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GardnerNet: An Interpretable Deep Learning Model for Quantitative Human Blastocyst Evaluation - A Retrospective Model Development and Validation Study

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SSRN

SSRN 2024年

作者： Liu, Hang Chen, Longbin Shan, Guanqiao Sun, Chen Liao, Hongqing Lu, Changfu Zhang, Shuoping Dong, Shaonan Xu, Xinxin Yan, Qiuyun Gong, Fei Zhang, Zhuoran Dai, Changsheng Chen, Wenyuan Song, Haocong Chen, Lei Sun, Haixiang Wang, Shanshan Lin, Ge Sun, Yu Gu, Yifan Department of Mechanical and Industrial Engineering University of Toronto 5 King’s College Road TorontoONM5S 3G8 Canada Institute of Reproductive and Stem Cell Engineering School of Basic Medical Science Central South University 172 Tongzipo Road Hunan Province Changsha China Hengyang Nanhua-Xinghui Reproductive Health Hospital 30 Jiefang Road Hunan Province Hengyang China The second Affiliated Hospital Hengyang Medical School University of South China 30 Jiefang Road Hunan Province Hengyang City China Reproductive & Genetic Hospital of CITIC-Xiangya 567 Tongzipo Road Hunan Province Changsha China NHC Key Laboratory of Human Stem Cell and Reproductive Engineering School of Basic Medical Science Central South University 172 Tongzipo Road Hunan Province Changsha China Clinical Research Center for Reproduction and Genetics in Hunan Province Reproductive & Genetic Hospital of CITIC-Xiangya 567 Tongzipo Road Hunan Province Changsha China School of Science and Engineering The Chinese University of Hong Kong-Shenzhen 2001 Longxiang Boulevard Longgang District Shenzhen China Institute of Robotics and Intelligent Systems Dalian University of Technolgy 2 Linggong Road Liaoning Province Dalian China Department of Computer Science University of Toronto 40 St George Street TorontoONM5S 2E4 Canada Center for Reproductive Medicine and Obstetrics and Gynecology Nanjing Drum Tower Hospital Nanjing University Medical School 321 Zhongshan Road Jiangsu Province Nanjing China National Engineering and Research Center of Human Stem Cell 8 Luyun Road Jiangsu Province Changsha China Department of Electrical and Computer Engineering 10 King’s College Road TorontoONM5S 3G8 Canada Institute of Biomedical Engineering University of Toronto 164 College Street TorontoONM5S 3G9 Canada

Background: Selecting the blastocyst with the highest potential for live birth from a cohort is crucial for the success of in vitro fertilization (IVF). While the Gardner and Schoolcraft morphological grading system, commonly known as the Gardner grading system, is widely used by embryologists worldwide, blastocysts having similar or the same inner cell mass (ICM) and trophectoderm (TE) grades cause challenges for embryologists in decision-making. Furthermore, human assessment is subjective and inconsistent in predicting which blastocysts have higher potential to result in live birth. This study aims to develop an interpretable, quantitative method aligned with the Gardner grading system, providing continuous scores that correlate with live birth outcomes, thereby assisting embryologists in improving blastocyst selection. Methods: In this retrospective study, we developed GardnerNet, an interpretable deep learning model that outputs expansion degree grade and continuous scores quantifying a blastocyst's ICM morphology and TE morphology, based on the Gardner grading system. The continuous ICM and TE scores were calculated by weighting each base grade's predicted probability and summing the predicted probabilities. To represent each blastocyst's overall potential for live birth, we combined the ICM and TE scores using their odds ratios (ORs) for live birth. We further assessed the correlation between the ICM score, TE score, and the OR-combined score (adjusted for expansion degree) with live birth rates by applying GardnerNet to blastocysts with known live birth outcomes. To test its generalizability, we also applied GardnerNet to an external IVF institution, accounting for variations in imaging conditions, live birth rates, and embryologists' experience levels. Findings: GardnerNet was developed using data from 2760 blastocysts with majority-voted grades for expansion degree, ICM, and TE. The model achieved mean area under the receiver operating characteristic curve

