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Microscopy Histopathology and Analytics, Microscopy 2024 - Part of Optica Biophotonics Congress: Biomedical Optics

作者： Zhuo, Yue Choi, Ji Sun Marin, Thibault Yu, Hojeong Harley, Brendan A. Cunningham, Brian T. Gordon Center for Medical Imaging Massachusetts General Hospital BostonMA02114 United States Center for Systems Biology Massachusetts General Hospital BostonMA02114 United States Department of Radiology Harvard Medical School BostonMA02114 United States Department of Bioengineering University of Illinois at Urbana-Champaign UrbanaIL61801 United States Department of Chemical and Biomolecular Engineering University of Illinois at Urbana-Champaign UrbanaIL61801 United States Department of Electrical and Computer Engineering University of Illinois at Urbana-Champaign UrbanaIL61801 United States Micro and Nanotechnology Laboratory University of Illinois at Urbana-Champaign UrbanaIL61801 United States Beckman Institute for Advanced Science and Technology University of Illinois at Urbana-Champaign UrbanaIL61801 United States Carl R. Woese Institute for Genomic Biology University of Illinois at Urbana-Champaign UrbanaIL61801 United States

With the Photonic Resonator Outcoupler Microscopy (PROM), it is possible to detect and monitor weak-adhesive HSC adhesion without labeling. These findings indicate that PROM can be used to quantitatively and dynamical... 详细信息

ISBN: (纸本)9781957171340

关键词： Stem cells

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The Effects of Boron Doping on the Bulk and Surface Acoustic Phonons in Single-Crystal Diamond

arXiv

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arXiv 2022年

作者： Guzman, Erick Kargar, Fariborz Angeles, Frank Meidanshahi, Reza Vatan Grotjohn, Timothy A. Hardy, Aaron Muehle, Matthias Wilson, Richard B. Goodnik, Stephen Balandin, Alexander A. Nano-Device Laboratory Phonon Optimized Engineered Materials Center Department of Electrical and Computer Engineering University of California RiversideCA92521 United States Department of Mechanical Engineering Materials Science and Engineering Program University of California RiversideCA92521 United States School of Electrical Computer and Energy Engineering Arizona State University TempeAZ85281 United States Department of Electrical and Computer Engineering Michigan State University East LansingMI48824 United States Fraunhofer USA Center Midwest East LansingMI48824 United States

We report the results of the investigation of bulk and surface acoustic phonons in the undoped and boron-doped single-crystal diamond films using the Brillouin-Mandelstam light scattering spectroscopy. The evolution of the optical phonons in the same set of samples was monitored with Raman spectroscopy. It was found that the frequency and the group velocity of acoustic phonons decrease non-monotonically with the increasing boron doping concentration, revealing pronounced phonon softening. The change in the velocity of the shear horizontal and the high-frequency pseudo-longitudinal acoustic phonons in the degenerately doped diamond, as compared to the undoped diamond, was as large as ~ 15% and ~12%, respectively. As a result of boron doping, the velocity of the bulk longitudinal and transverse acoustic phonons decreased correspondingly. The frequency of the optical phonons was unaffected at low boron concentration but experienced a strong decrease at the high doping level. The density-functional-theory calculations of the phonon band structure for the pristine and highly-doped sample confirm the phonon softening as a result of boron doping in diamond. The obtained results have important implications for thermal transport in heavily doped diamond, which is a promising material for ultra-wide-band-gap electronics. Copyright © 2022, The Authors. All rights reserved.

关键词： Density functional theory

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Distributed Embedded Platform for Controllers following the Supervisory Control Theory 3

Distributed Embedded Platform for Controllers following the ...

