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Annual International Conference of the IEEE engineering in Medicine and Biology Society (EMBC)

作者： Shun-Cheng Chang Pochuang Wang Weichung Wang Tung-Hung Su Jia-Horng Kao Che Lin Graduate Institute of Communication Engineering National Taiwan University (NTU) Taipei Taiwan Department of Computer Science and Information Engineering NTU Taipei Taiwan NTU Institute of Applied Mathematical Sciences Taipei Taiwan Department of Internal Medicine Division of Gastroenterology and Hepatology National Taiwan University Hospital Taipei Taiwan Department of Electrical Engineering NTU Taipei Taiwan NTU Center for Advanced Computing and Imaging in Biomedicine Taipei Taiwan NTU Smart Medicine and Health Informatics Program Taipei Taiwan

ISBN: (数字)9798350371499

ISBN: (纸本)9798350371505

The Barcelona Clinic Liver Cancer (BCLC) staging system plays a crucial role in clinical planning, offering valuable insights for effectively managing hepatocellular carcinoma. Accurate prediction of BCLC stages can significantly ease the workload on radiologists. However, few datasets are explicitly designed for discerning BCLC stages. Despite the common practice of appending BCLC labels to clinical data within datasets, the inherent imbalance in BCLC distribution is further amplified by the diverse purposes for which datasets are curated. In this study, we aim to develop a BCLC staging system using the advanced Swin Transformer model. Additionally, we explore the integration of two datasets, each originally intended for separate objectives, highlighting the critical challenge of preserving class distribution in practical study designs. This exploration is pivotal for ensuring the applicability of our developed staging system in the designed clinical settings. Our resulting BCLC staging system demonstrates an accuracy of 55.81% (±7.8%), contributing to advancing medical image-based research for predicting BCLC stages.

关键词： Liver cancer Accuracy Computed tomography Biological system modeling Transformers Planning Biomedical imaging

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Near-field microwave microscopy of nanostructured materials: Modeling and experiment

Near-field microwave microscopy of nanostructured materials:...

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Low-Dimensional Materials and Devices 2021

作者： Lopez, Diego C. Ohlberg, Douglas A. A. Giraldo, Brian Ramirez, Jhonattan C. Kobayashi, Nobuhiko P. Do Rego, Cássio G. Medeiros-Ribeiro, Gilberto Electrical Engineering Graduate Program Universidade Federal de Minas Gerais Belo HorizonteMG 31270-901 Brazil Microscopy Center Universidade Federal de Minas Gerais Belo HorizonteMG 31270-901 Brazil Department of Electrical and Computer Engineering Baskin School of Engineering University of California Santa Cruz Santa CruzCA95064 United States Computer Science Department Universidade Federal de Minas Gerais Belo HorizonteMG 31270-901 Brazil

ISBN: (数字)9781510644397

ISBN: (纸本)9781510644380

Synthesis of novel material often times requires novel analysis and characterization techniques. The possibility of combining sputtering (SPU) and Atomic Layer Deposition (ALD) in the same chamber, Sputtering Atomic Layer Augmented Deposition (SALAD), has produced interesting meta-dielectric nanocomposite systems that have unique optical and electronic properties, which may find novel applications [1]. Scanning Microwave Impedance Microscopy (sMIM) is a relatively novel characterization tool which permits assessment of local impedance. More recently, the utilization of microwaves in the near field regime has been an exciting topic in the field of high-resolution microscopy. We were able to demonstrate 1 nm resolution using scanning Microwave Impedance Microscopy (sMIM) where a spontaneously forming water meniscus concentrated the microwave fields in small regions [2]. Here we analyzed numerically sMIM with Finite Element Method (FEM) to investigate complex metal-dielectric structures created in a SALAD system. sMIM measurements provide information on both real and imaginary parts of the reflected microwave signal, which can be associated with the local conductivity and permittivity. Yet, these quantities can be influenced by the local topography, so extraction of the electronic contribution is a challenge. In this work, we perform tip-surface distance scans in order to gain a better understanding of the substrate response and compare with the FEM results. © COPYRIGHT SPIE. Downloading of the abstract is permitted for personal use only.

