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Technology Roadmap for Flexible Sensors

ACS NANO 2023年第6期17卷 5211-5295页

作者： Luo, Yifei Abidian, Mohammad Reza Ahn, Jong-Hyun Akinwande, Deji Andrews, Anne M. Antonietti, Markus Bao, Zhenan Berggren, Magnus Berkey, Christopher A. Bettinger, Christopher John Chen, Jun Chen, Peng Cheng, Wenlong Cheng, Xu Choi, Seon-Jin Chortos, Alex Dagdeviren, Canan Dauskardt, Reinhold H. Di, Chong-an Dickey, Michael D. Duan, Xiangfeng Facchetti, Antonio Fan, Zhiyong Fang, Yin Feng, Jianyou Feng, Xue Gao, Huajian Gao, Wei Gong, Xiwen Guo, Chuan Fei Guo, Xiaojun Hartel, Martin C. He, Zihan Ho, John S. Hu, Youfan Huang, Qiyao Huang, Yu Huo, Fengwei Hussain, Muhammad M. Javey, Ali Jeong, Unyong Jiang, Chen Jiang, Xingyu Kang, Jiheong Karnaushenko, Daniil Khademhosseini, Ali Kim, Dae-Hyeong Kim, Il-Doo Kireev, Dmitry Kong, Lingxuan Lee, Chengkuo Lee, Nae-Eung Lee, Pooi See Lee, Tae-Woo Li, Fengyu Li, Jinxing Liang, Cuiyuan Lim, Chwee Teck Lin, Yuanjing Lipomi, Darren J. Liu, Jia Liu, Kai Liu, Nan Liu, Ren Liu, Yuxin Liu, Yuxuan Liu, Zhiyuan Liu, Zhuangjian Loh, Xian Jun Lu, Nanshu Lv, Zhisheng Magdassi, Shlomo Malliaras, George G. Matsuhisa, Naoji Nathan, Arokia Niu, Simiao Pan, Jieming Pang, Changhyun Pei, Qibing Peng, Huisheng Qi, Dianpeng Ren, Huaying Rogers, John A. Rowe, Aaron Schmidt, Oliver G. Sekitani, Tsuyoshi Seo, Dae-Gyo Shen, Guozhen Sheng, Xing Shi, Qiongfeng Someya, Takao Song, Yanlin Stavrinidou, Eleni Su, Meng Sun, Xuemei Takei, Kuniharu Tao, Xiao-Ming Tee, Benjamin C. K. Thean, Aaron Voon-Yew Trung, Tran Quang Wan, Changjin Wang, Huiliang Wang, Joseph Wang, Ming Wang, Sihong Wang, Ting Wang, Zhong Lin Weiss, Paul S. Wen, Hanqi Xu, Sheng Xu, Tailin Yan, Hongping Yan, Xuzhou Yang, Hui Yang, Le Yang, Shuaijian Yin, Lan Yu, Cunjiang Yu, Guihua Yu, Jing Yu, Shu-Hong Yu, Xinge Zamburg, Evgeny Zhang, Haixia Zhang, Xiangyu Zhang, Xiaosheng Zhang, Xueji Zhang, Yihui Zhang, Yu Zhao, Siyuan Zhao, Xuanhe Zheng, Yuanjin Zheng, Yu-Qing Zheng, Zijian Zhou, Tao Zhu, Bowen Zhu, Ming Zhu, Rong Zhu, Yangzhi Zhu, Yong Zou, Guijin Chen, Xiaodong 08-03 Innovis Singapore 138634 Republic of Singapore Innovative Centre for Flexible Devices (iFLEX) School of Materials Science and Engineering Nanyang Technological University Singapore 639798 Singapore Department of Biomedical Engineering University of Houston Houston Texas 77024 United States School of Electrical and Electronic Engineering Yonsei University Seoul 03722 Republic of Korea Department of Electrical and Computer Engineering The University of Texas at Austin Austin Texas 78712 United States Microelectronics Research Center The University of Texas at Austin Austin Texas 78758 United States Department of Chemistry and Biochemistry California NanoSystems Institute and Department of Psychiatry and Biobehavioral Sciences Semel Institute for Neuroscience and Human Behavior and Hatos Center for Neuropharmacology University of California Los Angeles Los Angeles California 90095 United States Colloid Chemistry Department Max Planck Institute of Colloids and Interfaces 14476 Potsdam Germany Department of Chemical Engineering Stanford University Stanford California 94305 United States Laboratory of Organic Electronics Department of Science and Technology Campus Norrköping Linköping University 83 Linköping Sweden Wallenberg Initiative Materials Science for Sustainability (WISE) and Wallenberg Wood Science Center (WWSC) SE-100 44 Stockholm Sweden Department of Materials Science and Engineering Stanford University Stanford California 94301 United States Department of Biomedical Engineering and Department of Materials Science and Engineering Carnegie Mellon University Pittsburgh Pennsylvania 15213 United States Department of Bioengineering University of California Los Angeles Los Angeles California 90095 United States School of Chemistry Chemical Engineering and Biotechnology Nanyang Technological University Singapore 637457 Singapore Nanobionics Group Department of Chemical and Biological Engineering Monash University Clayton Australia 3800 Monash

