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26th Annual Computational Neuroscience Meeting (CNS*2017) of the Organization for Computational Neuroscience Antwerp, Belgium, July 15-20, 2017

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BMC NEUROscience 2017年第SUPPL 1期18卷 59-59页

作者： [Anonymous] Indiana University Purdue University Indianapolis Indianapolis IN 46032 USA Stark Neurosciences Research Institute Indiana University School of Medicine Indianapolis IN 46032 USA Department of Mathematics East Carolina University Greenville NC 27858 USA Jülich Supercomputing Centre Forschungszentrum Jülich 52425 Jülich Germany Future Systems Swiss National Supercomputing Centre 8092 Zurich Switzerland User Engagement and Support Swiss National Supercomputing Centre 6900 Lugano Switzerland Institut de Neurosciences des Systèmes Aix Marseille Univ 13005 Marseille France Simulation Lab Neuroscience Forschungszentrum Jülich Jülich Germany Department of Experimental Psychology Ghent University 9000 Ghent Belgium Donders Center for Cognitive Neuroimaging Radboud University 6525HR Nijmegen The Netherlands Department of Electrical Computer and Energy Engineering University of Colorado Boulder CO 80309 USA Department of Neurosurgery Johns Hopkins School of Medicine Baltimore MD 21287 USA Department of Neurology Johns Hopkins School of Medicine Baltimore MD 21287 USA Department of Otolaryngology Johns Hopkins School of Medicine Baltimore MD 21287 USA INSERM U968 Paris France Sorbonne Universités UPMC University Paris 06 UMR_S 968 Institut de la Vision Paris France CNRS UMR_7210 Paris France Department of Computer Architecture and Technology University of Granada (CITIC) Granada Spain Sorbonne Universités UPMC Univ Paris 06 INSERM CNRS Institut de la Vision Paris France Department of Adaptive Machine Systems Osaka University Osaka Japan Department of Computer Science University of Cergy-Pontoise Cergy-Pontoise France Department of Physics and Astronomy College of Charleston Charleston SC 29424 USA School of Physics Faculty of Science University of Sydney Sydney NSW 2006 Australia Center of Excellence for Integrative Brain Function Australian Research Council Sydney Australia Max Planck Institute for Human Cognitive and Brain Sciences Saxony Lei

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RETRACTION: DDX5 and its associated lncRNA Rmrp modulate TH17 cell effector functions (Retraction of Vol 528, Pg 517, 2015)

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NATURE 2018年第7725期562卷 150-150页

作者： Huang, Wendy Thomas, Benjamin Flynn, Ryan A. Gavzy, Samuel J. Wu, Lin Kim, Sangwon V. Hall, Jason A. Miraldi, Emily R. Ng, Charles P. Rigo, Frank Meadows, Sarah Montoya, Nina R. Herrera, Natalia G. Domingos, Ana I. Rastinejad, Fraydoon Myers, Richard M. Fuller-Pace, Frances V. Bonneau, Richard Chang, Howard Y. Acuto, Oreste Littman, Dan R. The Kimmel Center for Biology and Medicine of the Skirball Institute New York University School of Medicine New York New York 10016 USA. Sir William Dunn School of Pathology University of Oxford Oxford OX1 3RE UK. Center for Personal Dynamic Regulomes Stanford University Stanford California 94305 USA. Center for Genomics and Systems Biology Department of Biology New York University New York New York 10003 USA. Courant Institute of Mathematical Sciences Computer Science Department New York University New York New York 10012 USA. Simons Center for Data Analysis Simons Foundation New York New York 10010 USA. Isis Pharmaceuticals Carlsbad California 92010 USA. HudsonAlpha Institute for Biotechnology Huntsville Alabama 35806 USA. Instituto Gulbenkian de Ciencia Oeiras 2780-156 Portugal. Integrative Metabolism Program Sanford Burnham Prebys Medical Discovery Institute Orlando Florida 32827 USA. Division of Cancer Research University of Dundee Dundee DD1 9SY UK. The Kimmel Center for Biology and Medicine of the Skirball Institute New York University School of Medicine New York New York 10016 USA. Dan.Littman@med.nyu.edu. Howard Hughes Medical Institute New York University School of Medicine New York New York 10016 USA. Dan.Littman@med.nyu.edu.

