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arXiv 2024年

作者： Wang, Fanxin Cheng, Yikun Mukherjee, Sudipta S. Bhargava, Rohit Kesavadas, Thenkurussi Department of Mechatronics and Robotics Xi'an Jiaotong-Liverpool University 215123 China Department of Mechanical Science and Engineering University of Illinois Urbana-Champaign ChampaignIL61801 United States Beckman Institute for Advanced Science and Technology Departments of Bioengineering Electrical & Computer Engineering Mechanical Science & Engineering Chemical and Biomolecular Engineering University of Illinois Urbana-Champaign ChampaignIL61801 United States Beckman Institute for Advanced Science and Technology University of Illinois Urbana-Champaign ChampaignIL61801 United States Division of Research and Economic Development University at Albany State University of New York AlbanyNY12222 United States

Image-guided minimally invasive robotic surgery is commonly employed for tasks such as needle biopsies or localized therapies. However, the nonlinear deformation of various tissue types presents difficulties for surgeons in achieving precise needle tip placement, particularly when relying on low-fidelity biopsy imaging systems. In this paper, we introduce a method to classify needle biopsy interventions and identify tissue types based on a comprehensive needle-tissue contact model that incorporates both position and force parameters. We trained a transformer model using a comprehensive dataset collected from a formerly developed robotics platform, which consists of synthetic and porcine tissue from various locations (liver, kidney, heart, belly, hock) marked with interaction phases (pre-puncture, puncture, post-puncture, neutral). This model achieves a significant classification accuracy of 0.93. Our demonstrated method can assist surgeons in identifying transitions to different tissues, aiding surgeons with tissue awareness. © 2024, CC BY.

关键词： Biopsy

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Investigation of Noise at a Microelectrode during a Faradaic Reaction

ACS Electrochemistry

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ACS Electrochemistry 2025年第4期1卷 552-559页

作者： Kaden Wheeler Joseph Gott Brian Roehrich Julia Chung Kajal Kajal Jaroslaw Syzdek Joao Hespanha Lior Sepunaru Department of Chemistry and Biochemistry University of California at Santa Barbara Santa Barbara California 93106 United States Interdepartmental Program in Biomolecular Science and Engineering University of California at Santa Barbara Santa Barbara California 93106 United States Bio-Logic USA LLC 9050 Executive Park Dr. Ste. 110C Knoxville Tennessee 37923 United States Electrical and Computer Engineering Department University of California at Santa Barbara Santa Barbara California 93106 United States

Measurement of small currents is often impeded by a suboptimal signal-to-noise ratio, largely due to background noise. This background noise significantly constrains the range of catalysts accessible for interrogation via micro- and nanoscale electrochemistry. In response, this work reveals how background noise scales in the presence of induced Faradaic reactions. We measured noise under a series of electrochemical conditions and discovered that the induced noise from a Faradaic reaction scales directly with current. Complementary electrochemical impedance spectroscopy measurements demonstrated that diffusional resistance dictates the noise of Faradaic reactions, independent of the electrochemical mechanism. The noise source is thermal in origin and propagates in a predictable trend, which is inversely proportional to the equivalent diffusional resistance of the analyte. The universality of the observed phenomenon allows for better deconvolution of measured charge from background noise, thus assisting in achieving higher resolution and measurement precision, which is a key in micro- and nanoscale electrochemical measurements.

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Coherent Acoustic Phonons in Bi2Se3 Ultrathin Films Probed by Femtosecond, Optical Pump-Probe Spectroscopy

Coherent Acoustic Phonons in Bi2Se3 Ultrathin Films Probed b...

