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Frontiers in Biological Detection: From Nanosensors to Systems XVII 2025

作者： An, Huijin Laibinis, Paul E. Locke, Andrea K. Weiss, Sharon M. Interdisciplinary Material Science Program Vanderbilt University Nashville 37235 TN United States Department of Chemical and Biomolecular Engineering Vanderbilt University Nashville 37235 TN United States Department of Chemistry Vanderbilt University Nashville 37235 TN United States Department of Biomedical Engineering Vanderbilt University Nashville 37235 TN United States Department of Electrical and Computer Engineering Vanderbilt University Nashville 37235 TN United States

ISBN: (纸本)9781510684249

A paper-based biosensor integrating a functionalized porous silicon (PSi) membrane as the active sensing element for quantifiable protein detection has been developed. For similar short-time exposures to an analyte, improved molecular transport in PSi membranes when on paper leads to larger signal changes compared to traditional PSi films that remain on a silicon substrate. In this work, we discuss controlling the incubation time of the analyte and the overall testing time of the sensor by incorporating different combinations of wicking and absorbent paper beneath the PSi membrane. With this control, the PSi-on-paper sensor platform has the potential to serve as an effective low-cost rapid diagnostic test with highly sensitive, quantitative readout for a wide range of analytes. © 2025 SPIE.

关键词： optical biosensor paper-based sensor porous silicon rapid diagnostic test

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DESCRIPTION AND PERFORMANCE OF A FIBEROPTIC CONFOCAL FLUORESCENCE SPECTROMETER

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APPLIED SPECTROSCOPY 1994年第3期48卷 350-355页

作者： RICHARDSKORTUM, R DURKIN, A ZENG, J Biomedical Engineering Program Department of Electrical and Computer Engineering University of Texas at Austin Austin Texas 78712

We describe a fiber-optic-based confocal fluorescence spectrometer for obtaining depth-resolved, attenuated fluorescence emission spectra with lateral resolution of several microns and depth resolution of tens of microns. The confocal optics of the spectrometer are small, inexpensive, and easy to construct and to interface to existing spectrometers. We compare the performance of this system to that of conventional fluorescence spectrometers for nonscattering homogeneous and inhomogeneous samples. We demonstrate that the confocal measurements readily provide information about the sample geometry and optical properties not available from nonconfocal measurements. Potential applications of the technique are discussed.

关键词： FLUORESCENCE SPECTROSCOPY CONFOCAL FIBER OPTIC

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ACOUSTIC TRANSMISSION OF THE RESPIRATORY SYSTEM USING SPEECH STIMULATION

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IEEE TRANSACTIONS ON BIOMEDICAL engineering 1991年第2期38卷 126-132页

作者： COHEN, A BERSTEIN, AD Department of Electrical and Computer Engineering Biomedical Engineering Program Ben-Gurion University of the Negev Beersheba Israel

Two methods for the analysis of the acoustic transmission of the respiratory system are presented. Continuous speech utterance is used as acoustic stimulation. The transmitted acoustic signal is recorded from various sites over the chest wall. The AR method analyzes the power spectral density function of the transmitted sound, which heavily depends on the microphone assembly and the utterance. The method was applied to a screening problem and was tested on a small database that consisted of 19 normal and five abnormal patients. Using the first five AR coefficients and the prediction error of an AR(10) model, as discriminating features, the system screened all abnormals. An ARMA method is suggested, which eliminates the dependence on microphone and utterance. In this method, the generalized least squares identification algorithm is used to estimate the ARMA transfer function of the respiratory system. The normal transfer function demonstrates a peak at the range of 130-250 Hz and sharp decrease in gain for higher frequencies. A pulmonary fibrotic patient demonstrated a peak at the same frequency range, a much higher gain in the high frequency range with an additional peak at about 700 Hz.

关键词： Microphone Device Component Error of prediction frequency ranges Respiratory System Thoracic Wall power spectral density function TRANSFER FUNCTIONS sound transmission

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Unavoidable multilevel biaxial symmetry breaking in chiral hybrid liquid crystals

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Physical Review E 2025年第4期111卷 045410-045410页

作者： Jin-Sheng Wu Marina Torres Lázaro Souvik Ghosh Haridas Mundoor Henricus H. Wensink Ivan I. Smalyukh Department of Physics and Chemical Physics Program University of Colorado Boulder Colorado 80309 USA Laboratoire de Physique des Solides–UMR 8502 Université Paris-Saclay and CNRS 91405 Orsay France International Institute for Sustainability with Knotted Chiral Meta Matter Hiroshima University Higashihiroshima Japan Department of Electrical Computer and Energy Engineering Materials Science and Engineering Program and Soft Materials Research Center University of Colorado Boulder Colorado 80309 USA Renewable and Sustainable Energy Institute National Renewable Energy Laboratory and University of Colorado Boulder Colorado 80309 USA