Humans rely increasingly on sensors to address grand challenges and to improve quality of life in the era of digitalization and big data. For ubiquitous sensing, flexible sensors are developed to overcome the limitations of conventional rigid counterparts. Despite rapid advancement in bench-side research over the last decade, the market adoption of flexible sensors remains limited. To ease and to expedite their deployment, here, we identify bottlenecks hindering the maturation of flexible sensors and propose promising solutions. We first analyze continued...challenges in achieving satisfactory sensing performance for real-world applications and then summarize issues in compatible sensor-biology interfaces, followed by brief discussions on powering and connecting sensor networks. Issues en route to commercialization and for sustainable growth of the sector are also analyzed, highlighting environmental concerns and emphasizing nontechnical issues such as business, regulatory, and ethical considerations. Additionally, we look at future intelligent flexible sensors. In proposing a comprehensive roadmap, we hope to steer research efforts towards common goals and to guide coordinated development strategies from disparate communities. Through such collaborative

关键词： soft materials mechanics engineering flexible electronics conformable sensors bioelectronics human-machine interfaces body area sensor networks technology translation sustainable electronics

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2-[(Hydroxymethyl)amino]ethanol in water as a preservative: Study of formaldehyde released by Taguchi's method 5

2-[(Hydroxymethyl)amino]ethanol in water as a preservative: ...

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5th International Conference on Chemical and Bioprocess engineering, ICCBPE 2015

作者： Wisessirikul, W. Loykulnant, S. Montha, S. Fhulua, T. Prapainainar, P. Interdisciplinary Graduate Program in Advanced and Sustainable Environmental Engineering Thailand Advanced Institute of Science and Technology Tokyo Institute of Technology Kasetsart University Bangkok10900 Thailand Natural Rubber Focus Unit National Metal and Materials Technology Center NSTDA 111 Paholyothin Rd. Klong 1 Klong Luang Pathumthani12120 Thailand Environment Research Unit National Metal and Materials Technology Center NSTDA 111 Paholyothin Rd. Klong 1 Klong Luang Pathumthani12120 Thailand National Center of Excellence for Petroleum Petrochemicals and Advance Materials Department of Chemical Engineering Faculty of Engineering Kasetsart University Thailand Center of Excellence of Nanotechnology Kasetsart University Thailand

This research studied the quantity of free formaldehyde released from 2- [(hydroxymethyl)amino]ethanol (HAE) in DI water and natural rubber latex mixture using high-performance liquid chromatography (HPLC) technique. The quantity of formaldehyde retained in the solution was cross-checked by using titration technique. The investigated factors were the concentration of preservative (HAE), pH, and temperature. Taguchi's method was used to design the experiments. The number of experiments was reduced to 16 experiments from all possible experiments by orthogonal arrays (3 factors and 4 levels in each factor). Minitab program was used as a tool for statistical calculation and for finding the suitable condition for the preservative system. HPLC studies showed that higher temperature and higher concentration of the preservative influence the amount of formaldehyde released. It was found that conditions at which formaldehyde was released in the lowest amount were 1.6%w/v HAE, 4 to 40 °C, and the original pH. Nevertheless, the pH value of NR latex should be more than 10 (the suitable pH value was found to be 13). This preservative can be used to replace current preservative systems and can maintain the quality of latex for long-term storage. Use of the proposed preservative system was also shown to have reduced impact on the toxicity of the environment. © Published under licence by IOP Publishing Ltd.

