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Pioneering Astaxanthin-Tumor Cell Membrane Nanoparticles for Innovative Targeted Drug Delivery on Melanoma

International journal of nanomedicine 2024年 19卷 2395-2407页

作者： Jui-Jen Chang Yi-Chen Wang Shu-Hui Yang Ju-Yu Wu Ming-Wei Chang Hui-Min David Wang Department of Medical Research China Medical University Hospital China Medical University Taichung 40447 Taiwan. Graduate Institute of Integrated Medicine China Medical University Taichung 40447 Taiwan. Division of Cardiology Department of Internal Medicine Kaohsiung Armed Forces General Hospital Kaohsiung City 802 Taiwan. Institute of Medical Science and Technology National Sun Yat-sen University Kaohsiung 807 Taiwan. Graduate Institute of Biomedical Engineering National Chung Hsing University Taichung 402 Taiwan. Bachelor Program of Biotechnology National Chung Hsing University Taichung 402 Taiwan. Doctoral Program in Tissue Engineering and Regenerative Medicine National Chung Hsing University Taichung 402 Taiwan. Nanotechnology and Integrated Bioengineering Centre University of Ulster Belfast BT15 1AB Northern Ireland UK. Graduate Institute of Medicine College of Medicine Kaohsiung Medical University Kaohsiung 807 Taiwan. Department of Medical Laboratory Science and Biotechnology China Medical University Taichung 404 Taiwan. Center of Applied Nanomedicine National Cheng Kung University Tainan 701 Taiwan.

Background:Recently, the use of the tumor or its secretions as drug carriers has gradually become popular, with the advantages of high biocompatibility and enhanced drug delivery to specific cells. Melanoma is the most malignant tumor of all skin cancers; it is the most metastatic and, therefore, the most difficult to treat. The main purpose of this study is to develop nanovesicles with tumor cell membrane secretion properties to encapsulate target substances to enhance the therapeutic effect of cancer. Methods:Astaxanthin was selected as an anticancer drug due to our previous research finding that astaxanthin has extremely high antioxidant, anti-ultraviolet damage, and anti-tumor properties. The manufacturing method of the astaxanthin nanovesicle carrier is to mix melanoma cells and astaxanthin in an appropriate ratio and then remove the genetic material and inflammatory factors of cancer cells by extrusion. Results:In terms of results, after the co-culture of astaxanthin nanovesicles and melanoma cancer cells, it was confirmed that the ability of astaxanthin nanovesicles to inhibit the growth and metastasis of melanoma cancer cells was significantly better than the same amount of astaxanthin alone, and it had no effect on normal Human cells are also effective. There was no apparent harm on normal cells, indicating the ability of the vesicles to be selectively transported. Conclusion:Our findings illustrated the potential of astaxanthin nanovesicles as an anticancer drug.

关键词： astaxanthin melanoma nanoparticle

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The effect of chitosan hybrid nanoparticle-based nanovaccines (C-Nps) on the tissue damage of cantang grouper fish infected with viral nervous necrosis

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AIP Conference Proceedings 2024年第1期3027卷

作者： Uun Yanuhar Gunanti Mahasri Heru Suryanto Salman Bin Yunus Syamlan Nur Sakinah Junirahma Nico Rahman Caesar Aquatic Resources Management Faculty of Fisheries and Marine Science Universitas Brawijaya Malang East Java 65145 Indonesia Department of Aquaculture Faculty of Fisheries and Marine Universitas Airlangga Surabaya East Java 60115 Indonesia Department of Mechanical Engineering Faculty of Engineering Universitas Negeri Malang Malang East Java Indonesia Master Program of Aquaculture Faculty of Fisheries and Marine Science University of Brawijaya Malang East Java 65145 Indonesia Doctoral Program of Environmental Science Postgraduate Program University of Brawijaya Malang East Java 65415 Indonesia

The Cantang Grouper (Epinephelus fuscoguttatus-lanceoulatus) is a mating of the female Tiger Grouper fish (Epinephelus fuscoguttatus) and the male Kertang grouper fish (Epinephelus lanceoulatus). However, in farming activities, the Cantang Grouper fish can be affected by a VNN infection. One way to deal with the VNN infection is by giving recombinant nano-vaccine from the microalga Chlorella Vulgaris. This study aims to determine the effect of recombinant nano-vaccine administration of the microalgae Chlorella Vulgaris on the growth of the fish weight, length, and eye tissue in the Cantang grouper fish (Epinephelus fuscoguttatus lanceolatus) infected with Viral Nervous Necrosis (VNN). The method used in this study is experimental. The test results showed that the administration of the recombinant C. vulgaris (p-PerCv) vaccine affected the growth in length and weight of the Cantang grouper, this was because the growth in length and weight of its from the treatment group was significantly different from the control group (0.039<0.05). Known by the ANOVA test and also has a different effect on the level of damage to eye tissue both damage to hypertrophy, vacuolization, and necrosis. The results of the Tukey test showed that the treatment that had a significant effect was the T1 treatment (treatment of healthy fish +33l of recombinant C. vulgaris vaccine (p-PerCv) +8.5l of Chitosan nanoparticles).

