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Impacts of the Covid-19 pandemic on traditional oil mining at Wonocolo Village Kedewan Sub-District Bojonegoro Regency East Java

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IOP Conference Series: Earth and Environmental science 2021年第1期623卷

作者： L A Rahmawati N Afiati T T Putranto Doctoral Program in Environmental Science School of Postgraduate Universitas Diponegoro Semarang Central Java Indonesia 50273 Environmental Science Universitas Bojonegoro Lettu Suyitno No.2 Bojonegoro East Java Indonesia 62119 Department of Aquatic Resources Management Faculty of Fisheries and Marine Sciences Universitas Diponegoro Semarang Central Java Indonesia 50275 Department of Geology Engineering Faculty of Engineering Universitas Diponegoro Semarang Central Java Indonesia 50275

Mining in the world consists of modern and traditional mining. Various studies have discussed how field workers were precarious at being exposed to Covid-19 in modern mining. Many studies discuss ways of modern mines overcoming Covid-19, but discussion of research related to the impacts of Covid-19 on traditional mining has not been carried out. This study addressed the effect of the Covid-19 pandemic on traditional oil mining in Wonocolo, Bojonegoro Regency. This work is a descriptive study using observation and in-depth interviews and reviewing secondary data related to conventional mining activities. The results showed that the Covid-19 pandemic has an indirect effect on traditional oil mining activities in Wonocolo. The pandemic caused a decrease in demand, a drop in selling prices, lower production, and temporary closure of wells in Wonocolo traditional mining. In contrast, Covid-19 did not directly affect miners' activities since the miners believed that Covid-19 could not infect them due to the very extreme condition in the mining area that the Coronavirus would not survive.

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Author Correction: Single-cell transcriptomics uncovers EGFR signaling-mediated gastric progenitor cell differentiation in stomach homeostasis

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Nature communications 2023年第1期14卷 6540页

作者： Hitomi Takada Yohei Sasagawa Mika Yoshimura Kaori Tanaka Yoshimi Iwayama Tetsutaro Hayashi Ayako Isomura-Matoba Itoshi Nikaido Akira Kurisaki Laboratory of Stem Cell Technologies Graduate School of Science and Technology Nara Institute of Science and Technology Takayama-cho Ikoma Nara Japan. Laboratory for Bioinformatics Research RIKEN Center for Biosystems Dynamics Research Wako Saitama Japan. Department of Functional Genome Informatics Biological Data Science Medical Research Institute Tokyo Medical and Dental University Bunkyo Tokyo Japan. Laboratory for Bioinformatics Research RIKEN Center for Biosystems Dynamics Research Wako Saitama Japan. itoshi.nikaido@riken.jp. Department of Functional Genome Informatics Biological Data Science Medical Research Institute Tokyo Medical and Dental University Bunkyo Tokyo Japan. itoshi.nikaido@riken.jp. Master's/Doctoral Program in Life Science Innovation (Bioinformatics) Degree Programs in Systems and Information Engineering Graduate School of Science and Technology University of Tsukuba Tsukuba Ibaraki Japan. itoshi.nikaido@riken.jp. Laboratory of Stem Cell Technologies Graduate School of Science and Technology Nara Institute of Science and Technology Takayama-cho Ikoma Nara Japan. akikuri@bs.naist.jp.

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Effectiveness of expository based on digital learning repository for critical thinking skills of vocational students in digital simulation and communication subjects

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AIP Conference Proceedings 2023年第1期2590卷

作者： Basori Sajidan Muhammad Akhyar Wiranto Department of Education Science Doctoral Program Universitas Sebelas Maret Rd. Ir. Sutami 36A Kentingan Surakarta Indonesia Department of Informatics and Computer Engineering Education Universitas Sebelas Maret Rd. Ir. Sutami 36A Kentingan Surakarta Indonesia Department of Biology Education Universitas Sebelas Maret Rd. Ir. Sutami 36A Kentingan Surakarta Indonesia Department of Mechanical Engineering Education Universitas Sebelas Maret Rd. Ir. Sutami 36A Kentingan Surakarta Indonesia Department of Informatics Universitas Sebelas Maret Rd. Ir. Sutami 36A Kentingan Surakarta Indonesia

