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Correction to: Pharmacological Rescue With SR8278, A Circadian Nuclear Receptor REV-ERBα Antagonist As A Therapy for Mood Disorders In Parkinson's Disease

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Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 2022年第4期19卷 1432页

作者： Jeongah Kim Inah Park Sangwon Jang Mijung Choi Doyeon Kim Woong Sun Youngshik Choe Ji-Woong Choi Cheil Moon Sung Ho Park Han Kyoung Choe Kyungjin Kim Department of Brain Sciences Daegu Gyeongbuk Institute of Science and Technology (DGIST) Daegu 42988 Korea. Department of Anatomy College of Medicine Korea University Seoul Korea. Program in Neurosciences & Mental Health The Hospital for Sick Children Toronto ON Canada. Korea Brain Research Institute (KBRI) Daegu Korea. Department of Electrical Engineering and Computer Science DGIST Daegu Korea. Convergence Research Advanced Centre for Olfaction DGIST Daegu Korea. Department of Biological Sciences Ulsan National Institute of Science and Technology (UNIST) Ulsan 44919 Korea. Department of Brain Sciences Daegu Gyeongbuk Institute of Science and Technology (DGIST) Daegu 42988 Korea. kyungjin@dgist.ac.kr. Convergence Research Advanced Centre for Olfaction DGIST Daegu Korea. kyungjin@dgist.ac.kr.

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Pre-training of deep bidirectional protein sequence representations with structural information

arXiv

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arXiv 2019年

作者： Min, Seonwoo Park, Seunghyun Kim, Siwon Choi, Hyun-Soo Lee, Byunghan Yoon, Sungroh Department of Electrical and Computer engineering Seoul National University Seoul08826 Korea Republic of LG AI Research Seoul07796 Korea Republic of Clova AI Research NAVER Corp. Seongnam13561 Korea Republic of Department of Computer Science and Engineering Kangwon National University Chuncheon24341 Korea Republic of Department of Electronic and IT Media Engineering Seoul National University of Science and Technology Seoul01811 Korea Republic of Interdisciplinary Program in Artificial Intelligence ASRI INMC Institute of Engineering Research Seoul National University Seoul08826 Korea Republic of

Bridging the exponentially growing gap between the numbers of unlabeled and labeled protein sequences, several studies adopted semi-supervised learning for protein sequence modeling. In these studies, models were pre-trained with a substantial amount of unlabeled data, and the representations were transferred to various downstream tasks. Most pre-training methods solely rely on language modeling and often exhibit limited performance. In this paper, we introduce a novel pre-training scheme called PLUS, which stands for Protein sequence representations Learned Using Structural information. PLUS consists of masked language modeling and a complementary protein-specific pre-training task, namely same-family prediction. PLUS can be used to pre-train various model architectures. In this work, we use PLUS to pre-train a bidirectional recurrent neural network and refer to the resulting model as PLUS-RNN. Our experiment results demonstrate that PLUS-RNN outperforms other models of similar size solely pre-trained with the language modeling in six out of seven widely used protein biology tasks. Furthermore, we present the results from our qualitative interpretation analyses to illustrate the strengths of PLUS-RNN. PLUS provides a novel way to exploit evolutionary relationships among unlabeled proteins and is broadly applicable across a variety of protein biology tasks. We expect that the gap between the numbers of unlabeled and labeled proteins will continue to grow exponentially, and the proposed pre-training method will play a larger role. All the data and codes used in this study are available at https://***/mswzeus/PLUS. © 2019, CC BY-NC-ND.

关键词： Proteins

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Development of a smartphone-based app for determination of formaldehyde concentration indoors 15

Development of a smartphone-based app for determination of f...

