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15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011

作者： Hou, Chenlu Herr, Amy E. University of California Electrical Engineering and Computer Science Berkeley United States University of California Bioengineering Berkeley United States University of California UCSF Graduate Program in Bioengineering Berkeley United States

ISBN: (纸本)9781618395955

Western blotting readily identifies specific proteins amidst complex biological backgrounds [1, 2]. Nevertheless, immunob-lotting suffers from tremendous labor-intensive and time-intensive requirements [3]. The slab-gel assays require 1-2 days for completion with multiple hands-on "blotting" steps and yield semi-quantitative information. Recently, our group has introduced new approaches for completing Western blotting. The microfluidic integration strategies introduced and used allow rapid results reporting, full assay automation, and limited sample consumption (1-10 uL). Our integration strategies use spatial, temporal, and spatiotemporal modulation of separation mechanisms in fully electrophoretic systems. The present study reports on recapitulation of immunoaffinity in previously sized proteins, using novel in-transit electrophoretic removal of SDS from SDS-protein complexes. Early results show both the length- and timescales for protein 'renaturation' are compatible with on-chip operation. Further, substantial binding affinity is recapitulated using this streamlined and promising approach.

关键词： Sodium dodecyl sulfate

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Accelerated oxidation of silicon due to x-ray irradiation

Accelerated oxidation of silicon due to x-ray irradiation

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12th European Conference on Radiation and Its Effects on Component and Systems, RADECS 2011

作者： Bhandaru, Shweta Zhang, En Xia Fleetwood, Daniel M. Reed, Robert A. Weller, Robert A. Weiss, Sharon M. Interdisciplinary Graduate Program in Material Science Vanderbilt University Nashville TN 37235 United States Department of Electrical Engineering and Computer Science Vanderbilt University Nashville TN 37235 United States

Enhanced rates of oxide growth have been observed on silicon when exposed to high-energy x-ray irradiation. This observed effect could potentially be utilized for remote total ionizing dose-sensing applications. ©... 详细信息

ISBN: (纸本)9781457705878

关键词： Silicon

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A Clonal Selection Algorithm for the container stacking problem

A Clonal Selection Algorithm for the container stacking prob...

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World Congress on Nature & Biologically Inspired Computing (NaBIC)

作者： Luiz Antonio Carraro Leandro Nunes de Castro Computer and Informatics Faculty & Graduate Program in Electrical Engineering Mackenzie University Sao Paulo Brazil

Due to increasing demand, container terminals face the challenges of increasing its service capacity and minimize the time of ships loading and unloading. The assignment of storage locations for reshuffled containers is a problem to the efficiency of container terminals operations, as a wrong assignment may result in several future reshuffles. This paper proposes a meta-heuristic based on the Clonal Selection Algorithm to minimize reshuffle when retrieving containers from a stack. The model competitiveness in accuracy and time are established by extensive numerical experiments comparing with an existing Integer program model. The preliminary results obtained here suggest the proposed model is a promising optimization tool for the container stacking problem.

关键词： Containers Stacking Cloning Optimization Immune system Loading Computational modeling

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Plasmonics with spatially engineered polarization

Plasmonics with spatially engineered polarization

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IEEE Photonics Conference (IPC)

作者： Qiwen Zhan Electro-Optics Graduate Program & Electrical and Computer Engineering University of Dayton Dayton OH USA

In this talk, I will present examples of plasmonic nanofocusing devices inspired by the polarization mode matching concept in antenna theory. These plasmonic devices can be applied in photo detector designs to provide... 详细信息

关键词： Plasmons Lenses Antenna radiation patterns Spirals Antenna theory Lighting Focusing

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Modularity detection in protein-protein interaction networks

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BMC Research Notes 2011年第1期4卷 1-6页

作者： Narayanan, Tejaswini Gersten, Merril Subramaniam, Shankar Grama, Ananth Department of Electrical and Computer Engineering University of California San Diego United States Graduate Program in Bioinformatics and Systems Biology University of California San Diego United States Department of Bioengineering University of California San Diego United States Department of Computer Science Purdue University West Lafayette IN United States