关键词： Risk assessment

Asymmetric CNN for image super-resolution

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arXiv 2021年

作者： Tian, Chunwei Xu, Yong Zuo, Wangmeng Lin, Chia-Wen Zhang, David The Bio-Computing Research Center Harbin Institute of Technology ShenzhenShenzhenGuangdong518055 China Shenzhen Key Laboratory of Visual Object Detection and Recognition ShenzhenGuangdong518055 China The School of Computer Science and Technology Harbin Institute of Technology HarbinHeilongjiang150001 China The Peng Cheng Laboratory ShenzhenGuangdong518055 China Shenzhen Key Laboratory of Visual Object Detection and Recognition Shenzhen Guangdong518055 China The Department of Electrical Engineering The Institute of Communications Engineering National Tsing Hua University Hsinchu Taiwan ShenzhenGuangdong518172 China The Shenzhen Institute of Artificial Intelligence and Robotics for Society Shenzhen China

Deep convolutional neural networks (CNNs) have been widely applied for low-level vision over the past five years. According to nature of different applications, designing appropriate CNN architectures is developed. However, customized architectures gather different features via treating all pixel points as equal to improve the performance of given application, which ignores the effects of local power pixel points and results in low training efficiency. In this paper, we propose an asymmetric CNN (ACNet) comprising an asymmetric block (AB), a memory enhancement block (MEB) and a high-frequency feature enhancement block (HFFEB) for image super-resolution. The AB utilizes one-dimensional asymmetric convolutions to intensify the square convolution kernels in horizontal and vertical directions for promoting the influences of local salient features for SISR. The MEB fuses all hierarchical low-frequency features from the AB via residual learning (RL) technique to resolve the long-term dependency problem and transforms obtained low-frequency features into high-frequency features. The HFFEB exploits low- and high-frequency features to obtain more robust super-resolution features and address excessive feature enhancement problem. Additionally, it also takes charge of reconstructing a high-resolution (HR) image. Extensive experiments show that our ACNet can effectively address single image super-resolution (SISR), blind SISR and blind SISR of blind noise problems. The code of the ACNet is shown at https://***/hellloxiaotian/ACNet. © 2021, CC BY-NC-ND.

关键词： Image enhancement

POLY-HOOT: Monte-Carlo Planning in Continuous Space MDPs with Non-Asymptotic Analysis

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arXiv 2020年

作者： Mao, Weichao Zhang, Kaiqing Xie, Qiaomin Başar, Tamer Department of Electrical and Computer Engineering & Coordinated Science Laboratory University of Illinois at Urbana-Champaign UrbanaIL61801 United States School of Operations Research and Information Engineering Cornell University IthacaNY14853 United States

Monte-Carlo planning, as exemplified by Monte-Carlo Tree Search (MCTS), has demonstrated remarkable performance in applications with finite spaces. In this paper, we consider Monte-Carlo planning in an environment with continuous state-action spaces, a much less understood problem with important applications in control and robotics. We introduce POLY-HOOT, an algorithm that augments MCTS with a continuous armed bandit strategy named Hierarchical Optimistic Optimization (HOO) (Bubeck et al., 2011). Specifically, we enhance HOO by using an appropriate polynomial, rather than logarithmic, bonus term in the upper confidence bounds. Such a polynomial bonus is motivated by its empirical successes in AlphaGo Zero (Silver et al., 2017b), as well as its significant role in achieving theoretical guarantees of finite space MCTS (Shah et al., 2019). We investigate, for the first time, the regret of the enhanced HOO algorithm in non-stationary bandit problems. Using this result as a building block, we establish non-asymptotic convergence guarantees for POLY-HOOT: the value estimate converges to an arbitrarily small neighborhood of the optimal value function at a polynomial rate. We further provide experimental results that corroborate our theoretical findings. Copyright © 2020, The Authors. All rights reserved.

