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Detection of influenza a virus nucleoprotein through the self-assembly of nanoparticles in magnetic particle spectroscopy-based bioassays: A method for rapid, sensitive, and wash-free magnetic immunoassays

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arXiv 2019年

作者： Wu, Kai Liu, Jinming Saha, Renata Su, Diqing Krishna, Venkatramana D. Cheeran, Maxim C.-J. Wang, Jian-Ping Department of Electrical and Computer Engineering University of Minnesota MinneapolisMN55455 United States Department of Chemical Engineering and Material Science University of Minnesota MinneapolisMN55455 United States Department of Veterinary Population Medicine University of Minnesota St. PaulMN55108 United States

Magnetic nanoparticles (MNPs) with proper surface functionalization have been extensively applied as labels for magnetic immunoassays, carriers for controlled drug/gene delivery, tracers and contrasts for magnetic imaging, etc. Here, we introduce a new biosensing scheme based on magnetic particle spectroscopy (MPS) and the self-assembly of MNPs to quantitatively detect H1N1 nucleoprotein molecules. MPS monitors the harmonics of oscillating MNPs as a metric for the freedom of rotational motion, thus indicating the bound states of MNPs. These harmonics can be readily collected from nanogram quantities of iron oxide nanoparticles within 10 s. H1N1 nucleoprotein molecule hosts multiple different epitopes that forms binding sites for many IgG polyclonal antibodies. Anchoring IgG polyclonal antibodies onto MNPs triggers the cross-linking between MNPs and H1N1 nucleoprotein molecules, thereby forming MNP self-assemblies. Using MPS and the self-assembly of MNPs, we achieved the sensitivity of 44 nM (442 pmole) for detecting H1N1 nucleoprotein. In addition, the morphologies and the hydrodynamic sizes of the MNP self-assemblies are characterized to verify the MPS results. Different MNP self-assembly models such as classical cluster, open ring tetramer, chain model as well as multimers (from dimer to pentamer) are proposed in this paper. Herein, we claim the feasibility of using MPS and the self-assembly of MNPs as a new biosensing scheme for detecting ultralow concentrations of target biomolecules, which can be employed as rapid, sensitive, and wash-free magnetic immunoassays. Copyright © 2019, The Authors. All rights reserved.

关键词： Nanoparticles

Erratum: “Carrier leakage via interface-roughness scattering bridges gap between theoretical and experimental internal efficiencies of quantum cascade lasers” [Appl. Phys. Lett. 117, 051101 (2020)]

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Applied Physics Letters 2020年第10期117卷

作者： C. Boyle K. M. Oresick J. D. Kirch Y. V. Flores L. J. Mawst D. Botez 1Department of Electrical and Computer Engineering University of Wisconsin Madison Wisconsin 53706 USA 2Material Science Center Philipps-Universität Marburg 35032 Marburg Germany

An error has been detected in the original paper.1 That is, Eq. (4) on page 051101-03,

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Target-specificity of different amyrin subunits in impeding HCV influx mechanism inside the human cells considering the quantum tunnel profiles and molecular strings of the CD81 receptor: a combined in silico and in vivo study

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In silico pharmacology 2023年第1期11卷 8页