The competency to think critically is one of the skills that students must possess in the 21st century. This study aims to determine vocational students' critical thinking skills (CTs) in digital simulation and communication subjects using expository based on digital learning repository. This research uses quantitative descriptive. The samples of this study were students of class X SMK N 2 Surakarta. The instrument used is a multiple-choice test that developed based on indicators of CTs, according to Facione, which consist of interpretation, analysis, evaluation, inference, explanation, and self-regulation. The results of this study showed that the average percentage of students' CTs is in the sufficient category. The results of each indicator can be described as follows: (1) The interpretation indicator is 46.8% in the sufficient category, (2) The analysis indicator is 49.5% in the sufficient category, (3) The evaluation indicator is 60.5% in the sufficient category, (4) The inference indicator is 48, 4% in the sufficient category, (5) About 56.5% for the explanation indicator in the sufficient category, and (6) The self-regulation indicator is 64.5% in the high category. The results showed that students' CTs were still quite or moderate. Students' CTs need to be improved with innovative learning models and methods that will affect learning motivation and critical thinking skills towards various student problems in teaching and learning activities.

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Case-based games learning strategies to improve conceptual understanding in mathematics

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Journal of Physics: Conference Series 2020年第1期1663卷

作者： A M I T Asfar A M I A Asfar Department of Mathematics Education STKIP Muhammadiyah Bone Indonesia Doctoral Program Science Education Universitas Negeri Makassar Indonesia Department of Chemical Engineering of Politeknik Negeri Ujung Pandang Indonesia

Case-Based Games Learning (CBGL) is a strategy of active learning in which the students implement knowledge and analytical skill related to the real complex situation (contextual) and relevant with subject lessons. Give case-based task or question routinely can help students to solve case-based mathematics problems. This study aims to analyze the effectiveness of CBGL using Quizizz dan Case Base Learning (CBL) without Quizizz based on students' conceptual understanding in mathematics by finding out the percentage of the correct answer. Students were grouping by using a purposive sampling method based on the conceptual understanding indicator. The result of this study is the average conceptual understanding CBGL using Quizizz application strategy is more effective than CBL without Quizizz application in evaluating student work results quickly, precisely, and accurately. Therefore the use of Quizzes application with CBGL was more effective than CBL in assessing the work result quickly, right, and accurately.

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Biologically-induced synthetic manganese carbonate precipitate (BISMCP) for potential applications in heavy metal removal

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Heliyon 2023年第5期9卷

作者： Dewi, Anggraeni Kumala Sharma, Raju Kumar Das, Koyeli Sukul, Uttara Lin, Pin-Yun Huang, Yi-Hsun Lu, Chung Ming Lu, Cheng-Kang Chen, Tsung-Hsien Chen, Chien-Yen Department of Physics National Chung Cheng University University Road Minhsiung Chiayi County 62102 Taiwan Doctoral Program in Science Technology Environment and Mathematics Department of Earth and Environmental Sciences National Chung Cheng University 168 University Road Min-Hsiung Chiayi County 62102 Taiwan Department of Chemistry and Biochemistry National Chung Cheng University 168 University Road Min-Hsiung Chiayi County 62102 Taiwan Department of Biomedical Sciences Graduate Institute of Molecular Biology National Chung Cheng University 168 University Road Min-Hsiung Chiayi County 62102 Taiwan Department of Chemical Engineering National Chung Cheng University University Road Minhsiung Chiayi County 62102 Taiwan Department of Chest Division Internal Medicine Ditmanson Medical Foundation Chiayi Christian Hospital 600566 Taiwan Department of Internal Medicine Ditmanson Medical Foundation Chiayi Christian Hospital 600566 Taiwan Center for Nano Bio-Detection Center for Innovative Research on Aging Society AIM-HI National Chung Cheng University 168 University Road Min-Hsiung Chiayi County 62102 Taiwan