Chiral nematic or cholesteric liquid crystals (LCs) are fluid mesophases with long-ranged orientational order featuring a quasilayered periodicity imparted by a helical director configuration but lacking long-range positional order. Doping molecular cholesteric LCs with strongly anisotropic uniaxial colloidal particles adds another level of complexity because of the interplay between weak surface-anchoring boundary conditions and bulk-based elastic distortions near the particle-LC interface. Using cylindrical colloidal disks and rods with different geometric shapes and surface conditions, we demonstrate that these colloidal inclusions generically exhibit biaxial orientational probability distributions which may impart anomalously strong local biaxiality onto the hybrid cholesteric LC structure. Unlike nonchiral hybrid molecular-colloidal LCs, where biaxial order emerges only at critical colloid volume fractions exceeding some uniaxial-biaxial transition value, the orientational probability of the colloidal inclusions immersed in chiral nematic hosts is unambiguously biaxial even at infinite dilution. We demonstrate that the colloids induce local biaxial perturbations within the molecular orientational order of the LC host medium which strongly enhances the weak but native biaxial order of chiral nematic LC induced by the chiral symmetry breaking of the director field. With the help of analytical modeling and computer simulations based on the Landau–de Gennes free energy of the host LC around the colloids, we rationalize the observed multilevel biaxial order and conclude that it is not only unavoidable but also strongly enhanced compared to both achiral hybrid LCs and purely molecular cholesteric LCs.

关键词： Cholesteric liquid crystals

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MICROcomputer REALIZATIONS OF LYNN FAST DIGITAL-FILTERING DESIGNS

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MEDICAL & BIOLOGICAL engineering & COMPUTING 1980年第5期18卷 638-642页

作者： MALIK, NR Electrical & Computer Engineering Program University of Iowa Iowa City Iowa USA

The feasibility of real-time digital filtering using dedicated state-of-the-art microcomputers of 8-bit wordlength is demonstrated. Implementations of Lynn's integer filter structures by means of wrap-around queue data structures are shown to operate at sampling rates of over 8 kHz. An initial condition constraint unique to this filter class which must be satisfied to prevent inadvertent overflows or oscillations in microcomputers is discussed. The fast-filtering techniques are applied to the problem of calculating the average absolute value of a fast signal in real time.

关键词： Digital filters Microcomputers Online computing Signal processing

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Probabilistic genotype-phenotype maps reveal mutational robustness of RNA folding, spin glasses, and quantum circuits

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Physical Review Research 2025年第1期7卷 013118-013118页

作者： Anna Sappington Vaibhav Mohanty Department of Electrical Engineering and Computer Science Massachusetts Institute of Technology Cambridge Massachusetts 02139 USA Harvard-MIT Program in Health Sciences and Technology Harvard Medical School Boston Massachusetts 02115 USA and Massachusetts Institute of Technology Cambridge Massachusetts 02139 USA Harvard/MIT MD-PhD Program Harvard Medical School Boston Massachusetts 02115 USA and Massachusetts Institute of Technology Cambridge Massachusetts 02139 USA Department of Chemistry and Chemical Biology Harvard University Cambridge Massachusetts 02138 USA

Recent studies of genotype-phenotype maps have reported universally enhanced phenotypic robustness to genotype mutations, a feature essential to evolution. Virtually all of these studies make a simplifying assumption that each genotype—represented as a sequence—maps deterministically to a single phenotype, such as a discrete structure. Here we introduce probabilistic genotype-phenotype (PrGP) maps, where each genotype maps to a vector of phenotype probabilities, as a more realistic and universal language for investigating robustness in a variety of physical, biological, and computational systems. We study three model systems to show that PrGP maps offer a generalized framework which can handle uncertainty emerging from various physical sources: (1) thermal fluctuation in RNA folding, (2) external field disorder in the spin-glass ground state search problem, and (3) superposition and entanglement in quantum circuits, which are realized experimentally on IBM quantum computers. In all three cases, we observe a biphasic robustness scaling which is enhanced relative to random expectation for more frequent phenotypes and approaches random expectation for less frequent phenotypes. We derive an analytical theory for the behavior of PrGP robustness, and we demonstrate that the theory is highly predictive of empirical robustness.

