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A sudden period of high activity from repeating Fast Radio Burst 20201124A

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arXiv 2021年

作者： Lanman, Adam E. Andersen, Bridget C. Chawla, Pragya Josephy, Alexander Noble, Gavin Kaspi, Victoria M. Bandura, Kevin Bhardwaj, Mohit Boyle, Patrick J. Brar, Charanjot Breitman, Daniela Cassanelli, Tomas Dong, Fengqiu Fonseca, Emmanuel Gaensler, Bryan M. Good, Deborah Kaczmarek, Jane Leung, Calvin Masui, Kiyoshi W. Meyers, Bradley W. Ng, Cherry Patel, Chitrang Pearlman, Aaron B. Petroff, Emily Pleunis, Ziggy Rafiei-Ravandi, Masoud Rahman, Mubdi Sanghavi, Pranav Scholz, Paul Shin, Kaitlyn Stairs, Ingrid Tendulkar, Shriharsh Zwaniga, Andrew Department of Physics McGill University 3600 rue University MontréalQCH3A 2T8 Canada McGill Space Institute McGill University 3550 rue University MontréalQCH3A 2A7 Canada Dunlap Institute for Astronomy & Astrophysics University of Toronto 50 St. George Street TorontoONM5S 3H4 Canada David A. Dunlap Department of Astronomy & Astrophysics University of Toronto 50 St. George Street TorontoONM5S 3H4 Canada Lane Department of Computer Science and Electrical Engineering 1220 Evansdale Drive PO Box 6109 MorgantownWV26506 United States Center for Gravitational Waves and Cosmology West Virginia University Chestnut Ridge Research Building MorgantownWV26505 United States Department of Physics University of Toronto 60 St. George Street TorontoONM5S 1A7 Canada Department of Physics and Astronomy University of British Columbia 6224 Agricultural Road VancouverBCV6T 1Z1 Canada Department of Physics and Astronomy West Virginia University PO Box 6315 MorgantownWV26506 United States Center for Computational Astrophysics Flatiron Institute 162 Fifth Ave New YorkNY10010 United States Department of Physics University of Connecticut 196 Auditorium Road U-3046 StorrsCT06269-3046 United States Dominion Radio Astrophysical Observatory Herzberg Research Centre for Astronomy and Astrophysics National Research Council Canada PO Box 248 PentictonBCV2A 6J9 Canada MIT Kavli Institute for Astrophysics and Space Research Massachusetts Institute of Technology 77 Massachusetts Ave CambridgeMA02139 United States Department of Physics Massachusetts Institute of Technology 77 Massachusetts Ave CambridgeMA02139 United States Anton Pannekoek Institute for Astronomy University of Amsterdam Science Park 904 Amsterdam1098 XH Netherlands Perimeter Institute for Theoretical Physics 31 Caroline Street N WaterlooONN25 2YL Canada Department of Physics and Astronomy University of Waterloo WaterlooONN2L 3G1 Canada Sidrat Research PO Box 73527 RPO Wychwood Toront

The repeating FRB 20201124A was first discovered by CHIME/FRB in November of 2020, after which it was seen to repeat a few times over several months. It entered a period of high activity in April of 2021, at which time several observatories recorded tens to hundreds more bursts from the source. These follow-up observations enabled precise localization and host galaxy identification. In this paper, we report on the CHIME/FRB-detected bursts from FRB 20201124A, including their best-fit morphologies, fluences, and arrival times. The large exposure time of the CHIME/FRB telescope to the location of this source allows us to constrain its rates of activity. We analyze the repetition rates over different spans of time, constraining the rate prior to discovery to -1 (at 3σ), and demonstrate significant change in the event rate following initial detection. Lastly, we perform a maximum-likelihood estimation of a power-law luminosity function, finding a best-fit index α = -4.6 ± 1.3 ± 0.6, with a break at a fluence threshold of Fmin ∼ 16.6 Jy ms, consistent with the fluence completeness limit of the observations. This index is consistent within uncertainties with those of other repeating FRBs for which it has been determined. © 2021, CC BY.