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Mechanistic Insights into CLNS1A-Mediated Chemoresistance and Tumor Progression in Non-small Cell Lung Cancer

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Cancer letters 2025年 626卷 217783页

作者： Tong-You Wade Wei Jiun-Yi Hsia Tsung-Ying Yang Yu-Xu Huang Guo-Zhi Wang Yi-Chung Liu Yi-Wun Wang Fangzhou He Jo-Mei Maureen Chen Guo-Jun Zhao Ping-Chiang Lyu Li-Jen Su Shao-Chih Chiu Chang-Tze Ricky Yu Department of Applied Chemistry National Chi Nan University Nantou Taiwan Division of Cardiology Department of Medicine University of California San Diego La Jolla California USA. Electronic address: t1wei@health.ucsd.edu. Division of Thoracic Surgery Chung Shan Medical University Hospital Taichung Taiwan School of Medicine Chung Shan Medical University Taichung Taiwan. Department of Chest Medicine Taichung Veterans General Hospital Taichung Taiwan Doctoral Program in Translational Medicine National Chung Hsing University Taichung Taiwan. Department of Medicine JingGangShan University Ji'an China. Division of Thoracic Surgery Chung Shan Medical University Hospital Taichung Taiwan. Department of Life Sciences National Tsing Hua University Hsinchu Taiwan. Cardiovascular Research Center School of Basic Medical Sciences Xi'an Jiaotong University Health Science Center Xi'an China. Department of Applied Chemistry National Chi Nan University Nantou Taiwan. Department of Cardiology The First Affiliated Hospital of Zhengzhou University Zhengzhou China. Institute of Bioinformatics and Structural Biology Department of Life Science National Tsing Hua University Hsinchu Taiwan. Department of Biomedical Sciences and Engineering Education and Research Center for Technology Assisted Substance Abuse Prevention and Management and Core Facilities for High Throughput Experimental Analysis National Central University Taoyuan Taiwan. Graduate Institute of Biomedical Sciences China Medical University Taichung Taiwan Translational Cell Therapy Center Department of Medical Research China Medical University Hospital Taichung Taiwan. Electronic address: scchiu@mail.cmu.edu.tw. Department of Applied Chemistry National Chi Nan University Nantou Taiwan. Electronic address: ctyu@ncnu.edu.tw.

CLNS1A is a chloride channel protein and an essential component of the methylosome complex, which additionally comprises PRMT5 and MEP50. In this study, we investigated its contribution to lung cancer and its potential as a therapeutic target. Analysis of transcriptomic datasets and western blotting revealed that CLNS1A, PRMT5, and MEP50 were overexpressed in lung cancer tissues, with elevated CLNS1A expression correlating with poor patient survival. CLNS1A overexpression enhanced platinum clearance from cells, increased the IC values for chemotherapy, and improved cell survival. Conversely, the knockdown of CLNS1A increased drug accumulation, reduced survival, and increased sensitivity to chemotherapy. The 3W mutant, a chloride channel-defective variant with steric hindrance at key bottleneck residues, impaired chloride ion transport, thereby reducing drug resistance, migration, and anchorage-independent growth. Mechanistically, CLNS1A promotes drug efflux through its chloride channel activity and activates the FAK-SRC-RAC1 pathway to enhance motility and clonogenicity. It also facilitates PRMT5-mediated RUVBL1 methylation to support anti-apoptotic DNA damage response signaling. In vivo, CLNS1A overexpression accelerated tumor growth and reduced survival, whereas CLNS1A knockdown sensitized tumors to cisplatin, enhancing therapeutic efficacy. These findings suggest that CLNS1A is a potential biomarker and therapeutic target, and its inhibition offers a strategy to overcome drug resistance and limit the metastatic progression of lung cancer.