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15th Conference of the International Society of Indoor Air Quality and Climate, INDOOR AIR 2018

作者： Zhang, Siyang Shapiro, Nicholas Gehrke, Gretchen Castner, Jessica Liu, Zhenlei Guo, Beverly Zhang, Jianshun Haines, Sarah Kormos, David Frey, Paige Qin, Rongjun Dannemiller, Karen C. Department of Computer Science and Engineering Ohio State University United States Public Laboratory for Open Technology and Science Department of Mechanical and Aerospace Engineering Syracuse University Environmental Science Graduate Program Ohio State University United States Department of Civil Environmental and Geodetic Engineering College of Engineering Ohio State University United States Strand Associates Incorporated Department of Electrical and Computer Engineering Ohio State University United States Department of Environmental Health Sciences College of Public Health Ohio State University United States

ISBN: (纸本)9781713826514

Formaldehyde is a ubiquitous contaminant in the indoor environment that is both a carcinogen and irritant. The goal of this project is to develop a smartphone-based app for use by citizen scientists or researchers that can be paired with low-cost colorimetric badges for detection of indoor formaldehyde. We conducted both national and geographically-targeted surveys prior to app design. We have subsequently developed the app and conducted a beta test. Surveys of 147 individuals indicated broad public interest in formaldehyde testing using smartphone technology. Testing of the badges indicated consistent change in illumination with increasing formaldehyde exposure. Beta testing indicated users were able to navigate the existing app, and highlighted areas for improvement including incorporation of public surveys. Planned future analysis includes extensive calibration testing and a community-based field test. © 2018 15th Conference of the International Society of Indoor Air Quality and Climate, INDOOR AIR 2018. All rights reserved.

关键词： Formaldehyde

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The limits of near Field Immersion Microwave Microscopy evaluated by imaging bilayer graphene Moiré patterns

arXiv

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arXiv 2020年

作者： Ohlberg, Douglas A.A. Tami, Diego Gadelha, Andreij C. Neto, Eliel G.S. Santana, Fabiano C. Miranda, Daniel Avelino, Wellington Watanabe, Kenji Taniguchi, Takashi Campos, Leonardo C. Ramirez, Jhonattan C. do Rego, Cássio Gonçalves Jorio, Ado Medeiros-Ribeiro, Gilberto Microscopy Center Universidade Federal de Minas Gerais Belo HorizonteMG31270-901 Brazil Electrical Engineering Graduate Program Universidade Federal de Minas Gerais Belo HorizonteMG31270-901 Brazil Physics Department Universidade Federal de Minas Gerais Belo HorizonteMG31270-901 Brazil Instituto de Física Universidade Federal da Bahia Campus Universitário de Ondina Salvador - BA40170-115 Brazil 1-2-1 Sengen Tsukuba-cityIbaraki305-0047 Japan Department of Electronic Engineering School of Engineering Universidade Federal de Minas Gerais Belo HorizonteMG31270-901 Brazil Technology Innovation Graduate Program Universidade Federal de Minas Gerais Belo HorizonteMG31270-901 Brazil Computer Science Department Universidade Federal de Minas Gerais Belo HorizonteMG31270-901 Brazil

Molecular and atomic imaging required the development of electron and scanning probe microscopies to surpass the physical limits dictated by diffraction [1]. Nano-infrared experiments [2] and pico-cavity tip-enhanced Raman spectroscopy imaging later demonstrated that radiation in the visible range [3] can surpass this limit by using scanning probe tips to access the near-field regime [4]. Here we show that ultimate resolution can be obtained by using scanning microwave imaging microscopy to reveal structures with feature sizes down to 1 nm using a radiation of 0.1 m in wavelength. As a test material we use twisted bilayer graphene, which is not only a very important recent topic due to the discovery of correlated electron effects such as superconductivity [5], but also because it provides a sample where we can systematically tune a superstructure Moiré patterńs modulation from below one up to tens of nanometers. By analyzing the tip-sample distance dynamics, we demonstrate that this ultimate 108 probe-to-pattern resolution can be achieved by using liquid immersion microscopy concepts and exquisite force control exerted on nanoscale water menisci. Copyright © 2020, The Authors. All rights reserved.