关键词： Maximum likelihood estimation

CHIME/FRB catalog 1 results: Statistical cross-correlations with large-scale structure

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arXiv 2021年

作者： Rafiei-Ravandi, Masoud Smith, Kendrick M. Li, Dongzi Masui, Kiyoshi W. Josephy, Alexander Dobbs, Matt Lang, Dustin Bhardwaj, Mohit Patel, Chitrang Bandura, Kevin Berger, Sabrina Boyle, P.J. Brar, Charanjot Breitman, Daniela Cassanelli, Tomas Chawla, Pragya Dong, Fengqiu Adam Fonseca, Emmanuel Gaensler, B.M. Giri, Utkarsh Good, Deborah C. Halpern, Mark J., Kaczmarek V.M., Kaspi C., Leung H.-H., Lin J., Mena-Parra B.W., Meyers D., Michilli M., Münchmeyer C., Ng E., Petroff Z., Pleunis M., Rahman P., Sanghavi P., Scholz K., Shin I.H., Stairs S.P., Tendulkar K., Vanderlinde A., Zwaniga Perimeter Institute for Theoretical Physics 31 Caroline Street N WaterlooONN25 2YL Canada Department of Physics and Astronomy University of Waterloo WaterlooONN2L 3G1 Canada Cahill Center for Astronomy and Astrophysics California Institute of Technology 1216 E. California Boulevard PasadenaCA91125 United States MIT Kavli Institute for Astrophysics and Space Research Massachusetts Institute of Technology 77 Massachusetts Ave. CambridgeMA02139 United States Department of Physics Massachusetts Institute of Technology 77 Massachusetts Ave. CambridgeMA02139 United States Department of Physics McGill University 3600 rue University MontréalQCH3A 2T8 Canada McGill Space Institute McGill University 3550 rue University MontréalQCH3A 2A7 Canada Dunlap Institute for Astronomy & Astrophysics University of Toronto 50 St. George Street TorontoONM5S 3H4 Canada Lane Department of Computer Science and Electrical Engineering 1220 Evansdale Drive PO Box 6109 MorgantownWV26506 United States Center for Gravitational Waves and Cosmology West Virginia University Chestnut Ridge Research Building MorgantownWV26505 United States Department of Physics University of Toronto 60 St. George Street TorontoONM5S 1A7 Canada David A. Dunlap Department of Astronomy & Astrophysics University of Toronto 50 St. George Street TorontoONM5S 3H4 Canada Department of Physics and Astronomy University of British Columbia 6224 Agricultural Road VancouverBCV6T 1Z1 Canada Dominion Radio Astrophysical Observatory Herzberg Research Centre for Astronomy and Astrophysics National Research Council Canada PO Box 248 PentictonBCV2A 6J9 Canada Canadian Institute for Theoretical Astrophysics 60 St. George Street TorontoONM5S 3H8 Canada Department of Physics University of Wisconsin-Madison 1150 University Ave. MadisonWI53706 United States Anton Pannekoek Institute for Astronomy University of Amsterdam Science Park 904 Amsterdam1098 XH Netherlands Veni Sidrat Research PO Box

The CHIME/FRB Project has recently released its first catalog of fast radio bursts (FRBs), containing 492 unique sources. We present results from angular cross-correlations of CHIME/FRB sources with galaxy catalogs. We find a statistically significant (p-value ∼ 10−4, accounting for look-elsewhere factors) cross-correlation between CHIME FRBs and galaxies in the redshift range 0.3 . z . 0.5, in three photometric galaxy surveys: WISE×SCOS, DESI-BGS, and DESI-LRG. The level of cross-correlation is consistent with an order-one fraction of the CHIME FRBs being in the same dark matter halos as survey galaxies in this redshift range. We find statistical evidence for a population of FRBs with large host dispersion measure (∼ 400 pc cm−3), and show that this can plausibly arise from gas in large halos (M ∼ 1014M), for FRBs near the halo center (r . 100 kpc). These results will improve in future CHIME/FRB catalogs, with more FRBs and better angular resolution. Copyright © 2021, The Authors. All rights reserved.

关键词： Galaxies

Ramanujan Graphs in Polynomial Time

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Ramanujan Graphs in Polynomial Time

Annual IEEE Symposium on Foundations of computer science

作者： Michael B. Cohen Electrical Engineering and Computer Science MIT Cambridge MA

ISBN: (纸本)9781509039340

Recent work by Marcus, Spielman and Srivastava proves the existence of bipartite Ramanujan (multi) graphs of all degrees and all sizes. However, that paper did not provide a polynomial time algorithm to actually compute such graphs. Here, we provide a polynomial time algorithm to compute certain expected characteristic polynomials related to this construction. This leads to a deterministic polynomial time algorithm to compute bipartite Ramanujan (multi) graphs of all degrees and all sizes.

