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arXiv 2020年

作者： Huang, Ke Wu, Liang Wang, Maoyu Swain, Nyayabanta Motapothula, M. Luo, Yongzheng Han, Kun Chen, Mingfeng Ye, Chen Yang, Allen Jian Xu, Huan Qi, Dong-Chen N’Diaye, Alpha T. Panagopoulos, Christos Primetzhofer, Daniel Shen, Lei Sengupta, Pinaki Ma, Jing Feng, Zhenxing Nan, Ce-Wen Wang, X. Renshaw Division of Physics and Applied Physics School of Physical and Mathematical Sciences Nanyang Technological University Singapore637371 Singapore School of Materials Science and Engineering State Key Laboratory of New Ceramics and Fine Processing Tsinghua University Beijing100084 China Department of Physics and Astronomy Rutgers University PiscatawayNJ08854 United States School of Chemical Biological and Environmental Engineering Oregon State University CorvallisOR97331 United States Department of Physics and Astronomy Uppsala University Box 516 UppsalaSE-75120 Sweden Department of Physics SRM University AP Andhra Pradesh Amaravati522-502 India Department of Mechanical Engineering National University of Singapore Singapore117575 Singapore School of Electrical and Electronic Engineering Nanyang Technological University Singapore639798 Singapore ARC Centre of Excellence in Future Low-Energy Electronics Technologies School of Chemistry Physics and Mechanical Engineering Queensland University of Technology BrisbaneQLD4001 Australia Department of Chemistry and Physics La Trobe Institute for Molecular Science La Trobe University MelbourneVIC3086 Australia Advanced Light Source Lawrence Berkeley National Laboratory BerkeleyCA94720 United States

The ability to tune magnetic orders, such as magnetic anisotropy and topological spin texture, is desired in order to achieve high-performance spintronic devices. A recent strategy has been to employ interfacial engineering techniques, such as the introduction of spin-correlated interfacial coupling, to tailor magnetic orders and achieve novel magnetic properties. We chose a unique polar-nonpolar LaMnO3/SrIrO3 superlattice because Mn (3d)/Ir (5d) oxides exhibit rich magnetic behaviors and strong spin-orbit coupling through the entanglement of their 3d and 5d electrons. Through magnetization and magnetotransport measurements, we found that the magnetic order is interface-dominated as the superlattice period is decreased. We were able to then effectively modify the magnetization, tilt of the ferromagnetic easy axis, and symmetry transition of the anisotropic magnetoresistance of the LaMnO3/SrIrO3 superlattice by introducing additional Mn (3d) and Ir (5d) interfaces. Further investigations using in-depth first-principles calculations and numerical simulations revealed that these magnetic behaviors could be understood by the 3d/5d electron correlation and Rashba spin-orbit coupling. The results reported here demonstrate a new route to synchronously engineer magnetic properties through the atomic stacking of different electrons, contributing to future applications. Copyright © 2020, The Authors. All rights reserved.

关键词： Electrons

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Abstracts

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JOURNAL OF SPINAL CORD MEDICINE 2021年第SUPPL 1期44卷 S278-S324页

