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Gene sets enrichment analysis of miRNA expression profile

Gene sets enrichment analysis of miRNA expression profile

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IEEE International Conference on Bioinformatics and Biomedicine Workshops (BIBMW)

作者： Tzu-Hung Hsiao Hung-I Harry Chen Patricia C. Sanchez-Diaz Jaclyn Y. Hung Yidong Chen Yufei Huang Greehey Childrens Cancer Research Institute University of Texas Health Science Center San Antonio San Antonio TX USA University of Texas School of Public Health - El Paso El Paso TX US Department of Electrical and Computer Engineering University of Texas-San Antonio San Antonio TX USA

Alteration in expression levels of genes as well as their regulatory components, such as those levels of miRNAs in cancer cells will likely reflect in the enrichment of unique cellular functions and biological processes in their corresponding cell systems. By employing systems biology approaches, and instead of examining individual gene, we will directly and unambiguously identify the regulatory pathways and biological processes that are distinctive to specific disease states or responses to therapeutic treatment. In this study, we employ gene set enrichment analysis inspired method to explore the functional regulation of miRNAs. The analysis integrated a mathematic model that associates miRNAs to gene sets through miRNA target genes with a statistic test of enrichment to study the regulation change at a specific pathway. Different from conventional individual miRNA processing procedures, our method enables researchers to construct regulation hypothesis at pathway and functional levels.

关键词： Cancer Gene expression Proteins Humans Biological processes Tumors

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eDemocs: Electronic distributed election monitoring over cellular systems

eDemocs: Electronic distributed election monitoring over cel...

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5th International Conference on Internet and Web Applications and Services, ICIW 2010

作者： Osborn, Duncan Rangarajan, Karthik Ivey, Emily Narendra, Sumanth M. Hunter, Michael T. School of Electrical and Computer Engineering Georgia Institute of Technology United States School of Computer Science Georgia Institute of Technology United States School of Public Policy Georgia Institute of Technology United States

ISBN: (纸本)9780769540221

Formal election observation involves appointed observers recording and reporting remote observations over the duration of an election and analysts promptly issuing conclusions based on studying these observations. This paper discusses the design and performance of eDemocs (Electronic Distributed Election Monitoring over Cellular Systems), created to aid the election monitoring process by enabling rapid and trustworthy flow of observations from the reporting sites along with immediate access to the observations by the analysts. We discuss the architecture for our system and evaluate a prototype implementation and trial deployment in a US election. Our architecture is shown to be feasible and to demonstrate several desirable qualities, including integrity guarantees and full deployability in developing countries through reliance on SMS messaging without requiring Internet connectivity. © 2010 IEEE.

关键词： Monitoring

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Benefits of hybrid wind-pumped storage unit in a non-interconnected power system using optimal power flow

Benefits of hybrid wind-pumped storage unit in a non-interco...

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7th Mediterranean Conference and Exhibition on Power Generation, Transmission, Distribution and Energy Conversion, MedPower 2010

作者： Anastasiadis, A. Vatikalos, A. Vogiatzakis, G. Papathanasiou, S. Hatziargyriou, N. Greece Public Power Corporation Greece Electrical and Computer Engineering Department Power Division NTUA Greece

ISBN: (纸本)9781849193191

This work describes the benefits arising from the introduction of a hybrid wind - pumped storage unit into a non - interconnected power system such as Rhodes' Island power system. Optimal power flow (OPF) is one of the main tools for optimal operation and planning of modern power systems. The OPF was applied to the Rhodes' power system which consists of thermal power plants and Renewable Energy Sources (RES, mainly wind turbines). In order to increase the RES penetration, pumped storage is applied. The pumped storage unit is considered to be connected to grid bus where a wind park exists. Actual data regarding the wind speed, load, thermal stations, lines, transformers and RES were imported in Matlab environment for the simulation of the power system. Various scenarios about the operation of the hybrid unit were examined. The scope was to achieve "peak - shaving" during the high load demand period. Finally, the benefits of the investment were examined and evaluated.