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CLEO: Fundamental science, CLEO:FS 2024 - Part of Conference on Lasers and Electro-Optics, CLEO 2024

作者： Cheng, Jing Niherysh, Kiryl A. Francis, Peter Chakraborty, Debamitra Lombardi, Floriana Erts, Donats Prischepa, Serghej L. Laszcz, Adam Komissarov, Ivan V. Sobolewski, Roman Materials Science Graduate Program University of Rochester RochesterNY14627 United States Laboratory for Laser Energetics University of Rochester RochesterNY14623-1299 United States Department of Microtechnology and Nanoscience Chalmers University of Technology Gothenburg Sweden Institute of Chemical Physics University of Latvia Riga Latvia Department of Electrical and Computer Engineering University of Rochester RochesterNY14627 United States Dipartimento di Fisica "E.R. Caianiello" Università degli Studi di Salerno Sa FiscianoI-84084 Italy Lukasiewicz Research Network Institute of Microelectronics and Photonics WarszawaPL-02668 Poland

ISBN: (纸本)9781957171395

The dynamics of coherent acoustic phonons in the Bi2Se3 layered crystal system are investigated. The findings reveal that the frequency evolution of breathing modes with the number of the material quintuple layers and the dispersion relation both can be explained by a modified chain model with a nonuniform coupling force. © Optica Publishing Group 2024, © 2024 The Author(s)

关键词： Ultrathin films

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Field-controlled dynamics of skyrmions and monopoles

arXiv

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arXiv 2023年

作者： Tai, Jung-Shen B. Hess, Andrew J. Wu, Jin-Sheng Smalyukh, Ivan I. Department of Physics Chemical Physics Program University of Colorado BoulderCO80309 United States Department of Electrical Computer and Energy Engineering Materials Science and Engineering Program Soft Materials Research Center University of Colorado BoulderCO80309 United States Renewable and Sustainable Energy Institute National Renewable Energy Laboratory University of Colorado BoulderCO80309 United States

Magnetic monopoles, despite their ongoing experimental search as elementary particles, have inspired the discovery of analogous excitations in condensed matter systems. In chiral condensed matter systems, emergent monopoles are responsible for the onset of transitions between topologically distinct states and phases, like in the case of transitions from helical and conical phase to A-phase comprising periodic arrays of skyrmions. By combining numerical modeling and optical characterizations, we describe how different geometrical configurations of skyrmions terminating at monopoles can be realized in liquid crystals and liquid crystal ferromagnets. We demonstrate how such complex structures can be effectively manipulated by external magnetic and electric fields. Furthermore, we discuss how our findings may hint at similar dynamics in other physical systems, and their potential applications. © 2023, CC BY.

关键词： Liquid crystals

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Long-range photodetection of organic exciton-polaritons

Long-range photodetection of organic exciton-polaritons

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Conference on Lasers and Electro-Optics (CLEO)

作者： Bin Liu Xinjing Huang Stephen R. Forrest Department of Electrical Engineering and Computer Science University of Michigan Ann Arbor USA Applied Physics Program University of Michigan Ann Arbor USA Department of Physics University of Michigan Ann Arbor USA Department of Material Science and Engineering University of Michigan Ann Arbor USA

In light-matter strong coupling regime, we observe long-range photodetection response at room temperature mediated by organic exciton-polaritons, which results from strong interactions between organic excitons and low... 详细信息

ISBN: (数字)9781957171050

ISBN: (纸本)9781665466660

关键词： Couplings Surface waves Excitons Lasers and electrooptics Laser excitation Electrooptical waveguides

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A Magnetic Particle Imaging Approach for Minimally Invasive Imaging and Sensing with Implantable Bioelectronic Circuits

TechRxiv

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TechRxiv 2023年

作者： Tay, Zhiwei Kim, Han-Joon Ho, John S. Olivo, Malini Singapore National Institute of Advanced Industrial Science and Technology 1-2-1 Namiki Ibaraki Tsukuba305-8564 Japan National University of Singapore Department of Bioengineering Singapore Department of Electrical and Computer Engineering The Institute for Health Technology National University of Singapore Singapore 2 Fusionopolis Way Innovis 08-03 138634 Singapore

