving vehicles, the system captures real-time environmental data across diverse urban areas. This research addresses the limitations of static monitoring stations, offering broader geographical coverage and greater data collection flexibility. The proposed system includes low-cost components, enhanced sensor calibration, and optimized data processing algorithms to ensure accurate and reliable data. It also features real-time data transmission and a user-friendly dashboard for dynamic monitoring. The primary contribution of this study is to establish a robust foundation for an effective Vehicular Sensing system, providing valuable insights for researchers and policymakers to improve air quality management in smart cities. © 2024 IEEE.

关键词： Air quality

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OpenJava: A class-based macro system for Java

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1st OOPSLA Workshop on Reflection and Software engineering, OORaSE 1999

作者： Tatsubori, Michiaki Chiba, Shigeru Killijian, Marc-Olivier Itano, Kozo Doctoral Program in Engineering University of Tsukuba Tennohdai 1-1-1 Tsukuba Ibaraki Japan Department of Information Science and Electronics University of Tsukuba Japan LAAS-CNRS 7 Avenue du Colonel Roche 31077 Toulouse cedex 04 France

ISBN: (纸本)3540677615

This paper presents OpenJava, which is a macro system that we have developed for Java. With traditional macro systems designed for non object-oriented languages, it is difficult to write a number of macros typical in object-oriented programming since they require the ability to access a logical structure of programs. One of the drawbacks of traditional macro systems is that abstract syntax trees are used for representing source programs. This paper first points out this problem and then shows how OpenJava addresses this problem. A key idea of Open-Java is to use metaobjects, which was originally developed for reflective computing, for representing source programs. © Springer-Verlag Berlin Heidelberg 2000.

关键词： Object oriented programming

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The Effect of Mangrove on Fish Catch Using Belat at Teluk Pemedas and Sanipah of Kutai Kartanegara Regency, East Kalimantan Province, Indonesia 2

The Effect of Mangrove on Fish Catch Using Belat at Teluk Pe...

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2nd International Conference on Energy, Environmental and Information System, ICENIS 2017

作者： Sulaiman, Bustam Bambang, Azis Nur Purnaweni, Hartuti Lutfi, Mohammad Doctoral Program of Environmental Science School of Postgraduate Studies Diponegoro University Semarang Indonesia Faculty of Fishery and Ocean Diponegoro University Semarang50275 Indonesia Master Program of Environmental Science School of Post Graduate Studies Diponegoro University Semarang50275 Indonesia Faculty of Social Science and Political Science Diponegoro University Semarang50275 Indonesia Department of Oil and Gas Processing Engineering STT MIGAS Balikpapan76127 Indonesia Department of Petroleum Engineering STT MIGAS Balikpapan76127 Indonesia

The increasing population at Teluk Pemedas and Sanipah coastal areas of Kutai Kartanegara Regency, East Kalimantan Province, has led to coastal degradation. The problem was mainly caused by conversion of mangrove into aquaculture, agriculture, plantation industrial, and residential areas. This research was a study case, used descriptive analysis to describe the local fishermen activity using belat traditional device to catch fish. The results revealed that there were many fishermen still did not know the benefits of mangrove for economy growth, ecological, ecotourism etc. This condition affects to the decline of the mangrove function. Fisherman who used belat often move from one location to another location in order to find places that have many catches. The belat which are placed in good environment mangrove areas produces lots of catches that greatly benefit the fisherman, therefore mangrove ecosystem must be well preserved for the sustainability of fishermen's efforts to earn a living. © 2018 The Authors, published by EDP sciences.

关键词： Fish

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