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IEEE Workshop on Evolving and Adaptive Intelligent Systems (EAIS)

作者： Guilherme G. Netto Alexandre C. Barbosa Mateus N. Coelho Arthur R. L. Miranda Vitor N. Coelho Marcone J. F. Souza Frederico G. Guimarães Agnaldo J. R. Reis Department of Control and Automation Engineering Universidade Federal de Ouro Preto Ouro Preto MG Brazil Graduate Program of Electrical Engineering Univesidade Federal de Minas Gerais Belo Horizonte MG Brazil Department of Computer Science Universidade Federal de Ouro Preto Ouro Preto MG Brazil Departament of Electrical Engineering Univesidade Federal de Minas Gerais Belo Horizonte MG Brazil

Several works in the literature so far have been focused on deterministic point forecasts, which, usually, indicates the conditional mean of future observations. An increasing need for generating the entire conditional distribution of future observations has been required for the new generation of soft sensors. This study aims the probabilistic forecasts, reporting the use of a hybrid fuzzy forecasting model applied in two different forecasting problems. Our adapted model is applied to predict the rain of the city of Vitoria, in the state of Espírito Santo, Brazil. Real data from a wind farm, provided by the Irish EirGrid institute, was used for analyzing the proposal over a real time series with high fluctuations. Due to the stochasticity of the the hybrid model, which is calibrated through the use of an evolutionary metaheuristic, we adapted it in order to generate future using quantile regression. Computational experiments indicated the ability of the model in finding useful probabilistic quantiles, which were flexible enough in order to limit the lower and upper bounds of the historical datasets. While the probabilistic quantiles suggested the probability of rain and its magnitude, they were also able to predict expected ranges of the amount of energy generated from the wind farm.

关键词： Forecasting Predictive models Wind forecasting Probabilistic logic Wind power generation Adaptation models Time series analysis

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DOMMINO 2.0: Integrating structurally resolved protein-, RNA-, and DNA-mediated Macromolecular interactions

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Database 2016年第2016期2016卷 bav114页

作者： Kuang, Xingyan Dhroso, Andi Han, Jing Ginger Shyu, Chi-Ren Korkin, Dmitry Informatics Institute University of Missouri Columbia MO United States Department of Computer Science Bioinformatics and Computational Biology Program Worcester Polytechnic Institute Worcester MA United States Department of Electrical and Computer Engineering United States Department of Computer Science University of Missouri Columbia MO United States Ohio State University Comprehensive Cancer Center Columbus OH United States

Macromolecular interactions are formed between proteins, DNA and RNA molecules. Being a principle building block in macromolecular assemblies and pathways, the interactions underlie most of cellular functions. Malfunctioning of macromolecular interactions is also linked to a number of diseases. Structural knowledge of the macromolecular interaction allows one to understand the interaction's mechanism, determine its functional implications and characterize the effects of genetic variations, such as single nucleotide polymorphisms, on the interaction. Unfortunately, until now the interactions mediated by different types of macromolecules, e.g. protein-protein interactions or protein-DNA interactions, are collected into individual and unrelated structural databases. This presents a significant obstacle in the analysis of macromolecular interactions. For instance, the homogeneous structural interaction databases prevent scientists from studying structural interactions of different types but occurring in the same macromolecular complex. Here, we introduce DOMMINO 2.0, a structural Database Of Macro-Molecular INteractiOns. Compared to DOMMINO 1.0, a comprehensive database on protein-protein interactions, DOMMINO 2.0 includes the interactions between all three basic types of macromolecules extracted from PDB files. DOMMINO 2.0 is automatically updated on a weekly basis. It currently includes ∼1 040 000 interactions between two polypeptide subunits (e.g. domains, peptides, termini and interdomain linkers), ∼43 000 RNA-mediated interactions, and ∼12 000 DNA-mediated interactions. All protein structures in the database are annotated using SCOP and SUPERFAMILY family annotation. As a result, protein-mediated interactions involving protein domains, interdomain linkers, C- and N-termini, and peptides are identified. Our database provides an intuitive web interface, allowing one to investigate interactions at three different resolution levels: whole subunit network, binary intera

