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Multiscale modeling in rodent ventricular myocytes

Multiscale modeling in rodent ventricular myocytes

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作者： Lu, Shaoying Michailova, Anushka Saucerman, Jeffrey Cheng, Yuhui Yu, Zeyun Kaiser, Timothy Li, Wilfred Bank, Randolph Holst, Michael McCammon, J. Hayashi, Takeharu Hoshijima, Masahiko Arzberger, Peter McCulloch, Andrew Bioengineering Department University of Illinois United States Bioengineering Department UCSD United States Department of Biomedical Engineering University of Virginia United States Department of Mathematics UCSD United States UCSD United States College of Computer Science and Technology Jilin University China Department of Mathematics Center for Computational Mathematics and the Computational Science Mathematics and Engineering Doctoral Program at UCSD Department of Pharmacology UCSD United States Center for Research in Biological Systems UCSD United States Department of Bioengineering UCSD United States Department of Bioengineering PFBH 241 University of California San Diego 9500 Gilman Drive San Diego CA 92093-0412 United States

There is a growing body of experimental evidence suggesting that the Ca2+ signaling in ventricular myocytes is characterized by a high gradient near the cell membrane and a more uniform Ca2+ distribution in the cell interior [1]--[7]. An important reason for this phenomenon might be that in these cells the t-tubular system forms a network of extracellular space, extending deep into the cell interior. This allows the electrical signal, that propagates rapidly along the cell membrane, to reach the vicinity of the sarcoplasmic reticulum (SR), where intracellular Ca2+ required for myofilament activation is stored [1], [8]--[11]. Early studies of cardiac muscle showed that the t-tubules are found at intervals of about 2 lm along the longitudinal cell axis in close proximity to the Z-disks of the sarcomeres [12]. Subsequent studies have demonstrated that the t-tubular system has also longitudinal extensions [9]--[11], [13].

关键词： Cells

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Effect of tin on the recrystallization behavior and texture of grain oriented electrical steels

Effect of tin on the recrystallization behavior and texture ...

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Materials Processing and Texture - 15th International Conference on Textures of Materials, ICOTOM 15

作者： Liao, Chun-Chih Hou, Chun-Kan Graduate School of Engineering Science and Technology Doctoral Program National Yunlin University of Science and Technology 123 University Road Douliou Yunlin 64002 Taiwan Department of Mechanical Engineering National Yunlin University of Science and Technology 123 University Road Douliou Yunlin 64002 Taiwan

ISBN: (纸本)9780470408346

Influence of tin, range from 0-0.31wt%, on the recrystallization behavior and texture of grain oriented electrical has been investigated. Tin is susceptible to segregation at grain boundary and on surface that pinning down the grain boundary mobility. Annealed hot bands in 2.5mm are cold rolled to 0.35 mm in one-stage cold rolling. Cold-rolled sheets are decarburization annealing at 800°C for 5 minutes in wet H2-N2 atmosphere. During secondary recrystallization specimens are heated to 900~1200°C and soaked 12 hours with a heating rate 12 °C per hour after 700 °C. Both X-ray and EBSD are conducted to examine the grain orientation. It is found that pinning effect of tin is very strong for secondary recrystallization. The specimens containing less than 0.05wt% tin finish secondary recrystallization after SRT at 1000 °C. The secondary recrystallization grain growth became difficult as the tin content above 0.10wt%. According to EBSD results, after primary recrystallization, the intensity of (011) texture in the specimens with nitriding 30 seconds slightly increases with increasing tin content and reaches a maximum value at 0.05wt% tin. Then, it rapidly decreases with increasing tin and reaches a minimum at 0, 21wt% tin. Finally, it increases with increasing tin again. However, the intensity of (011) texture in the specimens without nitriding decreases with increasing tin content and reaches a minimum value at 0.21 wt% tin. Then, it increases with increasing tin. Both EBSD and XRD results show that the intensities of (111) textures in the specimens both with and without nitriding decreases with increasing tin content and reaches a value at 0.05 wt% tin. Then, it increases with increasing tin and reaches a peak at 0.1wt% tin. Finally, it decreases with increasing tin again. For the specimens without nitriding treatment, while the SRT is higher than 1100°C, best magnetic properties was occurred in the steel containing 0.05 wt% tin. However, the flux density increases and c

关键词： Nitriding

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Effect of tin on the texture of nonoriented electrical steels

Effect of tin on the texture of nonoriented electrical steel...