关键词： Formaldehyde

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Densified mixture design algorithm: A novel mix design concept and its application for green concretes incorporating industrial by-products

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environmental Progress and Sustainable Energy 2023年第4期42卷

作者： Nguyen, Tan-Hung Limongan, Andrian H. Nguyen, May Huu Hwang, Chao-Lung Huynh, Trong-Phuoc Department of Civil Engineering Can Tho University of Technology Can Tho Viet Nam Department of Civil and Construction Engineering National Taiwan University of Science and Technology Taipei Taiwan Department of Bridge and Tunnel Faculty of Civil Engineering University of Transport Technology Hanoi Viet Nam Civil and Environmental Engineering Program Graduate School of Advanced Science and Engineering Hiroshima University Hiroshima Japan Taiwan Building Technology Center National Taiwan University of Science and Technology Taipei Taiwan Faculty of Civil Engineering College of Engineering Can Tho University Can Tho Viet Nam

Despite the fact that densified mixture design algorithm (DMDA) has been identified as a promising tool for green concrete mix design, its use in real practice has still been minimal worldwide. Due to the lack of precise information on DMDA computation in earlier studies, this work proposes DMDA including fly ash and ground granulated blast-furnace slag as a viable way to improve the long-term performance of green concrete. To encourage the use of DMDA, this study offers a detailed description of the DMDA mix design, as well as a step-by-step standard operating procedure and an empirical example of the computation. Assessments of the long-term performance of green mixtures (self-consolidating concrete and high-performance concrete) and ordinary Portland cement concrete (designed using the conventional method of American Concrete Institute, ACI) were made. Performances of the ACI (O6000 mixture) and DMDA concretes (S6000 and H6000 mixtures) were then compared in terms of compressive strength, elastic modulus, shrinkage, and creep strain. As a result, all of the concrete samples attained the target strength of above 41 MPa (6000 psi) after only 28 days. Moreover, compressive strength, elastic modulus, shrinkage, and creep strain increased significantly in all of the concretes over curing time. Importantly, the experimental results confirmed that both types of DMDA concrete exhibited higher compressive strength and better long-term performance than the ACI concrete under elastic modulus, creep, and shrinkage aspects. © 2023 American Institute of Chemical Engineers.

关键词： Compressive strength

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Hazard evaluation for redox system of cumene hydroperoxide mixed with inorganic alkaline solutions

Hazard evaluation for redox system of cumene hydroperoxide m...

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作者： Hou, H.-Y. Duh, Y.-S. Lee, W.-L. Shu, C.-M. Department of Occupational Safety and Health Jen-Teh Junior College of Medicine Nursing and Management 1 Jen-Teh Rd. Houlong Miaoli 35664 Taiwan Department of Occupational Safety and Health and Graduate Program Chung Shan Medical University 110 Sec.1 Jianguo N. Rd. Taichung 40201 Taiwan Process Safety and Disaster Prevention Laboratory Department of Safety Health and Environmental Engineering National Yunlin University of Science and Technology 123 University Rd. Douliou Yunlin 64002 Taiwan

In petrochemistry, dicumyl peroxide (DCPO) is used in various resins for improving physical properties, which was produced by cumene hydroperoxide (CHP) with oxidization reaction, redox reaction, and dehydration reaction. The reactant, CHP, is a typical organic hydroperoxide and has been intrinsically unstable and reactive due to its bivalent -O-O- structure which can be broken readily with bond-dissociation energy. This sequence on sensitive study aimed at the thermal hazard evaluation for the reactive and incompatible characteristics of CHP mixed with various inorganic alkaline solutions. Differential scanning calorimetry (DSC) and vent sizing package 2 (VSP2) were used to analyze the thermal hazards and runaway reaction of redox system, such as decomposition of CHP in cumene solution and CHP react with inorganic alkaline solutions, exothermic onset temperature, peak power, heat of decomposition of dynamic scanning tests, adiabatic self-heating rate, pressure rise rate, maximum temperature, maximum pressure of reaction system, etc. The results of the tests have proven helpful in establishing safe handling, storage, transportation, and disposal guidelines. © 2009 Akadémiai Kiadó, Budapest.

关键词： Redox reactions

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Waters network's potential to transform environmental engineering education

Waters network's potential to transform environmental engine...