作者： [Anonymous] Department of Medicine Division of Physical Medicine and Rehabilitation University of Toronto Toronto ON CA KITE - Toronto Rehabilitation Institute University Health Network Toronto ON CA Institute for Health Policy Management and Evaluation University of Toronto Toronto ON CA Rehabilitation Sciences Institute University of Toronto Toronto ON CA Institute of Medical Sciences University of Toronto Toronto ON CA. Rehabilitation Sciences Institute University of Toronto ON CA KITE Research Institute-Toronto Rehab-University Health Network Toronto ON CA Physical Therapy Department University of Toronto ON CA Praxis Spinal Cord Institute Vancouver BC Université de Montréal (École de réadaptation) Montreal QC CA Institut de réadaptation Gingras-Linsay-de-Montréal Montreal QC CA Division of Physical Medicine & Rehabilitation Department of Medicine Faculty of Medicine & Dentistry University of Alberta Edmonton AB CA University of Calgary Calgary AB CA Alberta Health Services Centre for Family Medicine Kitchener ON CA McMaster University Department of Family Medicine Hamilton ON CA Dept. of Physical Therapy University of Toronto Toronto ON CA KITE-University Health Network Toronto ON CA Praxis Spinal Cord Institute Vancouver BC CA Center for Interdisciplinary Research in Rehabilitation and Social Integration (CIRRIS) Quebec City QC CA Dept. of Rehabilitation Laval University Quebec City QC CA Institute of Health Policy Management and Evaluation University of Toronto Toronto ON CA School of Rehabilitation Science University of Saskatchewan Saskatoon SK CA Ontario Neurotrauma Foundation Toronto ON CA Canadian Spinal Research Organization Toronto ON CA CIUSSS du Centre-Sud-de-l ‘Île-de-Montréal (Installation Gingras-Lindsay) Montréal QC CA École de réadaptation Université de Montréal Montréal QC CA First Steps Wellness Centre Regina SK CA Stan Cassidy Centre for Rehabilitation Horizon Health Network Fredericton NB CA Departmen

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Revealing the Side-Chain-Dependent Ordering Transition of Highly Crystalline Double-Cable Conjugated Polymers

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Angewandte Chemie 2021年第48期133卷

作者： Guitao Feng Wenliang Tan Safakath Karuthedath Cheng Li Xuechen Jiao Amelia C. Y. Liu Hariprasad Venugopal Zheng Tang Long Ye Frédéric Laquai Christopher R. McNeill Weiwei Li Beijing Advanced Innovation Center for Soft Matter Science and Engineering & State Key Laboratory of Organic-Inorganic Composites Beijing University of Chemical Technology Beijing 100029 China Beijing National Laboratory for Molecular Sciences Key Laboratory of Organic Solids Institute of Chemistry Chinese Academy of Sciences Beijing 100190 P. R. China Department of Materials Science and Engineering Monash University Wellington Road Clayton Victoria 3800 Australia King Abdullah University of Science and Technology (KAUST) KAUST Solar Center (KSC) Physical Sciences and Engineering Division (PSE) Material Science and Engineering Program (MSE) Thuwal 23955-6900 Kingdom of Saudi Arabia School of Physics and Astronomy Monash University Wellington Road Clayton Victoria 3800 Australia Ramaciotti Centre for Cryo-Electron Microscopy Monash University Clayton Victoria 3800 Australia Center for Advanced Low-dimension Materials College of Materials Science and Engineering Donghua University Shanghai 201620 P. R. China School of Materials Science and Engineering Tianjin Key Laboratory of Molecular Optoelectronic Science Tianjin University Tianjin 300350 P. R. China

We developed a series of highly crystalline double-cable conjugated polymers for application in single-component organic solar cells (SCOSCs). These polymers contain conjugated backbones as electron donor and pendant perylene bisimide units (PBIs) as electron acceptor. PBIs are connected to the backbone via alkyl units varying from hexyl (C 6 H 12 ) to eicosyl (C 20 H 40 ) as flexible linkers. For double-cable polymers with short linkers, the PBIs tend to stack in a head-to-head fashion, resulting in large d -spacings (e.g. 64 Å for the polymer P12 with C 12 H 24 linker) along the lamellar stacking direction. When the length of the linker groups is longer than a certain length, the PBIs instead adopt a more ordered packing likely via H -aggregation, resulting in short d -spacings (e.g. 50 Å for the polymer P16 with C 16 H 32 linker). This work highlights the importance of linker length on the molecular packing of the acceptor units and the influences on the photovoltaic performance of SCOSCs.