关键词： Finite element method

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Endoscopic Fourier-transform infrared spectroscopy through a fiber microprobe

arXiv

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arXiv 2024年

作者： Kim, Jaehyeon Tian, Yue Qiao, Guanhua Villarta, Julinna Abulencia Zhao, Fujia He, Andrew Ho, Ruo-Jing Liu, Haoran Bhargava, Rohit Zhang, Yingjie Department of Materials Science and Engineering University of Illinois UrbanaIL61801 United States Materials Research Laboratory University of Illinois UrbanaIL61801 United States Beckman Institute for Advanced Science and Technology University of Illinois UrbanaIL61801 United States Department of Bioengineering University of Illinois UrbanaIL61801 United States Department of Electrical and Computer Engineering University of Illinois UrbanaIL61801 United States Cancer Center at Illinois University of Illinois UrbanaIL61801 United States Department of Mechanical Science and Engineering University of Illinois UrbanaIL61801 United States Department of Chemical and Biomolecular Engineering University of Illinois UrbanaIL61801 United States Department of Chemistry University of Illinois UrbanaIL61801 United States

Fourier-transform infrared spectroscopy (FTIR) is a powerful analytical method for not only the chemical identification of solid, liquid, and gas species, but also the quantification of their concentration. However, the chemical quantification capability of FTIR is significantly hindered when the analyte is surrounded by a strong IR absorbing medium, such as liquid solutions. To overcome this limit, here we develop an IR fiber microprobe that can be inserted into liquid medium, and obtain full FTIR spectra at points of interest. To benchmark this endoscopic FTIR method, we insert the microprobe into bulk water covering a ZnSe substrate and measure the IR transmittance of water as a function of the probe–substrate distance. The obtained vibrational modes, overall transmittance vs z profiles, quantitative absorption coefficients, and micro z-section IR transmittance spectra are all consistent with the standard IR absorption properties of water. The results pave the way for endoscopic chemical profiling inside bulk liquid solutions, promising for applications in many biological, chemical, and electrochemical systems. Copyright © 2024, The Authors. All rights reserved.

关键词： Fourier transform infrared spectroscopy

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ReViT: A Hybrid Approach for BCLC Staging of Hepatocellular Carcinoma Using 3D CT with Multiple Instance Learning

ReViT: A Hybrid Approach for BCLC Staging of Hepatocellular ...

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IEEE EMBS International Conference on Information Technology Applications in Biomedicine (ITAB)

作者： Shun-Cheng Chang Hsin-Pei Yu Yi-Hsien Hsieh Pochuang Wang Weichung Wang Tung-Hung Su Jia-Horng Kao Che Lin Graduate Institute of Communication Engineering National Taiwan University (NTU) Taipei Taiwan Department of Computer Science and Information Engineering NTU Taipei Taiwan Institute of Applied Mathematical Sciences NTU Taipei Taiwan Department of Internal Medicine Division of Gastroenterology and Hepatology National Taiwan University Hospital Taipei Taiwan Department of Electrical Engineering NTU Taipei Taiwan Center for Advanced Computing and Imaging in Biomedicine NTU Taipei Taiwan Smart Medicine and Health Informatics Program NTU Taipei Taiwan

ISBN: (数字)9798350351552

ISBN: (纸本)9798350351569

Deep learning has revolutionized medical imaging, offering advanced methods for accurate diagnosis and treatment planning. The BCLC staging system is crucial for staging Hepatocellular Carcinoma (HCC), a high-mortality cancer. An automated BCLC staging system could significantly enhance diagnosis and treatment planning efficiency. However, we found that BCLC staging, which is directly related to the size and number of liver tumors, aligns well with the principles of the Multiple Instance Learning (MIL) framework. To effectively achieve this, we proposed a new preprocessing technique called Masked Cropping and Padding(MCP), which addresses the variability in liver volumes and ensures consistent input sizes. This technique preserves the structural integrity of the liver, facilitating more effective learning. Furthermore, we introduced Re ViT, a novel hybrid model that integrates the local feature extraction capabilities of Convolutional Neural Networks (CNNs) with the global context modeling of Vision Transformers (ViTs). Re ViT leverages the strengths of both architectures within the MIL framework, enabling a robust and accurate approach for BCLC staging. We will further explore the trade-off between performance and interpretability by employing TopK Pooling strategies, as our model focuses on the most informative instances within each bag.

关键词： Visualization Accuracy Three-dimensional displays Liver Transformers Planning Convolutional neural networks Context modeling Biomedical imaging Tumors

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Blip-Up Blip-Down Circular EPI (BUDA-cEPI) for Distortion-Free dMRI with Rapid Unrolled Deep Learning Reconstruction

arXiv

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arXiv 2023年

作者： Yarach, Uten Chatnuntawech, Itthi Liao, Congyu Teerapittayanon, Surat Iyer, Siddharth Srinivasan Kim, Tae Hyung Haldar, Justin Cho, Jaejin Bilgic, Berkin Hu, Yuxin Hargreaves, Brian Setsompop, Kawin Radiologic Technology Department Associated Medical Sciences Chiang Mai University Chiang Mai Thailand National Nanotechnology Center National Science and Technology Development Agency Pathum Thani Thailand Department of Radiology Stanford University StanfordCA United States Department of Electrical Engineering Stanford University StanfordCA United States Department of Electrical Engineering and Computer Science Massachusetts Institute of Technology CambridgeMA United States Department of Computer Engineering Hongik University Seoul Korea Republic of Signal and Image Processing Institute Ming Hsieh Department of Electrical and Computer Engineering University of Southern California Los AngelesCA United States Athinoula A. Martinos Center for Biomedical Imaging Massachusetts General Hospital CharlestownMA United States Department of Radiology Harvard Medical School BostonMA United States Department of Bioengineering Stanford University StanfordCA United States Packard Electrical Engineering Building 350 Jane Stanford Way StanfordCA94305 United States

