This paper describes a fully autonomous mobile urban robot-X1, which can perform multiple tasks autonomously in an unknown urban environment without human guidance, including mobile reconnaissance, target searching, a...
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Protein-protein interactions (PPI) play an important role in cellular processes and metabolic processes within a cell. An important task is to determine the existence of interactions among proteins. Unfortunately, exi...
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Protein-protein interactions (PPI) play an important role in cellular processes and metabolic processes within a cell. An important task is to determine the existence of interactions among proteins. Unfortunately, existing biological experimental techniques are expensive, time-consuming and labor-intensive. The network structures of many such networks are sparse, incomplete and noisy, containing many false positive and false negatives. Thus, state-of-the-art methods for link prediction in these networks often cannot give satisfactory prediction results, especially when some networks are extremely sparse. Noticing that we typically have more than one PPI network available, we naturally wonder whether it is possible to 'transfer' the linkage knowledge from some existing, relatively dense networks to a sparse network, to improve the prediction performance. Noticing that a network structure can be modeled using a matrix model, in this paper, we introduce the well-known Collective Matrix Factorization (CMF) technique to 'transfer' usable linkage knowledge from relatively dense interaction network to a sparse target network. Our approach is to establish the correspondence between a source and a target network via network similarities. We test this method on two real protein-protein interaction networks, Helicobacter pylori (as a target network) and Human (as a source network). Our experimental results show that our method can achieve higher and more robust performance as compared to some baseline methods.
All freshman engineering students at York College participate in a spring semester design challenge as part of a year-long, two-course introduction to engineering. This paper describes the course organization, the pro...
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All freshman engineering students at York College participate in a spring semester design challenge as part of a year-long, two-course introduction to engineering. This paper describes the course organization, the project goals, and project itself and how it supports the broader engineering curriculum goals of engaging freshman engineering students in a design project, exposing them in an interesting way to the breath of engineering, and motivating them in their engineering studies. The students work in small teams and have roughly 12 weeks to design an automated electromechanical system that first transports three empty Snapple bottles, three tennis balls, and 36 oz. of water to a 2/x3/ operational zone. The machine must fill each bottle with 12 oz. of water, cap each bottle by covering the top with a tennis ball, and then deliver the capped and filled bottles to an area outside of the operational zone. The bottle-filling project serves as the second of two interdisciplinary engineering design experiences during the freshman year. It introduces aspects of computer, electrical, and mechanical engineering, including the following five primary knowledge areas: (i) machining and fabrication;(ii) electronic circuit prototyping and programming;(iii) sensor and actuator applications;(iv) mechanical design;(v) project planning;and (vi) presentation skills. A project demonstration at the end of the semester determines the relative effectiveness of each machine based upon a number of quantitative factors, including the total time required to complete the overall process, the volume of water in each bottle, the number of bottles successfully capped, the amount of water spilled, and approximate manufacturing cost. Some qualitative factors considered are simplicity, creativity, and aesthetics. Student interest in this substantial hands-on experience, as measured by surveys and exhibited by attendance, enthusiasm, productivity, and success, appears to be high through the three y
In this work, the physiological phenomenon of leukocyte margination is mimicked in microfluidic systems for biological separation of malarial infected RBCs (iRBCs) from blood. Change in cell stiffness is a characteris...
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ISBN:
(纸本)9781618390622
In this work, the physiological phenomenon of leukocyte margination is mimicked in microfluidic systems for biological separation of malarial infected RBCs (iRBCs) from blood. Change in cell stiffness is a characteristic of iRBCs which can act as an intrinsic biomarker for separation. Tests were conducted using early ring stage and late trophozoite/schizont stage iRBCs which vary significantly in their deformability. Filtration efficiency was quantified by analyzing the dispersion of iRBCs across the microchannel width at the outlet. Flow cytometry analysis was conducted on the outlet samples indicating filtration efficiency of ∼80% for early stage iRBCs and >90% for late stage iRBCs. This is the first demonstration applying this unique biomimetic separation technique to iRBCs filtration for disease diagnostic application.
Continuous flow-based cell separations are indispensable for many biomedical applications and diagnostics including early detection of cancer. Here, we describe a high-throughput cell separation technique for sorting ...
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ISBN:
(纸本)9781618390622
Continuous flow-based cell separations are indispensable for many biomedical applications and diagnostics including early detection of cancer. Here, we describe a high-throughput cell separation technique for sorting circulating tumor cells (CTCs) from blood using microfluidics. The separation consists of a 2-step process to efficiently isolate CTCs from blood. In the first step, 99% of hematologic cells (erythrocytes (RBCs) and leukocytes) are removed using shear-modulated inertial focusing with >90% CTC recovery. This RBCs depleted sample is then run through a low aspect ratio spiral microchannel to completely isolate the CTCs. The operating principle of this separation method exploits the difference in cell size between CTCs (∼16-20 μm diameter) and other blood cells (RBCs ∼8 μm;leukocytes ∼8-14 μm).
In recent years, the semidefinite relaxation (SDR) technique has been at the center of some of very exciting developments in the area of signal processing and communications, and it has shown great significance and re...
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This study is part of a larger research project, supported by a National science Foundation Research on Gender in science and engineeringprogram grant, designed to determine the effect of self-efficacy and other fact...
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作者:
Roxworthy, Brian J.Toussaint, Kimani C.
Department of Mechanical Science and Engineering University of Illinois at Urbana-Champaign Urbana IL 61801 United States
Departments of Electrical and Computer Engineering and Bioengineering University of Illinois at Urbana-Champaign Urbana IL 61801 United States
Beckman Institute for Advanced Science and Technology University of Illinois at Urbana-Champaign Urbana IL 61801 United States
Ubiquitous physiological monitoring will be a key driving force in the upcoming wireless health revolution. Cardiac and brain signals in the form of ECG and EEG are two critical health indicators that directly benefit...
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Methods that measure energy balance accurately in real time represent promising avenues to address the obesity epidemic. We developed an electronic food diary on a mobile phone that includes an energy balance visualiz...
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