Change History: This Article has been retracted; see accompanying Retraction. Corrected online 20 January: In this Article, author Frank Rigo was incorrectly listed with a middle initial; this has been corrected in th...

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26th Annual Computational Neuroscience Meeting (CNS*2017): Part 3 Antwerp, Belgium. 15-20 July 2017 Abstracts

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BMC NEUROscience 2017年第SUPPL 1期18卷 95-176页

作者： [Anonymous] Department of Neuroscience Yale University New Haven CT 06520 USA Department Physiology & Pharmacology SUNY Downstate Brooklyn NY 11203 USA NYU School of Engineering 6 MetroTech Center Brooklyn NY 11201 USA Departament de Matemàtica Aplicada Universitat Politècnica de Catalunya Barcelona 08028 Spain Institut de Neurobiologie de la Méditerrannée (INMED) INSERM UMR901 Aix-Marseille Univ Marseille France Center of Neural Science New York University New York NY USA Aix-Marseille Univ INSERM INS Inst Neurosci Syst Marseille France Laboratoire de Physique Théorique et Modélisation CNRS UMR 8089 Université de Cergy-Pontoise 95300 Cergy-Pontoise Cedex France Department of Mathematics and Computer Science ENSAT Abdelmalek Essaadi’s University Tangier Morocco Laboratory of Natural Computation Department of Information and Electrical Engineering and Applied Mathematics University of Salerno 84084 Fisciano SA Italy Department of Medicine University of Salerno 84083 Lancusi SA Italy Dipartimento di Fisica Università degli Studi Aldo Moro Bari and INFN Sezione Di Bari Italy Data Analysis Department Ghent University Ghent Belgium Coma Science Group University of Liège Liège Belgium Cruces Hospital and Ikerbasque Research Center Bilbao Spain BIOtech Department of Industrial Engineering University of Trento and IRCS-PAT FBK 38010 Trento Italy Department of Data Analysis Ghent University Ghent 9000 Belgium The Wellcome Trust Centre for Neuroimaging University College London London WC1N 3BG UK Department of Electronic Engineering NED University of Engineering and Technology Karachi Pakistan Blue Brain Project École Polytechnique Fédérale de Lausanne Lausanne Switzerland Departement of Mathematics Swansea University Swansea Wales UK Laboratory for Topology and Neuroscience at the Brain Mind Institute École polytechnique fédérale de Lausanne Lausanne Switzerland Institute of Mathematics University of Aberdeen Aberdeen Scotland UK Department of Integrativ

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Author Correction: The challenge of mapping the human connectome based on diffusion tractography

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Nature communications 2019年第1期10卷 5059页