关键词： Wind turbines

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Fire evacuation model with confidence intervals

Fire evacuation model with confidence intervals

引用

IEEE International Conference on Automation Science and engineering (CASE)

作者： Yuan Gao Peter B. Luh Qianchuan Zhao Hui Zhang Nan Wu Lifeng Qiao Center for Intelligent and Networked Systems (CFINS) Tsinghua University Tsinghua-UTC Beijing China Communications and Information Technologies Department of Electrical and Computer Engineering University of Connecticut USA CFINS Tsinghua University Beijing China Center for Intelligent and Networked Systems (CFINS) Tsinghua University Beijing China Center for Public Safety Research Tsinghua University Beijing China UTRC China

In building fire evacuation, good guidance can speed up egress process and occupants may be injured due to lack of information and guidance. There are many studies on building egress systems, which use relevant information (e.g., fire condition and its evolution) to calculate and provide guidance to occupants. However, information used to generate guidance may be uncertain, and it is difficult to provide the guidance under uncertainty. How to provide effective guidance to occupants under uncertainty and how to evaluate the confidence of the guidance are critical issues. To describe the confidence of the guidance, the concept of “confidence intervals” is used. By comparing “confidence intervals” with a threshold, acceptable guidance is provided. Testing examples show that the confidence of the guidance can be evaluated and unacceptable guidance can be differentiated with the use of confidence intervals.

关键词： Fires Position measurement Uncertainty Buildings Optimization Electronic mail Layout

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Adaptive Load Management (ALM) in electric power systems

Adaptive Load Management (ALM) in electric power systems

引用

2010 International Conference on Networking, Sensing and Control, ICNSC 2010

作者： Joo, Jhi-Young Ilić, Marija D. Department of Electrical and Computer Engineering Carnegie Mellon University Pittsburgh PA 15213 United States Department of Engineering and Public Policy Carnegie Mellon University Pittsburgh PA 15213 United States Delft University of Technology Netherlands

ISBN: (纸本)9781424464531

In this work, we propose a multi-layered adaptive load management (ALM) system capable of integrating largescale demand response in electric power systems efficiently and reliably. Electric power systems can be seen as a composition of multiple subsystems: power producers, load aggregators/utilities, end-users, etc. Focusing on the demand side of the system, we decompose the whole power system into three layers: the primary layer at the lowest level consisting of end-users of electric energy, the secondary layer or load aggregators that aggregate these endusers and provide service to them, and the tertiary level or the system/market operator at the highest level that incorporates and optimizes the objectives of the system as a whole. We pose the ALM problem as the problem of decomposing a complex network system using Lagrange decomposition techniques. Given the recent changes in electric energy systems, we propose that including more information from demand side helps improve the system-wide optimization. This is done by signaling a demand function, i.e. optimal energy use as a function of electricity price in place of a single point of a Lagrange multiplier, from the end-users at the primary layer to the higher layers. We provide a formulation of the system's decomposition problems of this multi-layered multi-directional decision making and information exchange. Our novel contribution will be showing that exchanging sensitivities of Lagrange coefficients instead of point-wise values of price data is essential for having a converging interactive information exchange within at the rate needed in physical power systems without storage. We identify open questions and plan for our future work. ©2010 IEEE.

关键词： Decision making

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Toward PMU-based robust automatic voltage control (AVC) and automatic flow control (AFC)

Toward PMU-based robust automatic voltage control (AVC) and ...

引用

IEEE General Meeting Power& Energy Society

作者： Zhijian Liu Marija D. Ilić Electrical and Computer Engineering and Engineering and Public Policy Departments Delft University of Technnology Netherlands Department of Electrical and Computer Engineering Carnegie Mellon University Pittsburgh PA USA Carnegie Mellon University Pittsburgh PA Electrical and Computer Engineering and Engineering and Public Policy Departments Delft University of Technology Delft The Netherlands

This paper is motivated by the need to automate adjustments of deviations in key output variables from their scheduled values. In particular, it is important to maintain load voltages within their pre-specified limits in response to many disturbances, for example load power factor deviations. Similarly, it is important to regulate real power line flows to within their pre-specified limits as disturbances around scheduled real power generation dispatch take place. Such automation is a feasible goal since the PMUs could provide accurate and fast sensing of key output variables of interest. Given the number of PMUs, the selection of best locations of PMUs and the control design based on these measurements becomes an engineering design problem. In this paper we provide a problem formulation for a robust Automated Voltage Control (AVC) and Automated Flow Control (AFC) design based on selecting the best locations for placing the PMUs. The AVC and AFC designs are illustrated using a small 5-bus example first. This is followed by illustrating potential performance of such design on an equivalent NPCC 36-bus system. The results indicate that the (N-1) reliability criteria can be met by combining the economic dispatch for scheduling resources given demand forecast, and by relying on an automated feedback to ensure that voltage and line flow deviations remain within the pre-specified limits in between scheduling intervals. This is done without having to know the exact location and magnitude of disturbances.