关键词： cryo-transmission electron microscopy double-cable conjugated polymers lamellar stacking single-component organic solar cells

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Exploring Observational Heliophysics Across All Scales: Reflections and Insights From the 2023 NASA Heliophysics Summer School

Perspectives of Earth and Space Scientists

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Perspectives of Earth and Space Scientists 2024年第1期5卷

作者： S. R. Shaver A. R. Smith S. S. Babu Y. Baruah M. Bauer V. Chaturmutha H. Chen B. Dalal G. B. Dias da Silva T. Eddy G. González S. Gu E. Gülay A. P. Hoffmann O. R. Idolor R. Khan Y. Liou N. Liu X. Lyu A. Maharana D. K. V. Radhakrishnan O. M. Romeo P. O. C. Silva H. M. Salah C. Thibeault A. Weiss Laboratory for Atmospheric and Space Physics University of Colorado Boulder CO USA Geophysical Institute University of Alaska Fairbanks AK USA Department of Physics University of Alberta Edmonton AB Canada Department of Physical Sciences Indian Institute of Science Education and Research Kolkata Mohanpur West Bengal India Center of Excellence in Space Sciences India Indian Institute of Science Education and Research Kolkata Mohanpur West Bengal India Austrian Space Weather Office GeoSphere Austria Graz Austria Department of Physics & Astronomy Georgia State University Atlanta GA USA Department of Electrical and Computer Engineering University of Illinois Urbana-Champaign Urbana IL USA Space and Atmospheric Sciences Physical Research Laboratory Ahmedabad Gujarat India National Institute for Space Research (INPE) São Paulo Brazil Department of Climate and Space Sciences and Engineering University of Michigan Ann Arbor MI USA Space Sciences Laboratory University of California Berkeley Berkeley CA USA Department of Physics University of Texas at Dallas Richardson TX USA Istanbul Technical University Istanbul Turkiye Department of Physics Faculty of Science University of Lagos Lagos Nigeria Indian Institute of Astrophysics Bangalore Karnataka India Department of Engineering Physics Embry-Riddle Aeronautical University Daytona Beach FL USA New Jersey Institute of Technology Newark NJ USA West Virginia University Morgantown WV USA Katholieke Universiteit Leuven Leuven Belgium University of Texas at San Antonio San Antonio TX USA Southwest Research Institute San Antonio TX USA Physics Department Faculty of Science Space Weather Monitoring Center Helwan University Cairo Egypt Université de Montréal Montréal QC Canada NASA Postdoctoral Program Fellowship NASA Goddard Space Flight Center Greenbelt MD USA

The field of heliophysics encompasses a diverse range of research areas and rich plasma environments, from the solar dynamo and solar wind turbulence, to the complex terrestrial thermosphere-ionosphere-magnetosphere (TIM) system, to investigations of both induced and intrinsic magnetospheres across the solar system. This perspective paper delves into the experiences and outcomes of a summer school held in person in Boulder, Colorado, USA, from 7–11 August, which offered a platform for interdisciplinary learning and collaboration. The event, supported by NASA's Living with a Star program and hosted by the University Corporation for Atmospheric Research and Cooperative programs for the Advancement of Earth System science, assembled a cohort of 26 graduate students and postdoctoral researchers from around the world, all engaged in heliophysics research. The summer school included a series of lectures, interactive activities, and a culminating capstone project. The participants' diverse backgrounds enriched discussions and encouraged novel approaches to traditional problems. The capstone projects spanned an array of topics, including investigating the origins of solar wind switchbacks, dissecting the sequence of events from solar eruptions and their corresponding terrestrial consequences, investigating the energy transfer from solar coronal mass ejections to Earth's magnetosphere, and advocating for the exploration of Coulomb collisions in understanding large-scale global systems. Through this perspective, we shed light on the value of international and interdisciplinary collaboration in advancing heliophysics research. This perspective paper encapsulates the ethos of the summer school, serving as a testament to the continuing and collective pursuit of unraveling the mysteries of the heliosphere. Cooperative programs for the Advancement of Earth System science/University Corporation for Atmospheric Research held the seventeenth annual NASA Heliophysics Summer School bot

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Harmonized-Multinational qEEG norms (HarMNqEEG)

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NEUROIMAGE 2022年 256卷 119190-119190页

