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CLEO: science and Innovations, CLEO_SI 2011

作者： Gao, Yongkang Gan, Qiaoqiang Cheng, Xuanhong Bartoli, Filbert J. Center for Optical Technologies Electrical and Computer Engineering Department Lehigh University Bethlehem PA 18015 United States Materials Science and Engineering Department Bioengineering Department Lehigh University Bethlehem PA 18015 United States

We demonstrate a plasmonic Mach-Zehnder interferometer on a microfluidic chip for sensitive optical sensing with an enhanced sensitivity of more than 4200nm/RIU observed with a far-field optical microscope. © 201... 详细信息

ISBN: (纸本)9781557529107

关键词： Microfluidic chips

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Investigation of collagen fiber organization in cornea and sclera using quantitative SHG microscopy

Investigation of collagen fiber organization in cornea and s...

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Frontiers in Optics, FiO 2011

作者： Ambekar, Raghu Toussaint, Kimani C. Department of Electrical and Computer Engineering University of Illinois Urbana-Champaign IL 61820 United States Department of Mechanical Science and Engineering University of Illinois Urbana-Champaign IL 61820 United States Departments of Electrical and Computer Engineering and Bioengineering University of Illinois Urbana-Champaign IL 61820 United States

We propose the application of Fourier transform-second harmonic generation and polarization-resolved second-harmonic generation microscopy to quantify collagen fiber organization and content, respectively. As an examp... 详细信息

ISBN: (纸本)9781557529176

关键词： Harmonic generation

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Size-independent deformability cytometry with active feedback control of microfluidic channels

Size-independent deformability cytometry with active feedbac...

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15th International Conference on Miniaturized Systems for Chemistry and Life sciences 2011, MicroTAS 2011

作者： Guan, Guofeng Bhagat, Ali Asgar Peng, Weng Kung Lee, Wong Cheng Ong, Chong Jin Chen, Peter C. Y. Han, Jongyoon Department of Mechanical Engineering National University of Singapore Singapore Singapore Department of Bioengineering National University of Singapore Singapore Department of Biological Engineering Massachusetts Institute of Technology United States Department of Electrical Engineering and Computer Science Massachusetts Institute of Technology United States

ISBN: (纸本)9781618395955

Mechanical properties of cells can be correlated with various cell states and are now considered as an important biophysical marker. While there are many microfluidic and other techniques emerged recently to assay cell mechanical properties, most of them are affected by the inherent cell size variation of a given cell population. In this work, we present a new microfluidic technique with real-time feedback control system to evaluate single cell deformability while minimizing cell-size dependence of the measurement. We demonstrate the device using breast cancer cells (MCF-7) as well as primary human mesenchymal stem cells (hMSCs). It is anticipated that this system would be useful to profile the stiffness of cells in a complex, diverse cell populations such as mesenchymal stem cells. Copyright © (2011) by the Chemical and Biological Microsystems Society.

关键词： Cell culture

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Autonomous passive light tracking utilizing single-wall carbon nanotube enhanced opto-thermo-mechanical elastomer actuators

Autonomous passive light tracking utilizing single-wall carb...

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International Solid-State Sensors, Actuators and Microsystems Conference

作者： Liu, Ye Li, Chensha Lo, Chi-Wei Jiang, Hongrui Electrical and Computer Engineering Department University of Wisconsin Madison WI United States Materials Science Program University of Wisconsin Madison WI United States

ISBN: (纸本)9781457701573

We have developed novel opto-thermo-mechanical actuators by effectively distributing a significant amount of single-wall carbon nanotube (SWCNT, up to 0.7%w/w) into liquid crystal elastomer (LCE) matrices. These SWCNT/LCE actuators exhibit a great potential to be utilized in MEMS applications, as they respond to a wide spectrum of visible/near-infrared light, and possess a large reversible compressive strain (up to 35%) when stimulated. Autonomous and passive light tracking is demonstrated here as one of the applications. With a simple design, the actuators are able to adaptively tilt a solar cell towards the light source by a degree of ∼15° (with an incident light intensity of 1.6 kW/m2). As a result, the photocurrent output of the solar cell is significantly enhanced (up to 247.10%) without any other control system or external energy source. © 2011 IEEE.