关键词： Automatic voltage control Reactive power Phasor measurement units Clustering algorithms Voltage measurement Generators

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Transforming supervisory control and data acquisition (SCADA) into Dynamic Monitoring and Decision Systems (DYMONDS): The missing link in smart grids

Transforming supervisory control and data acquisition (SCADA...

引用

IEEE General Meeting Power& Energy Society

作者： Marija Ilić Electrical and Computer Engineering (ECE) and Engineering and Public Policy (EPP) Departments Carnegie Mellon University Pittsburgh USA

In this paper we describe an effort which is under way at Carnegie Mellon University (CMU) in the Electric Energy Systems Group (EESG). We refer to this effort as the Dynamic Monitoring and Decision Systems (DYMONDS) initiative. Its objective is to develop an Information Technology (IT)-enabled framework in support of sustainable evolution of today's electric power systems into future energy systems capable of meeting dynamically evolving complex tradeoffs of business, societal and energy service users' needs both short-term and very long-term.

关键词： Industries Decision making Systematics Security Biological system modeling Reliability Monitoring

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Adaptive reliability revisited

Adaptive reliability revisited

引用

IEEE General Meeting Power& Energy Society

作者： Marija Ilić Electrical and Computer Engineering (ECE) and Engineering and Public Policy (EPP) Departments Carnegie Mellon University Pittsburgh PA USA

In this paper we start by recalling the seminal concepts underlying adaptive reliability of Tom Dy Liacco conceived almost four decades ago. Unfortunately, these concepts have not developed nor have been adopted by the industry yet. Recent efforts toward grid modernization will fall short of the anticipated expectations unless this gets implemented. Two distinct, yet related, challenges and opportunities are: 1) making electric energy services reliable and secure over broad ranges of conditions created by un-intended and/or intended system failures; and, 2) ensuring at the same time environmental and economic sustainability of energy services. We stress that even in the regulated industry this can be achieved only by implementing adaptive reliability. Moreover, as the industry restructures and novel resources get deployed the notions of adaptive reliability must evolve as well.

关键词： Reliability Power system reliability Industries Uncertainty Economics Risk management

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Making transmission systems smart: An opportunity which should not be missed

Making transmission systems smart: An opportunity which shou...

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IEEE General Meeting Power& Energy Society

作者： Marija Ilić Electrical and Computer Engineering (ECE) and Engineering and Public Policy (EPP) Departments Carnegie Mellon University Pittsburgh PA USA

The paper points out that while many efforts are under way to making distribution systems smart, very little serious attention has been given to rethinking the enhancements of transmission systems. Future electric energy systems are likely to require a qualitatively different management of the existing transmission system in order to enable their rapidly changing needs and objectives. The paper discusses an incremental enhancement of transmission systems in order to meet future needs. The thinking that the transmission systems already have control centers and SCADA and many analysis and decision tools misses major opportunities on the way to sustainable electric energy services of the future.

关键词： Low voltage Monitoring Decision making Sensors Particle measurements Electric potential Energy resources

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Teaching smart grids: Yet another challenge and opportunity for transforming power systems curriculum

Teaching smart grids: Yet another challenge and opportunity ...

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IEEE General Meeting Power& Energy Society

作者： Marija Ilić Electrical and Computer Engineering (ECE) and Engineering and Public Policy (EPP) Departments Carnegie Mellon University Pittsburgh PA USA

This paper concerns the challenge of teaching future energy systems using concepts familiar to engineering students. It is stressed that unless operating and design problems are formulated in a way understandable to those who do not specialize in electric power systems it becomes very difficult to identify what may be the roadblocks to innovation and better performance of the evolving energy systems. In particular, it becomes difficult to formulate problems underlying effective integration of novel resources and responsive demand by means of information technology (IT) unless these are "translated" into the frameworks understandable to those working with complex systems and to the IT designers.

关键词： Industries Education Power system dynamics Biological system modeling Smart grids Technological innovation

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