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Chiral liquid crystal colloids

arXiv

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arXiv 2017年

作者： Yuan, Ye Martinez, Angel Senyuk, Bohdan Tasinkevych, Mykola Smalyukh, Ivan I. Department of Physics and Soft Materials Research Center University of Colorado BoulderCO80309 United States Max-Planck-Institut für Intelligente Systeme Heisenbergstr. 3 StuttgartD-70569 Germany IV. Institut für Theoretische Physik Universität Stuttgart Pfaffenwaldring 57 StuttgartD-70569 Germany Centro de Física Teórica e Computacional Departamento de Física Faculdade de Ciências Universidade de Lisboa Campo Grande LisboaP-1749-016 Portugal Department of Electrical Computer and Energy Engineering Materials Science and Engineering Program University of Colorado BoulderCO80309 United States Renewable and Sustainable Energy Institute National Renewable Energy Laboratory University of Colorado BoulderCO80309 United States

Colloidal particles disturb the alignment of rod-like molecules of liquid crystals, giving rise to long-range interactions that minimize the free energy of distorted regions. Particle shape and topology are known to guide this self-assembly process. However, how chirality of colloidal inclusions affects these long-range interactions is unclear. Here we study the effects of distortions caused by chiral springs and helices on the colloidal self-organization in a nematic liquid crystal using laser tweezers, particle tracking and optical imaging. We show that chirality of colloidal particles interacts with the nematic elasticity to pre-define chiral or racemic colloidal superstructures in nematic colloids. These findings are consistent with numerical modelling based on the minimization of Landau-de Gennes free energy. Our study uncovers the role of chirality in defining the mesoscopic order of liquid crystal colloids, suggesting that this feature may be a potential tool to modulate the global orientated self-organization of these systems. Copyright © 2017, The Authors. All rights reserved.

关键词： Chirality

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Spin-Josephson effects in exchange coupled antiferromagnetic insulators

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Physical Review B 2016年第9期94卷 094434-094434页

作者： Yizhou Liu Gen Yin Jiadong Zang Roger K. Lake Yafis Barlas Department of Electrical and Computer Engineering University of California Riverside California 92521 USA Center of Spins and Heat in Nanoscale Electronic Systems University of California Riverside California 92521 USA Department of Physics and Materials Science Program University of New Hampshire Durham New Hampshire 03824 USA Department of Physics and Astronomy University of California Riverside California 92521 USA

The spin superfluid analogy can be extended to include Josephson-like oscillations of the spin current. In a system of two antiferromagnetic insulators (AFMIs) separated by a thin metallic spacer, a threshold spin chemical potential established perpendicular to the direction of the Néel vector field drives terahertz oscillations of the spin current. This spin current also has a nonlinear, time-averaged component which provides a “smoking gun” signature of spin superfluidity. The time-averaged spin current can be detected via the inverse spin Hall effect in a metallic spacer with large spin-orbit coupling. The physics illustrated here with AFMIs also applies to easy-plane ferromagnetic insulators. These findings may provide a new approach for experimental verification of spin superfluidity and realization of a terahertz spin oscillator.

关键词： Antiferromagnetism Exchange interaction Micromagnetism Spin current Magnetic insulators

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The intrinsic geometry of the human brain connectome

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Brain Informatics 2015年第4期2卷 197-210页

作者： Ye, Allen Q. Ajilore, Olusola A. Conte, Giorgio GadElkarim, Johnson Thomas-Ramos, Galen Zhan, Liang Yang, Shaolin Kumar, Anand Magin, Richard L. G. Forbes, Angus Leow, Alex D. Department of Bioengineering University of Illinois at Chicago 218 SEO 851 S Morgan St ChicagoIL60607 United States Department of Psychiatry University of Illinois at Chicago ChicagoIL United States Department of Computer Science University of Illinois at Chicago ChicagoIL United States Computer Engineering Program Engineering and Technology Department University of Wisconsin-Stout MenomonieWI United States Department of Radiology University of Illinois at Chicago ChicagoIL United States

This paper describes novel methods for constructing the intrinsic geometry of the human brain connectome using dimensionality-reduction techniques. We posit that the high-dimensional, complex geometry that represents this intrinsic topology can be mathematically embedded into lower dimensions using coupling patterns encoded in the corresponding brain connectivity graphs. We tested both linear and nonlinear dimensionality-reduction techniques using the diffusion-weighted structural connectome data acquired from a sample of healthy subjects. Results supported the nonlinearity of brain connectivity data, as linear reduction techniques such as the multidimensional scaling yielded inferior lower-dimensional embeddings. To further validate our results, we demonstrated that for tractography-derived structural connectome more influential regions such as rich-club members of the brain are more centrally mapped or embedded. Further, abnormal brain connectivity can be visually understood by inspecting the altered geometry of these three-dimensional (3D) embeddings that represent the topology of the human brain, as illustrated using simulated lesion studies of both targeted and random removal. Last, in order to visualize brain’s intrinsic topology we have developed software that is compatible with virtual reality technologies, thus allowing researchers to collaboratively and interactively explore and manipulate brain connectome data. © 2015, The Author(s).