关键词： Yarn

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The experimental determination of the onset of electrical and thermal conductivity percolation thresholds in carbon nanotube-polymer composites

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2010 MRS Fall Meeting

作者： Kim, Byung-Wook Pfeifer, Steven Park, Sung-Hoon Bandaru, Prabhakar R. Department of Electrical and Computer Engineering University of California San Diego CA United States Materials Science Program Department of Mechanical Engineering University of California San Diego CA United States

ISBN: (纸本)9781605112893

We show evidence of electrical and thermal conductivity percolation in polymer based carbon nanotube (CNT) composites, which follow power law variations with respect to the CNT concentrations in the matrix. The experimentally obtained percolation thresholds, i.e., ∼ 0.074 vol % for single walled CNTs and ∼ 2.0 vol % for multi-walled CNTs, were found to be aspect ratio dependent and in accordance with those determined theoretically from excluded volume percolation theory. A much greater enhancement, over 10 orders of magnitude, was obtained in the electrical conductivity at the percolation threshold, while a smaller increase of ∼ 100% was obtained in the thermal conductivity values. Such a difference is qualitatively explained on the basis of the respective conductivity contrast between the CNT filler and the polymer matrix. © 2011 Materials Research Society.

关键词： Aspect ratio

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QUANTITATIVE ANALYSIS OF MRI-MEASURED WATER MOBILITY INCREASES IN RESPONSE TO CHEMOTHERAPY VIA MULTIPLE CELL-DEATH MECHANISMS

QUANTITATIVE ANALYSIS OF MRI-MEASURED WATER MOBILITY INCREAS...

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第十三届国际体视学大会

作者： Will G Xia David Morse Robert J Gillies Bioengineering Program Department of Electrical Engineering and Computer Science University of Arizona Cancer Center Tueson AZ 85724USA

Numerous pre-clinical and clinical reports have demonstrated that the MRI-measured apparent diffusion coefficient of water(ADC) increases early in the response to a wide variety of anti-cancer *** has been proposed that this increase in ADC generally results from an increase in the tumor extracellular volume fraction leading to a greater degree of unrestricted water ***,an increase in extracellular volume has been ascribed to the cell shrinkage that occurs early in the process of programmed cell ***,other modes of death can be initiated soon after beginning *** other modes of death include mitotic catastrophe and necrosis,and may also involve changes in the fraction of water with unrestricted *** work quantitatively examines whether MRI-measured ADC is altered in response to therapies that induce cell death via non-apoptotic mechanisms and correlates ADC changes with cell death modalities regionally within the *** morphometric analysis show apoptotic responses were limited to the tumor periphery in apoptosis-proficient *** was not observed in deficient *** catastrophe was observed after treatment at the periphery and deeper into the *** was the predominant response in the center of the *** changes were moderate in the periphery and larger in the *** results indicate that early and significant changes in ADC can occur in concert with mitotic catastrophe and lytic necrosis in the absence of ***,changes in ADC may be a generalized measure of cytotoxic response to chemotherapy.

关键词： diffusion MRI imaging morphometry cell death

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Electrochemical supercapacitor based on flexible pillar graphene nanostructures

Electrochemical supercapacitor based on flexible pillar grap...

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69th Device Research Conference, DRC 2011

作者： Lin, Jian Zhong, Jiebin Bao, Duoduo Reiber-Kyle, Jennifer Wang, Wei Vullev, Valentine Ozkan, Mihrimah Ozkan, Cengiz S. Department of Mechanical Engineering Riverside CA 92521 United States Department of Bioengineering Riverside CA 92521 United States Department of Electrical Engineering Riverside CA 92521 United States Materials Science and Engineering Program University of California Riverside CA 92521 United States

ISBN: (纸本)9781612842417

Here we report the fabrication of high conductive and large surface-area 3D pillar graphene nanostructures (PGN) films from assembly of vertically aligned CNT pillars on flexible copper foils and directly employed for the application in electrochemical double layer capacitance (EDLC) supercapacitor. The fabricated supercapacitor based on PGN films with excellent mechanical flexibility and electrical conductivity has high energy storage capability. The PGN films which were one-step synthesized on flexible copper foil (25 um) by CVD process exhibit high conductivity with sheet resistance as low as 1.6 ohm per square and high mechanical flexibility. The fabricated EDLC supercapacitor based on high surface-area PGN electrodes (563m2/g) shows high performance with high specific capacitance of 330F/g and energy density as high as 45.8Wh/kg. All of these make this 3D graphene/CNTs hybrid carbon nanostructures highly attractive material for high performance supercapacitor and other energy storage material. © 2011 IEEE.

关键词： Nanostructures

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Accelerated oxidation of silicon due to x-ray irradiation

Accelerated oxidation of silicon due to x-ray irradiation

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12th European Conference on Radiation and Its Effects on Component and Systems, RADECS 2011

作者： Bhandaru, Shweta Zhang, En Xia Fleetwood, Daniel M. Reed, Robert A. Weller, Robert A. Weiss, Sharon M. Interdisciplinary Graduate Program in Material Science Vanderbilt University Nashville TN 37235 United States Department of Electrical Engineering and Computer Science Vanderbilt University Nashville TN 37235 United States

Enhanced rates of oxide growth have been observed on silicon when exposed to high-energy x-ray irradiation. This observed effect could potentially be utilized for remote total ionizing dose-sensing applications. ©... 详细信息