作者： Klaus H Maier-Hein Peter F Neher Jean-Christophe Houde Marc-Alexandre Côté Eleftherios Garyfallidis Jidan Zhong Maxime Chamberland Fang-Cheng Yeh Ying-Chia Lin Qing Ji Wilburn E Reddick John O Glass David Qixiang Chen Yuanjing Feng Chengfeng Gao Ye Wu Jieyan Ma Renjie He Qiang Li Carl-Fredrik Westin Samuel Deslauriers-Gauthier J Omar Ocegueda González Michael Paquette Samuel St-Jean Gabriel Girard François Rheault Jasmeen Sidhu Chantal M W Tax Fenghua Guo Hamed Y Mesri Szabolcs Dávid Martijn Froeling Anneriet M Heemskerk Alexander Leemans Arnaud Boré Basile Pinsard Christophe Bedetti Matthieu Desrosiers Simona Brambati Julien Doyon Alessia Sarica Roberta Vasta Antonio Cerasa Aldo Quattrone Jason Yeatman Ali R Khan Wes Hodges Simon Alexander David Romascano Muhamed Barakovic Anna Auría Oscar Esteban Alia Lemkaddem Jean-Philippe Thiran H Ertan Cetingul Benjamin L Odry Boris Mailhe Mariappan S Nadar Fabrizio Pizzagalli Gautam Prasad Julio E Villalon-Reina Justin Galvis Paul M Thompson Francisco De Santiago Requejo Pedro Luque Laguna Luis Miguel Lacerda Rachel Barrett Flavio Dell'Acqua Marco Catani Laurent Petit Emmanuel Caruyer Alessandro Daducci Tim B Dyrby Tim Holland-Letz Claus C Hilgetag Bram Stieltjes Maxime Descoteaux Division of Medical Image Computing German Cancer Research Center (DKFZ) Heidelberg 69120 Germany. k.maier-hein@dkfz.de. Division of Medical Image Computing German Cancer Research Center (DKFZ) Heidelberg 69120 Germany. Sherbrooke Connectivity Imaging Lab (SCIL) Université de Sherbrooke Sherbrooke QC J1K 0A5 QC Canada. Department of Intelligent Systems Engineering School of Informatics and Computing Indiana University Bloomington IN 47408 USA. Krembil Research Institute University Health Network Toronto Canada M5G 2C4. Department of Neurological Surgery University of Pittsburgh School of Medicine Pittsburgh PA 15213 USA. IMT-Institute for Advanced Studies Lucca 55100 Italy. Department of Diagnostic Imaging St. Jude Children's Research Hospital Memphis TN 38105 USA. University of Toronto Institute of Medical Science Toronto Canada M5S 1A8. Institute of Information Processing and Automation Zhejiang University of Technology Hangzhou 310023 Zhejiang China. United Imaging Healthcare Co Shanghai 201807 China. Shanghai Advanced Research Institute Shanghai 201210 China. Laboratory of Mathematics in Imaging Harvard Medical School Boston MA 02215 USA. Center for Research in Mathematics Guanajuato 36023 Mexico. PROVIDI Lab Image Sciences Institute University Medical Center Utrecht Utrecht 3508 The Netherlands. Cardiff University Brain Research Imaging Centre School of Psychology Cardiff University Maindy Road Cardiff CF24 4HQ UK. Department of Radiology University Medical Center Utrecht Utrecht 3508 The Netherlands. Centre de recherche institut universitaire de geriatrie de Montreal (CRIUGM) Université de Montréal Montreal QC Canada H3W 1W5. Sorbonne Universités UPMC Univ Paris 06 CNRS INSERM Laboratoire d'Imagerie Biomédicale (LIB) 75013 Paris France. Center for Advanced Research in Sleep Medicine Hôpital du Sacré-Coeur de Montréal Montreal Canada H4J 1C5. Neuroimaging Unit Institute of Bioimaging and Molecular Physiology (IBFM) Nat

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

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25th Annual Computational Neuroscience Meeting CNS-2016, Seogwipo City, South Korea, July 2-7, 2016 Abstracts

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BMC NEUROscience 2016年第1期17卷 1-112页