关键词： Quantum computers

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Set-theoretic detection of data corruption attacks on cyber physical power systems

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Journal of Modern Power Systems and Clean Energy 2018年第5期6卷 872-886页

作者： Efstathios KONTOURAS Anthony TZES Leonidas DRITSAS Electrical and Computer Engineering Department University of Patras Electrical and Computer Engineering Program New York University Abu Dhabi Department of Electrical and Electronic Engineering Educators School of Pedagogical and Technological EducationASPETE 14121 Athens Greece

This paper addresses a set-theoretic method for the detection of data corruption cyber-attacks on the load frequency control loop of a networked power system. The system consists of several interconnected control areas forming a power grid. Based on the overall discrete-time network dynamics, a convex and compact polyhedral robust invariant set is extracted and is used as a set-induced anomaly detector. If the state vector exits the invariant set,then an alarm will be activated, and the potential threat is considered disclosed. The attack scenario used to assess the efficiency of the proposed anomaly detector concerns corrupted frequency sensor measurements transmitted to the automatic generation control unit of a compromised control area. Simulation studies highlight the ability of a set-theoretic approach to disclose persistent and intermittent attack patterns even when they occur at the same time with changes in the power load demand.

关键词： Power systems Load frequency control Cyber-attacks Set-theoretic methods

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FAULT TOLERANCE ANALYSIS OF THE CLASS OF REARRANGEABLE INTERCONNECTION NETWORKS

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JOURNAL OF PARALLEL AND DISTRIBUTED COMPUTING 1989年第1期7卷 148-164页

作者： PAKZAD, S Computer Engineering Program Department of Electrical Engineering The Pennsylvania State University University Park Pennsylvania 16802 USA

The issue of the fault tolerance of interconnection networks has received considerable attention since the last decade. The theoretical framework developed by J. P. Shen and J. P. Hays ( IEEE Trans. Comput. C-33 , 3 (Mar. 1984), 241–248) and extended by S. Pakzad and S. Lakshmivarahan ( Internat. J. Comput. Syst. Sci. Engrg. 3 , 2 (April 1988), 91–99) can be used as a guideline to analyze the fault tolerance behavior of the interconnection networks in a multicomputer environment. This paper analyzes the fault tolerance characteristics of a range of rearrangeable β-networks based on the concepts and the framework developed by S. Pakzad and S. Lakshmivarahan (cited earlier). These rearrangeable β-networks include the Benes network, the Waksman network, the Joel network, and the serial network. In addition, this paper presents a comparative analysis of the aforementioned networks according to their hardware cost, performance, and degree of fault tolerance.

关键词： computer Systems, Digital

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Investigation of Noise at a Microelectrode during a Faradaic Reaction

ACS Electrochemistry

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ACS Electrochemistry 2025年第4期1卷 552-559页

作者： Kaden Wheeler Joseph Gott Brian Roehrich Julia Chung Kajal Kajal Jaroslaw Syzdek Joao Hespanha Lior Sepunaru Department of Chemistry and Biochemistry University of California at Santa Barbara Santa Barbara California 93106 United States Interdepartmental Program in Biomolecular Science and Engineering University of California at Santa Barbara Santa Barbara California 93106 United States Bio-Logic USA LLC 9050 Executive Park Dr. Ste. 110C Knoxville Tennessee 37923 United States Electrical and Computer Engineering Department University of California at Santa Barbara Santa Barbara California 93106 United States

Measurement of small currents is often impeded by a suboptimal signal-to-noise ratio, largely due to background noise. This background noise significantly constrains the range of catalysts accessible for interrogation via micro- and nanoscale electrochemistry. In response, this work reveals how background noise scales in the presence of induced Faradaic reactions. We measured noise under a series of electrochemical conditions and discovered that the induced noise from a Faradaic reaction scales directly with current. Complementary electrochemical impedance spectroscopy measurements demonstrated that diffusional resistance dictates the noise of Faradaic reactions, independent of the electrochemical mechanism. The noise source is thermal in origin and propagates in a predictable trend, which is inversely proportional to the equivalent diffusional resistance of the analyte. The universality of the observed phenomenon allows for better deconvolution of measured charge from background noise, thus assisting in achieving higher resolution and measurement precision, which is a key in micro- and nanoscale electrochemical measurements.

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Sources of contrast in confocal reflectance imaging

引用

APPLIED OPTICS 1996年第19期35卷 3441-3446页

作者： Dunn, AK Smithpeter, C Welch, AJ RichardsKortum, R []The authors are with the Department of Electrical and Computer Engineering Biomedical Engineering Program University of Texas at Austin Austin Texas 78712

The relationship between optical properties and image contrast in confocal imaging is investigated. A Monte Carlo simulation has been developed to analyze the effects of changes in scattering, index of refraction, and absorption in a three-layer medium. Contrast was calculated from the computed signal-to-background ratios for changes in tissue optical properties. Results show that the largest source of contrast is changes in refractive index. (C) 1996 Optical Society of America

关键词： .Monte Carlo optical properties pinhole detector relative contributions signal-to-background source of contrast signal contrast

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