ISBN: (纸本)9781457705878

关键词： Silicon

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282

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Cytokine 2013年第3期63卷 310-310页

作者： Elia D. Tait Wojno Mario Noti Brian S. Kim Mark C. Siracusa Paul R. Giacomin Meera G. Nair Alain J. Benitez Kathryn R. Ruymann Amanda B. Muir David A. Hill Kudakwashe R. Chikwava Amin E. Moghaddam Quentin J. Sattentau Aneesh Alex Chao Zhou Paul Menard-Katcher Masato Kubo Kazushige Obata-Ninomiya Hajime Karasuyama Michael R. Comeau David Artis Department of Microbiology University of Pennsylvania Philadelphia PA USA Institute for Immunology Perelman School of Medicine University of Pennsylvania Philadelphia PA USA Queensland Tropical Health Alliance and School of Public Health and Tropical Medicine James Cook University Cairns Australia Division of Gastroenterology Hepatology and Nutrition Children’s Hospital of Philadelphia Philadelphia PA USA Department of Pediatrics Division of Allergy and Immunology Children’s Hospital of Philadelphia Philadelphia PA USA Department of Pathology and Laboratory Medicine Children’s Hospital of Philadelphia Philadelphia PA USA The Sir William Dunn School of Pathology The University of Oxford Oxford UK Department of Electrical and Computer Engineering Lehigh University Bethlehem PA USA Center for Photonics and Nanoelectronics Lehigh University BethlehemPA USA Bioengineering Program Lehigh University Bethlehem PA USA Division of Gastroenterology Hospital of the University of Pennsylvania Philadelphia PA USA Laboratory for Signal Network Research Center for Allergy and Immunology RIKEN Yokohama Institute Yokohama Japan Division of Molecular Pathology Research Institute for Biological Science Tokyo University of Science Chiba Japan Department of Immune Regulation Tokyo Medical and Dental University Graduate School Tokyo Japan JST CREST Tokyo Medical and Dental University Graduate School Tokyo Japan Inflammation Research Amgen Inc. Seattle WA USA Department of Pathobiology School of Veterinary Medicine University of Pennsylvania Philadelphia PA USA

Eosinophilic esophagitis (EoE) is a food allergy-associated disease characterized by esophageal eosinophilia and associated inflammation. EoE has become increasingly common in industrialized countries. However, current management strategies, such as treatment with swallowed steroids and dietary restrictions, are nonspecific or negatively impact the quality of life of EoE patients. In addition, use of more specific therapies that target immunoglobulin E (IgE) and interleukin (IL)-5 have been largely unsuccessful in ameliorating EoE. Thus, there is an urgent need to identify novel, specific immunological pathways that underlie the pathogenesis of EoE that could be targeted to treat this disease. Recently, a genome-wide association study identified that EoE is associated with a gain-of-function polymorphism in the gene that encodes thymic stromal lymphopoietin (TSLP). TSLP is an IL-7 family member cytokine that promotes allergic inflammation by eliciting T helper type 2 cytokine responses, IgE production, and the expansion of a distinct population of basophils . However, whether TSLP directly promotes allergic inflammation in the esophagus and the mechanisms by which TSLP might contribute to the pathogenesis of EoE remain unknown. Here, we describe a new murine model of experimental EoE-like disease that was used to investigate the role of TSLP in allergic inflammation of the esophagus. Murine experimental EoE-like disease developed independently of IgE but was dependent on TSLP-elicited basophils. Critically, therapeutic antibody-mediated neutralization of TSLP or depletion of basophil populations ameliorated established EoE-like disease in mice. Finally, elevated TSLP levels and exaggerated basophil responses were observed in esophageal biopsies from EoE patients, and a gain-of-function polymorphism in TSLP correlated with increased basophil responses in patients with EoE. Together, these data indicate that TSLP-elicited basophil responses may play a key role in medi

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Non-interferometric generation of vector beams

Non-interferometric generation of vector beams

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Frontiers in Optics, FiO 2011

作者： Tripathi, Santosh Toussaint, Kimani C. University of Illinois Urbana-Champaign IL 61820 United States Department of Electrical and Computer Engineering University of Illinois Urbana-Champaign IL 61820 United States Department of Mechanical Science and Engineering University of Illinois Urbana-Champaign IL 61820 United States Affiliate in the departments of Electrical and Computer Engineering and Bioengineering University of Illinois Urbana-Champaign IL 61820 United States

We present a non-interferometric method for generating vector beams. Potential gain in stability obtained from using this non-interferometric approach is expected to facilitate the use of vector beams in metrology and... 详细信息

ISBN: (纸本)9781557529176

关键词： Azimuthally polarized beams Laser beams Liquid crystal modulators Nematic liquid crystals Phase shift Vector beams Optical properties (160.4760) Microscopy (180.0180)

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