关键词： Monte Carlo methods

A multi-objective deep reinforcement learning algorithm for spatio-temporal latency optimization in mobile IoT-enabled edge computing networks

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Simulation Modelling Practice and Theory 2025年 143卷

作者： Khoshvaght, Parisa Haider, Amir Rahmani, Amir Masoud Gharehchopogh, Farhad Soleimanian Anka, Ferzat Lansky, Jan Hosseinzadeh, Mehdi Institute of Research and Development Duy Tan University Da Nang Viet Nam School of Engineering & Technology Duy Tan University Da Nang Viet Nam Centre for Research Impact & Outcome Chitkara University Institute of Engineering and Technology Chitkara University Punjab Rajpura140401 India Department of AI and Robotics Sejong University Seoul05006 Korea Republic of Future Technology Research Center National Yunlin University of Science and Technology Yunlin Taiwan Department of Computer Engineering Ur. C. Islamic Azad University Urmia Iran Fatih Sultan Mehmet Vakif University Istanbul Turkey Department of Computer Science and Mathematics Faculty of Economic Studies University of Finance and Administration Prague Czech Republic Pattern Recognition and Machine Learning Laboratory School of Computing Gachon University Seongnam Korea Republic of

The rapid increase in Mobile Internet of Things (IoT) devices requires novel computational frameworks. These frameworks must meet strict latency and energy efficiency requirements in Edge and Mobile Edge Computing (MEC) systems. Spatio-temporal dynamics, which include the position of edge servers and the timing of task schedules, pose a complex optimization problem. These challenges are further exacerbated by the heterogeneity of IoT workloads and the constraints imposed by device mobility. The balance between computational overhead and communication challenges is also a problem. To solve these issues, advanced methods are needed for resource management and dynamic task scheduling in mobile IoT and edge computing environments. In this paper, we propose a Deep Reinforcement Learning (DRL) multi-objective algorithm, called a Double Deep Q-Learning (DDQN) framework enhanced with Spatio-temporal mobility prediction, latency-aware task offloading, and energy-constrained IoT device trajectory optimization for federated edge computing networks. DDQN was chosen for its optimize stability and reduced overestimation in Q-values. The framework employs a reward-driven optimization model that dynamically prioritizes latency-sensitive tasks, minimizes task migration overhead, and balances energy efficiency across devices and edge servers. It integrates dynamic resource allocation algorithms to address random task arrival patterns and real-time computational demands. Simulations demonstrate up to a 35 % reduction in end-to-end latency, a 28 % improvement in energy efficiency, and a 20 % decrease in the deadline-miss ratio compared to benchmark algorithms. © 2025 Elsevier B.V.

关键词： Resource allocation

Online multi-object tracking and segmentation with GMPHD filter and mask-based affinity fusion

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arXiv 2020年

作者： Song, Young-Min Yoon, Young-Chul Yoon, Kwangjin Jeon, Moongu Lee, Seong-Whan Pedrycz, Witold The School of Electrical Engineering and Computer Science Gwangju Institute of Technology Gwangju61005 Korea Republic of The Robotics Laboratory Hyundai Motor Company Gyeonggi-do 16082 Korea Republic of SI Analytics Co. Ltd. Daejeon34051 Korea Republic of The Department of Artificial Intelligence Korea University Seoul02841 Korea Republic of The Department of Brain and Cognitive Engineering Korea University Seoul02841 Korea Republic of The Department of Electrical and Computer Engineering University of Alberta EdmontonABT6R 2H5 Canada The Department of Electrical and Computer Engineering Faculty of Engineering King Abdulaziz University Jeddah21589 Saudi Arabia The Systems Research Institute Polish Academy of Sciences Warsaw01-447 Poland

