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19th IFIP WG 6.11 Conference on e-Business, e-Services, and e-Society, I3E 2020

作者： Varghese, Christina Varde, Aparna S. Du, Xu Department of Computer Science Montclair State University MontclairNJ United States Department of Earth and Environmental Science Montclair State University MontclairNJ United States Environmental Science and Management PhD Program Montclair State University MontclairNJ United States

ISBN: (纸本)9783030450014

This paper focuses on how populations by the use of technology, more specifically an app, can comprehend the enactment of ordinances (local laws) in an urban area along with their public reactions expressed as tweets. Furthermore, they can understand how well the area is developing and enhancing as a Smart City. The main goal of this research is to develop an Ordinance-Tweet Mining App that disseminates the results of analyzing ordinances and tweets about them, especially related to Smart City Characteristics such as Smart Environment, Smart Mobility etc. This app would be beneficial to various users such as environmental scientists, policy makers, city committees as well as the common public in becoming more aware of legislative bodies, and possibly contributing in different aspects to make the urban area improve as a Smart City. This work fits the realm of Smart Governance due to transparency via public involvement. © 2020, IFIP International Federation for Information Processing.

关键词： Sentiment analysis

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Wastewater-based surveillance of respiratory viruses in Northern Tuscany (Italy): Challenges and added value for public health purposes

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science of the Total Environment 2024年 957卷 177752页

作者： Carducci, Annalaura Federigi, Ileana Pagani, Alessandra Atomsa, Nebiyu Tariku Conte, Beatrice Angori, Alessandra Lauretani, Giulia Profili, Francesco Viviani, Luca Odone, Anna Verani, Marco Department of Biology University of Pisa Laboratory of Hygiene and Environmental Virology Pisa Italy Regional Health Agency of Tuscany Epidemiological Observatory Florence Italy PhD National Program in One Health Approaches to Infectious Diseases and Life Science Research Department of Public Health Experimental and Forensic Medicine University of Pavia Pavia Italy Department of Public Health Experimental and Forensic Medicine University of Pavia Pavia Italy Medical Direction Fondazione IRCCS Policlinico San Matteo Pavia Italy

During the COVID-19 pandemic, wastewater-based surveillance (WBS) showed great potential as an early warning system and could complement human clinical surveillance. This study aimed to highlight the added value of WBS for respiratory infections alongside different clinical surveillance systems. Sewage collected at the entry of four Wastewater Treatment Plants in Northern Tuscany (Italy) were analyzed for SARS-CoV-2, Human Adenovirus (HAdV), Respiratory Syncytial Virus (RSV) and Influenza Virus (IV), over two years. Clinical data for COVID-19 were available for the study area, while data for other viruses came from national virological surveillance. For SARS-CoV-2, the correlation was highly significant between clinical and hospitalization data (ρ = 0.8460), but not significant between wastewater and clinical or hospitalization data (ρ = 0.1682 and ρ = 0.0569, respectively). SARS-CoV-2 RNA was found in wastewater even in period when clinical cases were not reported, indicating a continuous community circulation. HAdVs were detected in 74.3 % of samples, but most of the sequences identified belonged to enteric species (HAdV-F41), indicating the need of distinguishing the species causing respiratory diseases for the surveillance. RSV were found only in winter 2022–2023, while IV had not been detected in wastewater, probably due to poor test sensitivity. In conclusion, although there may be various challenges in testing different targets, WBS can provide pathogen-specific situational assessment which complements existing surveillance systems. © 2024 The Authors

关键词： COVID-19

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Demethoxymurrapanine, an indole-naphthoquinone alkaloid, inhibits the proliferation of oral cancer cells without major side effects on normal cells

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environmental Toxicology 2024年第3期39卷 1221-1234页

