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16th International Conference on Miniaturized Systems for Chemistry and Life sciences, MicroTAS 2012

作者： Chen, Chia-Hung Miller, Miles A. Sarkar, Aniruddh Beste, Michael T. Lauffenburger, Douglas A. Griffith, Linda G. Han, Jongyoon Department of Bioengineering National University of Singapore Singapore Department of Biological Engineering MIT United States Department of Electrical Engineering and Computer Science MIT United States

ISBN: (纸本)9780979806452

In this study, we integrated several components, including a droplet generator, a pico-injector, and an analytical inference technique, Proteolytic Activity Matrix Analysis (PrAMA), to create a platform for assessing multiple specific protease activity assays with minimal liquid handling and sample-requirement for personal medicine analysis. The microfluidic platform enables the direct measurements of protease enzyme activity, which is more physiologically informative than the standard measurements to determine the enzyme concentration alone. By tracking hundreds of picoliter droplets containing biological samples mixed with unique FRET-based protease substrates and inhibitors, the assay simultaneously infers multiple specific protease activities with minimal (

关键词： Drops

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Effect of growth pressure and gas-phase chemistry on the optical quality of InGaN/GaN multi-quantum wells

Effect of growth pressure and gas-phase chemistry on the opt...

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2013 MRS Spring Meeting

作者： Armour, E.A. Byrnes, D. Arif, R.A. Lee, S.M. Berkman, E.A. Papasouliotis, G.D. Li, C. Stokes, E.B. Hefti, R. Moyer, P. Veeco Instruments Turbodisc Operations 394 Elizabeth Avenue Somerset NJ 08873 United States Department of Electrical and Computer Engineering University of North Carolina at Charlotte 9201 University City Blvd Charlotte NC 28223 United States Nanoscale Science Program University of North Carolina at Charlotte 9201 University City Blvd Charlotte NC 28223 United States Department of Physics and Optical Science University of North Carolina at Charlotte 9201 University City Blvd Charlotte NC 28223 United States Center for Optoelectronics and Optical Communications University of North Carolina at Charlotte 9201 University City Blvd Charlotte NC 28223 United States

ISBN: (纸本)9781605115153

Blue light-emitting diodes (LED's), utilizing InGaN-based multi-quantum well (MQW) active regions deposited by organometallic chemical vapor epitaxy (OMVPE), are one of the fundamental building-blocks for current solid-state lighting applications. Studies [1,2] have previously been conducted to explore the optical and physical properties of the active MQW's over a variety of different OMVPE growth conditions. However, the conclusions of these papers have often been contradictory, possibly due to a limited data set or lack of understanding of the fundamental fluid dynamics and gas-phase chemistry that occurs during the deposition process. Multi-quantum well structures grown over a range of pressures from typical low-pressure production processes at 200 Torr, up to near-atmospheric growth conditions at 700 Torr, have been investigated in this study. At all growth pressures, clear trends of gas-phase chemical reactions are observed for increased gas residence times (lower gas speeds from the injector flange and lower rotation rates) and increased V/III ratios (higher NH3 flows). Confocal microscopy, excitation-dependent PL (PLE), and time-resolved photo-luminescence (TRPL) have been employed on these MQW structures to investigate the carrier lifetime characteristics. Confocal emission images show spatially-separated bright and dark regions. The bright regions are red-shifted in wavelength relative to the dark regions, suggesting microscopic spatial localization of high indium content regions. As the growth pressure and gas residence times are reduced, a larger difference in band-gap between bright and dark regions, longer lifetimes, and higher average PL intensities can be obtained, indicating that higher optical quality material can be realized. Optimized MQW's grown at high pressure exhibit higher PLE slope intensities and IQE characteristics than lower pressure samples. Results on simple LED structures indicate that the improvement in MQW optical quality at high pre

关键词： Organometallics

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Fluctuation-conductivity Characterization of Superconducting Bi 2 Sr 2 CaCu 2 O 8+d Thin Films Prepared by the Metal-organic Decomposition Method

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Physics Procedia 2013年 45卷 193-196页

作者： Y. Deguchi H. Kikuchi N. Mori Y. Yamada T. Atsumi K. Yoshida T. Ishibashi Department of Electrical and Computer Engineering Oyama National College of Technology Oyama-shi Tochigi 323-0806 Japan Department of Materials Chemistry and Bioengineering Oyama National College of Technology Oyama-shi Tochigi 323-0806 Japan K&R Creation Co. Ltd. Ikeda-shi Osaka 563-0055 Japan Department of Materials Science and Technology Nagaoka University of Technology Nagaoka-shi Niigata 940-2188 Japan