Background: Many recent studies have investigated modularity in biological networks, and its role in functional and structural characterization of constituent biomolecules. A technique that has shown considerable promise in the domain of modularity detection is the Newman and Girvan (NG) algorithm, which relies on the number of shortest-paths across pairs of vertices in the network traversing a given edge, referred to as the betweenness of that edge. The edge with the highest betweenness is iteratively eliminated from the network, with the betweenness of the remaining edges recalculated in every iteration. This generates a complete dendrogram, from which modules are extracted by applying a quality metric called modularity denoted by Q. This exhaustive computation can be prohibitively expensive for large networks such as Protein-Protein Interaction Networks. In this paper, we present a novel optimization to the modularity detection algorithm, in terms of an efficient termination criterion based on a target edge betweenness value, using which the process of iterative edge removal may be terminated. Results: We validate the robustness of our approach by applying our algorithm on real-world protein-protein interaction networks of Yeast, *** and Drosophila, and demonstrate that our algorithm consistently has significant computational gains in terms of reduced runtime, when compared to the NG algorithm. Furthermore, our algorithm produces modules comparable to those from the NG algorithm, qualitatively and quantitatively. We illustrate this using comparison metrics such as module distribution, module membership cardinality, modularity Q, and Jaccard Similarity Coefficient. Conclusions: We have presented an optimized approach for efficient modularity detection in networks. The intuition driving our approach is the extraction of holistic measures of centrality from graphs, which are representative of inherent modular structure of the underlying network, and the applic

关键词： Biological Network Jaccard Index Input Network High Betweenness Jaccard Similarity Coefficient

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Fiber Bragg grating sensing applications in temperature monitoring of three-phase induction motors

Fiber Bragg grating sensing applications in temperature moni...

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SBMO/IEEE MTT-S International Conference on Microwave and Optoelectronics (IMOC)

作者： Kleiton de Morais Sousa Angelo Alfredo Hafner Marcos Crespim Jonas Somenzi Valmir de Oliveira Hypolito José Kalinowski Jean Carlos Cardozo da Silva Electrical Engineering Graduate Program (PPGEE) Federal University of Technology of Paraná (UTFPR) Brazil Graduate Program on Electrical Engineering and Applied Computer Science (CPGEI) Federal University of Technology of Paraná (UTFPR) Brazil

This paper presents an analysis of simultaneous temperature and electrical parameters measurements in a three phase induction motor (TIM). The electrical parameters, namely voltage and current in the motor windings, were measured with Hall effect sensors and the temperature in the stator slots were monitored using fiber Bragg grating sensors (FBG). In the performed temperature analysis, two sets of sensors were used, containing four FBG in each fiber. Eight FBG sensors were uniformly distributed in the TIM stator. A special encapsulation of the sensor was elaborated to minimize mechanical disturbances in the fiber due to motor operation. Tests were performed with motor running at no load and with intentional voltage disturbances in the windings produced at every 15 minutes periods. It was observed that the temperature distribution is not uniform in the TIM stator either with or without a balanced voltage in the windings. A mean level increase of 0.5°C in temperature was registered in all of the sensors when there is a lack of balance in the voltage windings.

关键词： Temperature sensors Induction motors Optical sensors Temperature measurement Stators Bragg gratings

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EQTL AND MUTATIONAL ANALYSIS OF NB-LRR MEDIATED IMMUNITY TO POWDERY MILDEW

EQTL AND MUTATIONAL ANALYSIS OF NB-LRR MEDIATED IMMUNITY TO ...

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The 13th International Cereal Rusts and Powdery Mildews Conference(第13届国际禾谷类锈病与白粉病大会)

作者： Roger WISE Priyanka SURANA Greg FUERST Ruo XU Divya MISTRY Julie DICKERSON Dan NETTLETON Department of Statistics Iowa State UniversityAmesIowa 50011 Department of Plant Pathology and Microbiology Center for Plant Responses to Environmental StressesIowa State UniversityAmesIowa 50011 Department of StatisticsIowa State UniversityAmesIowa 50011 Bioinformatics and Computational Biology Graduate ProgramIowa State UniversityAmesIowa 50011 Department of Electrical and Computer Engineering Iowa State UniversityAmesIowa 50011USA Bioinformatics and Computational Biology Graduate ProgramIowa State UniversityAmesIowa 50011 Bioinformatics and Computational Biology Graduate Program Iowa State UniversityAmesIowa 50011 Department of Plant Pathology and MicrobiologyCenter for Plant Responses to Environmental StressesIowa State UniversityAmesIowa 50011 Department of Plant Pathology and Microbiology Center for Plant Responses to Environmental StressesIowa State UniversityAmesIowa 50011 Bioinformatics and Computational Biology Graduate Program Iowa State UniversityAmesIowa 50011 Crop and Insect GeneticsGenomicsand Informatics Research UnitU.S.Department of Agriculture-Agricultural Research ServiceIowa State UniversityAmesIowa 50011 Crop and Insect Genetics Genomicsand Informatics Research UnitU.S.Department of Agriculture-Agricultural Research ServiceIowa State UniversityAmesIowa 50011

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A Compton scattering suppression based image reconstruction method for Digital Breast Tomosynthesis

A Compton scattering suppression based image reconstruction ...