关键词： Brain

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Drug Delivery: Uniform Drug Loading into Prefabricated Microparticles by Freeze-Drying (Part. Part. Syst. Charact. 5/2017)

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Particle & Particle Systems Characterization 2017年第5期34卷

作者： Seo Woo Song Hyung Jong Bae Sudeok Kim Dong Yoon Oh Okju Kim Yunjin Jeong Sunghoon Kwon Department of Electrical and Computer Engineering Seoul National University Gwanak-ro Kwanak-gu Seoul 151-744 South Korea Institute of Entrepreneurial Bio Convergence Seoul National University Gwanak-ro Kwanak-gu Seoul 151-744 South Korea Interdisciplinary Program of Bioengineering Seoul National University Gwanak-ro Kwanak-gu Seoul 151-744 South Korea

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Author Correction: Evaluating Tumor Evolution via Genomic Profiling of Individual Tumor Spheroids in a Malignant Ascites

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Scientific reports 2018年第1期8卷 17395页

作者： Sungsik Kim Soochi Kim Jinhyun Kim Boyun Kim Se Ik Kim Min A Kim Sunghoon Kwon Yong Sang Song Department of Electrical and Computer Engineering Seoul National University Seoul 08826 Republic of Korea. Interdisciplinary Program for Bioengineering Seoul National University Seoul 08826 Republic of Korea. Seoul National University Hospital Biomedical Research Institute Seoul National University Hospital Seoul 03080 Republic of Korea. Cancer Research Institute Seoul National University College of Medicine Seoul 03080 Republic of Korea. Department of Anesthesiology McGovern Medical School The University of Texas Health Science Center at Houston Houston TX USA. Department of Obstetrics and Gynecology Seoul National University College of Medicine Seoul 03080 Republic of Korea. Department of Pathology Seoul National University College of Medicine Seoul 03080 Republic of Korea. Department of Electrical and Computer Engineering Seoul National University Seoul 08826 Republic of Korea. skwon@snu.ac.kr. Institutes of Entrepreneurial BioConvergence Seoul National University Seoul 08826 Republic of Korea. skwon@snu.ac.kr. Seoul National University Hospital Biomedical Research Institute Seoul National University Hospital Seoul 03080 Republic of Korea. skwon@snu.ac.kr. Cancer Research Institute Seoul National University College of Medicine Seoul 03080 Republic of Korea. yssong@snu.ac.kr. Department of Obstetrics and Gynecology Seoul National University College of Medicine Seoul 03080 Republic of Korea. yssong@snu.ac.kr. Interdisciplinary Program in Cancer Biology Seoul National University College of Medicine Seoul 03080 Republic of Korea. yssong@snu.ac.kr. Biomodulation Department of Agricultural Biotechnology Seoul National University Seoul 03080 Republic of Korea. yssong@snu.ac.kr.

A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper.

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A custom low-noise preamplifier for Magnetic Particle Imaging

A custom low-noise preamplifier for Magnetic Particle Imagin...

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International Workshop on Magnetic Particle Imaging (IWMPI)

作者： Wencong Zhang Bo Zheng Patrick Goodwill Steven Conolly Department of Electrical Engineering and Computer Science UC Berkeley Department of Bioengineering UC Berkeley

The sensitivity of Magnetic Particle Imaging (MPI), at fewer than 1000 detectable iron-labeled cells, is already comparable to imaging techniques like nuclear medicine [1-2]. However, the true physical sensitivity limits in MPI have not yet been achieved. Importantly, the preamplifier stage of an MPI receiver chain must be optimized to achieve low noise figures (NF) for the reactive inductor sensors used in MPI [3]. For FET-based amplifiers, this can be achieved through the parallelization of multiple amplifiers [3], or through increasing the number of turns in the receiver coil, or through the use of a matching transformer [4]. The work presented here is the development of a MPI preamplifier that is noise-matched to standard MPI preclinical receiver systems. In particular, we aim to achieve 3 dB noise figure for a high inductance receiver coil (>300 μH) at a bandwidth approximately 400 kHz and gain >1000.