作者： [Anonymous] Computational Neurobiology Laboratory The Salk Institute for Biological Studies San Diego USA UNIC CNRS Gif sur Yvette France The European Institute for Theoretical Neuroscience (EITN) Paris France ATR Computational Neuroscience Laboratories Kyoto Japan Krembil Research Institute University Health Network Toronto Canada Department of Physiology University of Toronto Toronto Canada Department of Medicine (Neurology) University of Toronto Toronto Canada Department of Physics University of New Hampshire Durham USA Department of Neurophysiology Nencki Institute of Experimental Biology Warsaw Poland Department of Theory Wigner Research Centre for Physics of the Hungarian Academy of Sciences Budapest Hungary Department of Mathematical Sciences KAIST Daejoen Republic of Korea Department of Mathematics University of Houston Houston USA Department of Biochemistry & Cell Biology and Institute of Biosciences and Bioengineering Rice University Houston USA Department of Biology and Biochemistry University of Houston Houston USA Grupo de Neurocomputación Biológica Dpto. de Ingeniería Informática Escuela Politécnica Superior Universidad Autónoma de Madrid Madrid Spain Department of Biological Sciences University of Southern California Los Angeles USA Center for Neuroscience Korea Institute of Science and Technology Seoul South Korea Department of Neurology Albert Einstein College of Medicine Bronx USA Center for Neuroscience KIST Seoul South Korea Department of Neuroscience University of Science and Technology Daejon South Korea Systems Neuroscience Group QIMR Berghofer Medical Research Institute Herston Australia Department of Psychology Yonsei University Seoul South Korea Department of Psychiatry Kyung Hee University Hospital at Gangdong Seoul South Korea Department of Psychiatry Veterans Administration Boston Healthcare System and Harvard Medical School Brockton USA Department of Electrical and Electronic Engineering The University of Melbourne Parkvil

A1 Functional advantages of cell-type heterogeneity in neural circuits Tatyana O. Sharpee A2 Mesoscopic modeling of propagating waves in visual cortex Alain Destexhe A3 dynamics and biomarkers of mental disorders Mitsuo Kawato F1 Precise recruitment of spiking output at theta frequencies requires dendritic h-channels in multi-compartment models of oriens-lacunosum/moleculare hippocampal interneurons Vladislav Sekulić, Frances K. Skinner F2 Kernel methods in reconstruction of current sources from extracellular potentials for single cells and the whole brains Daniel K. Wójcik, Chaitanya Chintaluri, Dorottya Cserpán, Zoltán Somogyvári F3 The synchronized periods depend on intracellular transcriptional repression mechanisms in circadian clocks. Jae Kyoung Kim, Zachary P. Kilpatrick, Matthew R. Bennett, Kresimir Josić O1 Assessing irregularity and coordination of spiking-bursting rhythms in central pattern generators Irene Elices, David Arroyo, Rafael Levi, Francisco B. Rodriguez, Pablo Varona O2 Regulation of top-down processing by cortically-projecting parvalbumin positive neurons in basal forebrain Eunjin Hwang, Bowon Kim, Hio-Been Han, Tae Kim, James T. McKenna, Ritchie E. Brown, Robert W. McCarley, Jee Hyun Choi O3 Modeling auditory stream segregation, build-up and bistability James Rankin, Pamela Osborn Popp, John Rinzel O4 Strong competition between tonotopic neural ensembles explains pitch-related dynamics of auditory cortex evoked fields Alejandro Tabas, André Rupp, Emili Balaguer-Ballester O5 A simple model of retinal response to multi-electrode stimulation Matias I. Maturana, David B. Grayden, Shaun L. Cloherty, Tatiana Kameneva, Michael R. Ibbotson, Hamish Meffin O6 Noise correlations in V4 area correlate with behavioral performance in visual discrimination task Veronika Koren, Timm Lochmann, Valentin Dragoi, Klaus Obermayer O7 Input-location dependent gain modulation in cerebellar nucleus neurons Maria Psarrou, Maria Schilstra, Neil Davey, Benjamin Torben-Ni

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26th Annual Computational Neuroscience Meeting (CNS*2017): Part 1

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BMC Neurosci 2017年第SUPPL 1期18卷 58-58页