作者： Chuang, Ya-Ting Yen, Ching-Yu Shiau, Jun-Ping Chang, Fang-Rong Duh, Chang-Yih Sung, Ping-Jyun Chen, Kuan-Liang Tsai, Yi-Hong Tang, Jen-Yang Jeng, Jiiang-Huei Sheu, Jyh-Horng Chang, Hsueh-Wei Department of Biomedical Science and Environmental Biology PhD Program in Life Sciences College of Life Science Kaohsiung Medical University Kaohsiung Taiwan School of Dentistry Taipei Medical University Taipei Taiwan Department of Oral and Maxillofacial Surgery Chi-Mei Medical Center Tainan Taiwan Division of Breast Oncology and Surgery Department of Surgery Kaohsiung Medical University Hospital Kaohsiung Medical University Kaohsiung Taiwan Graduate Institute of Natural Products Kaohsiung Medical University Kaohsiung Taiwan Department of Marine Biotechnology and Resources National Sun Yat-sen University Kaohsiung Taiwan National Museum of Marine Biology and Aquarium Pingtung Taiwan Department of Pharmacy and Master Program College of Pharmacy and Health Care Tajen University Pingtung Taiwan School of Post-Baccalaureate Medicine Kaohsiung Medical University Kaohsiung Taiwan Department of Radiation Oncology Kaohsiung Medical University Hospital Kaohsiung Medical University Kaohsiung Taiwan School of Dentistry College of Dental Medicine Kaohsiung Medical University Kaohsiung Taiwan Department of Dentistry Kaohsiung Medical University Hospital Kaohsiung Taiwan Department of Dentistry National Taiwan University Hospital Taipei Taiwan Department of Medical Research China Medical University Hospital China Medical University Taichung Taiwan Department of Medical Research Kaohsiung Medical University Hospital Kaohsiung Taiwan Center for Cancer Research Kaohsiung Medical University Kaohsiung Taiwan

Antioral cancer drugs need a greater antiproliferative impact on cancer than on normal cells. Demethoxymurrapanine (DEMU) inhibits proliferation in several cancer cells, but an in-depth investigation was necessary. This study evaluated the proliferation-modulating effects of DEMU, focusing on oral cancer and normal cells. DEMU (0, 2, 3, and 4 μg/mL) at 48 h treatments inhibited the proliferation of oral cancer cells (the cell viability (%) for Ca9-22 cells was 100.0 ± 2.2, 75.4 ± 5.6, 26.0 ± 3.8, and 15.4 ± 1.4, and for CAL 27 cells was 100.0 ± 9.4, 77.2 ± 5.9, 57.4 ± 10.7, and 27.1 ± 1.1) more strongly than that of normal cells (the cell viability (%) for S-G cells was 100.0 ± 6.6, 91.0 ± 4.6, 95.0 ± 2.6, and 95.8 ± 5.5), although this was blocked by the antioxidant N-acetylcysteine. The presence of oxidative stress was evidenced by the increase of reactive oxygen species and mitochondrial superoxide and the downregulation of the cellular antioxidant glutathione in oral cancer cells, but these changes were minor in normal cells. DEMU also caused greater induction of the subG1 phase, extrinsic and intrinsic apoptosis (annexin V and caspases 3, 8, and 9), and DNA damage (γH2AX and 8-hydroxy-2-deoxyguanosine) in oral cancer than in normal cells. N-acetylcysteine attenuated all these DEMU-induced changes. Together, these data demonstrate the preferential antiproliferative function of DEMU in oral cancer cells, with the preferential induction of oxidative stress, apoptosis, and DNA damage in these cancer cells, and low cytotoxicity toward normal cells. © 2023 Wiley Periodicals LLC.

关键词： Oxidative stress

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Multispectral Drone Data Analysis on Coastal Dunes

Multispectral Drone Data Analysis on Coastal Dunes

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IEEE International Conference on Big Data

作者： Britnie Gonzalez-Moodie Shane Daiek Jorge Lorenzo-Trueba Aparna S. Varde Montclair State University NJ USA Environmental Science and Management PhD Program Montclair State University NJ USA Visiting Researcher Max Planck Institute for Informatics Saarbrucken Germany

ISBN: (纸本)9781665445993

We devise a method to study coastal dune vegetation based on drone data orthomosaic mapping and machine learning algorithms to distinguish objects with spatial and color accuracy from numerous high-quality drone multispectral images. It allows accurate surveying on the density of coastal dune vegetation and potentially individual species. We thus analyze big data to develop tools for coastal resiliency and sustainability.