We report on the preparation and characterization of Bi2Sr2CaCu2O8+d (Bi2212) thin films. These films on SrTiO3 substrates were fabricated by the metal-organic decomposition method and annealing at a temperature between 810~850 °C. On the basis of the analysis for the fluctuation conductivity σ’ above T c , we characterize properties of Bi2212 films by taking account of overall theoretical σ’ terms and momentum cutoff effects. In the analysis we estimate, as a function of T c , the fluctuation parameters, among which anisotropy and depairing parameters are found to be correlated with T c .

关键词： Fluctuation conductivity Bi2212 films MOD method Pair-breaking

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BT-02FUNCTIONALLY-DEFINED THERAPEUTIC TARGETS IN DIFFUSE INTRINSIC PONTINE GLIOMA

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Neuro-Oncology 2015年第SUPPL_3期17卷 iii3-iii3页

作者： Grasso, Catherine S. Tang, Yujie Truffaux, Nathalene Berlow, Noah E. Liu, Lining Debily, Marie-Anne Quist, Michael J. Davis, Lara Huang, Elaine C. Woo, Pamelyn J. Ponnuswami, Anitha Chen, Spenser Johung, Tessa Sun, Wenchao Kogiso, Mari Du, Yuchen Lin, Qi Huang, Yulun Hutt-Cabezas, Marianne Warren, Katherine E. Le Dret, Ludivine Meltzer, Paul S. Mao, Hua Quezado, Martha van Vuurden, Dannis G. Abraham, Jinu Fouladi, Maryam Svalina, Matthew N. Wang, Nicholas Hawkins, Cynthia Raabe, Eric Hulleman, Esther Spellman, Paul T. Li, Xiao-Nan Keller, Charles Pal, Ranadip Grill, Jacques Monje, Michelle Center for Spatial Systems Biomedicine Department of Molecular and Medical Genetics Oregon Health & Science University Portland OR USA These authors contributed equally to this work Depts. of Neurology Neurosurgery and Pediatrics Stanford University Stanford CA USA Unité Mixte de Recherche du Centre National de la Recherche Scientifique 8203 Institut Gustave Roussy et Université Paris-Sud Villejuif France Electrical and Computer Engineering Texas Tech University Lubbock TX USA Université d'Evry-Val d'Essone Evry France Pediatric Cancer Biology Program Papé Family Pediatric Research Institute Dept. of Pediatrics Oregon Health & Science University Portland OR USA Children's Cancer Therapy Development Institute Fort Collins CO USA Laboratory of Molecular Neurooncology Texas Children's Cancer Center Baylor College of Medicine Houston TX USA Department of Neurosurgery The First Affiliated Hospital of Soochow Suzhou China Departments of Oncology and Pathology Johns Hopkins University Baltimore MD USA National Cancer Institute Bethesda MD USA Department of Pediatric Oncology Hematology and Neuro-Oncology Research Group Cancer Center Amsterdam VU University Medical Center Amsterdam The Netherlands Cancer and Blood Diseases Institute Cincinnati Children's Hospital Medical Center Cincinnati OH USA Dept. of Paediatric Laboratory Medicine University of Toronto Scientist Labatt Brain Tumour Research Centre Hospital for Sick Children University of Toronto Toronto ON Canada Departement de Cancerologie de l'Enfant et de l'Adolescent Institut Gustave Roussy Université Paris-Sud Villejuif France

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A brain tumor molecular imaging strategy using a new triple-modality MRI-photoacoustic-Raman nanoparticle

A brain tumor molecular imaging strategy using a new triple-...

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Photons Plus Ultrasound: Imaging and Sensing 2013