作者： Sue Denham Panayiota Poirazi Erik De Schutter Karl Friston Ho Ka Chan Thomas Nowotny Dongqi Han Sungho Hong Sophie Rosay Tanja Wernle Alessandro Treves Sarah Goethals Romain Brette Tomas Van Pottelbergh Rodolphe Sepulchre Alex D. Bird Hermann Cuntz Pedro J. Gonçalves Jan-Matthis Lueckmann Giacomo Bassetto Marcel Nonnenmacher Jakob H. Macke Audrey J. Sederberg Jason N. MacLean Stephanie E. Palmer Ulisse Ferrari Christophe Gardella Olivier Marre Thierry Mora Emina Ibrahimovic Martin Müller Jean-Pascal Pfister Tushar Chauhan Timothée Masquelier Alexandre Montlibert Benoit R. Cottereau Moritz Helias Jannis Schuecker David Dahmen Sven Goedeke Alexandre Hyafil Ainhoa Hermoso-Mendizabal Pavel E. Rueda-Orozco Santiago Jaramillo David Robbe Jaime de la Rocha Marie Rooy Fani Koukouli David DiGregorio Uwe Maskos Boris Gutkin Andrey Yu Verisokin Darya V. Verveyko Dmitry E. Postnov Willy Wong Omid Talakoub Robert Chen Milos Popovic Dmitriy Lisitsyn Eric Drebitz Iris Grothe Sunita Mandon Andreas Kreiter Udo Ernst Peter A. Robinson Xuelong Zhao Kevin M. Aquino John D. Griffiths Grishma Mehta-Pandejee Natasha Gabay James MacLaurin Somwrita Sarkar Tim Kunze Jens Haueisen Thomas R. Knösche Subutai Ahmad Yuwei Cui Marcus Lewis Jeff Hawkins Simona Olmi Spase Petkoski Fabrice Bartolomei Maxime Guye Viktor Jirsa Hazem Toutounji Daniel Durstewitz Matteo Cantarelli Adrian Quintana Boris Marin Matt Earnshaw Padraig Gleeson Robert Court Robert McDougal R. Angus Silver Salvador Dura-Bernal Stephen Larson William W. Lytton Giovanni Idili Lorenzo Posani Simona Cocco Karel Ježek Rémi Monasson School of Psychology Faculty of Health & Human Sciences Plymouth University Plymouth Devon PL4 8AA UK Institute of Molecular Biology and Biotechnology (IMBB) Foundation for Research and Technology-Hellas (FORTH) Heraklion Crete Greece Okinawa Institute of Science and Technology Graduate University Okinawa Japan Wellcome Trust Centre for Neuroimaging Institute of Neurology UCL London WC1N 3BG UK School of Engineering and Informatics University of Sussex Brighton BN1 9QJ UK Graduate School Okinawa Institute of Science and Technology Okinawa 904-0495 Japan Computational Neuroscience Unit Okinawa Institute of Science and Technology Okinawa 904-0495 Japan Cognitive Neuroscience Area Scuola Internazionale Superiore di Studi Avanzati Trieste 34136 Italy Kavli Institute for Systems Neuroscience NTNU Trondheim 7030 Norway Institut de la Vision Sorbonne Universités UPMC Univ Paris 06 INSERM CNRS Paris 75012 France Department of Engineering University of Cambridge Cambridge Cambridgeshire CB2 1PZ UK Ernst Strüngmann Institute for Neuroscience Max Planck Society Frankfurt Germany Frankfurt Institute for Advanced Studies Frankfurt Germany Neural Systems Analysis Research Center Caesar An Associate of the Max Planck Society Bonn Germany Max Planck Institute for Biological Cybernetics Tübingen Germany Bernstein Center for Computational Neuroscience Tübingen Germany Present Address: Biomedical Engineering Department Georgia Institute of Technology Atlanta GA 30306 USA Department of Neurobiology University of Chicago Chicago IL 60637 USA Department of Organismal Biology and Anatomy University of Chicago Chicago IL 60637 USA Committee on Computational Neuroscience University of Chicago Chicago IL 60637 USA Institut de la Vision Sorbonne Universités INSERM Paris France Laboratoire de Physique Statistique Ecole Normale Supérieure Paris France Institute of Molecular Life Sciences University of Zürich 8057 Zürich Switzerland Institute of Neuroinformatics Univer

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Erratum to: Journal of the Korean Physical Society, Vol. 71, No. 10

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Journal of the Korean Physical Society 2017年第12期71卷 1075-1075页