关键词： Chemoresistance Chloride channel DNA damage response Lung cancer Metastasis

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NTRK3 exhibits a pro-oncogenic function in upper tract urothelial carcinomas

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Kaohsiung Journal of Medical sciences 2024年第5期40卷 445-455页

作者： Lim, Lee-Moay Lee, Yi-Chen Lin, Ting-Wei Hong, Zi-Xuan Hsu, Wei-Chi Ke, Hung-Lung Hwang, Daw-Yang Chung, Wen-Yu Li, Wei-Ming Lin, Hui-Hui Kuo, Hung-Tien Huang, A-Mei Graduate Institute of Clinical Medicine College of Medicine Kaohsiung Medical University Kaohsiung Taiwan Division of Nephrology Department of Internal Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Kaohsiung Taiwan School of Medicine College of Medicine Kaohsiung Medical University Kaohsiung Taiwan Graduate Institute of Medicine College of Medicine Kaohsiung Medical University Kaohsiung Taiwan Department of Anatomy School of Medicine College of Medicine Kaohsiung Medical University Kaohsiung Taiwan Department of Urology School of Medicine College of Medicine Kaohsiung Medical University Kaohsiung Taiwan Department of Urology Kaohsiung Medical University Hospital Kaohsiung Medical University Kaohsiung Taiwan Department of Urology Kaohsiung Municipal Ta-Tung Hospital Kaohsiung Medical University Kaohsiung Taiwan National Institute of Cancer Research National Health Research Institute Tainan Taiwan Department of Computer Science and Information Engineering National Kaohsiung University of Science and Technology Kaohsiung Taiwan Department of Urology Ministry of Health and Welfare Pingtung Hospital Pingtung Taiwan Department of Medical Research Kaohsiung Medical University Hospital Kaohsiung Medical University Kaohsiung Taiwan Doctoral Degree Program in Toxicology College of Pharmacy Kaohsiung Medical University Kaohsiung Taiwan Department of Biochemistry School of Medicine College of Medicine Kaohsiung Medical University Kaohsiung Taiwan Research Center for Environmental Medicine Kaohsiung Medical University Kaohsiung Taiwan

Neurotrophic receptor tyrosine kinase 3 (NTRK3) has pleiotropic functions: it acts not only as an oncogene in breast and gastric cancers but also as a dependence receptor in tumor suppressor genes in colon cancer and neuroblastomas. However, the role of NTRK3 in upper tract urothelial carcinoma (UTUC) is not well documented. This study investigated the association between NTRK3 expression and outcomes in UTUC patients and validated the results in tests on UTUC cell lines. A total of 118 UTUC cancer tissue samples were examined to evaluate the expression of NTRK3. Survival curves were generated using Kaplan–Meier estimates, and Cox regression models were used for investigating survival outcomes. Higher NTRK3 expression was correlated with worse progression-free survival, cancer-specific survival, and overall survival. Moreover, the results of an Ingenuity Pathway Analysis suggested that NTRK3 may interact with the PI3K-AKT-mTOR signaling pathway to promote cancer. NTRK3 downregulation in BFTC909 cells through shRNA reduced cellular migration, invasion, and activity in the AKT-mTOR pathway. Furthermore, the overexpression of NTRK3 in UM-UC-14 cells promoted AKT-mTOR pathway activity, cellular migration, and cell invasion. From these observations, we concluded that NTRK3 may contribute to aggressive behaviors in UTUC by facilitating cell migration and invasion through its interaction with the AKT-mTOR pathway and the expression of NTRK3 is a potential predictor of clinical outcomes in cases of UTUC. © 2024 The Authors. The Kaohsiung Journal of Medical sciences published by John Wiley & Sons Australia, Ltd on behalf of Kaohsiung Medical University.

关键词： AKT-mTOR pathway neurotrophic receptor tyrosine kinase 3 (NTRK3) prognosis tropomyosin-related kinase (TrK) upper tract urothelial carcinoma (UTUC)

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Multigoal-oriented error estimation and mesh adaptivity for fluid-structure interaction

arXiv

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arXiv 2021年

作者： Ahuja, K. Endtmayer, B. Steinbach, M.C. Wick, Thomas Discipline of Computer Science and Engineering Indian Institute of Technology Indore India Leibniz Universität Hannover Institut für Angewandte Mathematik Welfengarten 1 Hannover30167 Germany Leibniz Universität Hannover Germany Université Paris-Saclay ENS Paris-Saclay LMT - Laboratoire de Mécanique et Technologie Gif-sur-Yvette91190 France Johannes Kepler University Linz Doctoral Program on Computational Mathematics Altenbergerstr. 69 LinzA-4040 Austria Austrian Academy of Sciences Johann Radon Institute for Computational and Applied Mathematics Altenbergerstr. 69 LinzA-4040 Austria