In this paper, we propose a highly practical fully online multi-object tracking and segmentation (MOTS) method that uses instance segmentation results as an input. The proposed method is based on the Gaussian mixture probability hypothesis density (GMPHD) filter, a hierarchical data association (HDA), and a mask-based affinity fusion (MAF) model to achieve high-performance online tracking. The HDA consists of two associations: segment-to-track and track-to-track associations. One affinity, for position and motion, is computed by using the GMPHD filter, and the other affinity, for appearance is computed by using the responses from a single object tracker such as a kernalized correlation filter. These two affinities are simply fused by using a score-level fusion method such as min-max normalization referred to as MAF. In addition, to reduce the number of false positive segments, we adopt mask IoU-based merging (mask merging). The proposed MOTS framework with the key modules: HDA, MAF, and mask merging, is easily extensible to simultaneously track multiple types of objects with CPU-only execution in parallel processing. In addition, the developed framework only requires simple parameter tuning unlike many existing MOTS methods that need intensive hyperparameter optimization. In the experiments on the two popular MOTS datasets, the key modules show some improvements. For instance, ID-switch decreases by more than half compared to a baseline method in the training sets. In conclusion, our tracker achieves state-of-the-art MOTS performance in the test sets. Copyright © 2020, The Authors. All rights reserved.

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A Robust Ensemble Algorithm for Ischemic Stroke Lesion Segmentation: Generalizability and Clinical Utility Beyond the ISLES Challenge

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arXiv 2024年

作者： de la Rosa, Ezequiel Reyes, Mauricio Liew, Sook-Lei Hutton, Alexandre Wiest, Roland Kaesmacher, Johannes Hanning, Uta Hakim, Arsany Zubal, Richard Valenzuela, Waldo Robben, David Sima, Diana M. Anania, Vincenzo Brys, Arne Meakin, James A. Mickan, Anne Broocks, Gabriel Heitkamp, Christian Gao, Shengbo Liang, Kongming Zhang, Ziji Siddiquee, Md Mahfuzur Rahman Myronenko, Andriy Ashtari, Pooya Van Huffel, Sabine Jeong, Hyun-Su Yoon, Chi-Ho Kim, Chulhong Huo, Jiayu Ourselin, Sebastien Sparks, Rachel Clèrigues, Albert Oliver, Arnau Lladó, Xavier Chalcroft, Liam Pappas, Ioannis Bertels, Jeroen Heylen, Ewout Moreau, Juliette Hatami, Nima Frindel, Carole Qayyum, Abdul Mazher, Moona Puig, Domenec Lin, Shao-Chieh Juan, Chun-Jung Hu, Tianxi Boone, Lyndon Goubran, Maged Liu, Yi-Jui Wegener, Susanne Kofler, Florian Ezhov, Ivan Shit, Suprosanna Hernandez Petzsche, Moritz R. Menze, Bjoern Kirschke, Jan S. Wiestler, Benedikt Department of Quantitative Biomedicine University of Zurich Zurich Switzerland Department of Informatics Technical University Munich Germany Icometrix Leuven Belgium ARTORG Center for Biomedical Research University of Bern Bern Switzerland Department of Radiation Oncology University Hospital Bern University of Bern Switzerland University of Bern Bern Switzerland Chan Division of Occupational Science and Occupational Therapy University of Southern California Los AngelesCA United States Stevens Neuroimaging and Informatics Institute Department of Neurology Keck School of Medicine University of Southern California United States University Institute of Diagnostic and Interventional Neuroradiology Inselspital Bern Switzerland University Institute of Diagnostic and Interventional Neuroradiology University Hospital Bern Inselspital University of Bern Bern Switzerland Department of Diagnostic and Interventional neuroradiology University Medical Center Hamburg-Eppendorf Hamburg Germany Department of Medical Imaging Radboud University Medical Center Institute for Health Sciences Nijmegen Netherlands Deepwise AI Lab Beijing China Beijing University of Posts and Telecommunications Bejing China School of Computing and Augmented Intelligence Arizona State University TempeAZ United States NVIDIA Santa ClaraCA United States STADIUS Center for Dynamical Systems Signal Processing and Data Analytics KU Leuven Leuven Belgium Pohang Korea Republic of School of Biomedical Engineering & Imaging Sciences King’s College London United Kingdom Institute of Computer Vision and Robotics University of Girona Spain Wellcome Centre for Human Neuroimaging University College London London United Kingdom Laboratory of Neuro Imaging Stevens Institute for Neuroimaging and Informatics Keck School of Medicine University of Southern California Los Angeles United States KU Leuven Leuven Belgium CREATIS Université Lyon1 CNRS UMR5220 INSERM U1206 INSA-Lyon Villeurbanne696