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3rd International Conference on electrical, Communication and computer engineering, ICECCE 2021

作者： Assmann, Joao Vitor Gotz, Marcelo Muller, Ivan Rettberg, Achim Universidade Federal Do Rio Grande Do sul Department of Automation and Energy Porto Alegre Brazil Electrical Engineering Postgraduation Program Universidade Federal Do Rio Grande Do sul Porto Alegre Brazil University of Applied Sciences Hamm-Lippstadt Department of Computer Science Lippstadt Germany

ISBN: (纸本)9781665438971

Supervisory Control Theory (SCT) is a powerful framework to design a controller for a Discrete Event System (DES). However, several issues appear because of the different nature of SCT and synchronous-based systems, on which a controller will be executed. While SCT, which relies on automata theory, is based on the occurrence of asynchronous events, a computer-based system is based on a synchronous digital system. Even though most of the contributions to overcome the problems derived by this fact concentrate on the usability for programming Logic Controllers, no significant contribution has been made for embedded execution platform. If so, it relies on the hand-coded implementation of the supervisor controller. The work here proposed, combines previous research contributions to develop an embedded and distributed platform for supervisor automata model execution. No code translation is required, since the models, after simulation, can be directly executed on the proposed platform. The results obtained by two case studies show the feasibility of the conceived platform. © 2021 IEEE.

关键词： Controllers

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Demonstration of a polarization-agnostic geometric phase in nonlocal metasurfaces

Demonstration of a polarization-agnostic geometric phase in ...

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Conference on Lasers and Electro-Optics (CLEO)

作者： Adam C. Overvig Y. Kasahara Andrea Alù Photonics Initiative Advanced Science Research Center City University of New York New York NY USA Department of Electrical and Computer Engineering The University of Texas at Austin Austin TX USA Physics Program Graduate Center of the City University of New York New York NY USA

We theoretically propose and experimentally demonstrate nonlocal metasurfaces rationally designed using symmetry-breaking principles to manipulate the optical wavefront with a geometric phase selective to custom ellip... 详细信息

ISBN: (纸本)9781957171258

关键词： Circular polarization Constructive interference Fano resonance Polarization Polarized light Thermal emission

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Virtual Histological Staining of Label-Free Autopsy Tissue Sections via Deep Learning

Virtual Histological Staining of Label-Free Autopsy Tissue S...

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Conference on Lasers and Electro-Optics (CLEO)

作者： Yuzhu Li Nir Pillar Jingxi Li Tairan Liu Di Wu Songyu Sun Guangdong Ma Kevin De Haan Luzhe Huang Yijie Zhang Sepehr Hamidi Anatoly Urisman Tal Keidar Haran William Dean Wallace Jonathan E. Zuckerman Aydogan Ozcan Electrical and Computer Engineering Department Bioengineering Department California NanoSystems Institute (CNSI) Computer Science Department University of California Los Angeles CA USA School of physics Xi'an Jiaotong University Xi'an Shaanxi China Department of Pathology and Laboratory Medicine David Geffen School of Medicine University of California Los Angeles CA USA Department of Pathology University of California San Francisco CA USA Department of Pathology Hadassah Hebrew University Medical Center Jerusalem Israel Department of Pathology Keck School of Medicine University of Southern California Los Angeles CA USA Department of Surgery University of California Los Angeles CA USA

We present deep learning-based virtual staining of label-free autopsy tissue sections, eliminating severe autolysis-induced artifacts caused by delayed fixation inherent in traditional histochemical H&E staining.

ISBN: (纸本)9798350369311

关键词： Deep learning Autopsy Lasers and electrooptics Electro-optical waveguides

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OPRLM: A Web Tool and a Database for Positioning and Simulations of Proteins in Realistic Lipid Membranes

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Journal of Molecular Biology 2025年第15期437卷 168966页

作者： Park, Sang-Jun Schnitzer, Kyle A. Kovalenko, Alexey Cherepanov, Stanislav Patro, L. Ponoop Prasad Song, Zigang Pogozheva, Irina D. Lomize, Andrei L. Im, Wonpil Department of Computer Science and Engineering Lehigh University 111 Research Drive Bethlehem 18015 PA United States Department of Electrical Engineering and Computer Science College of Engineering University of Michigan 1221 Beal Ave Ann Arbor 48109-2102 MI United States Department of Computer Science College of Literature Science and the Arts University of Michigan 2260 Hayward Street Ann Arbor 48109-2121 MI United States Biophysics Program University of Michigan 930 N. University Avenue Ann Arbor 48109-1065 MI United States Department of Biological Sciences Lehigh University 111 Research Drive Bethlehem 18015 PA United States Department of Medicinal Chemistry College of Pharmacy University of Michigan 428 Church St. Ann Arbor 48109-1065 MI United States