In this work, we consider multigoal-oriented error estimation for stationary fluid-structure interaction. The problem is formulated within a variational-monolithic setting using arbitrary Lagrangian-Eulerian coordinates. Employing the dual-weighted residual method for goal-oriented a posteriori error estimation, adjoint sensitivities are required. For multigoal-oriented error estimation, a combined functional is formulated such that several quantities of interest are controlled simultaneously. As localization technique for mesh refinement we employ a partition-of-unity. Our algorithmic developments are substantiated with several numerical tests such as an elastic lid-driven cavity with two goal functionals, an elastic bar in a chamber with two goal functionals, and the FSI-1 benchmark with three goal *** Codes 65N30, 65N50, 74F10 © 2021, CC BY-NC-ND.

关键词： Fluid structure interaction

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Sanitation and challenges in sustainable urban water management

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AIP Conference Proceedings 2023年第1期2667卷

作者： D. D. Anggoro I. Sumantri Y. S. Sari H. R. Sunoko R. Bicer 1Department of Chemical Engineering Faculty Engineering Diponegoro University Semarang Central Java 50275 Indonesia 2Doctoral Program of Environmental Science School of Postgraduate Studies Diponegoro University Semarang Central Java 50241 Indonesia 3Faculty of Theology Sakarya University Serdivan Turkey

Water and good sanitation are essential elements to support human health. Unfortunately, the fulfillment of clean water and sanitation needs has not been fully implemented in several parts of the world. Sanitation development in Indonesia refers to the Sustainable Development Goals, which in 2030 are targeted to ensure the availability and sustainable management of clean water and sanitation for all communities. The problem in this study is to determine community participation in its contribution to achieving SDGs (6) goals in the use of public toilet facilities built from local government budgets in a sustainable effort in the SANIMAS program in Bandung City West Java. The research results that have been carried out show that the use of shared toilet facilities requires participation from the community and the increasing number of residents in each urban area. Policies from the government can anticipate problems in the future, and there is a need for collaboration between the government, the private sector, and the community by paying attention to the environment both for the sustainability of water reserves from dug wells and the use of technology that can prevent river water pollution in the city, as well as the sustainability of the sanitation program for all public.

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Structure and functional group of CuO nanoparticle-reinforced osmosis membrane based on bacterial cellulose from Sargassum sp. extract

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AIP Conference Proceedings 2024年第1期3110卷

作者： Uun Yanuhar Heru Suryanto Muhamad Amin Jibril Maulana Nico Rahman Caesar Department of Aquatic Resources Management Faculty of Fisheries and Marine Science Brawijaya University Jl. Veteran Malang Indonesia Department of Mechanical Engineering Faculty of Engineering Universitas Negeri Malang Malang Indonesia Department of Aquaculture Faculty of Fisheries and Marine Universitas Airlangga Surabaya Indonesia Doctoral Program of Environmental Science Postgraduate School Brawijaya University Malang Indonesia

Osmosis membranes have been widely used in industries for water purification, wastewater treatment, and biomedical applications. However, the current membranes still have some drawbacks, such as water flow resistance and vulnerability to fouling. Therefore, the development of more efficient and durable osmosis membranes is highly necessary. In this research, the researchers used bacterial nanocellulose extracted from Sargassum sp. as a material for producing more efficient osmosis membranes. The methods used in this study were experiments with two treatments: (1) control, and (2) Bacterial cellulose with a concentration of 1.0 wt% CuO nanoparticles. The nanocellulose was produced using a high-pressure homogenizer, followed by the synthesis of acetate nanocellulose and characterization of the nanocomposite membrane functionalized with CuO nanoparticles. The membranes were characterized using FTIR and XRD analysis. Bacterial cellulose from seaweed was successfully formed with a thickness of 1-3 cm. The results of the characterization analysis showed that the formed bacterial cellulose belonged to Cellulose type I with a crystalline degree ranging from 88.7% to 85.7%. The dry osmosis membranes were analyzed based on their functional groups using FTIR. The analysis revealed changes in transmittance at the peaks of O-H at wavenumbers 3122-3414 and Cu-O at wavenumber 424-673, resulting from the addition of CuO nanoparticles and causing changes in the value of the O-H bond in bacterial cellulose.