作者： Li, Min Wang, Ying Lopez-Naranjo, Carlos Hu, Shiang Reyes, Ronaldo Cesar Garcia Paz-Linares, Deirel Areces-Gonzalez, Ariosky Hamid, Aini Ismafairus Abd Evans, Alan C. Savostyanov, Alexander N. Calzada-Reyes, Ana Villringer, Arno Tobon-Quintero, Carlos A. Garcia-Agustin, Daysi Yao, Dezhong Dong, Li Aubert-Vazquez, Eduardo Reza, Faruque Razzaq, Fuleah Abdul Omar, Hazim Abdullah, Jafri Malin Galler, Janina R. Ochoa-Gomez, John F. Prichep, Leslie S. Galan-Garcia, Lidice Morales-Chacon, Lilia Valdes-Sosa, Mitchell J. Trondle, Marius Zulkifly, Mohd Faizal Mohd Rahman, Muhammad Riddha Bin Abdul Milakhina, Natalya S. Langer, Nicolas Rudych, Pavel Koenig, Thomas Virues-Alba, Trinidad A. Lei, Xu Bringas-Vega, Maria L. Bosch-Bayard, Jorge F. Valdes-Sosa, Pedro Antonio [a]The Clinical Hospital of Chengdu Brain Science Institute MOE Key Lab for Neuroinformation School of Life Science and Technology University of Electronic Science and Technology of China Chengdu China [b]Cuban Center for Neurocience La Habana Cuba [c]McGill Centre for Integrative Neuroscience Ludmer Centre for Neuroinformatics and Mental Health Montreal Neurological Institute Canada [d]Department of Neurosciences School of Medical Sciences Universiti Sains Malaysia Universiti Sains Malaysia Health Campus Kota Bharu Kelantan 16150 Malaysia [e]Brain and Behaviour Cluster School of Medical Sciences Universiti Sains Malaysia Health Campus Kota Bharu Kelantan 16150 Malaysia [f]Hospital Universiti Sains Malaysia Universiti Sains Malaysia Health Campus Kota Bharu Kelantan 16150 Malaysia [g]Humanitarian Institute Novosibirsk State University Novosibirsk 630090 Russia [h]Laboratory of Psychophysiology of Individual Differences Federal State Budgetary Scientific Institution Scientific Research Institute of Neurosciences and Medicine Novosibirsk 630117 Russia [i]Laboratory of Psychological Genetics at the Institute of Cytology and Genetics Siberian Branch of the Russian Academy of Sciences Novosibirsk 630090 Russia [j]University of Pinar del Río “Hermanos Saiz Montes de Oca” Pinar del Río Cuba [k]Department of Neurology Max Planck Institute for Human Cognitive and Brain Sciences Leipzig Germany [l]Department of Cognitive Neurology University Hospital Leipzig Leipzig Germany [m]Center for Stroke Research Charité-Universitätsmedizin Berlin Berlin Germany [n]Grupo Neuropsicología y Conducta - GRUNECO Faculty of Medicine Universidad de Antioquia Colombia [o]Research Department Institución Prestadora de Servicios de Salud IPS Universitaria Colombia [p]The Cuban center aging longevity and health Havana Cuba [q]Research Unit of NeuroInformation Chinese Academy of Medical Sciences Chengdu 2019RU035 China [r]School of Electrical Engineering Zhengzhou University Zhengzhou 4500