Molecular dynamics (MD) simulations in explicit lipid bilayers enable modeling of protein-lipid interactions essential for membrane protein functions and regulation. The newly developed computational web tool, OPRLM (Orientations of Proteins in Realistic Lipid Membranes), automates the assembly of membrane protein structures with explicit lipids corresponding to 18 biological membrane types with symmetric or asymmetric lipid distributions, as well as 5 types of two-component lipid bilayers with varying cholesterol content. Built upon the CHARMM-GUI toolset and the PPM method, OPRLM simplifies the setup of complex simulation system involving integral and/or peripheral membrane proteins with explicit lipid mixtures and generates all necessary files for subsequent all-atom MD simulations. OPRLM has successfully generated protein-membrane systems for 286 tested protein structures in various biomembranes, including 138 structures containing ligands. The OPRLM database, an advanced successor of the OPM database, includes explicit protein-lipid systems for tested proteins in their native biomembranes. It provides coordinates of integral and peripheral membrane proteins from the Protein Data Bank embedded in planar or curved implicit lipid bilayers. Additionally, it includes the classification of proteins into types, superfamilies, and families, along with the information on intracellular localizations and membrane topology and visualization options. The OPRLM web tool and the database are publicly accessible at https://***. © 2025 The Authors

关键词： biomembrane explicit lipid lipid bilayer peripheral membrane protein transmembrane

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Bifunctional Noble Metal-free Ternary Chalcogenide Electrocatalysts for Overall Water Splitting

arXiv

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arXiv 2024年

作者： Singh, Shantanu Irshad, Ahamed De la Cruz, Germany Diaz Zhao, Boyang Zayat, Billal Chang, Qiaowan Narayan, Sri Ravichandran, Jayakanth Mork Family Department of Chemical Engineering and Materials Science University of Southern California Los AngelesCA90089 United States Department of Chemistry University of Southern California Los AngelesCA90089 United States The Gene and Linda Voiland School of Chemical Engineering and Bioengineering Washington State University PullmanWA99164 United States Ming Department of Electrical and Computer Engineering University of Southern California Los AngelesCA90089 United States Core Center of Excellence in Nano Imaging University of Southern California Los AngelesCA90089 United States

Hydrogen has been identified as a clean, zero carbon, sustainable, and promising energy source for the future, and electrochemical water splitting for hydrogen production is an emission-free, efficient energy conversion technology. A major limitation of this approach is the unavailability of efficient, abundant, inexpensive catalysts, which prompts the need for new catalytic materials. Here, we report the synthesis and electrocatalytic properties of a novel transition metal-based ternary chalcogenide family, LaMS3 (M = Mn, Fe, Co, Ni). Powder X-ray diffraction confirms the phase purity of these materials, while composition analysis using energy dispersive spectroscopy (EDS) confirms the presence of the stoichiometric ratio of elements in these compounds. X-ray photoelectron spectroscopy (XPS) and X-ray absorption spectroscopy (XAS) were used to study the chemical states on the surface and in bulk, respectively. These materials exhibit bifunctional catalytic activity towards the two half-reactions of the water-splitting process, with LaNiS3 being the most active material for both hydrogen evolution reaction (HER) and oxygen evolution reaction (OER). The LaMS3 compounds show long-term stability with negligible change in the overpotential at a constant current density of 10 mA cm-2 over 18 hours of measurements. As compared to the corresponding ternary oxides, the LaMS3 materials exhibit higher activity and significantly lower Tafel slopes. The ability to catalyze both half-reactions of water electrolysis makes these materials promising candidates for bifunctional catalysts and presents a new avenue to search for high-efficiency electrocatalysts for water splitting. © 2024, CC BY.