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114th Annual ASEE Conference and Exposition, 2007

作者： Eschenbach, Elizabeth Montgomery, Jami Johnson, James Brus, Chris Carlson, Patricia Giammar, Dan Grauer, Bette Hotaling, Liesl Oguntimein, Gbekeloluwa Safferman, Steven Wentling, Tim Humboldt State University United States Department of Environmental Resources Engineering Humboldt State University United States WATERS Network - CLEANER Project Office Network Howard University United States Department of Environmental Engineering College of Engineering Architecture and Computer Sciences Howard University United States American Academy of Environmental Engineers United States University of Iowa United States Program University of Iowa United States Rose-Hulman Institute of Technology United States Department of Rhetoric Rose-Hulman Institute of Technology United States National Research Council U. S. Air Force United States NASA's Classroom of the Future Wheeling WV United States Washington University United States Department of Energy Environmental and Chemical Engineering Washington University St. Louis United States Environmental Studies Program Center for Materials Innovation United States McPherson High School United States McPherson High School McPherson KS United States Stevens Institute of Technology United States Stevens Institute of Technology United States Morgan State University United States Michigan State University United States Biosystems and Agricultural Engineering Department Michigan State University United States University of Dayton United States Education Planning Committee National Center for Supercomputing Applications United States Department of Information Science Graduate School of Library and Information Science National Center for Supercomputing Applications University or Illinois United States Knowledge and Learning Systems Group NCSA United States

The WATERS Network (WATer and environmental Research Systems Network) will be an integrated real-time distributed observing system which will enable academic and government scientists, engineers, educators, and practitioners to advance effective management of our nation's water resources by understanding human interactions with water and the natural and built environment. WATERS will provide easily accessible real time environmental data as well as analysis tools to engineers, scientists, educators, K- graduate students and policymakers so they can better understand how water quantity, quality and related components of the hydrologic cycle are impacted by natural and human influences. The WATERS strategic plan will be completed by July 2007 and requires constituent input. This paper describes the draft Conceptual Design and the Education Plan of WATERS Network. This paper will highlight the potential impact of WATERS on undergraduate and graduate environmental engineering education in order to elicit input from the environmental engineering education community on how WATERS Network could better meet the future needs of undergraduate and graduate students and educators. More information can be found at ***. © American Society for engineering Education, 2007.

关键词： Water resources

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Optimizing cultivation strategies and scaling up for fucoxanthin production using Pavlova sp.

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Bioresource Technology 2024年 399卷 130609页

作者： Chen, Chun-Yen Liu, Ping-Yung Chang, Yu-Han Nagarajan, Dillirani Latagan, Mary Joy D. de Luna, Mark Daniel G. Chen, Jih-Heng Chang, Jo-Shu University Center for Bioscience and Biotechnology National Cheng Kung University Tainan Taiwan Department of Biotechnology and Bioindustry Sciences National Cheng Kung University Tainan701 Taiwan Department of Chemical Engineering National Cheng Kung University Tainan Taiwan Institute of Aquatic Science and Technology College of Hydrosphere Science National Kaohsiung University of Science and Technology Nanzih Campus Kaohsiung City Taiwan Energy Engineering Program National Graduate School of Engineering University of the Philippines Diliman Quezon City1101 Philippines Environmental Engineering Program National Graduate School of Engineering University of the Philippines Quezon City Diliman1101 Philippines Department of Chemical Engineering University of the Philippines Diliman Quezon City1101 Philippines Department of Chemical and Materials Engineering National Kaohsiung University of Science and Technology Kaohsiung807 Taiwan Department of Chemical and Materials Engineering Tunghai University Taichung407 Taiwan Research Center for Smart Sustainable Circular Economy Tunghai University Taichung407 Taiwan Department of Chemical Engineering and Materials Science Yuan Ze University Chung-Li Taiwan

The microalgal-based production of fucoxanthin has emerged as an imperative research endeavor due to its antioxidant, and anticancer properties. In this study, three brown marine microalgae, namely Skeletonema costatum, Chaetoceros gracilis, and Pavlova sp., were screened for fucoxanthin production. All strains displayed promising results, with Pavlova sp. exhibiting the highest fucoxanthin content (27.91 mg/g) and productivity (1.16 mg/L·day). Moreover, the influence of various cultivation parameters, such as culture media, salinity, sodium nitrate concentration, inoculum size, light intensity, and iron concentration, were investigated and optimized, resulting in a maximum fucoxanthin productivity of 7.89 mg/L·day. The investigation was further expanded to large-scale outdoor cultivation using 50 L tubular photobioreactors, illustrating the potential of Pavlova sp. and the cultivation process for future commercialization. The biomass and fucoxanthin productivity for the large-scale cultivation were 70.7 mg/L·day and 4.78 mg/L·day, respectively. Overall, the findings demonstrated considerable opportunities for fucoxanthin synthesis via microalgae cultivation and processing. © 2024 Elsevier Ltd

关键词： Microalgae

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Evaluations on thermal runaway characteristics for three liquid organic peroxides

Evaluations on thermal runaway characteristics for three liq...