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IEEE International Workshop on Genomic Signal Processing and Statistics (GENSIPS)

作者： Shiyu Xu Ying Chen Department of Electrical and Computer Engineering Southem Illinois University Carbondale IL USA Department of Electrical and Computer Engineering and Biomedical Engineering Graduate Program Southem Illinois University Carbondale IL USA

In this paper, we present a novel statistical reconstruction method based on Compton noise suppression for Digital Breast Tomosynthesis. The physical modeling for X-ray's interaction with tissues was investigated. A Compton noise based statistical model with a conjugate prior was introduced. Results from our proposed method, Backprojection (BP) method, Simultaneous Algebraic Reconstruction Technique (SART) and Maximum Likelihood with Convex Algorithm (MLCA) were compared based on image quality analysis. Compared with other algorithms, our proposed method shows comparable performance. It also produces even better results in the Contrast to Noise Ratio (CNR) evaluation.

关键词： Image reconstruction Noise Attenuation Scattering Breast Reconstruction algorithms Image quality

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SYSTEMS BIOLOGY IN BARLEY POWDERY MILDEW INTERACTIONS

SYSTEMS BIOLOGY IN BARLEY POWDERY MILDEW INTERACTIONS

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The 13th International Cereal Rusts and Powdery Mildews Conference(第13届国际禾谷类锈病与白粉病大会)

作者： Roger WISE Priyanka SURANA Greg FUERST Ruo XU Dan NETTLETON Divya MISTRY Julie DICKERSON Lin WANG Tom BRUTNELL Department of Plant Pathology and Microbiology Center for Plant Responses to Environmental StressesIowa State UniversityAmesIowa 50011USA Department of Statistics Iowa State UniversityAmesIowa 50011USA Bioinformatics and Computational Biology Graduate ProgramIowa State UniversityAmesIowa 50011USA Bioinformatics and Computational Biology Graduate ProgramIowa State UniversityAmesIowa 50011USA Bioinformatics and Computational Biology Graduate Program Iowa State UniversityAmesIowa 50011USA Department of Plant Pathology and MicrobiologyCenter for Plant Responses to Environmental StressesIowa State UniversityAmesIowa 50011USA Crop and Insect Genetics Genomicsand Informatics Research UnitU.S.Department of Agriculture-Agricultural Research ServiceIowa State UniversityAmesIowa 50011USA Department of Plant Pathology and Microbiology Center for Plant Responses to Environmental StressesIowa State UniversityAmesIowa 50011USA Department of StatisticsIowa State UniversityAmesIowa 50011USA Bioinformatics and Computational Biology Graduate ProgramIowa State UniversityAmesIowa 50011USA Bioinformatics and Computational Biology Graduate Program Iowa State UniversityAmesIowa 50011USA Crop and Insect GeneticsGenomicsand Informatics Research UnitU.S.Department of Agriculture-Agricultural Research ServiceIowa State UniversityAmesIowa 50011USA Department of Electrical and Computer Engineering Iowa State UniversityAmesIowa 50011USA Boyce Thompson Institute for Plant ResearchCornell UniversityIthacaNY

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An Extension to the Contract-Net Protocol Applied to the Transport Planning Problem of Oil Products

An Extension to the Contract-Net Protocol Applied to the Tra...

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Workshop and School of Agent Systems, their Environment and Applications (WESAAC)

作者： Roni F. Banaszewski Kelvin E. Nogueira Jean M. Simão Lucia V. Arruda Cesar A. Tacla Graduate Program in Electrical Engineering and Industrial Computer Science (CPGEI) Federal University of Technology of Paraná (UTFPR) Curitiba Brazil

In supply chains of petroleum industry, maintaining a proper inventory level for multiple petroleum products is a crucial issue. Basically, this chain has several elements like producer bases, consumer bases and terminals that are linked by means of a multi-modal transport network. These elements must cooperate to achieve the global goal of the system with a minimized cost. To achieve this goal, this paper presents a multiagent protocol for simultaneous negotiations based on the Contract-Net and the application of this in the chain aforementioned. As a result, this protocol proved to be very efficient to return a feasible solution in a low processing time.

关键词： Computational modeling Waste materials Protocols Educational institutions Planning Proposals Conferences

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