关键词： Machine learning algorithms Data analysis Image color analysis Sea measurements Vegetation mapping Forestry Big Data

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Mining GIS data to predict urban sprawl

arXiv

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arXiv 2021年

作者： Pampoore-Thampi, Anita Varde, Aparna S. Yu, Danlin Department of Computer Science Montclair State University MontclairNJ United States Department of Earth and Environmental Studies Montclair State University MontclairNJ United States Environmental Management PhD Program Montclair State University MontclairNJ United States

This paper addresses the interesting problem of processing and analyzing data in geographic information systems (GIS) to achieve a clear perspective on urban sprawl. The term "urban sprawl" refers to overgrowth and expansion of low-density areas with issues such as car dependency and segregation between residential versus commercial use. Sprawl has impacts on the environment and public health. In our work, spatiotemporal features related to real GIS data on urban sprawl such as population growth and demographics are mined to discover knowledge for decision support. We adapt data mining algorithms, Apriori for association rule mining and J4.8 for decision tree classification to geospatial analysis, deploying the ArcGIS tool for mapping. Knowledge discovered by mining this spatiotemporal data is used to implement a prototype spatial decision support system (SDSS). This SDSS predicts whether "urban sprawl" is likely to occur. Further, it estimates the values of pertinent variables to understand how the variables impact each other. The SDSS can help decision-makers identify problems and create solutions for avoiding future sprawl occurrence and conducting urban planning where sprawl already occurs, thus aiding sustainable development. This work falls in the broad realm of geospatial intelligence and sets the stage for designing a large scale SDSS to process big data in complex environments, which constitutes part of our future work. © 2021, CC BY-SA.

关键词： Association rules

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Synthesis of bioactive evodiamine and rutaecarpine analogues under ball milling conditions

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Organic and Biomolecular Chemistry 2024年第13期22卷 2620-2629页

作者： Hu, Hao-Chun Yu, Szu-Yin Tsai, Yi-Hong Hsieh, Pei-Wen Wang, Hui-Chun Chen, Yan-Ning Chuang, Ya-Ting Lee, Min-Yu Chang, Hsueh-Wei Wu, Yang-Chang Chang, Fang-Rong Szatmári, István Fülöp, Ferenc Graduate Institute of Natural Products College of Pharmacy Kaohsiung Medical University Kaohsiung80708 Taiwan Institute of Pharmaceutical Chemistry HUN-REN-Stereochemistry Research Group University of Szeged Szeged6720 Hungary Graduate Institute of Natural Products School of Traditional Chinese Medicine College of Medicine Chang Gung University Taoyuan333 Taiwan Institute of Pharmacognosy University of Szeged Szeged6720 Hungary Department of Pharmacy and Master Program College of Pharmacy and Health Care Tajen University Pingtung County907101 Taiwan Graduate Institute of Biomedical Sciences College of Medicine Chang Gung University Taoyuan333 Taiwan Department of General Surgery Chang Gung Memorial Hospital Chiayi613 Taiwan Department of Biomedical Science and Environmental Biology PhD Program in Life Sciences College of Life Science Kaohsiung Medical University Kaohsiung80708 Taiwan Graduate Institute of Medicine College of Medicine Kaohsiung Medical University Kaohsiung80708 Taiwan Department of Otorhinolaryngology-Head and Neck Surgery Fu Jen Catholic University Hospital Fu Jen Catholic University New Taipei City242062 Taiwan School of Medicine College of Medicine Fu Jen Catholic University New Taipei City242062 Taiwan Chinese Medicine Research and Development Center China Medical University Hospital Taichung404 Taiwan Graduate Institute of Integrated Medicine China Medical University Taichung404 Taiwan Drug Development and Value Creation Research Center Kaohsiung Medical University Kaohsiung807378 Taiwan Department of Medical Research Kaohsiung Medical University Hospital Kaohsiung Medical University Kaohsiung807378 Taiwan Department of Marine Biotechnology and Resources National Sun Yat-sen University Kaohsiung80424 Taiwan