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爆炸科学与技术国家重点实验室2011年学术年会暨International Workshop on Intensive Loading and Its Effects

作者： Chi(M)(i)(n)Shu Yung(Ch)an Chu Process Safety and Disaster Prevention Laboratory Department of SafetyHealthand Environmental EngineeringNYUST123University Rd.Sec.3DouliouYunlinTaiwan 64002ROC Doctoral ProgramGraduate School of Engineering Science and TechnologyNational Yunlin University of Science and Technology (NYUST)123University Rd.Sec.3DouliouYunlinTaiwan 64002ROC

In virtue of operating improperly, many exigent accidents of chemical industries are emerged frequently.1, l-Di-(tert-butylperoxy)-3,3,5-trimethylcyclohexane (TMCH), 1,1-di (tert-butylperoxy) cyclohexane (BPCH) and tert-butyl hydroperoxide (TBHP) are commonly well-known as thermal instability materials which were used as hardening and curing *** aim was to evaluate the safety operating parameters which play an important role in reaction *** this study, differential scanning calorimetry (DSC) was applied to measure the heat of decomposition reactions, which can contribute to understanding the reaction characteristics of those *** sizing package 2 (VSP2) was employed to evaluate rates of increase for temperature and pressure in decomposition reactions, and then the thermokinetic parameters of three organic peroxides were *** last, Semenov's model derived to criticality characteristics of various stirring rate situation were clearly identified.

关键词： Criticality characteristics organic peroxides thermal instability thermokinetic parameters vent sizing package 2 (VSP2)

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A First-Principles and Calphad-Assisted Phase-Field Model for Microstructure Evolution: Application to Mo-V Binary Alloy Systems

SSRN

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SSRN 2023年

作者： Thakur, Abhishek Kumar Kovacevic, Sasa Manga, Venkateswara Rao Deymier, Pierre Alix Muralidharan, Krishna Department of Materials Science and Engineering University of Arizona TucsonAZ85721 United States Department of Civil and Environmental Engineering Imperial College London LondonSW7 2AZ United Kingdom Lunar and Planetary Laboratory University of Arizona TucsonAZ85721 United States Graduate Interdisciplinary Program in Applied Mathematics India

A multiscale computational framework combining the first-principles calculations and the CALPHAD approach with the phase-field method is presented to simulate the microstructure evolution in multicomponent steel alloys. We demonstrate the potential of the framework by predicting the microstructural evolution in elastically periodic arrays of the Mo-V binary sub-system. The framework utilizes the first-principles calculations using special quasi-random structures. Hitherto unavailable thermodynamic and material properties of the alloy are obtained by employing the first-principles calculations and the CALPHAD approach and fed into the phase-field model to predict the microstructure evolution at different temperatures within the miscibility gap region. In addition to the temperature and cooling rates, the model incorporates the role of mechanical fields in decomposition kinetics in the Mo-V binary alloy system. Regimes for temperatures and cooling rates at which spinodal decomposition occurs are identified. Applying external loading leads to directional phase separation in the Mo-V binary system. The elastic inhomogeneity in terms of material properties between the two phases initiates the directional alignment while eigenstrains and applied external loading control the degree of alignment. The framework developed is general and extendable to higher multicomponent sub-systems in steel alloys. © 2023, The Authors. All rights reserved.

关键词： Temperature

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Spatiotemporal dynamics of ecosystem fires and biomass burning-induced carbon emissions in China over the past two decades

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Geography and Sustainability 2020年第1期1卷 47-58页

作者： Anping Chen Rongyun Tang Jiafu Mao Chao Yue Xiran Li Mengdi Gao Xiaoying Shi Mingzhou Jin Daniel Ricciuto Sam Rabin Phillippe Ciais Shilong Piao Department of Biology Colorado State UniversityFort CollinsCO 80523USA Graduate Degree Program in Ecology Colorado State UniversityFort CollinsCO 80523USA Department of Industrial and Systems Engineering University of TennesseeKnoxvilleTN 37996USA Environmental Sciences Division and Climate Change Science Institute Oak Ridge National LaboratoryOak RidgeTN 37831USA State Key Laboratory of Soil Erosion and Dryland Farming on the Loess Plateau Northwest Agriculture&Forestry UniversityYanglingShanxi 712100China College of Urban and Environmental Sciences Central China Normal UniversityWuhanHubei 430079China Sino-French Institute for Earth System Science College of Urban and Environmental SciencesPeking UniversityBeijing 100871China Atmospheric Environmental Research(IMK-IFU) Institute of Meteorology and Climate ResearchKarlsruhe Institute of Technology(KIT)Kreuzeckbahnstraße 19Garmisch-Partenkirchen 82467Germany LSCE UMR CEA-CNRSBat.709CEL’Orme des MerisiersGif-sur-Yvette 91191France