This paper extends frequency domain quantitative electroencephalography (qEEG) methods pursuing higher sensitivity to detect Brain Developmental Disorders. Prior qEEG work lacked integration of cross-spectral information omitting important functional connectivity descriptors. Lack of geographical diversity precluded accounting for site-specific variance, increasing qEEG nuisance variance. We ameliorate these weaknesses. (i) Create lifespan Riemannian multinational qEEG norms for cross-spectral tensors. These norms result from the HarMNqEEG project fostered by the Global Brain Consortium. We calculate the norms with data from 9 countries, 12 devices, and 14 studies, including 1564 subjects. Instead of raw data, only anonymized metadata and EEG cross spectral tensors were shared. After visual and automatic quality control, developmental equations for the mean and standard deviation of qEEG traditional and Riemannian DPs were calculated using additive mixed-effects models. We demonstrate qEEG "batch effects " and provide methods to calculate harmonized z-scores. (ii) We also show that harmonized Riemannian norms produce z-scores with increased diagnostic accuracy predicting brain dysfunction produced by malnutrition in the first year of life and detecting COVID induced brain dysfunction. (iii) We offer open code and data to calculate different individual z-scores from the HarMNqEEG dataset. These results contribute to developing bias-free, low-cost neuroimaging technologies applicable in various health settings.

关键词： Quantitative EEG EEG cross-spectrum Riemannian geometry Batch effects Z-score Harmonization Malnutrition Covid induced brain dysfunction Developmental Brain Chart

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Suppression of the antiferromagnetic metallic state in the pressurized MnBi2Te4 single crystal

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physical Review Materials 2019年第9期3卷 094201-094201页

作者： K. Y. Chen B. S. Wang J.-Q. Yan D. S. Parker J.-S. Zhou Y. Uwatoko J.-G. Cheng Beijing National Laboratory for Condensed Matter Physics and Institute of Physics Chinese Academy of Sciences Beijing 100190 China School of Physical Sciences University of Chinese Academy of Sciences Beijing 100190 China Songshan Lake Materials Laboratory Dongguan Guangdong 523808 China Materials Science and Technology Division Oak Ridge National Laboratory Oak Ridge Tennessee 37831 USA Materials Science and Engineering Program Mechanical Engineering University of Texas at Austin Austin Texas 78712 USA Institute for Solid State Physics University of Tokyo 5-1-5 Kashiwanoha Kashiwa Chiba 277-8581 Japan

We study the effect of hydrostatic pressure on the electrical transport, magnetic, and structural properties of MnBi2Te4 by measuring its resistivity, Hall effect, and x-ray diffraction under pressures up to 12.8 GPa supplemented by the first-principles calculations. At ambient pressure, MnBi2Te4 shows a metallic conducting behavior with a cusplike anomaly at around TN≈24K, where it undergoes a long-range antiferromagnetic (AF) transition. With increasing pressure, TN determined from the resistivity anomaly first increases slightly with a maximum at around 2 GPa and then decreases until vanishing completely at about 7 GPa. Intriguingly, its resistivity is enhanced gradually by pressure and even evolves from metallic to semimetal or semiconductinglike behavior as TN is suppressed. However, the density of the n-type charge carrier that remains dominant under pressure increases with pressure. In addition, the interlayer AF coupling seems to be strengthened under compression, since the critical field Hc1 for the spin-flop transition to the canted AF state is found to increase with pressure. No structural transition was evidenced up to 12.8 GPa, but some lattice softening was observed at about 2 GPa, signaling the occurrence of an electronic transition or crossover from a localized to itinerant state. We have rationalized these experimental findings by considering the pressure-induced enhancement of antiferromagnetic/ferromagnetic competition and partial delocalization of Mn−3d electrons, which not only destroys long-range AF order but also promotes charge-carrier localization through enhanced spin fluctuations and/or the formation of a hybridization gap at high pressure.

关键词： Pressure effects Topological materials Antiferromagnets Single crystal materials Density functional theory Resistivity measurements

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Controlling photonic spin Hall effect via exceptional points

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physical Review B 2019年第11期100卷 115429-115429页