关键词： Bipartite graph Symmetric matrices Eigenvalues and eigenfunctions computer science Indexes Probability distribution Nickel

Competing Cognitive Resilient Networks

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IEEE Transactions on Cognitive Communications and Networking 2016年第1期2卷 95-109页

作者： Dastangoo, Siamak Fossa, Carl E. Gwon, Youngjune L. Kung, Hsiang-Tsung Tactical Networks Group MIT Lincoln Laboratory LexingtonMA02421 United States Computer Science Harvard John A. Paulson School of Engineering and Applied Sciences Harvard University CambridgeMA02138 United States MIT Lincoln Laboratory LexingtonMA02421 United States Computer Science and Electrical Engineering Harvard John A. Paulson School of Engineering and Applied Sciences Harvard University CambridgeMA02138 United States

We introduce competing cognitive resilient network (CCRN) of mobile radios challenged to optimize data throughput and networking efficiency under dynamic spectrum access and adversarial threats (e.g., jamming). Unlike the conventional approaches, CCRN features both communicator and jamming nodes in a friendly coalition to take joint actions against hostile networking entities. In particular, this paper showcases hypothetical blue force and red force CCRNs and their competition for open spectrum resources. We present state-agnostic and stateful solution approaches based on the decision theoretic framework. The state-agnostic approach builds on multiarmed bandit to develop an optimal strategy that enables the exploratory-exploitative actions from sequential sampling of channel rewards. The stateful approach makes an explicit model of states and actions from an underlying Markov decision process and uses multiagent Q-learning to compute optimal node actions. We provide a theoretical framework for CCRN and propose new algorithms for both approaches. Simulation results indicate that the proposed algorithms outperform some of the most important algorithms known to date. © 2016 IEEE.

关键词： Cognitive radio

Cochlear tuning… of mice and men

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AIP Conference Proceedings 2018年第1期1965卷

作者： Shirin Farrahi Roozbeh Ghaffari Jonathan B. Sellon Hideko H. Nakajima Dennis M. Freeman 1Research Laboratory of Electronics MIT Cambridge Massachusetts USA 2Department of Electrical Engineering and Computer Science MIT Cambridge Massachusetts USA 3Harvard-MIT Program in Health Sciences and Technology Cambridge Massachusetts USA 4Department of Otolaryngology Harvard Medical School and Massachusetts Eye and Ear Boston Massachusetts USA

It has been suggested that humans discriminate different frequency sounds with greater selectivity than other mammals. However, mechanisms that could underlie higher frequency selectivity in humans are unclear. Recent studies show that the tectorial membrane (TM) supports longitudinally propagating waves, and the spread of excitation of these TM waves has been implicated in controlling the tuning properties in a mutant mouse model of hearing. Here we compare TM morphology and waves in humans and mice and show that despite some differences in morphology, the spread of excitation of TM waves is similar in spatial extent. However, the cochlear maps of humans and mice differ significantly, with similar cochlear distances mapping to a narrower range of best frequencies in humans than in mice. By coupling different frequency ranges, TM waves could contribute to differences in frequency tuning in mammals, with the smaller human range of frequencies corresponding to sharper frequency tuning.

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CHIME/FRB Outriggers: Design Overview