Diffusion-weighted MRI (DWI) is essential for stroke diagnosis, treatment decisions, and prognosis. However, image and disease variability hinder the development of generalizable AI algorithms with clinical value. We address this gap by presenting a novel ensemble algorithm derived from the 2022 Ischemic Stroke Lesion Segmentation (ISLES) challenge. ISLES’22 provided 400 patient scans with ischemic stroke from various medical centers, facilitating the development of a wide range of cutting-edge segmentation algorithms by the research community. By assessing them against a hidden test set, we identified strengths, weaknesses, and potential biases. Through collaboration with leading teams, we combined top-performing algorithms into an ensemble model that overcomes the limitations of individual solutions. Our ensemble model combines the individual algorithms’ strengths and achieved superior ischemic lesion detection and segmentation accuracy (median Dice score: 0.82, median lesion-wise F1 score: 0.86) on our internal test set compared to individual algorithms. This accuracy generalized well across diverse image and disease variables. Furthermore, the model excelled in extracting clinical biomarkers like lesion types and affected vascular territories. Notably, in a Turing-like test, neuroradiologists consistently preferred the algorithm’s segmentations over manual expert efforts, highlighting increased comprehensiveness and precision. Validation using a real-world external dataset (N=1686) confirmed the model’s generalizability (median Dice score: 0.82, median lesion-wise F1 score: 0.86). The algorithm’s outputs also demonstrated strong correlations with clinical scores (admission NIHSS and 90-day mRS) on par with or exceeding expert-derived results, underlining its clinical relevance. This study offers two key findings. First, we present an ensemble algorithm that detects and segments ischemic stroke lesions on DWI across diverse scenarios on par with expert (neuro)rad

关键词： Diagnosis

Perovskite superlattices with efficient carrier dynamics

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Research Square

research Square 2021年

作者： Xu, Sheng Lei, Yusheng Li, Yuheng Lu, Chengchangfeng Yan, Qizhang Gong, Huaxin Zhang, Song Zhou, Jiayun Zhang, Ruiqi Chen, Yimu Tsai, Hsinhan Gu, Yue Hu, Hongjie Lo, Yu-Hwa Nie, Wanyi Lee, Taeyoon Luo, Jian Yang, Kesong Jang, Kyung-In Department of Nanoengineering University of California San Diego La Jolla CA92093-0448 United States Department of Chemical Engineering Stanford University StanfordCA94305 United States Department of Electrical and Computer Engineering University of California San Diego La Jolla CA92093 United States Material Science and Engineering Program University of California San Diego La Jolla CA92093-0418 United States Los Alamos National Laboratory Los AlamosNM87545 United States School of Electrical and Electronic Engineering Yonsei University Seoul03722 Korea Republic of Department of Bio and Brain Engineering Korea Institute of Science and Technology Korea Republic of Department of Robotics Engineering Daegu Gyeongbuk Institute of Science and Technology Daegu42988 Korea Republic of Department of Bioengineering University of California San Diego La Jolla CA92093-0412 United States