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Materials Processing and Texture - 15th International Conference on Textures of Materials, ICOTOM 15

作者： Hou, Chun-Kan Lee, Tong-Han Liao, Chun-Chih Department of Mechanical Engineering National Yunlin University of Science and Technology I23 University Road Section 3 Douliou Yunlin 64002 Taiwan Graduate School of Engineering Science and Technology Doctoral Program National Yunlin University of Science and Technology I23 University Road Section 3 Douliou Yunlin 64002 Taiwan

ISBN: (纸本)9780470408346

The effect of tin (range from 0.029-0.21 wt%) on the inclusion size in hot bands, grain size and texture of four non-oriented electrical steels after final annealing has been investigated. The steel ingots were reheated to 1200C and finished rolled at 950C. Then hot bands were annealed at 750C for two hours and cold rolled to 0.5mm. After annealing the cold rolled sheets at 750-950 °C for one minute, both X-ray diffractometer with texture attachment and EBSD analyses were conducted to measure specimen texture. It was found that 5-10 μm coarse MnS + AlN inclusions existed in the hot bands containing 0.029 wt% tin. However, 1-2 μm fine MnS+AlN inclusions were found in the hot bands containing 0.21 wt% tin. After final annealing, grain size decreased with increasing tin content and began to level off when tin reached 0.10wt%. At the same cold rolled annealing temperature, the intensity of {011} texture increased with increasing tin content. In the same steel, the intensity of {011} texture increased with increasing annealing texture and reached a maximum value and then declined sharply. The temperature to obtain maximum intensity of {011} texture strongly correlated with tin content, EBSD showed that the number and volume fraction of {011} grain per mm2 increased with increasing tin content. It is concluded that adding tin in the range of 0.100-0.210wt% to non-oriented electrical steels can enhance the volume fraction of Goss grain, The mechanisms are that tin not only enhances the nucleation of Goss grain, but also promotes its growth. Conversely, adding 0.055wt% tin to non-oriented electrical steels can lead to the best cube texture. This tin content maximizes the nucleation density of cube grains during annealing at 850C.

关键词： Annealing

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Analytical modeling of the pulsation torque of an induction motor under Steinmetz circuit

Analytical modeling of the pulsation torque of an induction ...

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IEEE Conference on Industrial Electronics and Applications (ICIEA)

作者： Yaw-Juen Wang Ming-Hsueh Lee Department of Electrical Engineering National Yunlin University of Science and Technology Yunlin Taiwan School of Engineering Science and Technology (Doctoral Program) National Yunlin University of Science and Technology Yunlin Taiwan

Three-phase voltage unbalance has long been a problem in electric power system. It not only increases the system losses but has detrimental effects on three-phase rotating machines. This paper deals with the pulsating torque of an induction motor caused by Steinmetz connection which has been used for a three-phase motor operating on a single-phase supply. An analytical model based on the positive-sequence and negative sequence equivalent circuits of the motor is developed, and the pulsating torque as a function of the capacitance and slip rate are then derived. The proposed analytical method is verified by the Universal Machine Model of the EMTP. Finally it is provided to show the relation between site measurement, mathematical analysis and EMTP simulation. It is expected that the proposed method can be used to get a solution for pulsating torque by Three-phase voltage unbalance.

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Fuzzy Fusion for Affective State Assessment in Distance Learning Based on Image Detection

Fuzzy Fusion for Affective State Assessment in Distance Lear...