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Classification of images containing sensitive and non-sensitive information using the convolutional neural network

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AIP Conference Proceedings 2023年第1期2865卷

作者： Yudhi Ardiyanto Kusworo Adi Kurnianingsih Kurnianingsih Adi Wibowo Budi Warsito Doctoral Program of Information System School of Postgraduate Studies Diponegoro University Semarang 50241 Indonesia Department of Electrical Engineering Faculty of Engineering Universitas Muhammadiyah Yogyakarta Bantul 55183 Indonesia Department of Physics Faculty of Science and Mathematics Diponegoro University Semarang 50275 Indonesia Department of Electrical Engineering Politeknik Negeri Semarang Semarang 50275 Indonesia

Currently, social media is used by almost all ages, from pre-teens to the elderly. They use social media to socialize and express their activities by uploading pictures; however, they sometimes do not realize that the images they upload contain sensitive information. They do not carefully analyze the images to be uploaded due to a lack of knowledge, irresponsible acts, or impaired vision. Therefore, we propose a method to classify images with sensitive or non-sensitive content using Convolutional Neural Network (CNN). This research was performed through several steps: image public dataset collection, data pre-processing, model architecture design, model training, and model validation. A randomly selected sample of 2,000 of 5,537 images from the VizWiz-Priv dataset was used to train the classification model. The CNN architecture was compiled using two max-pooling layers and four convolution layers. Finally, the model was trained and validated using images containing sensitive and non-sensitive information. The results revealed that the model accuracy during training and validation achieved 98.75% and 83.30%, respectively.

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The Effect of Road Network and the Freight Transport Operation to the Development of the Region and Welfare of the Society in Langkat Regency

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Journal of Physics: Conference Series 2021年第1期1811卷

作者： Harimin Tarigan A. Rahim Matondang Suwardi Lubis Sirojuzilam Doctoral Program in Regional Planning Universitas Sumatera Utara Medan Indonesia Department of Industrial Engineering Universitas Sumatera Utara Medan Indonesia Department of Communication Science Universitas Sumatera Utara Medan Indonesia Department of Development Economics Universitas Sumatera Utara Medan Indonesia

This study aims to determine the effect of the road network and the implementation of freight transportation on regional development and the community welfare in Langkat Regency. This type of research is associative and explanatory research whose data are obtained through surveys. The study population was drivers of motor vehicles transporting goods in Langkat Regency. The number of samples is 305 respondents by means of probability sampling and data analysis techniques using Structural Equation Modelling (SEM). The results showed that the road network variables did not significantly influence the community welfare, but the road network had a significant and positive effect on the community welfare through the development of the Langkat Regency. The implementation of freight transportation has a significant and positive effect on the community welfare partially, directly and through the development of the Langkat Regency. Regional development has a significant and positive effect on the community welfare of Langkat Regency.

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The impact of soil erosion on sedimentation/silting and decreasing water quality in oxbow lake, Grogol Sub-district, Sukoharjo District

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AIP Conference Proceedings 2024年第1期3019卷

作者： Andi Renata Ade Yudono Suntoro Conrad Danisworo Cahyono Ikhsan Doctoral Program of Environmental Science Graduate School of Universitas Sebelas Maret Surakarta City Central Java Indonesia Environment Engineering UPN Veteran Yogyakarta Special Region of Yogyakarta Indonesia Graduate School of Universitas Sebelas Maret Surakarta City Central Java Indonesia

Land use changes that are not under its designation (carrying capacity and capacity) will cause environmental degradation such as erosion. Erosion that occurs, in general, will result in a reduction in soil fertility, a reduction in soil volume, and may result in silting/sedimentation and a decrease in water quality due to an increase in Total Suspended Solid (TSS) levels. The purpose of this study was to determine the Erosion Hazard Level (EHL) that occurred around the oxbow lake and the impact caused by the erosion on the sustainability of the function of the oxbow lake. The methods used in this research are field survey and mapping methods, laboratory analysis methods, and spatial analysis methods on topography and bathymetry as well as Sentinel Satellite Imagery to find out the estimated size of the existing TSS. Erosion rate measurements were carried out using the erosion measuring stick method to measure soil loss over a certain time. Based on the results of the study, it was found that there were two TBE in the study area, including areas with Very Heavy TBE (SB) due to having soil solum > 90 cm and erosion of 653.01 tons/ha/yr. (PME 1), 581.34 tons/ha /yr. (PME 2), and 1022 tons/ha/yr. (PME 3) (> 480 tons/ha/yr.); and areas with heavy TBE (B) due to having soil solum > 90 cm and erosion of 387.80 tons/ha/year (180 - 480 tons/ha/year). The impact of erosion can also result in silting/sedimentation in the oxbow lake so that it can indirectly lead to a reduction in oxbow lake capacity/reservoir and an increase in the TSS parameter which is expected to continue due to an increase in the trendline both in the amount of rainfall and the average rain that occurred in 3 years. and in 2022 (January – June).

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