Heavy metal pollution of water is a burning issue of today's world. Among several strategies involved for heavy metal remediation purpose, biomineralization has shown great potential. Of late, research has been focused on developing effective mineral adsorbents with reduced time and cost consumption. In this present paper, the Biologically-Induced Synthetic Manganese Carbonate Precipitate (BISMCP) was produced based on the biologically-induced mineralization method, employing Sporosarcina pasteurii in aqueous solutions containing urea and MnCl₂. The prepared adsorbent was characterized using Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), SEM-energy dispersive X-ray spectroscopy (SEM-EDX), X-ray diffraction (XRD) and BET surface area analyzer. EDX analysis showed the elements in the crystal BISMCP were Mn, C, and O. XRD result of BISMCP determined the crystal structure, which is close to rhodochrosite (MnCO₃). Spectral peaks of FTIR at 1641.79 cm⁻¹ confirmed the appearance of C[dbnd]O binding, with strong stretching of CO₃²⁻ in Amide I. From the six kinds of BISMCP produced, sample MCP-6 has the higher specific surface area by BET analysis at 109.01 m²/g, with pore size at 8.76 nm and higher pore volume at 0.178 cm³/g. These specifications will be suitable as an adsorbent for heavy metal removal by adsorption process. This study presents a preliminary analysis of the possibility of BISMCP for heavy metals adsorption using ICP multi-element standard solution XIII (As, Cr, Cd, Cu, Ni, and Zn). BISMCP formed from 0.1 MnCl₂ and 30 ml of bacteria volume (MCP-6) produced a better adsorbent material than others concentrations, with the adsorption efficiency of total As at 98.9%, Cr at 97.0%, Cu at 94.7%, Cd at 88.3%, Zn at 48.6%, and Ni at 29.5%. Future work could be examined its efficiency adsorbing individual heavy metals. © 2023

关键词： Adsorbent material Biologically induced mineralization Biomineralization Heavy metal removal Manganese carbonate (MnCO3) Sporosarcina pasteurii

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Design and synthesis of hydroxychloroquine-sugar conjugates as promising antimalarial agents

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Bioorganic & Medicinal Chemistry Letters 2025年 125-126卷 130289页

作者： Emil Salim Hilkatul Ilmi Aty Widyawaruyanti Natsuhisa Oka Department of Chemistry and Biomolecular Science Faculty of Engineering Gifu University 1-1 Yanagido Gifu 501-1193 Japan Department of Chemistry Faculty of Mathematics and Natural Sciences Universitas Andalas Padang 25163 Indonesia Doctoral Program at the Faculty of Pharmacy Universitas Airlangga Surabaya 60115 Indonesia Natural Product Medicine Research and Development Institute of Tropical Disease Universitas Airlangga Surabaya 60286 Indonesia Department of Pharmaceutical Sciences Faculty of Pharmacy Universitas Airlangga Surabaya 60115 Indonesia Institute for Glyco-core Research (iGCORE) Gifu University 1-1 Yanagido Gifu 501-1193 Japan Center for One Medicine Innovative Translational Research (COMIT) Institute for Advanced Study Gifu University 1-1 Yanagido Gifu 501-1193 Japan

Novel hydroxychloroquine (HCQ)-sugar conjugates were evaluated for their antimalarial activity against chloroquine-sensitive ( Pf 3D7) and multi-resistant ( Pf Dd2) strains of Plasmodium falciparum , cytotoxicity, and hydrolytic stability. HCQ-galactose conjugate with a 1,2-orthioester linkage exhibited the highest activity against Pf 3D7 (IC 50 value of 0.018 ± 0.001 μg/mL). Per- O -acetyl-β- d -glucopyranosyl-HCQ exhibited the highest activity against Pf Dd2 (IC 50 = 0.20 ± 0.02 μg/mL), while also maintaining comparable activity against Pf 3D7. Orthoester-linked conjugates were gradually hydrolyzed in human serum, resulting in HCQ release, which may contribute to their high activity. Glycosidic bond-linked conjugates showed high hydrolytic stability, retaining a certain level of activity, possibly without releasing HCQ. Toxicity assessments using the BHK21 cell line indicated significantly lower cytotoxicity for all HCQ-sugar conjugates compared to HCQ.

关键词： Glycosylation Hydroxychloroquine Malaria Plasmodium falciparum Sugar conjugate

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Assessment on Improvement of Early Detection Systems in Electrical Rooms of High-Tech Facilities 8

Assessment on Improvement of Early Detection Systems in Elec...