关键词： Moire fringes

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Multi-UAVs communication for payload data link enhancement under asynchronous access

Multi-UAVs communication for payload data link enhancement u...

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International Conference on Wireless and Optical Communications ( WOCC)

作者： Yun-Ruei Li Hsin-Piao Lin Li-Chun Wang Abebe Belay Adege Li-Yong Chen Department of Electronic Engineering National Taipei University of Technology Taipei Taiwan Department of Electrical Engineering National Chiao Tung University Hsinchu Taiwan Department of International Graduate Program in Electrical Engineering and Computer Science (EECS) National Taipei University of Technology Taipei Taiwan

Recently, unmanned Aerial Vehicles (UAVs) are widely applied in civilian and commercial areas. In order to rapidly arrange the UAVs in a variable and changeable environment, the technique of maintaining stable and reliable communication link between Ground Control Station (GCS) and UAVs is one of the main issues [1]. However, UAVs deployment can significantly increase the efficiency of missions execution and the flexibility of task allocation. As discussed by different scholars, multi-UAVs have a number of advantages depending on the application areas: disaster areas monitoring, wireless sensor data collection in precision agriculture, and relay-aided of UAVs network topology [2].

关键词： OFDM Resource management Interference Wireless communication Payloads Bandwidth Optical filters

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P-2: Hydrogenated SnO for p-channel oxide Thin Film Transistor

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SID Symposium Digest of Technical Papers 2020年第1期51卷

作者： Alex Wootae Lee Kosuke Matsuzaki Kenji Nomura Materials Science and Engineering program University of California San Diego La Jolla California 92092 USA Materials and Structures Laboratory Tokyo Institute of Technology Nagatsuta Midori-ku Yokohama 226-8503 Japan Department of Electrical and Computer Engineering University of California San Diego La Jolla California 92092 USA

Subgap defect termination for p-type Tin monoxide (SnO) is developed with thermal annealing in hydrogen ambient for p-channel oxide thin-film transistor (TFT). High-performance p-channel oxide TFT with the TFT mobility of ~1.4-1.8 cm 2 /Vs and large on-to-off current as large as 10 5 was demonstrated. Hydrogen-containing annealing also maintains SnO phase stable up to 390 °C and effectively reduces the subgap defect, which offer the improvement in TFT characteristics.

关键词： p-channel oxide thin film transistor tin monoxide hydrogen defect termination hydrogenated SnO

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Computationally designed proteins mimic antibody immune evasion in viral evolution

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Immunity 2025年第6期58卷 1411-1421.e6页

作者： Youssef, Noor Gurev, Sarah Ghantous, Fadi Brock, Kelly P. Jaimes, Javier A. Thadani, Nicole N. Dauphin, Ann Sherman, Amy C. Yurkovetskiy, Leonid Soto, Daria Estanboulieh, Ralph Kotzen, Ben Notin, Pascal Kollasch, Aaron W. Cohen, Alexander A. Dross, Sandra E. Erasmus, Jesse Fuller, Deborah H. Bjorkman, Pamela J. Lemieux, Jacob E. Luban, Jeremy Seaman, Michael S. Marks, Debora S. Department of Systems Biology Harvard Medical School Boston 02115 MA United States Broad Institute of Harvard and MIT Cambridge 02139 MA United States Department of Electrical Engineering and Computer Science MIT Cambridge 02139 MA United States Center for Virology and Vaccine Research Beth Israel Deaconess Medical Center Boston 02215 MA United States Program in Molecular Medicine University of Massachusetts Chan Medical School Worcester 01655 MA United States Division of Infectious Diseases Department of Medicine Brigham and Women's Hospital Boston 02115 MA United States Massachusetts General Hospital Boston 02114 MA United States Division of Biology and Biological Engineering California Institute of Technology Pasadena 91125 CA United States Department of Microbiology University of Washington Seattle 98195 WA United States National Primate Research Center Seattle 98109 WA United States HDT Bio Seattle 98109 WA United States Massachusetts Consortium on Pathogen Readiness Boston 02115 MA United States Ragon Institute of MGH MIT and Harvard Cambridge 02139 MA United States