Mechanochemical reactions achieved by processes such as milling and grinding are promising alternatives to traditional solution-based chemistry. This approach not only eliminates the need for large amounts of solvents, thereby reducing waste generation, but also finds applications in chemical and materials synthesis. The focus of this study is on the synthesis of quinazolinone derivatives by ball milling, in particular evodiamine and rutaecarpine analogues. These compounds are of interest due to their diverse bioactivities, including potential anticancer properties. The study examines the reactions carried out under ball milling conditions, emphasizing their efficiency in terms of shorter reaction times and reduced environmental impact compared to conventional methods. The ball milling reaction of evodiamine and rutaecarpine analogues resulted in yields of 63-78% and 22-61%, respectively. In addition, these compounds were tested for their cytotoxic activity, and evodiamine exhibited an IC50 of 0.75 ± 0.04 μg mL−1 against the Ca9-22 cell line. At its core, this research represents a new means to synthesise these compounds, providing a more environmentally friendly and sustainable alternative to traditional approaches. © 2024 The Royal Society of Chemistry.

关键词： Ball milling

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Active Degradation-Nitrification Microbial Assemblages in the Hypoxic Zone in a Subtropical Estuary

SSRN

引用

SSRN 2022年

作者： Lu, Yanhong Cheung, Shunyan Koh, Xiu Pei Xia, Xiaomin Jing, Hongmei Lee, Puiyin Kao, Shuh-Ji Gan, Jianping Dai, Minhan Liu, Hongbin SZU-HKUST Joint PhD Program in Marine Environmental Science Shenzhen University Shenzhen China Department of Ocean Science The Hong Kong University of Science and Technology Hong Kong Division of Environment and Sustainability The Hong Kong University of Science and Technology Clear Water Bay Kowloon Hong Kong Key Laboratory of Tropical Marine Bio-resources and Ecology South China Sea Institute of Oceanology Chinese Academy of Sciences Guangzhou China CAS Key Laboratory for Experimental Study under Deep-sea Extreme Conditions Institute of Deep-sea Science and Engineering Chinese Academy of Sciences Sanya China State Key Laboratory of Marine Environmental Science Xiamen University China The Hong Kong University of Science and Technology Hong Kong

In 2017 summer, we observed a widespread bottom hypoxic zone at the lower estuary of the Pearl River estuary (PRE). We observed i) bacterial and AOA biomass accumulation, ii) oxygen consumption rates (respiration and nitrification) in the hypoxic zone. The potential microbial interaction of both oxygen-consuming microbes in the hypoxia remained unclear. To investigate the potential microbial interaction between AOA and heterotrophic bacteria in the hypoxic zone, we used bacterial and AOA communities (inferred from 16S rRNA gene and amoA gene, respectively) and multi-comparisons between the co-occurrence networks retrieved from DNA and RNA levels to reflect the pattern. We observed a highly diverse and active bacterial community in the hypoxia zone. The network topology revealed that Gammaproteobacteria, Bacteroidetes (Flavobacteriales), Alphaproteobacteria (Rhodobacterales and Rhodospirillales), Marinimicrobia, Cyanobacteria (Synechococcales), and AOA sublineages were module hubs and connectors, indicating that they were the keystone taxa of the microbial communities. The hub-subnetwork further showed robust co-occurrence between Gammaproteobacteria, Bacteroidetes (Flavobacteriales), Alphaproteobacteria (Rhodobacterales and Rhodospirillales), Marinimicrobia with AOA sublineages, and Nitrospinae (presumably NOB)) reflecting the formation of Degradation-Nitrification microbial assemblage in the hypoxia zone. The subnetworks revealed AOA ecotype-specific modularization and niche partitioning of different AOA sublineages. Interestingly, the recurring co-occurrence of SCM1-like II sublineages with Nitrospinae OTUs formed nitrifiers assemblage in the RNA subnetworks suggested an interaction via nitrite exchange. The Degradation-Nitrification microbial assemblage may contribute substantially to the oxygen consumption in the hypoxia formation in PRE. Our results provide new insight into the nitrifier-associated microbial assemblage that should be further explored in the mar