作者： Anika Jabin Mohammad Fahim Uddin Salauddin Al Azad Ashfaque Rahman Fawzia Tabassum Pritthy Sarker A K M Helal Morshed Samiur Rahman Fatima Fairuz Raisa Musfiqur Rahman Sakib Abeer Hasan Olive Tabassum Islam Ramisha Tahsin Shahlaa Zernaz Ahmed Partha Biswas Mst Umme Habiba Mahbuba Siddiquy Maryam Jafary Department of Biochemistry and Microbiology North South University Dhaka 1229 Bangladesh. College of Material Science and Engineering Zhejiang Sci-Tech University Hangzhou 310018 Zhejiang People's Republic of China. Key Laboratory of Industrial Biotechnology Ministry of Education School of Biotechnology Jiangnan University Wuxi 214122 Jiangsu Province People's Republic of China. Department of Genetic Engineering and Biotechnology Shahjalal University of Science and Technology Sylhet 3114 Bangladesh. Pathology and Pathophysiology Major Academy of Medical Science Zhengzhou University Zhengzhou City 450001 Henan Province People's Republic of China. Department of Electrical and Electronic Engineering Brac University Dhaka 1212 Bangladesh. Department of Pharmacy Bangabandhu Sheikh Mujibur Rahman Science and Technology University Gopalganj 8100 Bangladesh. Department of Pharmacy East West University Dhaka 1212 Bangladesh. Department of Computer Science and Engineering East West University Dhaka 1212 Bangladesh. Department of Pharmaceutical Sciences North South University Dhaka 1229 Bangladesh. Department of Genetic Engineering and Biotechnology Jashore University of Science and Technology Jashore 7408 Bangladesh. Data Science Research Unit RPG Interface Lab Jashore 7400 Bangladesh. State Key Laboratory of Food Science and Technology Jiangnan University Wuxi 214122 Jiangsu Province People's Republic of China. Division of Food Safety and Hygiene Department of Environmental Health Engineering School of Public Health Tehran University of Medical Sciences Tehran *** Iran.

HCV is a hepatotropic RNA virus recognized for its frequent virulence and fatality worldwide. Despite many vaccine development programs underway, researchers are on a quest for natural bioactive compounds due to their multivalent efficiencies against viral infections, considering which the current research aimed to figure out the target-specificity and therapeutic potentiality of α, β, and δ subunits of amyrin, as novel bioactive components against the HCV influx mechanism. Initially, the novelty of amyrin subunits was conducted from 203 pharmacophores, comparing their in-silico pharmacokinetic and pharmacodynamic profiles. Besides, the best active site of CD81 was determined following the quantum tunneling algorithm. The molecular dynamic simulation was conducted (100 ns) following the molecular docking steps to reveal the parameters- RMSD (Å); Cα; RMSF (Å); MolSA (Å); Rg (nm); PSA (Å); SASA (Å), and the MM-GBSA dG binding scores. Besides, molecular strings of CD81, along with the co-expressed genes, were classified, as responsible for encoding CD81-mediated protein clusters during HCV infection, resulting in the potentiality of amyrins as targeted prophylactics in HCV infection. Finally, in vivo profiling of the oxidative stress marker, liver-specific enzymes, and antioxidant markers was conducted in the DMN-induced mice model, where -amyrin scored the most significant values in all aspects.

关键词： CD81 receptor Co-expressed genes behind HCV invasion DMN-induced hepatic fibrosis HCV infection In-silico pharmacokinetics and pharmacodynamics Target-specificity of amyrins

Publisher Correction: Twisted moiré conductive thermal metasurface

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Nature communications 2024年第1期15卷 2876页

作者： Huagen Li Dong Wang Guoqiang Xu Kaipeng Liu Tan Zhang Jiaxin Li Guangming Tao Shuihua Yang Yanghua Lu Run Hu Shisheng Lin Ying Li Cheng-Wei Qiu Department of Electrical and Computer Engineering National University of Singapore Kent Ridge 117583 Republic of Singapore. State Key Laboratory of Extreme Photonics and Instrumentation ZJU-Hangzhou Global Scientific and Technological Innovation Center Zhejiang University Hangzhou 310027 China. International Joint Innovation Center Key Lab. of Advanced Micro/Nano Electronic Devices & Smart Systems of Zhejiang The Electromagnetics Academy of Zhejiang University Zhejiang University Haining 314400 China. Wuhan National Laboratory for Optoelectronics and State Key Laboratory of Material Processing and Die and Mould Technology School of Materials Science and Engineering Huazhong University of Science and Technology Wuhan 430074 China. Smart Materials for Architecture Research Lab Innovation Center of Yangtze River Delta Zhejiang University Jiaxing 314100 China. State Key Laboratory of Coal Combustion School of Energy and Power Engineering Huazhong University of Science and Technology Wuhan 430074 China. Chongqing 2D Materials Institute Chongqing 400015 China. State Key Laboratory of Extreme Photonics and Instrumentation ZJU-Hangzhou Global Scientific and Technological Innovation Center Zhejiang University Hangzhou 310027 China. eleying@***. International Joint Innovation Center Key Lab. of Advanced Micro/Nano Electronic Devices & Smart Systems of Zhejiang The Electromagnetics Academy of Zhejiang University Zhejiang University Haining 314400 China. eleying@***. Department of Electrical and Computer Engineering National University of Singapore Kent Ridge 117583 Republic of Singapore. chengwei.qiu@nus.edu.sg.