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arXiv 2025年

作者： Amiri, Mandana Andersen, Bridget C. Andrew, Shion Bandura, Kevin Bhardwaj, Mohit Bhopi, Kalyani Bidula, Vadym Boyle, P.J. Brar, Charanjot Carlson, Mark Cassanelli, Tomas Cassity, Alyssa Chatterjee, Shami Cliche, Jean-François Curtin, Alice P. Darlinger, Rachel DeBoer, David R. Dobbs, Matt Dong, Fengqiu Adam Eadie, Gwendolyn Fonseca, Emmanuel Gaensler, B.M. Gusinskaia, Nina Halpern, Mark Hendricksen, Ian Hessels, Jason Joseph, Ronniy C. Kaczmarek, Jane Kaspi, Victoria M. Khairy, Kholoud Landecker, T.L. Lanman, Adam E. Kit Lau, Albert Wai Lazda, Mattias Leung, Calvin Main, Robert A. Masui, Kiyoshi W. McKinven, Ryan Mena-Parra, Juan Meyers, Bradley W. Michilli, Daniele Milutinovic, Nikola Nimmo, Kenzie Noble, Gavin Pandhi, Ayush Pearlman, Aaron B. Peterson, Jeffrey B. Petroff, Emily Pleunis, Ziggy Pollak, Alexander W. Rafiei-Ravandi, Masoud Renard, Andre Sammons, Mawson W. Sand, Ketan R. Sanghavi, Pranav Scholz, Paul Shah, Vishwangi Shin, Kaitlyn Siegel, Seth R. Siemion, Andrew Sievers, Jonathan L. Smith, Kendrick Spear, David Stairs, Ingrid Vanderlinde, Keith Wang, Haochen Willis, Jacob P. Zegmott, Tarik J. Department of Physics and Astronomy University of British Columbia 6224 Agricultural Road VancouverBCV6T 1Z1 Canada Department of Physics McGill University 3600 rue University MontréalQCH3A 2T8 Canada Trottier Space Institute McGill University 3550 rue University MontréalQCH3A 2A7 Canada MIT Kavli Institute for Astrophysics and Space Research Massachusetts Institute of Technology 77 Massachusetts Ave CambridgeMA02139 United States Department of Physics Massachusetts Institute of Technology 77 Massachusetts Ave CambridgeMA02139 United States Lane Department of Computer Science and Electrical Engineering 1220 Evansdale Drive PO Box 6109 MorgantownWV26506 United States Center for Gravitational Waves and Cosmology West Virginia University Chestnut Ridge Research Building MorgantownWV26505 United States McWilliams Center for Cosmology & Astrophysics Department of Physics Carnegie Mellon University PittsburghPA15213 United States National Research Council of Canada Herzberg Astronomy and Astrophysics 5071 West Saanich Road VictoriaBCV9E2E7 Canada Department of Electrical Engineering Universidad de Chile Av. Tupper 2007 Santiago8370451 Chile Cornell Center for Astrophysics and Planetary Science Cornell University IthacaNY14853 United States Department of Astronomy University of California BerkeleyCA94720 United States National Radio Astronomy Observatory 520 Edgemont Rd CharlottesvilleVA22903 United States Department of Astronomy and Astrophysics University of Toronto 50 St. George Street ONM5S 3H4 Canada Department of Statistical Sciences University of Toronto 700 University Ave. TorontoONM5G 1Z5 Canada Data Sciences Institute University of Toronto 700 University Ave. TorontoONM5G 1Z5 Canada Department of Physics and Astronomy West Virginia University PO Box 6315 MorgantownWV26506 United States Department of Astronomy and Astrophysics University of California Santa Cruz 1156 High Street Santa CruzCA95060 United States

The Canadian Hydrogen Intensity Mapping Experiment (CHIME) has emerged as the world’s premier facility for studying fast radio bursts (FRBs) through its fast transient search backend CHIME/FRB. The CHIME/FRB Outriggers project will augment this high detection rate of 2–3 FRBs per day with the ability to precisely localize them using very long baseline interferometry (VLBI). Using three strategically located stations in North America and deploying recently developed synoptic VLBI observing techniques, the Outriggers will provide ∼ 50 milliarcsecond localization precision for the majority of detected FRBs. This paper presents an overview of the design and implementation of the Outriggers, covering their geographic distribution, structural design, and observational capabilities. We detail the scientific objectives driving the project, including the characterization of FRB populations, host galaxy demographics, and the use of FRBs as cosmological probes. We also discuss the calibration strategies available to mitigate ionospheric and instrumental effects, ensuring high-precision localization. With two stations currently in science operations, and the third in commissioning, the CHIME/FRB Outriggers project is poised to become a cornerstone of the FRB field, offering unprecedented insights into this enigmatic cosmic phenomenon. Copyright © 2025, The Authors. All rights reserved.

关键词： Dark Matter

Percolation thresholds for photonic quantum computing

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arXiv 2017年

作者： Pant, Mihir Towsley, Don Englund, Dirk Guha, Saikat Department of Electrical Engineering and Computer Science MIT CambridgeMA02139 United States Quantum Information Processing group Raytheon BBN Technologies 10 Moulton Street CambridgeMA02138 United States College of Information and Computer Sciences University of Massachusetts AmherstMA01003 United States