Purpose: We implemented the blip-up, blip-down circular echo planar imaging (BUDA-cEPI) sequence with readout and phase partial Fourier to reduced off-resonance effect and T2* blurring. BUDA-cEPI reconstruction with S-based low-rank modeling of local k-space neighborhoods (S-LORAKS) is shown to be effective at reconstructing the highly under-sampled BUDA-cEPI data, but it is computationally intensive. Thus, we developed an ML-based reconstruction technique termed "BUDA-cEPI RUN-UP" to enable fast reconstruction. Methods: BUDA-cEPI RUN-UP – a model-based framework that incorporates off-resonance and eddy current effects was unrolled through an artificial neural network with only six gradient updates. The unrolled network alternates between data consistency (i.e., forward BUDA-cEPI and its adjoint) and regularization steps where U-Net plays a role as the regularizer. To handle the partial Fourier effect, the virtual coil concept was also incorporated into the reconstruction to effectively take advantage of the smooth phase prior, and trained to predict the ground-truth images obtained by BUDA-cEPI with S-LORAKS. Results: BUDA-cEPI with S-LORAKS reconstruction enabled the management of off-resonance, partial Fourier, and residual aliasing artifacts. However, the reconstruction time is approximately 225 seconds per slice, which may not be practical in a clinical setting. In contrast, the proposed BUDA-cEPI RUN-UP yielded similar results to BUDA-cEPI with S-LORAKS, with less than a 5% normalized root mean square error detected, while the reconstruction time is approximately 3 seconds. Conclusion: BUDA-cEPI RUN-UP was shown to reduce the reconstruction time by ~88x when compared to the state-of-the-art technique, while preserving imaging details as demonstrated through DTI application. © 2023, CC BY.

关键词： Magnetic resonance imaging

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Photonic Metacrystal: Design and Experimental Results

Photonic Metacrystal: Design and Experimental Results

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CLEO: science and Innovations, S and I 2022

作者： Hu, S. Khater, M. Kratschmer, E. Engelmann, S. Arnold, K.P. Green, W.M.J. Weiss, S.M. Department of Electrical and Computer Engineering Vanderbilt University NashvilleTN37235 United States IBM T J Watson Center 1101 Kitchawan Road Yorktown HeightsNY10598 United States INanoBio Inc 1600 Adams Drive Menlo ParkCA94025 United States Interdisciplinary Materials Science Program Vanderbilt University NashvilleTN37235 United States

ISBN: (纸本)9781557528209

Going beyond the limited design freedoms of traditional photonic crystals, we experimentally show how photonic metacrystals exploit the inclusion of subwavelength dielectric scatterers in the unit cell to deterministically modify k-space and real space profiles. © Optica Publishing Group 2022, © 2022 The Authors.

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Implantable Biosensor for Continuous Serotonin Detection in Freely Moving Crayfish

Implantable Biosensor for Continuous Serotonin Detection in ...

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International Conference on Solid State Sensors and Actuators (TRANSDUCERS)

作者： Jinjing Han Tawen Ho Justin M. Stine Michael A. Straker Jens Herberholz Reza Ghodssi Department of Electrical and Computer Engineering University of Maryland College Park MD USA Institute for System Research University of Maryland College Park MD USA Robert E. Fischell Institute for Biomedical Devices University of Maryland College Park MD USA Department of Psychology University of Maryland College Park MD USA Program in Neuroscience and Cognitive Science University of Maryland College Park MD USA Fischell Department of Bioengineering University of Maryland College Park MD USA

This work presents, for the first time, an implantable biosensor for continuous in vivo serotonin (5-HT) monitoring in freely moving crayfish. 5-HT is an important neurotransmitter that regulates animal behaviors. Conventional methods for detecting 5-HT do not provide real-time information. Our approach facilitates continuous electrochemical monitoring of 5-HT levels without impeding animal natural behavior. The sensing system shows a linear range of 0.4 - 1.2 μΜ with a sensitivity of 0.07 μΑ/μΜ for 5-HT detection. With a 3D-printed package, the sensor can be easily attached to crayfish dorsal carapace allowing electrodes implantation into crayfish heart to monitor neurohormonal dynamics of 5-HT. The implantable biosensor system displayed a significant increase in oxidation currents after 5-HT injections. The device successfully demonstrates the application for in vivo detection of 5-HT in the hemolymph (i.e., blood) of freely behaving crayfish underwater.