作者： Shin, Dong Hee Heo, Jin Hyuck Im, Sang Hyuk Lee, Rena Kim, Kyubo Cho, Samju Lim, Sangwook Lee, Suk Shim, Jang Bo Huh, Hyun Do Lee, Sang Hoon Ahn, Sohyun Nobi, Ashadun Lee, Jae Woo Lim, Hyunwoo Lee, Hunwoo Cho, Hyosung Seo, Changwoo Je, Uikyu Park, Chulkyu Kim, Kyuseok Kim, Guna Park, Soyoung Lee, Dongyeon Kang, Seokyoon Lee, Minsik Cao, Jingtai Zhao, Xiaohui Li, Zhaokun Liu, Wei Gu, Haijun Kang, In Ho Na, Moon Kyong Seok, Ogyun Moon, Jeong Hyun Kim, H. W. Kim, Sang Cheol Bahng, Wook Kim, Nam Kyun Park, Him-Chan Yang, Chang Heon Kim, Kyungil Kim, Youngman Lee, Kang Seog Hong, Yoo-Seung Cho, Chun-Hyung Sung, Hyuk-Kee Hyun, June-Won Kim, Gang Bae Lee, Ju Ho Kim, Yeon Jung Hwang, Seungjin Jeong, Jihoon Cho, Seryeyohan Lee, Jongmin Yu, Tae Jun Lee, Kang Il Lee, Geon Joon Park, Gyungsoon Choi, Eun Ha Kim, Dong-Hwan Jeong, Jun-Seok Eom, Su-Keun Lee, Jae-Gil Seo, Kwang-Seok Cha, Ho-Young Ko, Young Joon Kim, Hyun Soo Jung, Jong Hoon Jeong, Inho Song, Hyunwook Lee, B. C. Jang, Hyunchul Kim, Byongju Koo, Sangmo Park, Seran Ko, Dae-Hong Ahn, Kwang Jun Cho, Sungwan Kim, Sang Goon Hong, Kimin Shim, Seung-Bo Jo, Myunglae Cho, Sung Un Park, Yun Daniel Kim, Hee-Cheol Kim, Seok Department of Chemical and Biological Engineering Korea University Seoul Korea Department of radiation Oncology College of Medicine Ewha Womans University Seoul Korea Department of Radiation Oncology Kosin University College of Medicine Busan Korea Department of Radiation Oncology College of Medicine Korea University Seoul Korea Department of Radiation Oncology Inha University Hospital Incheon Korea Department of Radiation Oncology Cheil General Hospital & Women’s Heathcare Center Seoul Korea Department of Radiation Oncology College of Medicine Yonsei University Seoul Korea Department of Computer Science and Telecommunication Engineering Noakhali Science and Technology University Noakhali Bangladesh Department of Physics Inha University Incheon Korea Department of Radiation Convergence Engineering Yonsei University Wonju Korea Department of Radiation Oncology University of Maryland School of Medicine Baltimore USA College of communication Engineering Jilin University Jilin China Changchun Institute of Optics Fine Mechanics and Physics Chinese Academy of Sciences Changchun China College of Geoexploration Science and Technology Jilin University Jilin China Power Semiconductor Research Center Korea Electrotechnology Research Institute (KERI) Changwon Korea Department of Electrical Engineering Kyungnam University Changwon Korea R&D team Maple Semiconductors. Inc. Pohang Korea Rare Isotope Science Project Institute for Basic Science Daejeon Korea Department of Physics Chonnam National University Gwangju Korea School of Electronic and Electrical Engineering Hongik University Seoul Korea Department of Electronic & Electrical Engineering College of Science and Technology Hongik University Sejong Korea Department of Physics Dankook University Cheonan Korea Center for Innovative Engineering Education Dankook University Yongin Korea Department of Advanced Green Energy and Environment Handong Global University Pohang Korea Global Institute of Laser T

Regrettably, due to a technical error during the production process, there were discrepancies in DOI of the mentioned articles between HTML and PDF files. The DOIs are correct in the PDF files but were incorrect in HTML. The original articles have been corrected. The Publisher apologizes for any inconvenience and confusion caused.