关键词： Electrocatalysts

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Room-temperature multiple ligands-tailored SnO_(2) quantum dots endow in situ dual-interface binding for upscaling efficient perovskite photovoltaics with high V_(OC)

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Light(science & Applications) 2021年第12期10卷 2467-2481页

作者： Zhiwei Ren Kuan Liu Hanlin Hu Xuyun Guo Yajun Gao Patrick W.K.Fong Qiong Liang Hua Tang Jiaming Huang Hengkai Zhang Minchao Qin Li Cui Hrisheekesh Thachoth Chandran Dong Shen Ming-Fai Lo Annie Ng Charles Surya Minhua Shao Chun-Sing Lee Xinhui Lu Frédéric Laquai Ye Zhu Gang Li Department of Electronic and Information Engineering Research Institute for Smart Energy(RISE)Guangdong-Hong Kong-Macao(GHM)Joint Laboratory for Photonic-Thermal-Electrical Energy Materials and DevicesThe Hong Kong Polytechnic UniversityHung HomKowloonHong KongChina Department of Electrical and Computer Engineering Nazarbayev UniversityNur-SultanKazakhstan The Hong Kong Polytechnic University Shenzhen Research Institute Shenzhen 518057China Hoffmann Institute of Advanced Materials Shenzhen Polytechnic7098 Liuxian BoulevardShenzhen 518055China Department of Applied Physics The Hong Kong Polytechnic UniversityHung HomKowloonHong KongChina Department of Chemical and Biological Engineering The Hong Kong University of Science and TechnologyClear Water BayKowloonHong KongChina King Abdullah University of Science and Technology(KAUST) KAUST Solar Center(KSC)Physical Sciences and Engineering Division(PSE)Material Science and Engineering Program(MSE)Thuwal 23955-6900Kingdom of Saudi Arabia Department of Physics The Chinese University of Hong KongShatin 999077 Hong KongChina Center of Super-Diamond and Advanced Films(COSDAF) Department of ChemistryCity University of Hong KongHong KongChina

The benchmark tin oxide(SnO_(2))electron transporting layers(ETLs)have enabled remarkable progress in planar perovskite solar cell(PSCs).However,the energy loss is still a challenge due to the lack of“hidden interface”*** report a novel ligand-tailored ultrafine SnO_(2) quantum dots(QDs)via a facile rapid room temperature ***,the ligand-tailored SnO_(2) QDs ETL with multi-functional terminal groups in situ refines the buried interfaces with both the perovskite and transparent electrode via enhanced interface binding and perovskite *** novel ETLs induce synergistic effects of physical and chemical interfacial modulation and preferred perovskite crystallization-directing,delivering reduced interface defects,suppressed non-radiative recombination and elongated charge carrier *** conversion efficiency(PCE)of 23.02%(0.04 cm^(2))and 21.6%(0.98 cm^(2),V_(OC) loss:0.336 V)have been achieved for the blade-coated PSCs(1.54 eV E_(g))with our new ETLs,representing a record for SnO_(2) based blade-coated ***,a substantially enhanced PCE(V_(OC))from 20.4%(1.15 V)to 22.8%(1.24 V,90 mV higher V_(OC),0.04 cm^(2) device)in the blade-coated 1.61 eV PSCs system,via replacing the benchmark commercial colloidal SnO_(2) with our new ETLs.

关键词： perovskite interface quantum

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Combining Experimental and Observational Data for Identification and Estimation of Long-Term Causal Effects

arXiv

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arXiv 2022年

作者： Ghassami, AmirEmad Yang, Alan Richardson, David Shpitser, Ilya Tchetgen, Eric Tchetgen Department of Computer Science Johns Hopkins University United States Department of Electrical Engineering Stanford University United States Department of Environmental and Occupational Health Program in Public Health University of California Irvine United States Department of Statistics and Data Science The Wharton School University of Pennsylvania United States