作者： De La Zerda, Adam Kircher, Moritz F. Jokerst, Jesse V. Zavaleta, Cristina L. Kempen, Paul J. Mittra, Erik Pitter, Ken Huang, Ruimin Campos, Carl Habte, Frezghi Sinclair, Robert Brennan, Cameron W. Mellinghoff, Ingo K. Holland, Eric C. Gambhir, Sanjiv S. Molecular Imaging Program at Stanford Department of Radiology Stanford University Stanford CA 94305 United States Department of Electrical Engineering Stanford University Stanford CA 94305 United States Department of Radiology Memorial Sloan-Kettering Cancer Center New York NY 10065 United States Brain Tumor Center Memorial Sloan-Kettering Cancer Center New York NY 10021 United States Department of Materials Science and Engineering Stanford University Stanford CA 94305 United States Department of Cancer Biology and Genetics Memorial Sloan-Kettering Cancer Center New York NY 10021 United States Department of Neurology Memorial Sloan-Kettering Cancer Center New York NY 10021 United States Human Oncology and Pathogenesis Program Memorial Sloan-Kettering Cancer Center New York NY 10021 United States Department of Pharmacology Weill-Cornell Medical College New York NY 10065 United States Department of Neurosurgery Memorial Sloan-Kettering Cancer Center New York NY 10021 United States Department of Surgery Memorial Sloan-Kettering Cancer Center New York NY 10021 United States Department of Bioengineering Bio-X Program Stanford University Stanford CA 94305 United States

ISBN: (纸本)9780819493507

The difficulty in delineating brain tumor margins is a major obstacle in the path toward better outcomes for patients with brain tumors. Current imaging methods are often limited by inadequate sensitivity, specificity and spatial resolution. Here we show that a unique triplemodality magnetic resonance imaging - photoacoustic imaging - Raman imaging nanoparticle (termed here MPR nanoparticles), can accurately help delineate the margins of brain tumors in living mice both preoperatively and intraoperatively. The MPRs were detected by all three modalities with at least a picomolar sensitivity both in vitro and in living mice. Intravenous injection of MPRs into glioblastoma-bearing mice led to MPR accumulation and retention by the tumors, with no MPR accumulation in the surrounding healthy tissue, allowing for a noninvasive tumor delineation using all three modalities through the intact skull. Raman imaging allowed for guidance of intraoperative tumor resection, and a histological correlation validated that Raman imaging was accurately delineating the brain tumor margins. This new triple-modality-nanoparticle approach has promise for enabling more accurate brain tumor imaging and resection. © 2013 Copyright SPIE.

关键词： Nanoparticles

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Configurable clutter models for radar simulation

Configurable clutter models for radar simulation

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International Waveform Diversity and Design Conference, WDD 2012

作者： Jezak, Joseph A. Gadola, Guy Berdanier, Charles Levitan, Steven P. Chiarulli, Donald M. Computer Engineering Graduate Program University of Pittsburgh United States Department of Electrical Engineering Wright State University United States Department of Electrical and Computer Engineering University of Pittsburgh United States Department of Computer Science University of Pittsburgh United States

ISBN: (纸本)9781509005987

In this paper we describe an extension to the MATLAB Phased Array Toolkit that adds a configurable clutter object to model clutter signals returned along a specified signal path. The clutter model is based on the Simkins Unified Clutter Model[1]. The current implementation supports sea clutter in any of five sea states with configurable polarization, grazing angle, and beam width. We describe the implementation and give examples of modeled clutter returns. © 2012 IEEE.

关键词： MATLAB

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Encoding of liquid capped microcapsule and heterogeneous assembly for multiplexed assay

Encoding of liquid capped microcapsule and heterogeneous ass...

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16th International Conference on Miniaturized Systems for Chemistry and Life sciences, MicroTAS 2012

作者： Song, Younghoon Kwon, Taehong Lee, Daewon Kim, Junhoi Oh, Dongyoon Park, Taejoon Kwon, Sunghoon School of Electrical Engineering and Computer Science Seoul Naional University Korea Republic of Inter-University Semiconductor Research Center Korea Republic of Interdisciplinary Program for Bioengineering Korea Republic of

ISBN: (纸本)9780979806452

In this paper, we have demonstrated a technology for encoding of liquid capped microcapsule and dispensing thousands of heterogeneous encoded liquid drops into microwell array with only a single pipetting step, which would normally requires thousands of individual pipetting. With our technology, we can take advantages of both high coding capacity and liquid-liquid reaction, which is impossible in conventional droplet and bead-based assay platforms.

关键词： Liquids

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Review on engineering and Regulatory aspects associated with Frequency Control Capabilities of Wind Power Plants

Review on Engineering and Regulatory aspects associated with...