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DDX5 and its associated lncRNA Rmrp modulate T_H17 cell effector functions

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Nature 2015年第7583期528卷 517-522页

作者： Huang, Wendy Thomas, Benjamin Flynn, Ryan A. Gavzy, Samuel J. Wu, Lin Kim, Sangwon V. Hall, Jason A. Miraldi, Emily R. Ng, Charles P. Rigo, Frank W. Meadows, Sarah Montoya, Nina R. Herrera, Natalia G. Domingos, Ana I. Rastinejad, Fraydoon Myers, Richard M. Fuller-Pace, Frances V. Bonneau, Richard Chang, Howard Y. Acuto, Oreste Littman, Dan R. Kimmel Center for Biology and Medicine Skirball Institute New York University School of Medicine New York 10016 NY United States Sir William Dunn School of Pathology University of Oxford Oxford OX1 3RE United Kingdom Center for Personal Dynamic Regulomes Stanford University Stanford 94305 CA United States Center for Genomics and Systems Biology Department of Biology New York University New York 10003 NY United States Courant Institute of Mathematical Sciences Computer Science Department New York University New York 10012 NY United States Simons Center for Data Analysis Simons Foundation New York 10010 NY United States Isis Pharmaceuticals Carlsbad 92010 CA United States HudsonAlpha Institute for Biotechnology Huntsville 35806 AL United States Instituto Gulbenkian de Ciencia Oeiras 2780-156 Portugal Integrative Metabolism Program Sanford Burnham Prebys Medical Discovery Institute Orlando 32827 FL United States Division of Cancer Research University of Dundee Dundee DD1 9SY United Kingdom Howard Hughes Medical Institute New York University School of Medicine New York 10016 NY United States

T helper 17 (TH17) lymphocytes protect mucosal barriers from infections, but also contribute to multiple chronic inflammatory diseases. Their differentiation is controlled by RORγt, a ligand-regulated nuclear recepto...

T helper 17 (T_H17) lymphocytes protect mucosal barriers from infections, but also contribute to multiple chronic inflammatory diseases. Their differentiation is controlled by RORγt, a ligand-regulated nuclear receptor. Here we identify the RNA helicase DEAD-box protein 5 (DDX5) as a RORγt partner that coordinates transcription of selective T_H17 genes, and is required for T_H17-mediated inflammatory pathologies. Surprisingly, the ability of DDX5 to interact with RORγt and coactivate its targets depends on intrinsic RNA helicase activity and binding of a conserved nuclear long noncoding RNA (lncRNA), Rmrp, which is mutated in patients with cartilage-hair hypoplasia. A targeted Rmrp gene mutation in mice, corresponding to a gene mutation in cartilage-hair hypoplasia patients, altered lncRNA chromatin occupancy, and reduced the DDX5-RORγt interaction and RORγt target gene transcription. Elucidation of the link between Rmrp and the DDX5-RORγt complex reveals a role for RNA helicases and lncRNAs in tissue-specific transcriptional regulation, and provides new opportunities for therapeutic intervention in T_H17-dependent diseases. © 2015 Macmillan Publishers Limited. All rights reserved.

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A Robust Scheduling Approach for a Single Machine to Optimize a Risk Measure

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Procedia CIRP 2014年 19卷 148-153页

作者： Marcello Urgo József Váncza Manufacturing and Production Systems Laboratory Mechanical Engineering Department Politecnico di Milano Milano Italy Fraunhofer Project Center for Production Management and Informatics Computer and Automation Research Institute Hungarian Academy of Sciences Budapest Hungary Department of Manufacturing Science and Technology Budapest University of Technology and Economics Budapest Hungary

Robustness in scheduling addresses the capability of devising schedules which are not sensitive – to a certain extent – to the disruptive effects of unexpected events. The paper presents a novel approach for protecting the quality of a schedule by taking into account the rare occurrence of very unfavourable events causing heavy losses. This calls for assessing the risk associated to the different scheduling decisions. In this paper we consider a stochastic scheduling problem with a set of jobs to be sequenced on a single machine. The release dates and processing times of the jobs are generally distributed independent random variables, while the due dates are deterministic. We present a branch-and-bound approach to minimize the Value-at-Risk of the distribution of the maximum lateness and demonstrate the viability of the approach through a series of computational experiments.