关键词： Bandwidth Receivers Preamplifiers Noise figure Capacitance Noise Imaging

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Synthesis and characterization of Fe-Ti-Sb intermetallic compounds: Discovery of a new Slater-Pauling phase

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Physical Review B 2016年第10期93卷 104424-104424页

作者： N. Naghibolashrafi S. Keshavarz Vinay I. Hegde A. Gupta W. H. Butler J. Romero K. Munira P. LeClair D. Mazumdar J. Ma A. W. Ghosh C. Wolverton Tri-campus materials science program The University of Alabama Tuscaloosa Alabama 35487 USA Center for Materials for Information Technology The University of Alabama Tuscaloosa Alabama 35487 USA Department of Physics and Astronomy The University of Alabama Tuscaloosa Alabama 35487 USA Department of Materials Science and Engineering Northwestern University Evanston Illinois 60208 USA Department of Chemistry The University of Alabama Tuscaloosa Alabama 35487 USA Department of Chemical and Biological Engineering The University of Alabama Tuscaloosa Alabama 35487 USA Department of Physics Southern Illinois University Carbondale Illinois 62901 USA Department of Electrical and Computer Engineering University of Virginia Charlottesville Virginia 22904 USA

Compounds of Fe, Ti, and Sb were prepared using arc melting and vacuum annealing. Fe2TiSb, expected to be a full Heusler compound crystallizing in the L21 structure, was shown by XRD and SEM analyses to be composed of weakly magnetic grains of nominal composition Fe1.5TiSb with iron-rich precipitates in the grain boundaries. FeTiSb, a composition consistent with the formation of a half-Heusler compound, also decomposed into Fe1.5TiSb grains with Ti-Sb rich precipitates and was weakly magnetic. The dominant Fe1.5TiSb phase appears to crystallize in a defective L21-like structure with iron vacancies. Based on this finding, a first-principles DFT-based binary cluster expansion of Fe and vacancies on the Fe sublattice of the L21 structure was performed. Using the cluster expansion, we computationally scanned >103 configurations and predict a novel, stable, nonmagnetic semiconductor phase to be the zero-temperature ground state. This new structure is an ordered arrangement of Fe and vacancies, belonging to the space group R3m, with composition Fe1.5TiSb, i.e., between the full- and half-Heusler compositions. This phase can be visualized as alternate layers of L21 phase Fe2TiSb and C1b phase FeTiSb, with layering along the [111] direction of the original cubic phases. Our experimental results on annealed samples support this predicted ground-state composition, but further work is required to confirm that the R3m structure is the ground state.

关键词： Heusler alloy First-principles calculations Machine learning X-ray imaging

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UV Organic Semiconductor Photoconductor with Low Dark Current at High Electric Field

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MRS Online Proceedings Library 2015年第1期1698卷 53-58页

作者： Shafique, Umar Karim, Karim S. Department of Electrical and Computer Engineering Nanotechnology Program University of Waterloo Waterloo Canada Center for Bioengineering and Biotechnology (CBB) University of Waterloo Waterloo Canada

Organic semiconductor technology paves the way to low cost lightweight, flexible, printable electronics circuits and sensors. A novel lateral multilayer organic semiconductor photosensor is fabricated using small molecule organic semiconductor. A specialized interface layer is introduced between the metal electrodes and the organic semiconductor layer. The interface layer material is a large band gap and low electronic conductivity material. The use of interface layer limits the charge injection from the electrodes to the organic semiconductor and overall improves the photosensor dark current performance with an additional advantage to apply high voltage for improved collection. This design has low dark current with high photo-to-dark current ratio and can be set to high bias mode of operation. Lateral interdigitated photodetector, with bottom contact Metal Semiconductor Metal (MSM) is fabricated consisting of interface layer and organic semiconductor bilayer. Small molecule organic semiconductor 3,4,9,10 perylenetetracarboxylic bisbenzimidazole (PTCBI) and Copper-Phthalocyanine (CuPc) are used as the active bilayer, where as polyamide forms the interface layer. Current through the sensor is measured in both dark and in light (wavelength 400nm). The dark current density in a 1mm2 photosensor area with 5µm lateral electrode spacing at 10V/µm measured equal to 10−5mA/cm2 and a photocurrent density of 10−3 mA/cm2 under 0.3mW/cm2 incident optical power. The photo to dark current ratio is measured to be equal to ~103. This photosensor has an application in large area imaging for example portable lightweight detectors. Other applications of this sensor include indirect medial imaging and as a biosensor in UV Spectroscopy study of bacteria cultures.

关键词： organic photoconductivity sensor

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