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2017 8th International Conference on Fire science and Fire Protection engineering, ICFSFPE 2017

作者： Chen, Yu-Jen Shu, Chi-Min Ho, San-Ping Ho, Hsin-Hsiu Chang, Hue-Pei Doctoral Program Graduate School of Engineering Science and Technology National Yunlin University of Science and Technology Douliou Yunlin64002 Taiwan Department of Safety Health and Environmental Engineering YunTech Douliou Yunlin64002 Taiwan Department of Occupational Safety and Health Chang Jung Christian University Tainan71101 Taiwan

Past air sampling detection (ASD) systems had no definitive positioning;most allocation of sampling points was based on experience. This research discovered that sampling points inside the electrical rooms were significantly affected by the ambient airflow, causing the detection system to have difficulties in fire detection. Fire dynamics simulator (FDS) was used to simulate very early smoke detection apparatus (VESDA) effectiveness within the protection area of an electrical room. Results showed that ASD sampling points in electrical rooms should be placed above high-voltage transformers and capacitors, while rearranging the high risk machines together to avoid long detection pipelines, which increases the transportation time of the gas, thus hindering early detection by the ASD system. Field tests using a smoke detector tester yielded transportation times of 33 s, which was in very good agreement with the simulated results of 35 s by ASPIRE, showing the accuracy of using software to simulate transportation times. Therefore, this research combined FDS with the transportation times of different pipeline designs to conduct performance assessment of VESDA. After appropriate rearrangement of machines, VESDA detection times dropped from 106.0-171.0 s during the original setup to 21.0-31.7 s, assuring the facility to have more time for emergency response. However, it was noticed that FDS software did not have the estimation tool for VESDA transportation times;therefore software such as ASPIRE should be used to calculate the gas transportation times inside the detection pipelines, and then compiled with FDS results to avoid underestimation of actuation times. © 2017 The Authors. Published by Elsevier Ltd.

关键词： Pipelines

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Tidal Influence on Water Quality of Kapuas Kecil River Downstream 2

Tidal Influence on Water Quality of Kapuas Kecil River Downs...

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2nd International Conference on Energy, Environmental and Information System, ICENIS 2017

作者： Purnaini, Rizki Sudarmadji Purwono, Suryo Doctoral Program of Environmental Science School of Postgraduate Studies Gadjah Mada University Yogyakarta Indonesia Department of Environmental Geography Faculty of Geography Gadjah Mada University Yogyakarta Indonesia Department of Chemical Engineering Faculty of Engineering Gadjah Mada University Yogyakarta Indonesia

The Kapuas Kecil River is strongly influenced by tidal, in the dry season the intrusion of surface water is often a problem for the WTP because it causes the change of raw water quality to be processed. The purpose of this study was to examine the effect of sea tides on water quality of the Kapuas Kecil River. The study was conducted in Kapuas River downstream along ± 30 km from the upper boundary to the estuary. Water sampling is carried out during the dry and rainy season, when the tidal conditions at 7 (seven) locations of the monitoring station. Descriptive analysis methods and regression-correlation statistics are used to determine the effect of tides on water quality in Kapuas River downstream. In general, the water quality of the Kapuas Kecil River has exceeded the criteria of first class water quality, ie water that can be used for drinking water. The status of water quality of the Kapuas Kecil River based on the pollution index calculation shows the condition of the river is "mild to medium pollutants". The result of multiple linear regression analysis got the value of coefficient of determination (adjusted R square) = 0,760, which in whole show that independent variable (tidal and distance) influence to dependent variable (value of TDS) equal to 76%. © 2018 The Authors, published by EDP sciences.