Recurrent waves of viral infection necessitate vaccines and therapeutics that remain effective against emerging viruses. Our ability to evaluate interventions is currently limited to assessments against past or circulating variants, which likely differ in their immune escape potential compared with future variants. To address this, we developed EVE-Vax, a computational method for designing antigens that foreshadow immune escape observed in future viral variants. We designed 83 SARS-CoV-2 spike proteins that transduced ACE2-positive cells and displayed neutralization resistance comparable to variants that emerged up to 12 months later in the COVID-19 pandemic. Designed spikes foretold antibody escape from B.1-BA.4/5 bivalent booster sera seen in later variants. The designed constructs also highlighted the increased neutralization breadth elicited by nanoparticle-based, compared with mRNA-based, boosters in non-human primates. Our approach offers targeted panels of synthetic proteins that map the immune landscape for early vaccine and therapeutic evaluation against future viral strains. © 2025 The Authors

关键词： antibody escape generative protein models immune landscape machine learning protein design vaccine evaluation viral evolution

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Biaxial optical accelerometer based on ultra-high numerical aperture fiber for structural and electrical machines vibrations analysis

Biaxial optical accelerometer based on ultra-high numerical ...

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Bragg Gratings, Photosensitivity and Poling in Glass Waveguides and Materials, BGPPM 2018

作者： Linessio, Rafael Pomorski da Silva, Jean Carlos Cardozo Tavares, Lucas Henrique dos Santos da Silva, Thiago Bavastri, Carlos Alberto Antunes, Paulo Fernando da Costa Graduate Program in Electrical and Computer Engineering Federal University of Technology - Paraná Av. Sete de Setembro 3165 Curitiba Paraná80.230-901 Brazil Graduate Program in Mechanical Engineering Federal University of Paraná Av. Coronel Francisco Heráclito dos Santos 100 Curitiba Paraná81.531-980 Brazil Instituto de Telecomunicações and I3N Departamento de Física University of Aveiro 3810-193 Portugal

This paper presents a biaxial optical accelerometer using the Ultra-High NA fiber, for vibrations analysis in structures and electrical machines. The main characteristic of this sensor is smaller size and the higher n... 详细信息

ISBN: (纸本)9781943580439

关键词： Vibration analysis

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Aperture-Coupled Koch Fractal on-Chip Antennas for 60 GHz ISM Band

Aperture-Coupled Koch Fractal on-Chip Antennas for 60 GHz IS...

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IEEE MTT-S Latin America Microwave Conference (LAMC)

作者： Samuel Medeiros Araújo Morais Alexandre Jean René Serres Ivana Soares Guarany Raimundo Carlos da Silverio Freire Paulo Fernandes da Silva Ewaldo Elder Carvalho Santana Paulo Henrique da Fonseca Silva Post-Graduation Program in Electrical Engineering Federal University of Campina Grande Campina Grande Brazil Post-Graduation Program in Computer Engineering and Systems State University of Maranhão São Luis Brazil Post-Graduation Program in Electrical Engineering Federal Institute of Education Science and Technology of Paraíba João Pessoa Brazil

ISBN: (纸本)9781538673348;9781538673331

This paper presents Koch fractal aperture-coupled patch antennas operating in industrial scientific and medical band at 60 GHz (57 GHz to 64 GHz), for on-chip application. This work is the continuation of the development of aperture-coupled antennas with aperture and patch element built in 2 μm-thick aluminum lying on two layers of silicon with a height of 200 μm. The use of Koch fractal allowed the development of aperture-coupled antennas of greater perimeter with more metal in the patch elements, which promoted an increase in the gain. The observed gain for Koch fractal level 2 was of 10.55 dBi, with a bandwidth of 7.23 GHz, covering the ISM 60 GHz Band, and an increase of less than 10% in total patch dimension. For Koch fractal levels 0 (square), a polarization close to circular was achieved, with an axial ratio less than 6 at resonant frequencies.