Hetero-Magnetic Swinging Inductor (HMSI) and Its Application for Power Factor Correction Converters 10

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Hetero-Magnetic Swinging Inductor (HMSI) and Its Application...

10th Annual IEEE Energy Conversion Congress and Exposition, ECCE 2018

作者： Lu, Shengchang Mei, Yuhui Ding, Chao Ngo, Khai D.T. Liu, Lanbing Lu, Guo-Quan Bradley Department of Electrical and Computer Engineering Virginia Tech Center for Power Electronics Systems BlacksburgVA24061 United States School of Material Science and Engineering Tianjin University Center of High-Temperature Electronic Packaging Tianjin China Department of Materials Science and Engineering Virginia Tech BlacksburgVA24061 United States

ISBN: (纸本)9781479973118

A variable inductor concept based on a magnetic structure consisting of a composite of magnetic materials is introduced to meet designed inductance function of current. A design of the inductor, termed hetero-magnetic swinging inductor (HMSI), was fabricated using a toroid core with a gap that was filled by a custom-developed low-permeability magnetic powder + polymer material. Having the gap filled with the magnetic material allowed for greater flexibility in L-I design with added benefit of low fringe field. We applied this swinging inductor to a Critical Conduction Mode (CRM) Boost power factor correction (PFC) converter to reduce its switching frequency variation range. First, the required L-I curve of the HMSI needed for narrow range of switching frequency was calculated. Then, the HMSI core structure consisting of two magnetic materials was designed. Circuit simulations showed that for a 110-Vrms input, the converter with the HMSI had a switching frequency variation factor, defined as Deltatext{f}/text{fmin}, six times less than that of the converter using a linear inductor. A prototype of the HMSI was fabricated and tested. The effectiveness of using the HMSI to narrow the range of switching frequency variation was verified in a 150 W CRM PFC converter. © 2018 IEEE.

关键词： Magnetic materials

Hole mobility of strained GaN from first principles

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arXiv 2019年

作者： Poncé, Samuel Jena, Debdeep Giustino, Feliciano Department of Materials University of Oxford Parks Road OxfordOX1 3PH United Kingdom School of Electrical and Computer Engineering Cornell University IthacaNY14853 United States Department of Material Science and Engineering Cornell University IthacaNY14853 United States

Nitride semiconductors are ubiquitous in optoelectronic devices such as LEDs and Blu-Ray optical disks. A major limitation for further adoption of GaN in power electronics is its low hole mobility. In order to address this challenge, here we investigate the phonon-limited mobility of wurtzite GaN using the ab initio Boltzmann transport formalism, including all electron-phonon scattering processes, spin-orbit coupling, and many-body quasiparticle band structures. We demonstrate that the mobility is dominated by acoustic deformation-potential scattering, and we predict that the hole mobility can significantly be increased by lifting the split-off hole states above the light and heavy holes. This can be achieved by reversing the sign of the crystal-field splitting via strain or via coherent excitation the A1 optical phonon through ultrafast infrared optical pulses. Copyright © 2019, The Authors. All rights reserved.

关键词： Gallium nitride

Route to high hole mobility in GaN via reversal of crystal-field splitting

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arXiv 2019年

A fundamental obstacle toward the realization of GaN p-channel transistors is its low hole mobility. Here we investigate the intrinsic phonon-limited mobility of electrons and holes in wurtzite GaN using the ab initio Boltzmann transport formalism, including all electron-phonon scattering processes and many-body quasiparticle band structures. We predict that the hole mobility can be increased by reversing the sign of the crystal-field splitting, in such a way as to lift the split-off hole states above the light and heavy holes. We find that a 2% biaxial tensile strain can increase the hole mobility by 230%, up to a theoretical Hall mobility of 120 cm2/Vs at room temperature and 620 cm2/Vs at 100 K. Copyright © 2019, The Authors. All rights reserved.