Any quantum algorithm can be implemented by an adaptive sequence of single node measurements on an entangled cluster of qubits in a square lattice topology. Photons are a promising candidate for encoding qubits but assembling a photonic entangled cluster with linear optical elements relies on probabilistic operations. Given a supply of n-photon-entangled microclusters, using a linear optical circuit and photon detectors, one can assemble a random entangled state of photons that can be subsequently "renormalized" into a logical cluster for universal quantum computing. In this paper, we prove that there is a fundamental tradeoff between n and the minimum success probability λ(cn) that each two-photon linear-optical fusion operation must have, in order to guarantee that the resulting state can be renormalized: λ(cn) ≥ 1/(n − 1). We present a new way of formulating this problem where λc(n) is the bond percolation threshold of a logical graph and provide explicit constructions to produce a percolated cluster using n = 3 photon microclusters (GHZ states) as the initial resource. We settle a heretofore open question by showing that a renormalizable cluster can be created with 3-photon microclusters over a 2D graph without feedforward, which makes the scheme extremely attractive for an integrated-photonic realization. We also provide lattice constructions, which show that 0.5 ≤ λ(3) c ≤ 0.5898, improving on a recent result of λ(3) c ≤ 0.625. Finally, we discuss how losses affect the bounds on the threshold, using loss models inspired by a recently-proposed method to produce photonic microclusters using quantum dot emitters. Copyright © 2017, The Authors. All rights reserved.

关键词： Photons

Fast radio burst morphology in the first CHIME/FRB catalog

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arXiv 2021年

作者： Pleunis, Ziggy Good, Deborah C. Kaspi, Victoria M. McKinven, Ryan Ransom, Scott M. Scholz, Paul Bandura, Kevin Bhardwaj, Mohit Boyle, P.J. Brar, Charanjot Cassanelli, Tomas Chawla, Pragya Dong, Fengqiu Fonseca, Emmanuel Gaensler, B.M. Josephy, Alexander Kaczmarek, Jane F. Leung, Calvin Lin, Hsiu-Hsien Masui, Kiyoshi W. Mena-Parra, Juan Michilli, Daniele Ng, Cherry Patel, Chitrang Rafiei-Ravandi, Masoud Rahman, Mubdi Sanghavi, Pranav Shin, Kaitlyn Smith, Kendrick M. Stairs, Ingrid H. Tendulkar, Shriharsh P. Department of Physics McGill University 3600 rue University MontréalQCH3A 2T8 Canada McGill Space Institute McGill University 3550 rue University MontréalQCH3A 2A7 Canada Dept. of Physics and Astronomy 6224 Agricultural Road VancouverBCV6T 1Z1 Canada Dunlap Institute for Astronomy & Astrophysics University of Toronto 50 St. George Street TorontoONM5S 3H4 Canada David A. Dunlap Department of Astronomy & Astrophysics University of Toronto 50 St. George Street TorontoONM5S 3H4 Canada National Radio Astronomy Observatory 520 Edgemont Rd CharlottesvilleVA22903 United States Lane Department of Computer Science and Electrical Engineering 1220 Evansdale Drive PO Box 6109 MorgantownWV26506 United States Center for Gravitational Waves and Cosmology West Virginia University Chestnut Ridge Research Building MorgantownWV26505 United States National Research Council Canada Herzberg Astronomy and Astrophysics Research Centre Dominion Radio Astrophysical Observatory PO Box 248 PentictonBCV2A 6J9 Canada MIT Kavli Institute for Astrophysics and Space Research Massachusetts Institute of Technology 77 Massachusetts Ave CambridgeMA02139 United States Department of Physics Massachusetts Institute of Technology 77 Massachusetts Ave CambridgeMA02139 United States Canadian Institute for Theoretical Astrophysics 60 St. George Street TorontoONM5S 3H8 Canada Perimeter Institute for Theoretical Physics 31 Caroline Street N WaterlooONN2L 2Y5 Canada Department of Physics and Astronomy University of Waterloo WaterlooONN2L 3G1 Canada Sidrat Research PO Box 73527 RPO Wychwood TorontoONM6C 4A7 Canada Department of Astronomy and Astrophysics Tata Institute of Fundamental Research Mumbai400005 India National Centre for Radio Astrophysics Post Bag 3 Ganeshkhind Pune411007 India

We present a synthesis of fast radio burst (FRB) morphology (the change in flux as a function of time and frequency) as detected in the 400–800MHz octave by the FRB project on the Canadian Hydrogen Intensity Mapping Experiment (CHIME/FRB), using events from the first CHIME/FRB catalog. The catalog consists of 61 bursts from 18 repeating sources, plus 474 one-off FRBs, detected between 2018 July 25 and 2019 July 2. We identify four observed archetypes of burst morphology ("simple broadband," "simple narrowband," "temporally complex" and "downward drifting") and describe relevant instrumental biases that are essential for interpreting the observed morphologies. Using the catalog properties of the FRBs, we confirm that bursts from repeating sources, on average, have larger widths and we show, for the first time, that bursts from repeating sources, on average, are narrower in bandwidth. This difference could be due to a beaming or propagation effects, or it could be intrinsic to the populations. We discuss potential implications of these morphological differences for using FRBs as astrophysical tools. Copyright © 2021, The Authors. All rights reserved.