关键词： Rivers

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In-silico structural and functional analysis of nonsynonymous single nucleotide polymorphisms in human FOLH1 gene

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In silico pharmacology 2025年第1期13卷 32页

作者： Abtin Tondar Muhammad Irfan Sergio Sánchez-Herrero Hafsa Athar Aleena Haqqi Asim Kumar Bepari Laura Calvet Liñán David Hervás Marin Department of Computer Science Multimedia and Telecommunication Interuniversity Doctoral Program in Bioinformatics Universitat Oberta de Catalunya Barcelona (UOC) Spain. Stanford Deep Data Research Center Stanford University Stanford USA. Atta-Ur-Rahman School of Applied Biosciences (ASAB) National University of Sciences and Technology (NUST) Islamabad Punjab Pakistan. School of Medical Laboratory Technology Minhaj University Lahore (MUL) Lahore Punjab Pakistan. Department of Pharmaceutical Sciences North South University (NSU) Dhaka Bangladesh. Telecommunications and Systems Engineering Department Universitat Autònoma de Barcelona (UAB) Sabadell Spain. Department of Applied Statistics and Operational Research and Quality Alcoy Universitat Politècnica de València (UPV) Alcoy Spain.

Non-synonymous single nucleotide polymorphisms (nsSNPs), also known as missense SNPs, can seriously affect an individual’s vulnerability to numerous diseases, including cancer. In this study, we conducted a comprehensive in-silico analysis to examine the structural and functional implications of nsSNPs within the Folate Hydrolase 1(FOLH1) gene, which encodes the Prostate-Specific Membrane Antigen (PSMA). A total of 504 SNPs were retrieved, and after filtering, 15 pathogenic nsSNPs were identified using five different in-silico tools. Three of these SNPs—R255H (rs375565491), R255C (rs201789325), and G168E (rs267602926)—were consistently predicted to be pathogenic across all in-silico tools. MutPred2 was used to predict the structural and functional consequences of the identified mutations. The analysis revealed multiple alterations in the PSMA protein, including changes in helical conformations, glycosylation patterns, transmembrane properties, and solvent accessibility. Furthermore, I-Mutant 2.0 analysis demonstrated a decrease in protein stability for most nsSNPs, except for rs267602926 (G168E), which was predicted to increase stability. Conservation analysis using ConSurf revealed varying degrees of amino acid conservation, with R255H and R255C identified as highly conserved residues, indicating their potential functional and structural significance. Additionally, post-translational modification (PTM) analysis indicated that while phosphorylation and methylation sites remained unchanged, specific glycosylation sites were lost in two pathogenic mutant variants (R255H and R255C), potentially affecting PSMA function and adversely impacting prostate cancer. Our findings highlight the importance of in silico studies to investigate the structural and functional impacts of FOLH1 nsSNPs on the PSMA protein. Such in silico studies can deepen our understanding of the roles of nsSNPs in prostate cancer onset, progression, and drug resistance.

关键词： FOLH1 In-silico structural and functional analyses PSMA PTM nsSNPs

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Dynamic laplace: Efficient centrality measure for weighted or unweighted evolving networks

arXiv

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arXiv 2018年

作者： Cordeiro, Mário Sarmento, Rui Portocarrero Brazdil, Pavel Gama, João Doctoral Program in Informatics Engineering Faculty of Engineering University of Porto INESC TEC - Institute for Systems and Computer Engineering Technology and Science

With its origin in sociology, Social Network Analysis (SNA), quickly emerged and spread to other areas of research, including anthropology, biology, information science, organizational studies, political science, and computer science. Being it's objective the investigation of social structures through the use of networks and graph theory, Social Network Analysis is, nowadays, an important research area in several domains. Social Network Analysis cope with different problems namely network metrics, models, visualization and information spreading, each one with several approaches, methods and algorithms. One of the critical areas of Social Network Analysis involves the calculation of different centrality measures (i.e.: the most important vertices within a graph). Today, the challenge is how to do this fast and efficiently, as many increasingly larger datasets are available. Recently, the need to apply such centrality algorithms to non static networks (i.e.: networks that evolve over time) is also a new challenge. Incremental and dynamic versions of centrality measures are starting to emerge (betweenness, closeness, etc). Our contribution is the proposal of two incremental versions of the Laplacian Centrality measure, that can be applied not only to large graphs but also to, weighted or unweighted, dynamically changing networks. The experimental evaluation was performed with several tests in different types of evolving networks, incremental or fully dynamic. Results have shown that our incremental versions of the algorithm can calculate node centralities in large networks, faster and efficiently than the corresponding batch version in both incremental and full dynamic network setups. Copyright © 2018, The Authors. All rights reserved.

关键词： Laplace transforms

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