Minimally-invasive and biocompatible implantable bioelectronic circuits are used for long-term monitoring of physiological processes in the body. However, there is a lack of methods that can cheaply and conveniently image the device within the body while simultaneously extracting sensor information. Magnetic Particle Imaging (MPI) with zero background signal, high contrast, and high sensitivity with quantitative images is ideal for this challenge because the magnetic signal is not absorbed with increasing tissue depth and incurs no radiation dose. We show how to easily modify common implantable devices to be imaged by MPI by encapsulating and magnetically-coupling magnetic nanoparticles (SPIOs) to the device circuit. These modified implantable devices not only provide spatial information via MPI, but also couple to our handheld MPI reader to transmit sensor information by modulating harmonic signals from magnetic nanoparticles via switching or frequency-shifting with resistive or capacitive sensors. This paper provides proof-of-concept of an optimized MPI imaging technique for implantable devices to extract spatial information as well as other information transmitted by the implanted circuit (such as biosensing) via encoding in the magnetic particle spectrum. The 4D images present 3D position and a changing color tone in response to a variable biometric. Biophysical sensing via bioelectronic circuits that take advantage of the unique imaging properties of MPI may enable a wide range of minimally invasive applications in biomedicine and diagnosis. © 2023, CC BY.

关键词： Timing circuits

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Beating bandwidth limits for large aperture broadband nano-optics

arXiv

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arXiv 2024年

作者： Fröch, Johannes E. Chakravarthula, Praneeth K. Sun, Jipeng Tseng, Ethan Colburn, Shane Zhan, Alan Miller, Forrest Wirth-Singh, Anna Tanguy, Quentin A.A. Han, Zheyi Böhringer, Karl F. Heide, Felix Majumdar, Arka Department of Physics University of Washington SeattleWA98195 United States Department of Electrical and Computer Engineering University of Washington SeattleWA98195 United States Department of Computer Science Princeton University PrincetonNJ08540 United States Tunoptix Fluke Hall 4000 Mason Road 300 SeattleWA98195 United States Department of Bioengineering University of Washington SeattleWA98195 United States Institute for Nano-Engineered Systems University of Washington SeattleWA98195 United States

Flat optics have been proposed as an attractive approach for the implementation of new imaging and sensing modalities to replace and augment refractive optics. However, chromatic aberrations impose fundamental limitations on diffractive flat optics. As such, true broadband high-quality imaging has thus far been out of reach for low f-number, large aperture, flat optics. In this work, we overcome these intrinsic fundamental limitations, achieving broadband imaging in the visible wavelength range with a flat meta-optic, co-designed with computational reconstruction. We derive the necessary conditions for a broadband, 1 cm aperture, f/2 flat optic, with a diagonal field of view of 30° and an average system MTF contrast of 30% or larger for a spatial frequency of 100 lp/mm in the visible band (> 50 % for 70 lp/mm and below). Finally, we use a coaxial, dual-aperture system to train the broadband imaging meta-optic with a learned reconstruction method operating on pair-wise captured imaging data. Fundamentally, our work challenges the entrenched belief of the inability of capturing high-quality, full-color images using a single large aperture meta-optic. © 2024, CC BY.

关键词： Nanophotonics

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Fiber optic SERS sensors for rapid detection and identification of Salmonella in turkey products 25

Fiber optic SERS sensors for rapid detection and identificat...

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Optical Fibers and Sensors for Medical Diagnostics, Treatment, and Environmental Applications XXV 2025

作者： Abuhelwa, Mai Chenggeer, Fnu Bandara, Adheesha Liu, Jiayu Willoughby, Paige Carlson, Anna Trout, Kate E. Morey, Amit Kinzel, Ed Mustapha, Azlin Almasri, Mahmoud Department of Electrical Engineering and Computer Science University of Missouri ColumbiaMO65211 United States Food Science Program University of Missouri ColumbiaMO65211 United States Cargill Inc WichitaKS67202 United States College of Health Sciences University of Missouri ColumbiaMO65211 United States Department of Poultry Science Auburn University AuburnAL36849 United States University of Notre Dame IN46556 United States