关键词： Morphology

Towards a consensus atlas of human and mouse adipose tissue at single-cell resolution

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Nature metabolism 2025年第5期7卷 875-894页

作者： Loft, Anne Emont, Margo P. Weinstock, Ada Divoux, Adeline Ghosh, Adhideb Wagner, Allon Hertzel, Ann V. Maniyadath, Babukrishna Deplancke, Bart Liu, Boxiang Scheele, Camilla Lumeng, Carey Ding, Changhai Ma, Chenkai Wolfrum, Christian Strieder-Barboza, Clarissa Li, Congru Truong, Danh D. Bernlohr, David A. Stener-Victorin, Elisabet Kershaw, Erin E. Yeger-Lotem, Esti Shamsi, Farnaz Hui, Hannah X. Camara, Henrique Zhong, Jiawei Kalucka, Joanna Ludwig, Joseph A. Semon, Julie A. Jalkanen, Jutta Whytock, Katie L. Dumont, Kyle D. Sparks, Lauren M. Muir, Lindsey A. Fang, Lingzhao Massier, Lucas Saraiva, Luis R. Beyer, Marc D. Jeschke, Marc G. Mori, Marcelo A. Boroni, Mariana Walsh, Martin J. Patti, Mary-Elizabeth Lynes, Matthew D. Blüher, Matthias Rydén, Mikael Hamda, Natnael Solimini, Nicole L. Mejhert, Niklas Gao, Peng Gupta, Rana K. Murphy, Rinki Pirouzpanah, Saeed Corvera, Silvia Tang, Su'an Das, Swapan K. Schmidt, Søren F Zhang, Tao Nelson, Theodore M. Efthymiou, Vissarion Wang, Wenjing Tong, Yihan Tseng, Yu-Hua Mandrup, Susanne Rosen, Evan D. Center for Functional Genomics and Tissue Plasticity (ATLAS) Department of Biochemistry and Molecular Biology University of Southern Denmark (SDU) Odense Denmark Section of Endocrinology Diabetes and Metabolism University of Chicago Chicago IL United States Department of Medicine Section of Genetic Medicine University of Chicago Chicago IL United States Translational Research Institute Orlando FL United States Department of Health Sciences and Technology Institute of Food Nutrition and Health ETH Zurich Schwerzenbach Switzerland Department of Electrical Engineering and Computer Sciences University of California Berkeley CA United States Department of Molecular and Cell Biology University of California Berkeley CA United States Center for Computational Biology University of California Berkeley CA United States Department of Biochemistry Molecular Biology and Biophysics Institute on the Biology of Aging and Metabolism University of Minnesota-Twin Cities Minneapolis MN United States Center for Functional Genomics and Tissue Plasticity (ATLAS) Department of Biochemistry and Molecular Biology University of Southern Denmark (SDU) Odense Denmark Laboratory of Systems Biology and Genetics Institute of Bioengineering School of Life Sciences École Polytechnique Fédérale de Lausanne (EPFL) Lausanne Switzerland Department of Pharmacy and Pharmaceutical Sciences Faculty of Science National University of Singapore Singapore Department of Biomedical Informatics Yong Loo Lin School of Medicine National University of Singapore Singapore Genome Institute of Singapore (GIS) Agency for Science Technology and Research (A*STAR) Singapore Precision Medicine Translational Research Programme Yong Loo Lin School of Medicine National University of Singapore Singapore Cardiovascular-Metabolic Disease Translational Research Programme Yong Loo Lin School of Medicine National University of Singapore Singapore NUS Centre for Cancer Research Yong Loo Lin School of Medicine Nationa

Adipose tissue (AT) is a complex connective tissue with a high relative proportion of adipocytes, which are specialized cells with the ability to store lipids in large droplets. AT is found in multiple discrete depots throughout the body, where it serves as the primary repository for excess calories. In addition, AT has an important role in functions as diverse as insulation, immunity and regulation of metabolic homeostasis. The Human Cell Atlas Adipose Bionetwork was established to support the generation of single-cell atlases of human AT as well as the development of unified approaches and consensus for cell annotation. Here, we provide a first roadmap from this bionetwork, including our suggested cell annotations for humans and mice, with the aim of describing the state of the field and providing guidelines for the production, analysis, interpretation and presentation of AT single-cell data. © 2025. Springer Nature Limited.

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