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2008 International Conference on Audio，Language and Image Processing(2008国际声音、语言、图像过程大会)

作者： Kuoan Hwang Chiahao Yang Department of Computer Science and Information Engineering & Graduate Institute of Networking and Co Graduate Institute of Informatics Doctoral program Chaoyang University of Technology

Distance learning is a learning style that can overcome the limitation of time and space. Because of the distance, teachers can not handle the student's learning situation, and they do not know whether the student is attentive, drowsy or absent. If teachers can know the student's affective state, they can overcome the difficult. The research applies the image recognition technologies to capture the face images of students when they are learning and analyzes their face features to evaluate the student's affective state by Fuzzy Integral. Finally, teachers can monitor the student's behavior by the detection results on the system interface.

关键词： Distance learning Skin Computers Distance measurement Face Image color analysis Education

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Safety management on fire emergency response by VESDA applications at semiconductor plants

Safety management on fire emergency response by VESDA applic...

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IEEE International Conference on Systems, Man and Cybernetics

作者： Chun-Ping Lin Chi-Min Shu Doctoral Program Graduate School of Engineering Science and Technology National Yunlin University of Science and Technology Yunlin Taiwan Process Safety and Disaster Prevention Laboratory Department of Safety Health and Environmental Engineering National Yunlin University of Science and Technology Yunlin Taiwan

To take an advantageous stance in the recent competition of semiconductor industries, companies have made efforts to invest terms of technological advancements. From 1993 to 2006, enormous fire accidents occurred in three national science parks in Taiwan. This research focused on whether the very early smoke detection apparatus (VESDA), could adequately assist the emergency response center (ERC) members to take actions when alarm occurs. Besides, the research also analyzed every VESDA alarm that happened from 2004 to 2006 for the purpose of increasing ERC personnel's experience and coordinating ERC with departments of safety management, environmental protection, facility engineering, and equipment sections together to investigate better solutions to related problems.

关键词： Disaster management Fires Electronics industry Accidents Smoke detectors Personnel Safety devices Environmental management engineering management Protection

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Attentiveness Assessment in Learning Based on Fuzzy Logic Analysis

Attentiveness Assessment in Learning Based on Fuzzy Logic An...

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International Conference on Intelligent Systems Design and Applications (ISDA)

作者： Kuo-An Hwang Chia-Hao Yang Department of Computer Science and Information Engineering & Graduate Institute of Networking and CommunicationEngineering ChaoYang University of Technology Taiwan Graduate Institute of Informatics Doctoral program ChaoYang University of Technology Taiwan

Learner attention affects learning efficiency. However, in many classes, teachers cannot assess the degree of attention of every student. When a teacher is capable of addressing inattentive students immediately, he can avoid situations in which students are inattentive. Many studies have analyzed student attentiveness by the applying of image detection technologies. If this mechanism can be applied to in-class learning, it will help teachers keep students attentive, and reduce teacher load during class. This study mainly applies fuzzy logic analysis of student facial images when participating in class. Applying fuzzy logic can prevent erroneous judgments associated with a single term, and help teachers deal with student attentiveness.

关键词： Fuzzy logic Face detection Image analysis Image color analysis Education Eyes Design engineering Chaotic communication Image processing Face recognition

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Modeling the effect of population growth on stream nutrient concentration in turkey creek watershed using the WARMF model

Modeling the effect of population growth on stream nutrient ...

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11th National Symposium on Individual and Small Community Sewage Systems

作者： Geza, M. McCray, John E. Post Doctoral Researcher Environmental Science and Engineering Division Colorado School of Mines Department of Hydrologic Science and Engineering Program Environmental Science and Engineering Division Colorado School of Mines