关键词： Bacteria

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The environmental challenges of urban living: Why willingness to pay for apartments matters

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environmental Challenges 2023年 13卷

作者： Tehupeiory, Aarce Mulyana, Rachmat Sianipar, Imelda Masni Juniaty Suryawan, I Wayan Koko Septiariva, Iva Yenis Prayogo, Wisnu Doctor of Law Program Universitas Kristen Indonesia Jakarta Cawang 13630 Indonesia Department of Building Engineering Education Universitas Negeri Medan Medan Indonesia PhD Student in Asia-Pacific Regional Studies College of Humanities and Social Sciences National Dong Hwa University Hualien 974 Taiwan Department of International Relations Faculty of Social Science and Political Science Universitas Kristen Indonesia Jakarta 13630 Indonesia Department of Environmental Engineering Faculty of Infrastructure Planning Universitas Pertamina Jakarta 12220 Indonesia Civil Engineering Study Program Faculty of Engineering Universitas Sebelas Maret Surakarta 57126 Indonesia

This study aims to understand the willingness of urban communities in Jabodetabek (Jakarta, Bogor, Depok, Tangerang, Bekasi) to move to apartment dwellings, and a study was conducted using a quantitative survey method. The study aimed to analyze the sociodemographic factors influencing the decision to switch to vertical housing. The survey collected data from a sample of individuals representing the entire population in Jabodetabek. The participants in the study were selected from various locations within Jabodetabek, including Jakarta, Bogor, Depok, Tangerang, and Bekasi. These areas were chosen to comprehensively represent the metropolitan region and its urban communities. By including participants from different locations within Jabodetabek, the study aimed to capture individuals' diverse perspectives and experiences in this region. The survey covered a range of sociodemographic factors such as gender, income, education level, marital status, occupancy, and residence ownership. The participants were divided into two groups: those willing to pay for an apartment and those who wereilling to pay for an apartment and those not. By comparing the characteristics of these two groups, the study aimed to identify significant differences and understand the factors influencing the willingness to move to apartment dwellings. The study results showed significant differences in income level, education level, marital status, and occupancy between the two groups. Income level was the most significant factor affecting an individual's willingness to pay for an apartment. Additionally, the perception of better apartment productivity, which includes reduced transportation time and costs associated with work or other business purposes, increased the demand for apartments. The study found that income level was the most significant factor affecting an individual's willingness to pay for an apartment. The perception of better apartment productivity also increased demand for apartments,

关键词： Apartments Better productivity Jabodetabek Metropolitan cities Sociodemographics Willingness to Pay

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Bulk passivation of perovskite films utilizing halide anion ionic liquids

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International Journal of Thermofluids 2023年 20卷

作者： Alashkar, Adnan Ayoub, Mohamad Ibrahim, Taleb Khamis, Mustafa Nancarrow, Paul Alami, Abdul Hai Tabet, Nouar PhD Program in Materials Science and Engineering American University of Sharjah Sharjah 26666 United Arab Emirates Sustainable and Renewable Energy Engineering Department University of Sharjah Sharjah 27272 United Arab Emirates Sustainable Energy & Power Systems Research Centre RISE University of Sharjah Sharjah 27272 United Arab Emirates Department of Chemical Engineering American University of Sharjah Sharjah 26666 United Arab Emirates Department of Biology Chemistry and Environmental Sciences College of Arts and Sciences American University of Sharjah Sharjah 26666 United Arab Emirates Center for Advanced Materials Research Research Institute of Science and Engineering University of Sharjah Sharjah 27272 United Arab Emirates Department of Applied Physics and Astronomy University of Sharjah Sharjah 27272 United Arab Emirates