关键词： Gallium nitride

Angular dependence and absorption properties of the anapole mode of Si nano-disks

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arXiv 2020年

作者： Fornasari, Lucia Passoni, Marco Marabelli, Franco Chen, Yuyao Wang, Yu Dal Negro, Luca Plasmore s.r.l. viale Vittorio Emanuele II 4 PaviaI-27100 Italy Physics Department University of Pavia via Bassi6 PaviaI-27100 Italy Department of Electrical and Computer Engineering & Photonics Center Boston University 8 Saint Mary's Street BostonMA02215 United States Boston University Division of Material Science and Engineering 15 Saint Marys Street BostonMA02446 United States Boston University Department of Physics 590 Commonwealth Avenue BostonMA02215 United States

The polarization- and angle- resolved optical response of the anapole mode in silicon nano-disks array have been experimentally and theoretically investigated. The good agreement between measured data and simulations yields to a consistent description of the anapole mode behavior that exhibits different features for TE or TM polarization excitation. Scattering matrix calculation allows us to disentangle scattered and diffused light contributions and to provide a quantitative estimation of the absorbance enhancement associated to 2D excitation of the anapole mode. We performed the multipolar decomposition of the far-field scattered radiation for both TE and TM polarizations and unambiguously identified the anapole resonant condition in excellent agreement with the experimental results over a large range of incident angles. Our findings demonstrate the controlled excitation of electromagnetic anapole modes in engineered arrays of silicon nano-disks for the development of optical nanostructures with enhanced light-matter interaction. Copyright © 2020, The Authors. All rights reserved.

关键词： Silicon

Zero-field Sub-50-nm skyrmions in monolayer Janus Van der Waals magnets

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arXiv 2019年

作者： Yuan, Jiaren Yang, Yumeng Cai, Yongqing Wu, Yihong Feng, Yuan Ping Chen, Yuanping Yan, Xiaohong Shen, Lei College of Science School of Material Science and Engineering Jiangsu University Zhenjiang212013 China Department of Electrical and Computer Engineering National University of Singapore 4 Engineering Drive 3 Singapore117583 Singapore Institute of High Performance Computing A*STAR 1 Fusionopolis Way Singapore138632 Singapore Department of Physics and Centre for Advanced Two-Dimensional Materials National University of Singapore 2 Science Drive 3 117551 Singapore Department of Mechanical Engineering and Engineering Science National University of Singapore 9 Engineering Drive 1 117542 Singapore

Skyrmions are localized solitonic spin textures with protected topology, which are promising as information carriers in ultra-dense and energy-efficient logics and memories. Magnetic skyrmions have been recently observed in thick magnetic multilayers and are stabilized by the extrinsic interfacial Dzyaloshinskii–Moriya interaction (DMI) and external magnetic fields. Here, we investigate the intrinsic magnetic skyrmions in four monolayer Janus van der Waals magnets, MnSSe, MnSTe, MnSeTe, and VSeTe, by the first-principles calculations combined with micromagnetic simulations. It is found that the monolayer Janus MnSTe and MnSeTe with out-of-plane asymmetry and strong spin-orbit coupling (SOC) have a large intrinsic DMI. Using micromagnetic simulations, we demonstrate that skyrmions can be stabilized in monolayer MnSTe and MnSeTe within sub-50 nm scale in the absence of magnetic fields. On the other hand, VSeTe (in-plane easy axis) forms chiral magnetic domains. Finally, the size and shape of skyrmions can be regulated using an external magnetic field. Our work opens a new vista for seeking intrinsic skyrmions in atomic-scale van der Waals magnets. Copyright © 2019, The Authors. All rights reserved.

关键词： Tellurium compounds