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IEEE Energytech

作者： Venkatesh Yadav Singarao Vittal Rao Mark A. Harral multi-disciplinary Wind Science and Engineering PhD program Texas Tech University Department of Electrical & Computer Engineering Texas Tech University GroupNIRE clean energy development company

ISBN: (纸本)9781467344456

With the increasing grid penetration levels of wind power, there is an increasing need to study both the power control systems and the regulatory aspects associated with frequency control capabilities of wind power plants at various levels (turbine, wind farm and power system levels). This is especially very important in the United States with a goal of achieving 20% nation's electricity from wind energy by 2030. This paper provides observations and challenges identified with wind energy integration with respect to active power control strategies used in implementing frequency regulation at various levels. This paper also discusses the current and future aspects of market regulation of frequency responsive services offered by converter based variable generation technologies and the need for an appropriate utility market structure in order to provide settlements for these capabilities.

关键词： Inertial and Primary Frequency Response Frequency Regulation Standards Ancillary Service Markets Wind Power Plants

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Optical generation, templating, and polymerization of three-dimensional arrays of liquid-crystal defects decorated by plasmonic nanoparticles

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Physical Review E 2013年第3期87卷 032503-032503页

作者： Julian S. Evans Paul J. Ackerman Dirk J. Broer Jao van de Lagemaat Ivan I. Smalyukh Department of Physics and Materials Science and Engineering Program University of Colorado at Boulder Boulder Colorado 80309 USA Department of Electrical Computer and Energy Engineering and Liquid Crystals Materials Research Center University of Colorado at Boulder Boulder Colorado 80309 USA National Renewable Energy Laboratory Golden Colorado 80401 USA Functional Organic Materials and Devices Eindhoven University of Technology Box 513 5600 MB Eindhoven The Netherlands Renewable and Sustainable Energy Institute National Renewable Energy Laboratory and University of Colorado at Boulder Boulder Colorado 80309 USA

Defects in liquid crystals are used to model topological entities ranging from Skyrmions in high-energy physics to early-universe cosmic strings, as well as find practical applications in self-assembly of diffraction gratings and in scaffolding of plasmonic nanoparticles, but they are hard to control and organize into three-dimensional lattices. We laterally scan focused laser beams to produce periodic arrays of twist-stabilized defects forming either linear (fingers) or axially symmetric (torons) configurations in partially polymerizable liquid crystal films. Polymerization allows for stabilization of these structures and the formation of three-dimensional arrays of defects by stacking of the thin cholesteric films on top of each other. In the process of fabrication of such arrays, we polymerize the liquid crystal film with an array of torons or fingers and then sequentially produce and photopolymerize new liquid crystal layers on top of it, thus obtaining a three-dimensional structure of twist-stabilized defects in a layer-by-layer fashion. Templating by the polymerized layer spontaneously yields ordered organization of fingers and torons in the new cholesteric layer, thus enabling a three-dimensional ordered structure of defects. Nondestructive three-dimensional imaging of director fields by use of three-photon excitation fluorescence polarizing microscopy reveals the nature of topological singularities and physical underpinnings behind the observed templating effect. Three-dimensional patterning of defects templates the self-assembly of plasmonic nanoparticles into individual singularities and their arrays, laying the groundwork for potential applications in nanophotonics, plasmonics, metamaterial fabrication, and nanoscale energy conversion.

关键词： LIQUID crystals CRYSTAL defects POLYMERIZATION DIMENSIONAL analysis PLASMONS (Physics) NANOPARTICLES

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Multi-server MMO middleware: Unlocked

Multi-server MMO middleware: Unlocked

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2012 7th International Conference on P2P, Parallel, Grid, Cloud and Internet Computing, 3PGCIC 2012

作者： McKnight, Christopher Stubens, Carl Coady, Yvonne Li, Kin Fun Software Engineering Program University of Victoria Victoria BC Canada Department of Computer Science University of Victoria Victoria BC Canada Department of Electrical and Computer Engineering University of Victoria Victoria BC Canada

ISBN: (纸本)9781467329910

Massively multiplayer online (MMO) games consist of huge worlds populated by thousands of clients, far beyond the ability of a single server to maintain. This naturally leads to the division of the game world into many partitions, each controlled by a single server. To provide players with the illusion of a single large world, some MMO systems divide their game world across servers and synchronize all nearby activity between them. To accomplish and synchronize player movement and interaction between servers, a system of inter-server locks are employed. These locks introduce considerable software complexity and network traffic overhead. We discuss the practical problems of such locking systems, and present an alternate approach. A lockless middleware design is described which implements sequential consistency using inter-server remote writes. This approach provides consistency across all clients and servers, allowing for seamless movement of clients within an arbitrarily large game world. We compare the lockless architecture to the traditional locking design, and analyze its performance. © 2012 IEEE.

关键词： Middleware

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