关键词： Fractals Patch antennas Resonant frequency Aperture antennas Bandwidth Gain

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Quantum Simulation for High-Energy Physics

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PRX Quantum 2023年第2期4卷 027001-027001页

作者： Christian W. Bauer Zohreh Davoudi A. Baha Balantekin Tanmoy Bhattacharya Marcela Carena Wibe A. de Jong Patrick Draper Aida El-Khadra Nate Gemelke Masanori Hanada Dmitri Kharzeev Henry Lamm Ying-Ying Li Junyu Liu Mikhail Lukin Yannick Meurice Christopher Monroe Benjamin Nachman Guido Pagano John Preskill Enrico Rinaldi Alessandro Roggero David I. Santiago Martin J. Savage Irfan Siddiqi George Siopsis David Van Zanten Nathan Wiebe Yukari Yamauchi Kübra Yeter-Aydeniz Silvia Zorzetti Physics Division Lawrence Berkeley National Laboratory Berkeley California 94720 USA Department of Physics Maryland Center for Fundamental Physics and the NSF Institute for Robust Quantum Simulation University of Maryland College Park Maryland 20742 USA Department of Physics University of Wisconsin Madison Wisconsin 53706 USA T-2 Los Alamos National Laboratory Los Alamos New Mexico 87545 USA Fermi National Accelerator Laboratory Batavia Illinois 60510 USA Enrico Fermi Institute University of Chicago Chicago Illinois 60637 USA Kavli Institute for Cosmological Physics University of Chicago Chicago Illinois 60637 USA Department of Physics University of Chicago Chicago Illinois 60637 USA Department of Physics and Illinois Center for the Advanced Study of the Universe and Illinois Quantum Information Science and Technology Center University of Illinois Urbana Illinois 61801 USA QuEra Computing Inc Boston Massachusetts 02135 USA Department of Mathematics University of Surrey Guildford Surrey GU2 7XH United Kingdom Center for Nuclear Theory Department of Physics and Astronomy Stony Brook University New York 11794-3800 USA Department of Physics Brookhaven National Laboratory Upton New York 11973 USA Peng Huanwu Center for Fundamental Theory Hefei Anhui 230026 China Interdisciplinary Center for Theoretical Study University of Science and Technology of China Hefei Anhui 230026 China Pritzker School of Molecular Engineering Chicago Quantum Exchange and Kadanoff Center for Theoretical Physics University of Chicago Illinois 60637 USA qBraid Co. Harper Court 5235 Chicago Illinois 60615 USA Department of Physics Harvard University Cambridge Massachusetts 02138 USA Department of Physics and Astronomy University of Iowa Iowa City Iowa 52242 USA Duke Quantum Center Duke University Durham North Carolina 27701 USA Department of Electrical and Computer Engineering Duke University Durham North Carolina 27708 USA Department of Physics Duke University

It is for the first time that quantum simulation for high-energy physics (HEP) is studied in the U.S. decadal particle-physics community planning, and in fact until recently, this was not considered a mainstream topic in the community. This fact speaks of a remarkable rate of growth of this subfield over the past few years, stimulated by the impressive advancements in quantum information sciences (QIS) and associated technologies over the past decade, and the significant investment in this area by the government and private sectors in the U.S. and other countries. High-energy physicists have quickly identified problems of importance to our understanding of nature at the most fundamental level, from tiniest distances to cosmological extents, that are intractable with classical computers but may benefit from quantum advantage. They have initiated, and continue to carry out, a vigorous program in theory, algorithm, and hardware co-design for simulations of relevance to the HEP mission. This Roadmap is an attempt to bring this exciting and yet challenging area of research to the spotlight, and to elaborate on what the promises, requirements, challenges, and potential solutions are over the next decade and beyond.

关键词： Quantum simulation

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