作者： Xinxing Zhou Xiao Lin Zhicheng Xiao Tony Low Andrea Alù Baile Zhang Handong Sun Division of Physics and Applied Physics School of Physical and Mathematical Sciences Nanyang Technological University Singapore 637371 Singapore Synergetic Innovation Center for Quantum Effects and Applications School of Physics and Electronics Hunan Normal University Changsha 410081 China Department of Electrical and Computer Engineering The University of Texas at Austin Austin Texas 78712 USA Department of Electrical and Computer Engineering University of Minnesota Minneapolis Minnesota 55455 USA Photonics Initiative Advanced Science Research Center City University of New York New York 10031 USA Centre for Disruptive Photonic Technologies (CDPT) School of Physical and Mathematical Sciences Nanyang Technological University Singapore 637371 Singapore MajuLab CNRS-UCA-SU-NUS-NTU International Joint Research Unit Singapore 637371 Singapore

The photonic spin Hall effect (SHE), featured by a spin-dependent transverse shift of an impinging optical beam driven by its polarization handedness, has many applications including precise metrology and spin-based nanophotonic devices. It is highly desirable to control and enhance the photonic SHE. However, such a goal remains elusive, due to the weak spin-orbit interaction of light, especially for systems with optical loss. Here we reveal a flexible way to modulate the photonic SHE via exceptional points, by exploiting the transverse shift in a parity-time (PT) symmetric system with balanced gain and loss. The underlying physics is associated with the near-zero value and abrupt phase jump of the reflection coefficients at exceptional points. We find that the transverse shift is zero at exceptional points, but it is largely enhanced in their vicinity. Moreover, the transverse shift switches its sign across the exceptional point, resulting from spontaneous PT-symmetry breaking. Due to the sensitivity of transverse shift at exceptional points, our work also indicates that the photonic SHE can enable a precise way to probe the location of exceptional point in photonic systems.

关键词： Light-matter interaction Metamaterials Nanophotonics Spin-orbit coupling PT-symmetry

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Terahertz excitonics in carbon nanotubes: exciton autoionization and multiplication

arXiv

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arXiv 2020年

作者： Bagsican, Filchito Renee G. Wais, Michael Komatsu, Natsumi Gao, Weilu Weber, Lincoln W. Serita, Kazunori Murakami, Hironaru Held, Karsten Hegmann, Frank A. Tonouchi, Masayoshi Kono, Junichiro Kawayama, Iwao Battiato, Marco Institute of Laser Engineering Osaka University Suita Osaka565-0871 Japan Institute for Solid State Physics TU Wien Vienna1040 Austria Division of Physics and Applied Physics School of Physical and Mathematical Sciences Nanyang Technological University Singapore Department of Electrical and Computer Engineering Rice University HoustonTX77005 United States Department of Physics Southern Illinois University Carbondale CarbondaleIL62901 United States Department of Physics University of Alberta EdmontonABT6G 2E1 Canada Department of Physics and Astronomy Rice University HoustonTX77005 United States Department of Material Science and NanoEngineering Rice University HoustonTX77005 United States Graduate School of Energy Science Kyoto University Kyoto606-8501 Japan

Excitons play major roles in optical processes in modern semiconductors, such as single-wall carbon nanotubes (SWCNTs),1–3 transition metal dichalcogenides,4–6 and 2D perovskite quantum wells.7,8 They possess extremely large binding energies (>100 meV), dominating absorption and emission spectra even at high temperatures.9,10 The large binding energies imply that they are stable, that is, hard to ionize, rendering them seemingly unsuited for optoelectronic devices that require mobile charge carriers, especially terahertz emitters and solar cells. Here, we have conducted terahertz emission and photocurrent studies on films of aligned single-chirality semiconducting SWCNTs11 and find that excitons autoionize, i.e., spontaneously dissociate into electrons and holes. This process naturally occurs ultrafast ( Copyright © 2020, The Authors. All rights reserved.