Compared with their three-dimensional counterparts, low-dimensional metal halide perovskites with periodic inorganic/organic structures have shown promising stability and hysteresis-free electrical performance, which paves the way for next-generation optoelectronic devices. However, when integrated in devices, they have relatively limited efficiencies because devices usually require carrier transport through the film thickness direction. In conventionally grown single crystals, the carrier transport in the thickness direction is hindered by the insulating organic spacers. In addition, the strong quantum confinement from the organic spacers limits the generation and transport of free carriers. The carrier dynamics is further compromised by the presence of grain boundaries in polycrystals. Here, we report a low-dimensional metal halide perovskite superlattice with efficient carrier transport in three dimensions by epitaxial growth. Epitaxy on a slightly lattice-mismatched substrate compresses the organic spacers in the superlattice, which weakens the quantum confinement and further improves carrier dynamics. The performance of a low-dimensional perovskite superlattice solar cell has been certified under the quasi-steady state for the first time. Moreover, the device shows an unusually high open-circuit voltage, due to a unique intra-band exciton relaxation mechanism. © 2021, CC BY.

关键词： Grain boundaries

Automating Surgical Peg Transfer: Calibration with Deep Learning Can Exceed Speed, Accuracy, and Consistency of Humans

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arXiv 2020年

作者： Hwang, Minho Ichnowski, Jeff Thananjeyan, Brijen Seita, Daniel Paradis, Samuel Fer, Danyal Low, Thomas Goldberg, Ken Daegu Korea Republic of The Department of Electrical Engineering and Computer Sciences University of California Berkeley United States The Department of General Surgery University of California San Francisco East Bay OaklandCA94602 United States The Robotics Laboratory Sri International Menlo ParkCA94025 United States

Peg transfer is a well-known surgical training task in the Fundamentals of Laparoscopic Surgery (FLS). While human surgeons teleoperate robots such as the da Vinci to perform this task with high speed and accuracy, it is challenging to automate. This paper presents a novel system and control method using a da Vinci research Kit (dVRK) surgical robot and a Zivid depth sensor, and a human subjects study comparing performance on three variants of the peg-transfer task: unilateral, bilateral without handovers, and bilateral with handovers. The system combines 3D printing, depth sensing, and deep learning for calibration with a new analytic inverse kinematics model and time-minimized motion controller. In a controlled study of 3384 peg transfer trials performed by the system, an expert surgical resident, and 9 volunteers, results suggest that the system achieves accuracy on par with the experienced surgical resident and is significantly faster and more consistent than the surgical resident and volunteers. The system also exhibits the highest consistency and lowest collision rate. To our knowledge, this is the first autonomous system to achieve "superhuman" performance on a standardized surgical task. All data is available at https://***/view/surgicalpegtransfer. Copyright © 2020, The Authors. All rights reserved.

关键词： Calibration

Cover Image, Volume 6, Issue 10

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Health Science Reports 2023年第10期6卷

作者： Mohammad Faranoush Pooya Faranoush Iraj Heydari Mohammad Reza Foroughi-Gilvaee Azita Azarkeivan Ali Parsai Kia Negin Sadighnia Ali Elahinia Afsoon Zandi Mohammad Reza Rezvany Nahid Hashemi-Madani Amir Ziaee Reza Nekouian Farzaneh Rohani Pediatric Growth and Development Research Center Institute of Endocrinology Iran University of Medical Sciences Tehran Iran Cardio-Oncology Research Center Rajaie Cardiovascular Medical & Research Center Iran University of Medical Sciences Tehran Iran Nano Bio Electronic Devices Lab Cancer Electronics Research Group School of Electrical and Computer Engineering College of Engineering University of Tehran Tehran Iran Blood Transfusion Research Center High Institute for Research and Education in Transfusion Medicine Tehran Iran Robotics Research Laboratory School of Mechanical Engineering Iran University of Science and Technology Tehran Iran Department of Otolaryngology Head & Neck Surgery Taleghani Hospital Shahid Beheshti University of Medical Sciences Tehran Iran

The cover image is based on the research ArticleComplications in patients with transfusion dependent thalassemia: A descriptive cross‐sectional studyby Mohammad Faranoush et al.,https://***/10.1002/hsr2.1624

The cover image is based on the research Article Complications in patients with transfusion dependent thalassemia: A descriptive cross‐sectional study by Mohammad Faranoush et al., https://***/10.1002/hsr2.1624

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