Fire is a major type of disturbance that has important influences on ecosystem dynamics and carbon *** our understanding of ecosystem fires and their carbon cycle consequences is still limited,largely due to the difficulty of large-scale fire monitoring and the complex interactions between fire,vegetation,climate,and anthropogenic ***,using data from satellite-derived fire observations and ecosystem model simulations,we performed a comprehensive investigation of the spatial and temporal dynamics of China’s ecosystem fire disturbances and their carbon emissions over the past two decades(1997–2016).Satellite-derived results showed that on average about 3.47-4.53×10^(4) km^(2) of the land was burned annually during the past two decades,among which annual burned forest area was about 0.81-1.25×10^(4) km^(2),accounting for 0.33-0.51%of the forest area in *** burning emitted about 23.02 TgC per *** to satellite products,simulations from the Energy Exascale Earth System Land Model(ELM)strongly overestimated China’s burned area and fire-induced carbon *** burned area and fire-induced carbon emissions were high for boreal forest in Northeast China’s Daxing’anling region and subtropical dry forest in South Yunnan,as revealed by both the satellite product and the model *** results suggest that climate and anthropogenic factors play critical roles in controlling the spatial and seasonal distribution of China’s ecosystem fire *** findings highlight the importance of multiple complementary approaches in assessing ecosystem fire disturbance and its carbon *** studies are required to improve the methods of observing and modelling China’s ecosystem fire disturbances,which will provide valuable information for fire management and ecosystem sustainability in an era when both human activities and the natural environment are rapidly changing.

关键词： Fire emission Burned area Fire models China

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Anti-inflammatory and antinociceptive effects of Aloysia gratissima leaves essential oil: An in vivo study

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Journal of Traditional and Complementary Medicine 2024年

作者： Souza, Maryelen A. Kunh, Ketelin Sanaiotto, Otávio Provinelli, Ana C. Barufke, Mayara Schindler, Monica S.Z. Mazon, Samara Cristina Oliveira, J. Vladimir Brusco, Indiara Scapinello, Jaqueline Magro, Jacir Dal Müller, Liz G. Graduate Program in Environmental Sciences Community University of Chapecó Region (Unochapecó) Chapecó Brazil School of Health Sciences Community University of Chapecó Region (Unochapeco) Chapecó Brazil Department of Chemical and Food Engineering Federal University of Santa Catarina (UFSC) SC Florianópolis Brazil Graduate Program in Food Science and Technology - State University of Santa Catarina - UDESC Pinhalzinho Brazil

Background and aim: Aloysia gratissima is used in popular medicine as an analgesic and sedative. However, studies on its biological activities are still scarce. Therefore, this work aimed to evaluate the antinociceptive and anti-inflammatory effect of A. gratissima leaves essential oil (OAG) in mice. Experimental procedure: The OAG was obtained by hydrodistillation and its composition was determined by gas chromatography-mass spectrometry. The sesquiterpenes pinocamphone, β-pinene, and guaiol were the major constituents of OAG. The effect of OAG (1, 10, and 30 mg/kg, p.o.) was assessed by pre-treating male mice 1h before the formalin assay, carrageenan-induced peritonitis test, or the paw edema induced by arachidonic acid (AA). The acute toxicity of OAG (2000 mg/kg, p.o.) was also investigated. Results and conclusion: The minimum effective dose of OAG in the formalin test was 1 mg/kg. This dose did not affect the locomotor activity of mice. The OAG decreased the number of leukocytes/mm³ in the peritoneal exudate of mice and reduced paw edema 45 min after the arachidonic acid injection. OAG treatment elicited a reduction in NPSH levels in the paw tissue and increased NPSH levels in mice blood plasma and did not cause mice mortality. The OAG is devoid of acute toxicity and shows anti-inflammatory activity, which can be related to the presence of pinocamphone, guaiol, and β-pinene and is mediated, at least in part, by mechanisms that involve the participation of NPSH. © 2024 Center for Food and Biomolecules, National Taiwan University

关键词： Acute toxicity test Anti-inflammatory agents Antinociceptive agents Natural products Verbenaceae

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