关键词： Excitons

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Organic Semiconductors: Fast‐Response, Highly Air‐Stable, and Water‐Resistant Organic Photodetectors Based on a Single‐Crystal Pt Complex (Adv. Mater. 2/2020)

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Advanced Materials 2020年第2期32卷

作者： Dharmaraj Periyanagounder Tzu‐Chiao Wei Ting‐You Li Chun‐Ho Lin Théo Piechota Gonçalves Hui‐Chun Fu Dung‐Sheng Tsai Jr‐Jian Ke Hung‐Wei Kuo Kuo‐Wei Huang Norman Lu Xiaosheng Fang Jr‐Hau He Computer Electrical and Mathematical Sciences and Engineering Division King Abdullah University of Science & Technology Thuwal 23955–6900 Saudi Arabia Department of Molecular Science and Engineering National Taipei University of Technology Taipei 106 Taiwan ROC KAUST Catalyst Centre Physical Science and Engineering Division King Abdullah University of Science & Technology Thuwal 23955–6900 Saudi Arabia Institute of Organic and Polymeric Materials National Taipei University of Technology Taipei 106 Taiwan ROC Department of Materials Science Fudan University Shanghai 200433 China Department of Materials Science and Engineering City University of Hong Kong Kowloon Hong Kong SAR 999077 China

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The association between poor sleep health and Alzheimer's disease structural neuroimaging biomarkers

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Alzheimer's & dementia : the journal of the Alzheimer's Association 2025年第6期21卷

作者： Emma Nolan Yunyi Sun Hui Shi Derek Archer Arden Perry Kimberly Pechman Niranjana Shashikumar Bennett Landman Marissa Gogniat Dandan Liu Panpan Zhang Timothy J Hohman Angela L Jefferson Kelsie M Full Vanderbilt Memory and Alzheimer's Center Vanderbilt University School of Medicine Nashville Tennessee USA. Epidemiology Doctoral Program School of Medicine Vanderbilt University Nashville Tennessee USA. Department of Biostatistics Vanderbilt University Medical Center Nashville Tennessee USA. Vanderbilt Genetics Institute Vanderbilt University Medical Center Nashville Tennessee USA. Vanderbilt Brain Institute Vanderbilt University Medical Center Nashville Tennessee USA. Department of Radiology & Radiological Sciences Vanderbilt University Medical Center Nashville Tennessee USA. Vanderbilt University Institute of Imaging Science Vanderbilt University Medical Center Nashville Tennessee USA. Department of Biomedical Engineering Vanderbilt University Nashville Tennessee USA. Department of Electrical and Computer Engineering Vanderbilt University Nashville Tennessee USA. Department of Neurology University of Pittsburgh School of Medicine Pittsburgh Pennsylvania USA. Department of Medicine Vanderbilt University Medical Center Nashville Tennessee USA. Division of Epidemiology Department of Medicine Vanderbilt University Medical Center Nashville Tennessee USA.

INTRODUCTION:Poor sleep may be a risk factor for neurodegeneration and Alzheimer's disease (AD). Few studies have examined objectively measured sleep with structural neuroimaging measures. METHODS:Vanderbilt Memory and Aging Project participants (N = 407; median age: 70 years) wore ActiGraph accelerometers for 10 days to estimate sleep regularity, timing, efficiency, duration, wake-after-sleep onset, and awakening length. Volume in brain regions of interest (ROIs) and AD signatures were quantified using 3T brain magnetic resonance imaging (MRI). Cross-sectional linear regression models were adjusted for sociodemographic and lifestyle factors, depression, cognitive status, and cardiovascular risk. ROI and McEvoy models were adjusted for total intracranial volume. RESULTS:Greater sleep irregularity (β= -0.12, p = 0.005; β= -0.07, p = 0.024) and longer awakening length (β= -0.11, p = 0.009; β= -0.08, p = 0.012) were associated with smaller volumes in ROIs related to AD. DISCUSSION:More irregular and fragmented sleep was associated with smaller volume in ROIs vulnerable to AD, indicating a potential link between poor sleep and neurodegeneration. HIGHLIGHTS:Associations between sleep and brain health are poorly understood. Gray matter atrophy by irregular sleep may imply Alzheimer's disease (AD) decline. Increased sleep irregularity is associated with smaller brain region volume. Sleep disruption, estimated by awakening length, is linked to AD-related brain volume.

关键词： Alzheimer's disease actigraphy atrophy magnetic resonance imaging sleep

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