关键词： Robust Scheduling Risk Manufacturing-to-Order Production

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Build it, but will they come? A geoscience cyberinfrastructure baseline analysis

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Data science Journal 2016年 15卷

作者： Cutcher-Gershenfeld, Joel Baker, Karen S. Berente, Nicholas Carter, Dorothy R. DeChurch, Leslie A. Flint, Courtney C. Gershenfeld, Gabriel Haberman, Michael King, John Leslie Kirkpatrick, Christine Knight, Eric Lawrence, Barbara Lewis, Spenser Lenhardt, W. Christopher Lopez, Pablo Mayernik, Matthew S. McElroy, Charles Mittleman, Barbara Nichol, Victor Nolan, Mark Shin, Namchul Thompson, Cheryl A. Winter, Susan Zaslavsky, Ilya Heller School for Social Policy and Management Brandeis University 415 south street WalthaMA02453 2700 United States Graduate School of Information Sciences University of Illinois at Urbana-Champaign 501 E. Daniel St. ChampaignIL61820 United States Terry College of Business University of Georgia AthensGA30602 United States Psychology Department University of Georgia 125 Baldwin Street AthensGA30602 United States School of Psychology Georgia Institute of Technology 654 Cherry St. AtlantaGA30332 United States Dept of Sociology Social Work and Anthropology Utah State University 0730 Old Main Hill LoganUT84322 United States Gabe Gershenfeld Los Angeles Dodgers 1000 Elysian Park Ave. Los AngelesCA90012 United States National Center for Supercomputing Applications University of Illinois at Urbana-Champaign 1205 W. Clark St. UrbanaIL United States School of Information University of Michigan 105 S. State St. 3447 Ann ArborMI48109 United States San Diego Supercomputer Center University of California San Diego San DiegoCA92093-0505 United States University of Sydney NSW2006 Australia Anderson Graduate School of Management University of California Los Angeles Los AngelesCA90095-1481 United States Draper Labs 555 Technology Square CambridgeMA02139 United States Renaissance Computing Institute University of North Carolina 100 Europa Drive Chapel HillNC27517 United States Department of Statistics University of Illinois Urbana-Champaign 1205 W. Clark St. UrbanaIL61801 United States National Center for Atmospheric Research University Corporation for Atmospheric Research BoulderCO United States Department of Design and Innovation Weatherhead School of Management Case Western Reserve University 10900 Euclid Ave. ClevelandOH44106 United States WayMark Systems Inc. Enterprice Works 60 Hazelwood Drive ChampaignIL61820 United States University of Illinois at Urbana-Champaign EarthCube Project 130 West 1st Street NilesOH44446 U

Understanding the earth as a system requires integrating many forms of data from multiple fields. Builders and funders of the cyberinfrastructure designed to enable open data sharing in the geosciences risk a key failure mode: What if geoscientists do not use the cyberinfrastructure to share, discover and reuse data? In this study, we report a baseline assessment of engagement with the NSF EarthCube initiative, an open cyberinfrastructure effort for the geosciences. We find scientists perceive the need for cross-disciplinary engagement and engage where there is organizational or institutional support. However, we also find a possibly imbalanced involvement between cyber and geoscience communities at the outset, with the former showing more interest than the latter. This analysis highlights the importance of examining fields and disciplines as stakeholders to investments in the cyberinfrastructure supporting science. © 2016 The Author(s).

关键词： Investments

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