ISBN: (纸本)9781510683686

This study validates a fiber optics-based Surface Enhanced Raman Spectroscopy (SERS) sensor for detecting Salmonella in raw turkey samples. The sensor uses nanoantenna arrays on a side-polished optical fiber core with a fixed periodicity of 0.77 μm to maximize the SERS signal intensity. A 3D-printed chamber and microstructure optimize light reflection, improving sensitivity. The sensor detects Salmonella at 0.4-0.5 CFU/ml in 10 minutes, offering cost-effective, portable pathogen detection. © 2025 SPIE.

关键词： Multimode fibers

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A Multi-phase Deep Learning Approach for Predicting HCC Response to TACE using Complete Computed Tomography

A Multi-phase Deep Learning Approach for Predicting HCC Resp...

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Data science and engineering in Healthcare, Medicine and Biology, IEEE EMBS Special Topic Conference on

作者： Shun Cheng Chang Chien Fu Liu Marta Misztal Yi Hsien Hsieh Che Lin Graduate Institute of Communication Engineering National Taiwan University (NTU) Taiwan School of Electronic Engineering and Computer Science Queen Mary University of London UK Department of Electrical Engineering NTU Taiwan Center for Computational and Systems Biology and Center for Biotechnology NTU Taiwan Smart Medicine and Health Informatics Program NTU Taiwan

In this research study, we compare the predictive performance of two advanced deep learning-based models in order to provide a solution to TACE (Transarterial Chemoembolization) response prediction in HCC (Hepatocellular Carcinoma) patients. Using entire abdominal CT scans enabled a broader perspective available for the model, eliminating the need for segmentation during the preprocessing. Making use of both single-phase and multi-phase CT imaging, we have used DenseNet121 and have obtained an accuracy of 80% for the multi-phase *** Relevance: The ability to predict the effectiveness of TACE treatment prior to its administration makes it possible to provide a better decision-making aid for physicians and patients.

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Probabilistic genotype-phenotype maps reveal mutational robustness of RNA folding, spin glasses, and quantum circuits

引用

Physical Review Research 2025年第1期7卷 013118-013118页

作者： Anna Sappington Vaibhav Mohanty Department of Electrical Engineering and Computer Science Massachusetts Institute of Technology Cambridge Massachusetts 02139 USA Harvard-MIT Program in Health Sciences and Technology Harvard Medical School Boston Massachusetts 02115 USA and Massachusetts Institute of Technology Cambridge Massachusetts 02139 USA Harvard/MIT MD-PhD Program Harvard Medical School Boston Massachusetts 02115 USA and Massachusetts Institute of Technology Cambridge Massachusetts 02139 USA Department of Chemistry and Chemical Biology Harvard University Cambridge Massachusetts 02138 USA

Recent studies of genotype-phenotype maps have reported universally enhanced phenotypic robustness to genotype mutations, a feature essential to evolution. Virtually all of these studies make a simplifying assumption that each genotype—represented as a sequence—maps deterministically to a single phenotype, such as a discrete structure. Here we introduce probabilistic genotype-phenotype (PrGP) maps, where each genotype maps to a vector of phenotype probabilities, as a more realistic and universal language for investigating robustness in a variety of physical, biological, and computational systems. We study three model systems to show that PrGP maps offer a generalized framework which can handle uncertainty emerging from various physical sources: (1) thermal fluctuation in RNA folding, (2) external field disorder in the spin-glass ground state search problem, and (3) superposition and entanglement in quantum circuits, which are realized experimentally on IBM quantum computers. In all three cases, we observe a biphasic robustness scaling which is enhanced relative to random expectation for more frequent phenotypes and approaches random expectation for less frequent phenotypes. We derive an analytical theory for the behavior of PrGP robustness, and we demonstrate that the theory is highly predictive of empirical robustness.

关键词： Quantum computers

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