Chemical additives to perovskite precursors constitute a predominant route to passivate defects in perovskite films and improve carrier charge dynamics. In this work, ionic liquids (ILs) with chloride and iodide anions are used as additives for bulk passivation of perovskite films. The ionic liquids in the form of 1‑butyl‑4-methylpyradinium iodide (IL-I) and 1-ethylimidazolium chloride (IL-Cl) are mixed individually with a precursor of Cesium Formamidinium Lead Triiodide and Methylammonium Chloride (CsFAPbI3−MACl). The decay of charge carriers within the perovskite film before and after passivation with ILs was measured by Time Resolved Photoluminescence Spectroscopy (TRPL). The effect of added ILs on the recombination rate of the photocarriers was investigated by analyzing the decay of the TRPL signal in all samples. The average lifetimes obtained within one day of preparations were 79 ns, 73 ns and 275 ns for pristine perovskite, IL-I passivated perovskite and IL-Cl passivated perovskite films, respectively. These values show that the presence of the IL with chloride anion greatly improves the average lifetime of the charge carrier by around 250%, while IL with iodide anion decreased the lifetime by 32% as compared with the pristine perovskite sample. This finding renders the IL-Cl passivated perovskite films as a valuable resource in applications ranging from photoelectric to hydrogen generation devices. © 2023

关键词： Ionic liquids

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Piezoelectric and triboelectric nanogenerators: Promising technologies for self-powered implantable biomedical devices

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Nano Energy 2024年 119卷

作者： Khan, Arshad Joshi, Ravindra Sharma, Manish Kumar Ganguly, Anindita Parashar, Parag Wang, Ting-Wei Lee, Sangmin Kao, Fu-Cheng Lin, Zong-Hong Department of Biomedical Engineering National Taiwan University Taipei10167 Taiwan International Intercollegiate PhD Program National Tsing Hua University Hsinchu30013 Taiwan Department of Power Mechanical Engineering National Tsing Hua University Hsinchu30013 Taiwan Department of Materials Science and Engineering National Tsing Hua University Hsinchu30013 Taiwan Internet of Senses Research Center National Tsing Hua University Hsinchu30013 Taiwan Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University Hsinchu30013 Taiwan School of Mechanical Engineering Chung-Ang University Seoul06974 Korea Republic of Department of Orthopaedic Surgery Chang Gung Memorial Hospital Taoyuan33305 Taiwan College of Medicine Chang Gung University Taoyuan33302 Taiwan Department of Chemical Engineering National Taiwan University Taipei10167 Taiwan

Implantable biomedical devices (IBDs) have garnered wide-scale attention in recent years due to their enormous contribution to the biomedical sector. However, an uninterrupted and reliable power source has consistently been the primary barrier for IBDs, which is greatly alleviated by batteries. The widespread application of battery-powered IBDs is hindered by several limitations, including bulkiness, limited capacity and shelf-life, and expenditure associated with surgery-based battery recharge/replacement. To address these challenges, state-of-the-art self-powering technologies have emerged, including implantable piezoelectric nanogenerators (iPENGs) and implantable triboelectric nanogenerators (iTENGs). These technologies enable IBDs to operate autonomously by harnessing the minute mechanical movements of internal organs, such as heartbeat, respiration, blood circulation, muscle contraction/relaxation, and lung vibration. This review focuses on the recent advancements in iTENGs and iPENGs for the development of self-powered IBDs with a wide range of applications, including energy harvesting from biomechanical and ultrasound sources and energy storage using batteries and capacitors. This study also explores the extensive sensing applications of IBDs in various areas including cardiac, gastrointestinal, bladder, and ligament-strain monitoring. Finally, therapeutic applications of IBDs, such as nerve stimulation, bone stimulation, cartilage therapy, tissue regeneration, muscle stimulation, drug delivery, and diabetes management are discussed. © 2023 Elsevier Ltd

关键词： Nanogenerators

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