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Polarimetric coherent anti-Stokes Raman scattering microscopy of collagen

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Optics Letters 2025年第12期50卷 4010-4013页

作者： Lingxiao Yang Janet E Sorrells Rishyashring R Iyer Stephen A Boppart Beckman Institute for Advanced Science and Technology University of Illinois Urbana-Champaign Urbana Illinois 61801 USA Department of Electrical and Computer Engineering University of Illinois Urbana-Champaign Urbana Illinois 61801 USA Department of Bioengineering University of Illinois Urbana-Champaign Urbana Illinois 61801 USA Interdisciplinary Health Sciences Institute University of Illinois Urbana-Champaign Urbana Illinois 61801 USA NIH Center for Label-free Imaging and Multiscale Biophotonics (CLIMB) University of Illinois Urbana-Champaign Urbana Illinois 61801 USA

We demonstrate polarimetric coherent anti-Stokes Raman scattering (PCARS) microscopy for quantitative analysis of collagen orientation. Using polarization-modulated excitation and cross-polarized detection, we extract both chemical and orientational information from intact tissues. We introduce two complementary analyses: the CARS peak polarization ratio (PPR) and Fourier domain polarimetric analysis, providing a robust characterization of collagen organization. This method enables rapid, label-free imaging of a collagen structure with molecular specificity, offering what we believe to be new capabilities for studying collagen remodeling in biological processes.

关键词： Beam splitters Coherent antistokes Raman scattering spectroscopy Fourier transforms Photonic crystal fibers Raman microscopy Raman scattering

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Nernst-Ettingshausen effect in thin Pt and W films at low temperatures

arXiv

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arXiv 2023年

作者： Luo, Renjie Legvold, Tanner J. Chen, Liyang Natelson, Douglas Department of Physics and Astronomy Rice University HoustonTX77005 United States Applied Physics Graduate Program Smalley-Curl Institute Rice University HoustonTX77005 United States Department of Electrical and Computer Engineering Department of Materials Science and NanoEngineering Rice University HoustonTX77005 United States

As spin caloritronic measurements become increasingly common techniques for characterizing material properties, it is important to quantify potentially confounding effects. We report measurements of the Nernst-Ettingshausen response from room temperature to 5 K in thin film wires of Pt and W, metals commonly used as inverse spin Hall detectors in spin Seebeck characterization. Johnson-Nyquist noise thermometry is used to assess the temperature change of the metals with heater power at low temperatures, and the thermal path is analyzed via finite-element modeling. The Nernst-Ettingshausen response of W is found to be approximately temperature-independent, while the response of Pt increases at low temperatures. These results are discussed in the context of theoretical expectations and the possible role of magnetic impurities in Pt. Copyright © 2023, The Authors. All rights reserved.

关键词： Inverse problems

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Cantilever Actuator Capsule for Magnetically Triggered Drug Delivery in the GI Tract

Cantilever Actuator Capsule for Magnetically Triggered Drug ...

引用

IEEE SENSORS

作者： Joshua A. Levy Michael A. Straker Luke A. Beardslee Reza Ghodssi Department of Materials Science and Engineering University of Maryland College Park Maryland USA Institute for Systems Research University of Maryland College Park Maryland USA Robert E. Fischell Institute for Biomedical Devices University of Maryland College Park Maryland USA Fischell Department of Bioengineering University of Maryland College Park Maryland USA Department of Electrical and Computer Engineering University of Maryland College Park Maryland USA

In this research, we present the development of a simple reed switch enabled magnetically triggerable electronic actuation system for protection and localized delivery of drugs in the intestinal tract. This system relies on polymeric cantilevers that can be multiplexed and released on command by melting the adhesive that holds them in compression. These cantilevers are conformally wrapped around the capsule and hold drug-loaded microneedles that penetrate the intestinal tissue to release drugs when deployed. We demonstrate the assembly, modeling, mechanical characterization, and deployment of this actuation capsule. COMSOL analysis suggested cantilever thickness of 254 $\mu\mathrm{m}$ is ideal to achieve the desired actuation force. This result was corroborated by mechanical experiments, and deployment was achieved using a handheld magnet in 2.3 seconds. Overall, this system provides the potential for targeted drug delivery in the GI tract, improving drug efficacy while minimizing side effects.

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