We consider the task of identifying and estimating the causal effect of a treatment variable on a long-term outcome variable using data from an observational domain and an experimental domain. The observational domain is subject to unobserved confounding. Furthermore, subjects in the experiment are only followed for a short period of time;hence, long-term effects of treatment are unobserved but short-term effects will be observed. Therefore, data from neither domain alone suffices for causal inference about the effect of the treatment on the long-term outcome, and must be pooled in a principled way, instead. Athey et al. (2020) proposed a method for systematically combining such data for identifying the downstream causal effect in view. Their approach is based on the assumptions of internal and external validity of the experimental data, and an extra novel assumption called latent unconfoundedness. In this paper, we first review their proposed approach, and then we propose three alternative approaches for data fusion for the purpose of identifying and estimating average treatment effect as well as the effect of treatment on the treated. Our first approach is based on assuming equi-confounding bias for the short-term and long-term outcomes. Our second approach is based on a relaxed version of the equi-confounding bias assumption, where we assume the existence of an observed confounder such that the short-term and long-term potential outcome variables have the same partial additive association with that confounder. Our third approach is based on the proximal causal inference framework, in which we assume the existence of an extra variable in the system which is a proxy of the latent confounder of the treatment-outcome relation. We propose influence function-based estimation strategies for each of our data fusion frameworks and study the robustness properties of the proposed estimators. © 2022, CC BY.

关键词： Data fusion

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Layer-dependent optically induced spin polarization in InSe

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Physical Review B 2023年第11期107卷 115304-115304页

作者： Jovan Nelson Teodor K. Stanev Dmitry Lebedev Trevor LaMountain J. Tyler Gish Hongfei Zeng Hyeondeok Shin Olle Heinonen Kenji Watanabe Takashi Taniguchi Mark C. Hersam Nathaniel P. Stern Applied Physics Program Northwestern University Evanston Illinois 60208 USA Department of Physics and Astronomy Northwestern University Evanston Illinois 60208 USA Department of Material Science and Engineering Northwestern University Evanston Illinois 60208 USA Computational Science Division Argonne National Laboratory Lemont Illinois 60439 USA Material Science Division Argonne National Laboratory Lemont Illinois 60439 USA Research Center for Functional Materials National Institute for Materials Science 1-1 Namiki Tsukuba 305-0044 Japan International Center for Materials Nanoarchitectonics National Institute for Materials Science 1-1 Namiki Tsukuba 305-0044 Japan Department of Chemistry Northwestern University Evanston Illinois 60208 USA Department of Electrical Engineering and Computer Science Northwestern University Evanston Illinois 60208 USA

Optical control of spin in semiconductors has been pioneered using nanostructures of III-V and II-VI semiconductors, but the emergence of two-dimensional van der Waals materials offers an alternative low-dimensional platform for spintronic phenomena. Indium selenide (InSe), a group-III monochalcogenide van der Waals material, has shown promise for optoelectronics due to its high electron mobility, tunable direct band gap, and quantum transport. In addition to these confirmed properties, there are predictions of spin-dependent optical selection rules, suggesting the potential for all-optical excitation and control of spin in a two-dimensional layered material. Despite these predictions, layer-dependent optical spin phenomena in InSe have yet to be explored. Here, we present measurements of layer-dependent optical spin dynamics in few-layer and bulk InSe. Polarized photoluminescence reveals layer-dependent optical orientation of spin, thereby demonstrating the optical selection rules in few-layer InSe. Spin dynamics are also studied in many-layer InSe using time-resolved Kerr rotation spectroscopy. By applying out-of-plane and in-plane static magnetic fields for polarized emission measurements and Kerr measurements, respectively, the g factor for InSe was extracted. Further investigations are done by calculating precession values using a k·p model, which is supported by ab initio density functional theory. Comparison of predicted precession rates with experimental measurements highlights the importance of excitonic effects in InSe for understanding spin dynamics. Optical orientation of spin is an important prerequisite for optospintronic phenomena and devices, and these first demonstrations of layer-dependent optical excitation of spins in InSe lay the foundation for combining layer-dependent spin properties with advantageous electronic properties found in this material.

关键词： Magneto-optics Spin dynamics Chalcogenides Layered semiconductors Van der Waals systems Density functional theory Kerr effect Photoluminescence k dot p method

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