Population growth and water quality in the foothills of Jefferson County are of concern to County's Board of County Commissioners and the Planning and Zoning Department. The Department desires to meet the needs of residents for adequate supplies of good quality water. The Turkey Creek watershed is representative of the foothills portions of Jefferson County. In 2001 population in the Turkey Creek watershed is estimated at 11,064 residents with projected population growth, using a 2-percent per year rate, at 13,186 residents in 2010, and 15,313 residents in 2020. Wtershed based non-point source (NPS) studies have usually ignored the impact of on-site septic systems (OWS) on the quality of surface water. However, OWS can be a substantial source of nutrients to surface waters. Point discharges from Wastewater Treatment Plants (WWTPs) can also contribute to stream pollution from nutrients if treatment efficiency at the WWTP is low. Several models can handle point source discharges from WWTPs. Evaluating nutrient loading from septic systems to streams is a challenging task because most NPS models are not specifically developed to track the fate and transport of nutrients from on-site systems. The Watershed Analysis Risk Management Framework (WARMF) model is adapted to simulate on-site septic systems loading. The 122.2 square-kilometer Turkey Creek watershed is located in Jefferson County, southwest of Denver, Colorado. The topography is mostly steep with elevations ranging from about 1800 m to 3200 m. WARMF model hydrologic calibration was performed using data from the gage station located at Turkey Creek at mouth of canyon near Morrison. Water-quality data collected during flow calibration period was used to guide water quality calibration. The base case scenario is established at year 2001. The scenarios in this study are population at 1990 and projected population at year 2010. The scenario runs will also provide the contributions of different water treatment options

关键词： Nutrients

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Perpendicular Co-Zn-Gd Magnetic Film Electrodeposited by Molten Chlorozincate Electrolyte

Perpendicular Co-Zn-Gd Magnetic Film Electrodeposited by Mol...

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International Conference on Magnetics (INTERMAG)

作者： M. Shu T. Wu C. Yang Taiwan SPIN Research Center National Yunlin University of Science and Technology Yunlin Taiwan National Yunlin University of Science and Technology Douliou TW Graduate School of Engineering Science and Technology (Doctoral Program) National Yunlin University of Science and Technology Yunlin Taiwan Department of Environmental Resources Management Overseas Chinese Institute of Technology Taichung Taiwan

We have utilized ZnCl 2 -dimethylsulfone (DMSO 2 ) as the electrolyte with added CoCl 2 and GdCl 3 for electrodepositing a magnetic film. Moreover, the controlled potential method was utilized for film deposition. The voltammogram revealed that the reduction of Co-Zn-Gd film can be achieved by applying a potential in the range from -0.1 to -0.5 volts. From the results of AGM analyses, a high squareness value (Mr/Ms = 0.923) of the Co-Zn-Gd film at -0.3 volt was observed. In previous research, perpendicular magnetic materials have been applied to magnetic optic (MO) media, magnetic recording heads, and perpendicular magnetic tunneling junction (pMTJ). However, preparation of magnetic materials is normally carried out in high vacuum systems. Since electrodeposition methods for preparation of magnetic films have several advantages, such as simple equipment, ease of operation and relatively large area, the use of electrodeposition has great potential for preparing films.

关键词： Magnetic films Optical films Magnetic materials Magnetic analysis Perpendicular magnetic recording Optical recording Magnetic recording Magnetic heads Magnetic tunneling Vacuum systems

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Location management for PCS networks with consideration of mobility patterns

Location management for PCS networks with consideration of m...

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IEEE INFOCOM 2005

作者： Li, Jie Kubota, Atsushi Kameda, Hisao Department of Computer Science Graduate School of Systems and Information Engineering University of Tsukuba Tsukuba Sci. City Ibaraki 305-8573 Japan Doctoral Program in Science and Information Engineering University of Tsukuba Tsukuba Sci. City Ibaraki 305-8573 Japan

ISBN: (纸本)0780389689

This paper addresses the dynamic location management for personal communication service (PCS) networks with consideration of mobility patterns. The popular hexagonal cellular architecture is considered. In this paper, we first introduce a coordinate system for the hexagonal cellular architectures. Then, we develop an all-direction mobility model based on the coordinate system for the hexagonal cellular architecture to cope with the mobility patterns of mobile terminals (MTs). The shape and size of the local area (LA) in the dynamic location management scheme is determined by minimizing the total location management cost with bounding the paging cost The optimization problem is transferred to maximize expected number of cells traversed by the MT in the LA with a given size of the LA. The analytic model of calculating the probabilities of any MT's moving is established. An algorithm is proposed to solve the optimization problem efficiently. © 2005 IEEE.

关键词： Data transfer

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